| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi-Long Lu, Jing Su, Jian-Wei Li, Wen-Rong X. A molecular container providing supramolecular protection against acetylcholine hydrolysis. Organic & biomolecular chemistry. 2024-02-07. PMID:38323382. |
our study revealed highly efficient host-guest interactions with a binding ratio of 1 : 3, resulting in a significant reduction in acetylcholine hydrolysis from 91.1% to 7.4% in the presence of ache under otherwise identical conditions. |
2024-02-07 |
2024-02-09 |
Not clear |
| Keisuke Obara, Haruka Mori, Suzune Ihara, Kento Yoshioka, Yoshio Tanak. Inhibitory Actions of Antidepressants, Hypnotics, and Anxiolytics on Recombinant Human Acetylcholinesterase Activity. Biological & pharmaceutical bulletin. vol 47. issue 1. 2024-02-06. PMID:38296462. |
if these drugs also inhibit acetylcholinesterase (ache) activity, they may contribute to the suppression of ad progression by increasing brain acetylcholine concentrations. |
2024-02-06 |
2024-02-09 |
human |
| Rafal Madaj, Bartłomiej Gostyński, Arkadiusz Chworos, Marek Cypry. Novichok Nerve Agents as Inhibitors of Acetylcholinesterase-In Silico Study of Their Non-Covalent Binding Affinity. Molecules (Basel, Switzerland). vol 29. issue 2. 2024-01-23. PMID:38257251. |
quantum mechanical calculations, molecular docking, and molecular dynamics (md) with molecular mechanics generalized-born surface area (mm/gbsa) were applied to assess quantitatively differences between the binding energies of acetylcholine (ach; the natural agonist of ache) and neurotoxic, synthetic correlatives (so-called "novichoks", and selected compounds from the g- and v-series). |
2024-01-23 |
2024-01-25 |
Not clear |
| Abraham Asuk. Neuroprotective Effects of Virgin Coconut Oil Supplemented Diet against Sodium Benzoate-induced Acetylcholinesterase Dysfunction and Cognitive Impairment: Role of Nrf2/NfKb Signaling Pathway. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria. vol 37. issue 2. 2024-01-20. PMID:38243570. |
the brain was processed for nrf-2, nf-kb, and acetylcholine esterase (ache) gene expression levels. |
2024-01-20 |
2024-01-22 |
rat |
| Ahlam H Mahmoud, Doaa M Elhefnawei, Mohamed A El-Desouky, Mai O Kadr. Reciprocal crosslink among MeCP2/BDNF /CREB signaling pinpointed in autism spectrum disorder. Toxicology reports. vol 12. 2024-01-17. PMID:38229920. |
the neurotransmitters gamma amino-butyric acid (gaba), acetylcholine (ach), and acetylcholinesterase (ache) in addition to, the gene expressions of brain-derived neurotrophic factor (bdnf), camp response element-binding protein (creb), and methyl-cpg-binding protein 2 (mecp2) and the dna damage comet analysis at different time intervals of the study, were assessed. |
2024-01-17 |
2024-01-19 |
rat |
| Ashwaq H Bataw. The International journal of neuroscience. vol 134. issue 1. 2024-01-16. PMID:35634646. |
alzheimer's disease (ad) appears as a result of an increase in the accumulation of amyloid beta peptide (aβ) and a decrease in neurotransmitters (acetylcholine) within the brain cells which may be due to increase in acetylcholinesterase (ache) activity and change in expression of apolipoprotein e4 (apoe4) and clusterin (clu) genes. |
2024-01-16 |
2024-01-19 |
Not clear |
| Wenkai Chen, Jun Dou, Xueying Xu, Ximeng Ma, Jiying Chen, Xiangjiang Li. β-cyclocitral, a novel AChE inhibitor, contributes to the defense of Microcystis aeruginosa against Daphnia grazing. Journal of hazardous materials. vol 465. 2023-12-26. PMID:38147752. |
it could induce the accumulation of acetylcholine (ach) by inhibiting ache activity in d. sinensis. |
2023-12-26 |
2023-12-29 |
Not clear |
