| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Asma Gholami, Dariush Minai-Tehrani, Leif A Eriksso. In silico and in vitro studies confirm Ondansetron as a novel acetylcholinesterase and butyrylcholinesterase inhibitor. Scientific reports. vol 13. issue 1. 2023-01-12. PMID:36635365. |
studies show that a lack of acetylcholine and butyrylcholine due to the overexpression of enzymes acetylcholinesterase (ache) and butyrylcholinesterase (bche) may lead to reduced communication between neuron cells. |
2023-01-12 |
2023-08-14 |
Not clear |
| Atilla Topcu, Sinan Saral, Aykut Ozturk, Ozlem Saral, Ali Koray Kay. The effect of the calcium channel blocker nimodipine on hippocampal BDNF/Ach levels in rats with experimental cognitive impairment. Neurological research. 2023-01-04. PMID:36598971. |
nimodipine appears to possess the potential to reverse cognitive impairment-induced dysfunction in learning and memory through its regulatory effect on the brain-derived neurotrophic factor (bdnf), acetylcholine (ach), and acetylcholinesterase (ache) pathway in the hippocampus and prefrontal cortex. |
2023-01-04 |
2023-08-14 |
rat |
| Aso Hameed Hasan, Sonam Shakya, Faiq H S Hussain, Sankaranarayanan Murugesan, Subhash Chander, Mohammad Rizki Fadhil Pratama, Shajarahtunnur Jamil, Basundhara Das, Subhrajit Biswas, Joazaizulfazli Jamali. Design, synthesis, anti-acetylcholinesterase evaluation and molecular modelling studies of novel coumarin-chalcone hybrids. Journal of biomolecular structure & dynamics. 2023-01-02. PMID:36591704. |
the major enzyme responsible for the hydrolytic breakdown of the neurotransmitter acetylcholine (ach) is acetylcholinesterase (ache). |
2023-01-02 |
2023-08-14 |
Not clear |
| Duraisamy Kempuraj, Eric Zhang, Suneel Gupta, Ramesh C Gupta, Nishant R Sinha, Rajiv R Moha. Carbofuran pesticide toxicity to the eye. Experimental eye research. 2022-12-26. PMID:36572166. |
carbofuran and its two major metabolites (3-hydroxycarbofuran and 3-ketocarbofuran) are reversible inhibitors of acetylcholinesterase (ache) which regulates acetylcholine (ach), a neurohumoral chemical that plays an important role in corneal wound healing. |
2022-12-26 |
2023-08-14 |
human |
| Anastasia E Ibrahim, Henrik Ghantarchyan, Thucminh Le, Ankur Bhagat, Bahareh Maknouni, Sarkis Arabia. A Rare Presentation of Severe Organophosphate Poisoning: A Case Report and Review of Literature. Cureus. vol 14. issue 11. 2022-12-19. PMID:36532913. |
organophosphates are chemicals commonly used as pesticides and work to inhibit acetylcholinesterase, leading to acetylcholine build up at muscarinic and nicotinic receptors throughout the body. |
2022-12-19 |
2023-08-14 |
Not clear |
| Ashish Patel, Drashti Shah, Yug Patel, Stuti Patel, Meshwa Mehta, Tushar Bambharoliy. A Review on Recent Development of Novel Heterocycles as Acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Current drug targets. 2022-12-14. PMID:36515018. |
acetylcholinesterase (ache) has obtained a renewed interest as a therapeutic target in alzheimer's disease (ad) due to increased neural cells' function by increasing the concentration of acetylcholine. |
2022-12-14 |
2023-08-14 |
Not clear |
| Erkan Kilinc, Ibrahim Ethem Torun, Yasemin Baranoglu Kilin. Meningeal mast cell-mediated mechanisms of cholinergic system modulation in neurogenic inflammation underlying the pathophysiology of migraine. The European journal of neuroscience. 2022-12-09. PMID:36485173. |
effects of cholinergic agents (acetylcholinesterase inhibitor neostigmine, or acetylcholine, and muscarinic antagonist atropine) and mast cell stabilizer cromolyn or their combinations were tested in the in-vivo and in-vitro experiments. |
2022-12-09 |
2023-08-14 |
rat |
