| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masato Mashimo, Koichiro Kawashima, Takeshi Fuji. Non-neuronal Cholinergic Muscarinic Acetylcholine Receptors in the Regulation of Immune Function. Biological & pharmaceutical bulletin. vol 45. issue 6. 2022-06-01. PMID:35650095. |
immune cells such as t and b cells, monocytes and macrophages all express most of the cholinergic components of the nervous system, including acetylcholine (ach), choline acetyltransferase (chat), high affinity choline transporter, muscarinic and nicotinic ach receptors (machrs and nachrs, respectively), and acetylcholinesterase (ache). |
2022-06-01 |
2023-08-13 |
Not clear |
| Tomasz Tuzimski, Anna Petruczyni. Determination of Anti-Alzheimer's Disease Activity of Selected Plant Ingredients. Molecules (Basel, Switzerland). vol 27. issue 10. 2022-05-28. PMID:35630702. |
one of the most important therapeutic strategies is controlling the level of acetylcholine-a neurotransmitter in cholinergic synapses-by blocking the degradation of acetylcholine using acetylcholinesterase inhibitors such as tacrine, galantamine, donepezil and rivastigmine. |
2022-05-28 |
2023-08-13 |
Not clear |
| Xiao Wang, Xuechuan Wang, Rong Feng, Tao Fu, Jie Zhang, Xiaolong Su. Recent advances of chemosensors for nerve agents. Chemistry, an Asian journal. 2022-05-22. PMID:35599234. |
nerve agents are a branch of organophosphorus (op) compounds that chemically cause irreversible inhibition of acetylcholinesterase, thereby failing the hydrolysis of acetylcholine, resulting in severe neurological disease and death in organisms. |
2022-05-22 |
2023-08-13 |
Not clear |
| Kritika Kumari, Laishram R Sing. Trimethylamine N-oxide might impair cholinergic system by affecting the structural integrity of Acetylcholinesterase. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35555536. |
acetylcholinesterase (ache) is an important enzyme responsible for the breakdown of neurotransmitter, acetylcholine and therefore plays a crucial role in neuronal plasticity. |
2022-05-13 |
2023-08-13 |
human |
| Aishwarya Sriraman, Hannah Lee, C L Cadieu. Effects of Both Inherent Chemical Structure and Environment Conditions on the Enzyme-Small Molecule Relationship of a Non-Oxime Reactivator of Organophosphorus-Inhibited Human Acetylcholinesterase. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35560488. |
organophosphorus (op) nerve agents and pesticides inhibit the enzyme acetylcholinesterase (ache) via a covalent interaction at the active site, resulting in a buildup of excess acetylcholine in the synaptic cleft. |
2022-05-13 |
2023-08-13 |
human |
| Mohadeseh Kalari, Zeinab Abbasi, Marzieh Dehghan Shasaltaneh, Ali Khaleghian, Zahra Moosavi-Neja. A Cobalt-Containing Compound as a Stronger Inhibitor than Galantamine to Inhibit Acetylcholinesterase Activity: A New Drug Candidate for Alzheimer's Disease Treatment. Journal of Alzheimer's disease : JAD. 2022-05-09. PMID:35527546. |
acetylcholinesterase (ache) regulates the transmission of neural messages by hydrolyzing acetylcholine in synaptic spaces. |
2022-05-09 |
2023-08-13 |
Not clear |
| Vasudevan Mani, Minhajul Arfeen, Sultan Sajid, Yasser Almogbe. Aqueous Ajwa dates seeds extract improves memory impairment in type-2 diabetes mellitus rats by reducing blood glucose levels and enhancing brain cholinergic transmission. Saudi journal of biological sciences. vol 29. issue 4. 2022-05-09. PMID:35531250. |
