| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xianjuan Shen, Siyi Wang, Qian Lu, Yuehua Guo, Li Qia. Translating cancer exosomes detection into the color change of phenol red based on target-responsive DNA microcapsules. Analytica chimica acta. vol 1192. 2022-01-21. PMID:35057959. |
through a simple centrifugation separation, unreacted dna microcapsules were removed and the supernatant containing released acetylcholinesterase collected, which was then used for colorimetric exosomes detection through the ability of acetylcholinesterase to hydrolyze acetylcholine to release acetic acid. |
2022-01-21 |
2023-08-13 |
Not clear |
| Asmaa Magdy Zaazaa, Bosy Azmy Abd El-Motelp, Naglaa A Ali, Ahmed M Youssef, Mohamed Aly Sayed, Safaa H Mohame. Stem cell-derived exosomes and copper sulfide nanoparticles attenuate the progression of neurodegenerative disorders induced by cadmium in rats. Heliyon. vol 8. issue 1. 2022-01-14. PMID:35028441. |
however, the activities of each acetylcholine (ach), acetylcholinesterase (ache), total antioxidant status (tac) were measured. |
2022-01-14 |
2023-08-13 |
rat |
| Wei Li, Yikun Qi, Chuan Gao, Yucan Liu, Jinming Dua. A sensitive approach for screening acetylcholinesterase inhibition of water samples using ultra-performance liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 1190. 2022-01-14. PMID:35030473. |
a sensitive assay was developed to evaluate inhibitory effects of aqueous solution on acetylcholinesterase (ache) activity via measuring hydrolysis rates of acetylcholine (ach) based on ultra-performance liquid chromatography-tandem mass spectrometry (uplc-ms/ms). |
2022-01-14 |
2023-08-13 |
Not clear |
| Mingxian Lan, Xi Gao, Xiuan Duan, Hongmei Li, Hang Yu, Jinliang Li, Yueqin Zhao, Xiaojiang Hao, Yuhan Zhao, Xiao Ding, Guoxing W. Nematicidal activity of tirotundin and parthenolide isolated from Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2022-01-05. PMID:34983315. |
nematicidal activity of tirotundin and parthenolide isolated from acetylcholinesterase (ache) is an enzyme that catalyzes acetylcholine into choline and acetic acid. |
2022-01-05 |
2023-08-13 |
Not clear |
| Camila Fabiani, Brunella Biscussi, Juan Pablo Munafo, Ana Paula Murray, Jeremias Corradi, Silvia Susana Antollin. Molecular pharmacology. 2021-12-31. PMID:34969831. |
since cholinergic deficit is a major factor in this disease, two molecular targets for its treatment are the acetylcholinesterase (ache) and the nicotinic acetylcholine receptors (nachrs). |
2021-12-31 |
2023-08-13 |
Not clear |
| Luke Traeger, Hidde M Kroon, Sergei Bedrikovetski, James W Moore, Tarik Sammou. The impact of acetylcholinesterase inhibitors on ileus and gut motility following abdominal surgery: a clinical review. ANZ journal of surgery. 2021-12-20. PMID:34927331. |
acetylcholinesterase inhibitors, such as neostigmine and pyridostigmine, delay the degradation of acetylcholine at the synaptic cleft. |
2021-12-20 |
2023-08-13 |
Not clear |
| Kartheek Gavini, Euitaek Yang, Kodeeswaran Parameshwara. Developmental nicotine exposure impairs memory and reduces acetylcholine levels in the hippocampus of mice. Brain research bulletin. vol 176. 2021-12-10. PMID:34358612. |
furthermore, acetylcholine levels in the hippocampus of nicotine exposed mice were reduced along with reduced activity of acetylcholinesterase enzyme. |
2021-12-10 |
2023-08-13 |
mouse |
| Sumei Wang, Qian Zhao, Gaochun Li, Mengwei Wang, Hongliang Liu, Xingchen Yu, Jingwen Chen, Pei Li, Lixin Dong, Guoyu Zhou, Yushan Cui, Mengru Wang, Li Liu, Aiguo Wan. The cholinergic system, intelligence, and dental fluorosis in school-aged children with low-to-moderate fluoride exposure. Ecotoxicology and environmental safety. vol 228. 2021-12-07. PMID:34808511. |