| Zahra Abdulkarim Homoud, Muhammad Taha, Fazal Rahim, Naveed Iqbal, Muhammad Nawaz, Rai Khalid Farooq, Abdul Wadood, Munther Alomari, Imadul Islam, Shatha Algheribe, Ashfaq Ur Rehman, Khalid Mohammed Khan, Nizam Uddi. Synthesis of indole derivatives as Alzheimer inhibitors and their molecular docking study. Journal of biomolecular structure & dynamics. 2022-11-21. PMID:36404604. |
acetylcholinesterase prevails in the healthy brain, with butyrylcholinesterase reflected to play a minor role in regulating brain acetylcholine (ach) levels. |
2022-11-21 |
2023-08-14 |
Not clear |
| Nancy D Asen, Ogadimma D Okagu, Chibuike C Udenigwe, Rotimi E Aluk. Frontiers in nutrition. vol 9. 2022-11-07. PMID:36337665. |
compounds with structural similarities to the neurotransmitter (acetylcholine) are mostly used to inhibit the activity of acetylcholinesterase (ache) in alzheimer's disease (ad) therapy. |
2022-11-07 |
2023-08-14 |
Not clear |
| Zhikun Zhang, Liu Zhang, Ping Han, Qingju Li. A luminescent probe based on terbium-based metal-organic frameworks for organophosphorus pesticides detection. Mikrochimica acta. vol 189. issue 11. 2022-11-02. PMID:36319758. |
terbium-based metal-organic frameworks (tb-mof) prepared under mild conditions was utilized to construct a fluorescence probe for determination of organophosphorus pesticides (ops) coupled with acetylcholinesterase (ache), acetylcholine chloride (ach), and choline oxidase (cho). |
2022-11-02 |
2023-08-14 |
Not clear |
| Oksana Gerlits, Mikolai Fajer, Xiaolin Cheng, Donald K Blumenthal, Zoran Radić, Andrey Kovalevsk. Structural and dynamic effects of paraoxon binding to human acetylcholinesterase by X-ray crystallography and inelastic neutron scattering. Structure (London, England : 1993). 2022-10-20. PMID:36265484. |
organophosphorus (op) compounds, including nerve agents and some pesticides, covalently bind to the catalytic serine of human acetylcholinesterase (hache), thereby inhibiting acetylcholine hydrolysis necessary for efficient neurotransmission. |
2022-10-20 |
2023-08-14 |
human |
| Yueh-Ting Tsai, Shung-Te Kao, Chin-Yi Chen. Medicinal Herbs and Their Derived Ingredients Protect against Cognitive Decline in In Vivo Models of Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232612. |
this review delineates how in in vivo models mhdis suppress aβ deposition by downregulating β- and γ-secretase activities; inhibit oxidative stress by enhancing the antioxidant activities and reducing lipid peroxidation; prevent tau hyperphosphorylation by upregulating protein phosphatase 2a expression and downregulating glycogen synthase kinase-3β expression; reduce inflammatory mediators partly by upregulating brain-derived neurotrophic factor/extracellular signal-regulated protein kinase 1/2-mediated signaling and downregulating p38 mitogen-activated protein kinase (p38 mapk)/c-jun n-terminal kinase (jnk)-mediated signaling; attenuate synaptic dysfunction by increasing presynaptic protein, postsynaptic protein, and acetylcholine levels and preventing acetylcholinesterase activity; and protect against neuronal apoptosis mainly by upregulating akt/cyclic amp response element-binding protein/b-cell lymphoma 2 (bcl-2)-mediated anti-apoptotic signaling and downregulating p38 mapk/jnk/bcl-2-associated x protein (bax)/caspase-3-, bax/apoptosis-inducing factor-, c/ebp homologous protein/glucose-regulated protein 78-, and autophagy-mediated apoptotic signaling. |
2022-10-14 |
2023-08-14 |
Not clear |
| Teodorico C Ramalho, Alexandre A de Castro, Daniel H S Leal, Jessika P Teixeira, Elaine Fontes Ferreira de Cunha, Kamil Kuc. Assessing the therapeutic and toxicological profile of novel acetylcholinesterase reactivators: value of in silico and in vitro data. Current medicinal chemistry. 2022-10-14. PMID:36239718. |