| Géssica Oliveira Mendes, Moysés Fagundes de Araújo Neto, Deyse Brito Barbosa, Mayra Ramos do Bomfim, Lorena Silva Matos Andrade, Paulo Batista de Carvalho, Tiago Alves de Oliveira, Daniel Luciano Falkoski, Eduardo Habib Bechelane Maia, Marcelo Siqueira Valle, Laila Cristina Moreira Damázio, Alisson Marques da Silva, Alex Gutterres Taranto, Franco Henrique Andrade Leit. Identification of Potential Multitarget Compounds against Alzheimer's Disease through Pharmacophore-Based Virtual Screening. Pharmaceuticals (Basel, Switzerland). vol 16. issue 12. 2023-12-23. PMID:38139772. |
this study aims to present new multipurpose compounds capable of simultaneously inhibiting acetylcholinesterase (ache), butyrylcholinesterase (bche)-responsible for recycling acetylcholine in the synaptic cleft-and beta-secretase 1 (bace-1)-responsible for the generation of amyloid-β plaques. |
2023-12-23 |
2023-12-25 |
Not clear |
| Sandeep Kour, Nancy Sharma, Randeep Singh, Sumit G Gandhi, Puja Ohr. Metarhabditis amsactae: A Potential Biopesticide Isolated from Punjab (India) with Potent Insecticidal Activity and Immunomodulatory Effects against Galleria mellonella (Lepidoptera: Pyralidae). Journal of invertebrate pathology. 2023-12-22. PMID:38135246. |
to evaluate the immunomodulatory effects of m. amsactae, g. mellonella larvae were infected with 100 ijs/l and activities of antioxidant and detoxifying enzymes viz., superoxide dismutase (sod), catalase (cat), ascorbate peroxidase (apox), phenol oxidase (po), glutathione-s-transferase (gst) and acetylcholine esterase (ache) were appraised after 12, 24, 36 and 48h of nematode exposure. |
2023-12-22 |
2023-12-25 |
cat |
| Hussian Maanaki, Terry Xu, Guibing Chen, Xiuxia Du, Jun Wan. Development of integrated smartphone/resistive biosensor for on-site rapid environmental monitoring of organophosphate pesticides in food and water. Biosensors & bioelectronics: X. vol 15. 2023-12-21. PMID:38124900. |
the biosensor leverages the hydrolytic activity of acetylcholinesterase (ache) to its substrate, acetylcholine (ach), and unique transport properties of polyaniline nanofibers (pannfs) of chitosan/ache/pannf/carbon nanotube (cnt) nanocomposite film on a gold interdigitated electrode. |
2023-12-21 |
2023-12-23 |
Not clear |
| Bing Zhang, Yu Wang, Donghui Wu, Qilin Zhao, Yaoyao Chen, Yushu Li, Jian Sun, Xiurong Yan. Fluorescent assay for acetylcholinesterase activity and inhibitor screening based on lanthanide organic/inorganic hybrid materials. Analytical methods : advancing methods and applications. 2023-12-20. PMID:38116865. |
it is of great significance for the clinical diagnosis of alzheimer's disease (ad) to achieve the on-site activity evaluation of acetylcholinesterase (ache), the hydrolase of acetylcholine (ach). |
2023-12-20 |
2023-12-23 |
Not clear |
| João P C Veras, Victor L B França, Hernandes F Carvalho, Valder N Freir. Noncovalent binding of carbofuran to acetylcholinesterase from Homo sapiens, Danio rerio, Apis mellifera and Caenorhabditis elegans: Homology modelling, molecular docking and dynamics, and quantum biochemistry description. Chemico-biological interactions. 2023-12-15. PMID:38101596. |
this pesticide is a potent inhibitor of acetylcholinesterase (ache), which acts by preventing the hydrolysis of acetylcholine (ach). |
2023-12-15 |
2023-12-18 |
human |
| Narayanarao Alla, Sujatha Palatheeya, Siva Reddy Challa, Ramakrishna Kakarl. Tangeretin confers neuroprotection, cognitive and memory enhancement in global cerebral ischemia in rats. 3 Biotech. vol 14. issue 1. 2023-12-11. PMID:38074289. |
further, acetylcholine esterase (ache) enzyme activity, acetylcholine (ach), oxidative stress markers (ros, sod, mda, and cat), inflammation (il-6 and tnf-α), and apoptotic markers (cytochrome c, caspase 9, and caspase 3) in bccao rats were measured following tangeretin (5,10, and 20 mg/kg, oral) treatment. |