cholinergic system was assessed by the detection of choline acetyltransferase (chat), acetylcholinesterase (ache) and acetylcholine (ach) levels in serum. |
2021-12-07 |
2023-08-13 |
Not clear |
| Shuaizhang Li, Andrew J Li, Jameson Travers, Tuan Xu, Srilatha Sakamuru, Carleen Klumpp-Thomas, Ruili Huang, Menghang Xi. Identification of Compounds for Butyrylcholinesterase Inhibition. SLAS discovery : advancing life sciences R & D. vol 26. issue 10. 2021-12-04. PMID:34269114. |
bche plays a critical role in maintaining normal cholinergic function like acetylcholinesterase (ache) through hydrolyzing acetylcholine (ach). |
2021-12-04 |
2023-08-13 |
Not clear |
| Niraj Kumar Singh, Debapriya Garabad. Quercetin Exhibits α7nAChR/Nrf2/HO-1-Mediated Neuroprotection Against STZ-Induced Mitochondrial Toxicity and Cognitive Impairments in Experimental Rodents. Neurotoxicity research. vol 39. issue 6. 2021-12-03. PMID:34554409. |
quercetin significantly mitigated the stz-induced increase in cholinergic dysfunction, such as the increase in acetylcholinesterase activity, decrease in acetylcholine level, and activity of choline acetyltransferase, and increase in amyloid-beta aggregation and mitochondrial toxicity in respect of mitochondrial bioenergetics, integrity, and oxidative stress in memory-challenged rat hippocampus, prefrontal cortex and, amygdala. |
2021-12-03 |
2023-08-13 |
rat |
| Ryohei Tanaka-Kanegae, Koichiro Hamad. A novel in vitro assay model developed to measure both extracellular and intracellular acetylcholine levels for screening cholinergic agents. PloS one. vol 16. issue 10. 2021-11-30. PMID:34637466. |
cholinergic neurons utilize choline (ch) to synthetize acetylcholine (ach) and contain a high-affinity ch transporter, ch acetyltransferase (chat), ach receptors, and acetylcholinesterase (ache). |
2021-11-30 |
2023-08-13 |
Not clear |
| Israel Silma. The multiple biological roles of the cholinesterases. Progress in biophysics and molecular biology. vol 162. 2021-11-25. PMID:33307019. |
the rapid hydrolysis of acetylcholine by acetylcholinesterase generates high local proton concentrations. |
2021-11-25 |
2023-08-13 |
Not clear |
| Sílvia Chaves, Katalin Várnagy, M Amélia Santo. Recent Multi-target Approaches on the Development of Anti- Alzheimer's Agents Integrating Metal Chelation Activity. Current medicinal chemistry. vol 28. issue 35. 2021-11-25. PMID:33602068. |
currently available drugs are used, mainly to compensate the decline of the neurotransmitter acetylcholine by acetylcholinesterase (ache) inhibition, though they only provide temporary symptomatic benefits and cannot stop ad progression. |
2021-11-25 |
2023-08-13 |
Not clear |
| Kazuhiro Murata, Naotaka Yoshikawa, Kanji Yoshimoto, Akira Namera, Haruo Takeshita, Masataka Naga. BIMP affects tubulin structure and causes abnormalities in cell division. Legal medicine (Tokyo, Japan). vol 53. 2021-11-25. PMID:34225093. |
these agents mainly irreversibly inhibit the action of acetylcholinesterase, an enzyme that breaks down acetylcholine, a neurotransmitter, and are believed to cause acute symptoms of poisoning. |
2021-11-25 |
2023-08-13 |
Not clear |