these toxic substances act through the inhibition of the acetylcholinesterase (ache) enzyme, which results in elevated synaptic acetylcholine (ach) levels, leading to serious adverse effects under the cholinergic syndrome. |
2022-10-14 |
2023-08-14 |
Not clear |
| Qiaoya Ma, Chen Li, Ya He, Pan Liu, Fuhua Gong, Wanggang Zhan. Isorhapontigenin prevents β‑amyloid‑associated cognitive impairments through activation of the PI3K/AKT/GSK‑3β pathway. Acta neurobiologiae experimentalis. vol 82. issue 3. 2022-10-10. PMID:36214721. |
aβ1‑42 is significantly associated with memory deficits and it can increase the level of acetylcholine, promote the activity of acetylcholinesterase (ache), and cause cognitive dysfunction. |
2022-10-10 |
2023-08-14 |
rat |
| Fang Wang, Teng Jia, Yu Wang, Haiyuan Hu, Yuying Wang, Li Chang, Xiaojun Shen, Gaisheng Li. Polycyclic aromatic hydrocarbons exposure was associated with microRNA differential expression and neurotransmitter changes: a cross-sectional study in coal miners. Environmental science and pollution research international. 2022-09-26. PMID:36161575. |
compared to the low pah exposure group, the high-exposure group had higher levels of 5-hydroxytryptamine (5-ht), epinephrine (e), and acetylcholine (ach), and lower levels of acetylcholinesterase (ache). |
2022-09-26 |
2023-08-14 |
human |
| Muslum Gok, Cigdem Cicek, Suat Sari, Ebru Bodu. Novel activity of human BChE: Lipid hydrolysis. Biochimie. 2022-09-20. PMID:36126749. |
acetylcholinesterase and butyrylcholinesterase (bche) typically hydrolyze the neurotransmitter acetylcholine. |
2022-09-20 |
2023-08-14 |
human |
| Hafiz Muhammad Abdullah Asif, Shagufta Kamal, Aziz-Ur Rehman, Shahid Rasool, Muhammad Sajid Hamid Akas. Synthesis, Characterization, and Enzyme Inhibition Properties of 1,2,4-Triazole Bearing Azinane Analogues. ACS omega. vol 7. issue 36. 2022-09-19. PMID:36119993. |
considering the importance of acetylcholine esterase (ache, bche) and α-glucosidase in the treatment of alzheimer's disease and diabetes mellitus, the synthesis of novel azinane triazole-based derivatives as effective acetylcholinesterase (ache), α-glucosidase, urease, lipoxygenase (lox), and butyrylcholinesterase (bche) inhibitors is described. |
2022-09-19 |
2023-08-14 |
Not clear |
| Katelyn N Sette, Navatha Alugabelly, Lauren B Glenn, Shirley X Guo-Ross, M Katherine Parkes, Juliet R Wilson, Caitlin N Seay, Russell L Car. The Mechanistic Basis for the Toxicity Difference Between Juvenile Rats and Mice following Exposure to the Agricultural Insecticide Chlorpyrifos. Toxicology. 2022-09-12. PMID:36096317. |
at high exposure levels, organophosphorus insecticides (ops) exert their toxicity in mammals through the inhibition of brain acetylcholinesterase (ache) leading to the accumulation of acetylcholine in cholinergic synapses and hyperactivity of the nervous system. |
2022-09-12 |
2023-08-14 |
mouse |
| Farida Begum, Najeeb Ur Rehman, Ajmal Khan, Sajid Iqbal, Rehan Zafar Paracha, Jalal Uddin, Ahmed Al-Harrasi, Muhammad Arif Lodh. 2-Mercaptobenzimidazole clubbed hydrazone for Alzheimer's therapy: Frontiers in pharmacology. vol 13. 2022-09-05. PMID:36059999. |
it is a multifactorial disease, developed by the breakdown of the neurotransmitter acetylcholine via acetylcholinesterase (ache). |
2022-09-05 |
2023-08-14 |
Not clear |
| H F Seabra, A C Campello, E F G Chagas, L P A Martins, R B Suzuki, M O Ruiz, E A Donadi, W Baleot. The role of cholinesterases in chagas disease. Parasitology international. 2022-08-27. PMID:36029960. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) hydrolyze acetylcholine (ach) in neural synaptic clefts and are primarily found in erythrocytes and blood plasma, respectively. |
2022-08-27 |
2023-08-14 |
Not clear |