| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huma Ikram, Rumaisa Zakir, Darakhshan Jabeen Halee. Memory enhancing and neuroprotective effects of apomorphine in a rat model of dementia. Metabolic brain disease. 2024-06-19. PMID:38896206. |
to monitor memory enhancing and neuroprotective effects of apomorphine, we determined the antioxidant enzymes activities, lipid peroxidation, acetylcholine esterase (ache) activity in brain and plasma, following repetitive administration of apomorphine in rat model of dementia. |
2024-06-19 |
2024-06-21 |
rat |
| Liyuan Guo, Zelei Chang, Jianbo Tong, Peng Gao, Yakun Zhang, Yuan Liu, Yulu Yang, Chunying Wan. Design of vilazodone-donepezil chimeric derivatives as acetylcholinesterase inhibitors by QSAR, molecular docking and molecular dynamics simulations. Physical chemistry chemical physics : PCCP. 2024-06-19. PMID:38896464. |
acetylcholinesterase (ache) can increase acetylcholine concentrations and improve cognitive function in patients, and is a potential target to develop small molecule inhibitors for the treatment of alzheimer's disease (ad). |
2024-06-19 |
2024-06-21 |
Not clear |
| Yashika Sarangle, Kiran Bamel, Ram Singh Purt. Role of acetylcholine and acetylcholinesterase in improving abiotic stress resistance/tolerance. Communicative & integrative biology. vol 17. issue 1. 2024-06-03. PMID:38827581. |
acetylcholine hydrolyzing enzyme acetylcholinesterase (ache) belongs to the gdsl lipase/acylhydrolase protein family and has been found in several plant species. |
2024-06-03 |
2024-06-05 |
Not clear |
| Haiyan Hao, Ailong Sh. Study on Anti-fatigue Effects and Mechanisms of Polysaccharide from Paris polyphylla. Doklady. Biochemistry and biophysics. vol 516. issue 1. 2024-05-25. PMID:38722403. |
the effects of pppm-1 on the contents of blood lactate, serum urea nitrogen, hepatic glycogen, muscle glycogen in the exercise fatigue model of mice, and acetylcholine (ach) content and acetylcholinesterase (ache) activity at the junction of the frog sciatic nerve-gastrocnemius under normal physiological, and na |
2024-05-25 |
2024-05-27 |
mouse |
| Yuxin Zhang, Xiaoqing Pei, Lingyang Jing, Qingyu Zhang, Hongfeng Zha. Lead induced cerebellar toxicology of developmental Japanese quail (Coturnix japonica) via oxidative stress-based Nrf2/Keap1 pathway inhibition and glutathione-mediated apoptosis signaling activation. Environmental pollution (Barking, Essex : 1987). vol 352. 2024-05-10. PMID:38718965. |
moreover, cerebellar neurotransmission was disturbed by pb with increasing acetylcholine (ach) and decreasing acetylcholinesterase (ache), dopamine (da), γ-aminobutyric acid (gaba) and na |
2024-05-10 |
2024-05-27 |
Not clear |
| Dayan Liu, Tao Song, Kang Na, Shudong Wan. PED: a novel predictor-encoder-decoder model for Alzheimer drug molecular generation. Frontiers in artificial intelligence. vol 7. 2024-05-01. PMID:38690194. |
acetylcholinesterase (ache) is an efficient hydrolase that catalyzes the hydrolysis of acetylcholine (ach), which regulates the concentration of ach at synapses and then terminates ach-mediated neurotransmission. |
2024-05-01 |
2024-05-03 |
Not clear |
| Qiyun Wu, Yingjie Xia, Maggie Suisui Guo, Tsz Yu Au, Gary K W Yuen, Ivan Kong, Zhengqi Wang, Yingyi Lin, Tina T X Dong, Karl W K Tsi. Acetylcholinesterase is regulated by exposure of ultraviolet B in skin keratinocytes: A potential inducer of cholinergic urticaria. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 9. 2024-05-01. PMID:38690717. |