acetylcholine (ach) and acetylcholinesterase (ache) levels were estimated from brain homogenates to assess cholinergic transmission. |
2022-05-09 |
2023-08-13 |
rat |
| Rzgar Tawfeeq Kareem, Fahimeh Abedinifar, Evan Abdolkareem Mahmood, Abdol Ghaffar Ebadi, Fatemeh Rajabi, Esmail Vessall. The recent development of donepezil structure-based hybrids as potential multifunctional anti-Alzheimer's agents: highlights from 2010 to 2020. RSC advances. vol 11. issue 49. 2022-05-02. PMID:35498922. |
acetylcholinesterase inhibitors (achei) affect acetylcholine levels in the brain and are broadly used to treat alzheimer's. |
2022-05-02 |
2023-08-13 |
Not clear |
| Faheem Hyder Pottoo, Abdallah Mohammad Ibrahim, Ali Alammar, Rida Alsinan, Mahdi Aleid, Ali Alshehhi, Muruj Alshehri, Supriya Mishra, Noora Alhajr. Thymoquinone: Review of Its Potential in the Treatment of Neurological Diseases. Pharmaceuticals (Basel, Switzerland). vol 15. issue 4. 2022-04-23. PMID:35455405. |
tq has been shown in clinical studies to block acetylcholinesterase (ache) activity, which increases acetylcholine (ach). |
2022-04-23 |
2023-08-13 |
Not clear |
| Stephan Rudzki, Stephan Prae. Five-Year PTSD Symptom Remission in Two Patients Following Treatment With Rivastigmine. Military medicine. 2022-04-21. PMID:35446431. |
the beneficial effect of rivastigmine, an acetylcholinesterase inhibitor (achei), which increases levels of acetylcholine (ach), was first reported in 2013. |
2022-04-21 |
2023-08-13 |
Not clear |
| Sandra Carolina Durán-Cristian. Cholinesterase activity in the eye? Central nervous system agents in medicinal chemistry. 2022-04-18. PMID:35431003. |
on the other hand, acetylcholinesterase, the enzyme responsible for the hydrolysis of acetylcholine, is implicated in cholinergic function. |
2022-04-18 |
2023-08-13 |
Not clear |
| Mukesh K Dhillon, Jagdish Jaba, Pallavi Mishra, Mir Asif Iquebal, Sarika Jaiswal, Aditya K Tanwar, Nareshkumar Bharat, Naveen Arora, Suraj Prasad Mishra, Shyam Prasad Gogineni, Fazil Hasan, Anil Rai, Dinesh Kumar, Hari C Sharm. Whole genome sequencing of spotted stem borer, Chilo partellus, reveals multiple genes encoding enzymes for detoxification of insecticides. Functional & integrative genomics. 2022-04-15. PMID:35426546. |
also, target receptors related to insecticide action, 4 acetylcholinesterase (ache), 14 γ-aminobutyric acid (gaba), and 15 nicotinic acetylcholine (nachr) receptors were detected. |
2022-04-15 |
2023-08-13 |
Not clear |
| Congying Chen, Lingling Bu, Huan Liu, Yifeng Rang, Huiying Huang, Xueman Xiao, Genghua Ou, Chunhong Li. Learning and memory impairment induced by 1,4-butanediol is regulated by ERK1/2-CREB-BDNF signaling pathways in PC12 cells. Metabolic brain disease. 2022-03-29. PMID:35348994. |
assay kits results showed that 1,4-bd decreased the levels of glutathione (gsh), glutathione peroxidase (gsh-px), superoxide dismutase (sod), acetylcholine (ach) and increased the levels of malondialdehyde (mda), nitric oxide (no) and acetylcholinesterase (ache). |
2022-03-29 |
2023-08-13 |
Not clear |
| Feng Zhang, Sihui Li, Chao Liu, Kun Fang, Yongmei Jiang, Jianyong Zhang, Jie Lan, Lei Zhu, Hanqing Pang, Gang Wan. Rapid screening for acetylcholinesterase inhibitors in Selaginella doederleinii Hieron by using functionalized magnetic Fe Talanta. vol 243. 2022-03-07. PMID:35255433. |
rapid screening for acetylcholinesterase inhibitors in selaginella doederleinii hieron by using functionalized magnetic fe insufficient acetylcholine (ach) can cause cognitive and memory dysfunction, clinically known as, alzheimer's disease (ad). |