2023-12-11 |
2023-12-17 |
rat |
| Sneha Hariharan, Smarika Chauhan, Eswar Marcharla, Carlton Ranjith Wilson Alphonse, Rajesh Kannan Rajaretinam, Swamynathan Ganesa. Developmental toxicity and neurobehavioral effects of sodium selenite and selenium nanoparticles on zebrafish embryos. Aquatic toxicology (Amsterdam, Netherlands). vol 266. 2023-12-09. PMID:38070396. |
the nerve conductions and stimuli responses evaluated through acetylcholine esterase (ache) and cortisol assays, revealed a decrease in the activity in a dose-dependent manner of sodse and sens. |
2023-12-09 |
2023-12-17 |
zebrafish |
| Xiao Shi, Peng Liu, Yanyan Ma, Mingyuan Li, Zhenyu Zhang, Xinyue Zhang, Dahua Shi, Xinxin S. Identification of a 2-phenylthiazole derivative acetylcholinesterase modulator with in vitro antitumor activity in breast cancer cells. Chemical biology & drug design. 2023-11-27. PMID:38009562. |
acetylcholinesterase (ache) is a serine hydrolase with classical function to degrade acetylcholine and terminate neurotransmission. |
2023-11-27 |
2023-11-29 |
Not clear |
| Pavani K, D S N B K Prasanth, Murthy K R Shadakshara, Sheikh F Ahmad, Ramanjaneyulu Seemaladinne, Mithun Rudrapal, Praveen Kumar Pasal. Citronellal as a Promising Candidate for Alzheimer's Disease Treatment: A Comprehensive Study on In Silico and In Vivo Anti-Acetylcholine Esterase Activity. Metabolites. vol 13. issue 11. 2023-11-25. PMID:37999229. |
one of the primary therapeutic approaches for managing alzheimer's disease (ad) involves the modulation of acetylcholine esterase (ache) activity to elevate acetylcholine (ach) levels inside the brain. |
2023-11-25 |
2023-11-28 |
mouse |
| Showkat Ahmad Mir, Jamoliddin Razzokov, Vishwajeet Mukherjee, Iswar Baitharu, Binata Naya. An exploration of the binding prediction of anatoxin-a and atropine to acetylcholinesterase enzyme using multi-level computer simulations. Physical biology. 2023-11-14. PMID:37963412. |
acetylcholinesterase (ache) is crucial for the breakdown of acetylcholine to acetate and choline, while the inhibition of ache by anatoxin-a (atx-a) results in severe health complications. |
2023-11-14 |
2023-11-20 |
Not clear |
| Leila Vahdatiraad, Behrooz Heidari, Sevda Zarei, Tooraj Sohrabi, Hossein Ghafour. Protective effects of HSP Inducer on diazinon-exposed stellate sturgeon (Acipenser stellatus) fry: Insights on HSP70 gene expression, immune response, and enzyme indices. PloS one. vol 18. issue 11. 2023-11-13. PMID:37956191. |
to achieve this, several factors were analyzed, including the hsp70 gene expression, levels of immunity markers (lysozyme, igm, and c3), antioxidant status, and the activity of acetylcholine esterase (ache). |
2023-11-13 |
2023-11-20 |
cat |
| Ritu, Prakash Chandra, Asmita Da. "Cholinergic side Effect-Free anticancer drugs: paving the way for safer and more effective cancer treatment". Journal of biomolecular structure & dynamics. 2023-10-27. PMID:37885319. |
it appears that irinotecan or its metabolites directly interact with ache and inhibit its role of converting acetylcholine to choline, leading to an accumulation of acetylcholine and subsequent symptoms of the cholinergic syndrome. |
2023-10-27 |
2023-11-08 |
human |
| Sushil K Jain, Jeffrey Justin Margret, Marissa Lall. Positive association of acetylcholine esterase (AChE) with the neutrophil-to-lymphocyte ratio and HbA1c, and a negative association with hydrogen sulfide (H Free radical biology & medicine. 2023-10-22. PMID:37866755. |
positive association of acetylcholine esterase (ache) with the neutrophil-to-lymphocyte ratio and hba1c, and a negative association with hydrogen sulfide (h the incidence of alzheimer's disease (ad) is higher in people over the age of 65 and in african americans (aa). |
2023-10-22 |
2023-11-08 |
Not clear |