this skin problem is hypothesized to be attributed to a reduced expression of acetylcholinesterase (ache), an enzyme responsible for hydrolyzing acetylcholine (ach). |
2024-05-01 |
2024-05-03 |
Not clear |
| Yating Wen, Weiqing Xu, Yu Wu, Yinjun Tang, Mingwang Liu, Meng Sha, Jinli Li, Runshi Xiao, Liuyong Hu, Yongxin Lin, Chengzhou Zhu, Wenling G. Bifunctional enzyme-mimicking metal-organic frameworks for sensitive acetylcholine analysis. Talanta. vol 275. 2024-04-27. PMID:38677169. |
leveraging this capability, we replaced ache and pod with mof-808/pt nps and constructed a biosensor for sensitive detection of acetylcholine (ach). |
2024-04-27 |
2024-04-30 |
Not clear |
| Juan David Villeda-González, José Luis Gómez-Olivares, Luis Arturo Baiza-Gutma. New paradigms in the study of the cholinergic system and metabolic diseases: Acetyl-and-butyrylcholinesterase. Journal of cellular physiology. 2024-04-12. PMID:38605655. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that belong to the neuromuscular cholinergic system, their main function is to hydrolyze the neurotransmitter acetylcholine (ach), through their hydrolysis these enzymes regulate the neuronal and neuromuscular cholinergic system. |
2024-04-12 |
2024-04-14 |
Not clear |
| Maciej Zadrozny, Patrycja Drapich, Anna Gasiorowska-Bien, Wiktor Niewiadomski, Charles R Harrington, Claude M Wischik, Gernot Riedel, Grazyna Niewiadomsk. Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model. Cells. vol 13. issue 7. 2024-04-12. PMID:38607082. |
immunohistochemical staining and quantification of choline acetyltransferase (chat), tyrosine kinase a (trka)-positive neurons and relative optical intensity (roi) for vesicular acetylcholine transporter (vacht), and acetylcholinesterase (ache) reactivity confirmed reversal of the diminished cholinergic phenotype of interneurons (nucleus accumbens, striatum) and projection neurons (medial septum, nucleus basalis magnocellularis) by hmtm, to a greater extent than by rivastigmine alone in l1 mice. |
2024-04-12 |
2024-04-14 |
mouse |
| Surbhi Jaiswal, Brijeshwar Singh, Isha Dhingra, Abhijeet Joshi, Prashant Kodgir. Bioremediation and Bioscavenging for elimination of Organophosphorus threats: An approach using enzymatic advancements. Environmental research. 2024-04-10. PMID:38599448. |
these compounds inhibit the action of the acetylcholinesterase enzyme (ache) by phosphorylation, which prevents the breakdown of acetylcholine (ach) neurotransmitters into choline and acetate. |
2024-04-10 |
2024-04-13 |
human |
| Jae Yeon Park, Seong Doo Kang, Yun Gon Son, Ju Yeon Kim, Gihwan Lee, Kwang Dong Kim, Sang Won Lee, Jeong Yoon Ki. Eucalyptus globulus leaf-isolated isorhapontin serves as a natural insecticide via acetylcholinesterase inhibition. Pesticide biochemistry and physiology. vol 200. 2024-04-08. PMID:38582576. |
acetylcholinesterase (ache) inhibitors cause insect death by preventing the hydrolysis of the neurotransmitter acetylcholine, which overstimulates the nervous system. |
2024-04-08 |
2024-04-10 |
Not clear |
| Zahra Nekoukar, Homa Talabaki, Zakaria Zakariaei, Mahdi Mesri, Hossein Azade. Management of organophosphorus poisoning and the role of magnesium sulfate: A scoping review of literature. Clinical and experimental emergency medicine. 2024-04-07. PMID:38583865. |
organophosphorus agents are easily absorbed via respiratory, gastrointestinal, and dermal routes, and inhibit the acetylcholine transferase enzyme (ache), which is responsible for the majority of toxicity caused by organophosphates in the body. |