| Alastair J H Brown, Sophie J Bradley, Fiona H Marshall, Giles A Brown, Kirstie A Bennett, Jason Brown, Julie E Cansfield, David M Cross, Chris de Graaf, Brian D Hudson, Louis Dwomoh, João M Dias, James C Errey, Edward Hurrell, Jan Liptrot, Giulio Mattedi, Colin Molloy, Pradeep J Nathan, Krzysztof Okrasa, Greg Osborne, Jayesh C Patel, Mark Pickworth, Nathan Robertson, Shahram Shahabi, Christoffer Bundgaard, Keith Phillips, Lisa M Broad, Anushka V Goonawardena, Stephen R Morairty, Michael Browning, Francesca Perini, Gerard R Dawson, John F W Deakin, Robert T Smith, Patrick M Sexton, Julie Warneck, Mary Vinson, Tim Tasker, Benjamin G Tehan, Barry Teobald, Arthur Christopoulos, Christopher J Langmead, Ali Jazayeri, Robert M Cooke, Prakash Rucktooa, Miles S Congreve, Malcolm Weir, Andrew B Tobi. From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease. Cell. vol 184. issue 24. 2021-11-25. PMID:34822784. |
current therapies for alzheimer's disease seek to correct for defective cholinergic transmission by preventing the breakdown of acetylcholine through inhibition of acetylcholinesterase, these however have limited clinical efficacy. |
2021-11-25 |
2023-08-13 |
Not clear |
| Bhuvaneswari Sivaraman, Vijaykumar R, Bala Aakash Velmurugan, Ramalakshmi Nataraja. Acetylcholinesterase Enzyme Inhibitor Molecules with Therapeutic Potential for Alzheimer's Disease. CNS & neurological disorders drug targets. 2021-11-23. PMID:34602041. |
acetylcholinesterase (ache), hydrolase enzyme, regulates the hydrolysis of acetylcholine neurotransmitter in the neurons. |
2021-11-23 |
2023-08-13 |
Not clear |
| Palmer Taylor, Yan-Jye Shyong, Nathan Samskey, Kwok-Yiu Ho, Zoran Radic', William Fenical, K Barry Sharpless, Zrinka Kovarik, Gisela-Andrea Camacho-Hernande. Ligand design for human acetylcholinesterase and nicotinic acetylcholine receptors, extending beyond the conventional and canonical. Journal of neurochemistry. vol 158. issue 6. 2021-11-17. PMID:33638151. |
ligand design for human acetylcholinesterase and nicotinic acetylcholine receptors, extending beyond the conventional and canonical. |
2021-11-17 |
2023-08-13 |
mouse |
| Xiangguang Chen, Junyue Zheng, Miaomiao Teng, Jie Zhang, Le Qian, Manman Duan, Yi Cheng, Wentian Zhao, Zhao Wang, Chengju Wan. Tralopyril affects locomotor activity of zebrafish (Danio rerio) by impairing tail muscle tissue, the nervous system, and energy metabolism. Chemosphere. vol 286. issue Pt 3. 2021-11-17. PMID:34391112. |
in conjunction with the metabolomics results, changes in dopamine (da) and acetylcholine (ach), acetylcholinesterase (ache) activity, and the expression of genes involved in neurodevelopment, indicate that tp may disrupt the nervous system in zebrafish larvae. |
2021-11-17 |
2023-08-13 |
zebrafish |
| Vibhav Varshney, Debapriya Garabad. Ang (1-7)/Mas receptor-axis activation promotes amyloid beta-induced altered mitochondrial bioenergetics in discrete brain regions of Alzheimer's disease-like rats. Neuropeptides. vol 86. 2021-11-12. PMID:33508525. |
moreover, there was a significant increase in the level of aβ42, decrease in the cholinergic function (in terms of decreased acetylcholine and activity of cholinesterase, and increased activity of acetylcholinesterase), mitochondrial function, integrity and bioenergetics, and apoptosis in all the rat brain regions. |
2021-11-12 |
2023-08-13 |
rat |
| Jason M Kinchen, Robert P Mohney, Kirk L Pappa. Long-Chain Acylcholines Link Butyrylcholinesterase to Regulation of Non-neuronal Cholinergic Signaling. Journal of proteome research. 2021-11-11. PMID:34758617. |
acylcholines are metabolized by a class of cholinesterases, including acetylcholinesterase (a specific regulator of acetylcholine levels) and butyrylcholinesterase (bche, an enigmatic enzyme whose function has not been resolved by genetic knockout models). |
2021-11-11 |
2023-08-13 |
Not clear |