2022-03-07 |
2023-08-13 |
Not clear |
| Lukas G Schnitzler, Kathrin Baumgartner, Anna Kolb, Benedikt Braun, Christoph Westerhause. Acetylcholinesterase Activity Influenced by Lipid Membrane Area and Surface Acoustic Waves. Micromachines. vol 13. issue 2. 2022-02-25. PMID:35208411. |
according to the current model of nerve propagation, the function of acetylcholinesterase (ache) is to terminate synaptic transmission of nerve signals by hydrolyzing the neurotransmitter acetylcholine (ach) in the synaptic cleft to acetic acid (acetate) and choline. |
2022-02-25 |
2023-08-13 |
Not clear |
| Kalyani Bindu Karunakaran, Anand Thiyagaraj, Kirankumar Santhakuma. Novel insights on acetylcholinesterase inhibition by Convolvulus pluricaulis, scopolamine and their combination in zebrafish. Natural products and bioprospecting. vol 12. issue 1. 2022-02-25. PMID:35212831. |
acetylcholinesterase (ache) inhibitors increase the retention of acetylcholine (ach) in synapses. |
2022-02-25 |
2023-08-13 |
human |
| Xiyue Cao, Yanmei Guo, Mu Zhao, Jie Li, Chonglin Wang, Jianfei Xia, Tingting Zou, Zonghua Wan. An efficient multi-enzyme cascade platform based on mesoporous metal-organic frameworks for the detection of organophosphorus and glucose. Food chemistry. vol 381. 2022-02-17. PMID:35176684. |
and then three enzymes, including acetylcholinesterase, horseradish peroxidase and choline oxidase were encapsulated in cruciate flower-like zeolitic imidazolate framework-8 (cf-zif-8) through one-step co-precipitation to construct detection platform with acetylcholine chloride as substrate. |
2022-02-17 |
2023-08-13 |
Not clear |
| Jian Zhang, Jing Cao, Ailian Geng, Haihong Wang, Qin Chu, Zhixun Yan, Xiaoyue Zhang, Yao Zhang, Huagui Li. UHPLC-QTOF/MS-based comparative metabolomics in pectoralis major of fast- and slow-growing chickens at market ages. Food science & nutrition. vol 10. issue 2. 2022-02-14. PMID:35154685. |
in addition, the glycerophospholipid metabolism pathway was found to be associated with chicken meat flavor and the accumulation of sn-glycerol 3-phosphate and acetylcholine was more predominant in byc than that in cobb500, which were catalyzed by glycerophosphocholine phosphodiesterase (gpcpd1, ec:3.1.4.2), choline o-acetyltransferase (chat, ec:2.3.1.6), and acetylcholinesterase (ache, ec:3.1.1.7). |
2022-02-14 |
2023-08-13 |
chicken |
| Xian-Tao L. Alzheimer's disease therapy based on acetylcholinesterase inhibitor/blocker effects on voltage-gated potassium channels. Metabolic brain disease. 2022-01-31. PMID:35098414. |
to enhance the declined level of acetylcholine (ach) resulting from loss of cholinergic neurons, acetylcholinesterase (ache) inhibitors are developed and successfully approved for ad treatment in the clinic, with a limited therapeutic effectiveness. |
2022-01-31 |
2023-08-13 |
Not clear |
| Ankit Ganeshpurkar, Ravi Singh, Devendra Kumar, Pravin Gore, Shalini Shivhare, Divya Sardana, Swetha Rayala, Ashok Kumar, Sushil Kumar Sing. Identification of sulfonamide based butyrylcholinesterase inhibitors through scaffold hopping approach. International journal of biological macromolecules. 2022-01-29. PMID:35090939. |
butyrylcholinesterase (bche), a hydrolytic enzyme, is responsible for the termination of the action of acetylcholine besides acetylcholinesterase (ache) in the synaptic cleft of the brain. |
2022-01-29 |
2023-08-13 |
Not clear |