2024-04-07 |
2024-04-10 |
Not clear |
| Zahra Nekoukar, Homa Talabaki, Zakaria Zakariaei, Mahdi Mesri, Hossein Azade. Management of organophosphorus poisoning and the role of magnesium sulfate: A scoping review of literature. Clinical and experimental emergency medicine. 2024-04-07. PMID:38583865. |
inhibition of ache results in the accumulation of acetylcholine (ach) in synapses and stimulation of cholinergic receptors. |
2024-04-07 |
2024-04-10 |
Not clear |
| Asmaa R Hashim, Dina W Bashir, Eman Rashad, Mona K Galal, Maha M Rashad, Heba M A Khalil, Nasrallah M Deraz, El-Gharbawy S . Neuroprotective Assessment of Betaine against Copper Oxide Nanoparticle-Induced Neurotoxicity in the Brains of Albino Rats: A Histopathological, Neurochemical, and Molecular Investigation. ACS chemical neuroscience. 2024-04-02. PMID:38564598. |
significant decrease in glutathione (gsh), and downregulation of acetylcholine esterase (ache), nuclear factor erythroid 2-like protein 2 (nrf-2), and superoxide dismutase (sod). |
2024-04-02 |
2024-04-05 |
rat |
| Xiujuan Huang, Yuanyuan Cheng, Qi Zhou, Yifeng Tu, Jilin Ya. A simple fluorescence detection of acetylcholinesterase with peroxidase-like catalysis from iodide. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. vol 313. 2024-03-15. PMID:38490124. |
acetylcholinesterase (ache) is an important enzyme in the central and peripheral nervous system that regulates the balance of the neurotransmitter acetylcholine. |
2024-03-15 |
2024-03-18 |
Not clear |
| Anantha Krishnan Dhanabalan, Praveen Kumar, Saranya Vasudevan, Arkadiusz Chworos, Devadasan Velmuruga. Identification of a novel drug molecule for neurodegenerative disease from marine algae through Journal of biomolecular structure & dynamics. 2024-03-08. PMID:38456260. |
identification of a novel drug molecule for neurodegenerative disease from marine algae through cognitive functions are lost due to the rapid hydrolysis of acetylcholine including acetylcholinesterase (ache) and butyrylcholinesterase (bche). |
2024-03-08 |
2024-03-10 |
Not clear |
| Bichu Cheng, Qi Wang, Yi An, Fener Che. Recent advances in the total synthesis of galantamine, a natural medicine for Alzheimer's disease. Natural product reports. 2024-03-07. PMID:38450550. |
covering: 2006 to 2023(-)-galantamine is a natural product with distinctive structural features and potent inhibitory activity against acetylcholine esterase (ache). |
2024-03-07 |
2024-03-09 |
Not clear |
| Mennat-Allah M Hassan, Sara A Wahdan, Reem N El-Naga, Tamer M Abdelghany, Ebtehal El-Demerdas. Ondansetron attenuates cisplatin-induced behavioral and cognitive impairment through downregulation of NOD-like receptor inflammasome pathway. Toxicology and applied pharmacology. 2024-03-04. PMID:38437957. |
it increased the acetylcholine (ach) level and decreased the level of the acetylcholine esterase enzyme (ache). |
2024-03-04 |
2024-03-07 |
rat |
| Gasmelseed Y Ahmed, Ahmed A Osman, Ahlam Mukhta. Acetylcholinesterase enzyme among cancer patients a potential diagnostic and prognostic indicator a multicenter case-control study. Scientific reports. vol 14. issue 1. 2024-03-01. PMID:38429330. |
acetylcholinesterase enzyme (ache) activity is impaired by a variety of inhibitors including organophosphorus pesticides, leading to the accumulation of acetylcholine. |
2024-03-01 |
2024-03-04 |
human |