| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Spencer W Todd, Eric W Lumsden, Yasco Aracava, Jacek Mamczarz, Edson X Albuquerque, Edna F R Pereir. Gestational exposures to organophosphorus insecticides: From acute poisoning to developmental neurotoxicity. Neuropharmacology. vol 180. 2021-08-27. PMID:32814088. |
their broad-spectrum insecticidal effectiveness is accounted for by the irreversible inhibition of acetylcholinesterase (ache), the enzyme that catalyzes acetylcholine (ach) hydrolysis, in the nervous system of insects. |
2021-08-27 |
2023-08-13 |
Not clear |
| Xue-Lian Qi, Ruifeng Liu, Balbir Singh, David Bestue, Albert Compte, Almira I Vazdarjanova, David T Blake, Christos Constantinidi. Nucleus basalis stimulation enhances working memory by stabilizing stimulus representations in primate prefrontal cortical activity. Cell reports. vol 36. issue 5. 2021-08-27. PMID:34348147. |
cholinergic agonists and acetylcholinesterase inhibitors can enhance cognitive functioning, as does intermittent electrical stimulation of the cortical source of acetylcholine, the nucleus basalis (nb) of meynert. |
2021-08-27 |
2023-08-13 |
human |
| Liciane Fernandes Medeiros, Éllen Almeida Nunes, Bettega Costa Lopes, Andressa de Souza, Angélica Regina Cappellari, Joice Soares de Freitas, Isabel Cristina de Macedo, Jonnsin Kuo, Stefania Giotti Cioato, Ana Maria de Oliveira Battastini, Wolnei Caumo, Iraci L S Torre. Single exercise stress reduces central neurotrophins levels and adenosine A International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 80. issue 7. 2021-08-26. PMID:32798310. |
we also evaluated neurotrophins and cytokines levels; expressions of adenosine and acetylcholine receptors, and acetylcholinesterase enzyme at the spinal cord. |
2021-08-26 |
2023-08-13 |
rat |
| R M Foguth, T D Hoskins, G C Clark, M Nelson, R W Flynn, C de Perre, J T Hoverman, L S Lee, M S Sepúlveda, J R Canno. Single and mixture per- and polyfluoroalkyl substances accumulate in developing Northern leopard frog brains and produce complex neurotransmission alterations. Neurotoxicology and teratology. vol 81. 2021-08-20. PMID:32561179. |
dopamine and metabolites, serotonin and its metabolite, norepinephrine, γ-aminobutyric acid, and glutamate were quantified using high performance liquid chromatography with electrochemical detection while acetylcholine and acetylcholinesterase activity were quantified with the invitrogen amplex red acetylcholine assay. |
2021-08-20 |
2023-08-13 |
human |
| Meghan K Cash, Kenneth Rockwood, John D Fisk, Sultan Darves. Clinicopathological correlations and cholinesterase expression in early-onset familial Alzheimer's disease with the presenilin 1 mutation, Leu235Pro. Neurobiology of aging. vol 103. 2021-08-16. PMID:33789210. |
in sporadic alzheimer's disease (spad), acetylcholinesterase and butyrylcholinesterase, co-regulators of acetylcholine, are associated with β-amyloid plaques and tau neurofibrillary tangles in patterns suggesting a contribution to neurotoxicity. |
2021-08-16 |
2023-08-13 |
Not clear |
| Muskan Gori, Ashima Thakur, Abha Sharma, S J S Flor. Organic-Molecule-Based Fluorescent Chemosensor for Nerve Agents and Organophosphorus Pesticides. Topics in current chemistry (Cham). vol 379. issue 5. 2021-08-16. PMID:34346011. |
op compounds are highly toxic compounds that cause irreversible inhibition of enzyme acetylcholinesterase, which is essential for hydrolysis of neurotransmitter acetylcholine, leading to series of neurological disorders and even death. |
2021-08-16 |
2023-08-13 |
Not clear |
| Chonny Herrera-Acevedo, Camilo Perdomo-Madrigal, Kenyi Herrera-Acevedo, Ericsson Coy-Barrera, Luciana Scotti, Marcus Tullius Scott. Machine learning models to select potential inhibitors of acetylcholinesterase activity from SistematX: a natural products database. Molecular diversity. vol 25. issue 3. 2021-08-06. PMID:34132933. |
the enzyme acetylcholinesterase (ache) cleaves the ester bonds in acetylcholine and plays an important role in the termination of acetylcholine activity at cholinergic synapses in various regions of the nervous system. |
2021-08-06 |
2023-08-13 |
Not clear |
| Ümit M Koçyiğit, Hayreddin Gezegen, Parham Taslim. Synthesis, characterization, and biological studies of chalcone derivatives containing Schiff bases: Synthetic derivatives for the treatment of epilepsy and Alzheimer's disease. Archiv der Pharmazie. vol 353. issue 12. 2021-08-03. PMID:32815568. |
in addition, the inhibitory effects of the newly synthesized compounds on the activities of hca and acetylcholinesterase (ache) were investigated in vitro, using the esterase and acetylcholine iodide method. |
2021-08-03 |
2023-08-13 |
human |
| Irina Zueva, Oksana Lenina, Ramilya Kayumova, Konstantin Petrov, Patrick Masso. Protective effects of m-(tert-butyl) trifluoroacetophenone, a transition state analogue of acetylcholine, against paraoxon toxicity and memory impairments. Chemico-biological interactions. vol 345. 2021-08-02. PMID:34147486. |
m-(tert-butyl) trifluoroacetophenone (tfk), a slow-binding inhibitor of acetylcholinesterase (ache), a transition state analog of acetylcholine, was investigated as a potential neuroprotectant of central and peripheral ache against organophosphate paraoxon (pox) toxicity. |
2021-08-02 |
2023-08-13 |
mouse |
| Yati Sharma, Debapriya Garabad. Intracerebroventricular streptozotocin administration impairs mitochondrial calcium homeostasis and bioenergetics in memory-sensitive rat brain regions. Experimental brain research. vol 238. issue 10. 2021-07-28. PMID:32728854. |
further, icv-stz decreased the level of acetylcholine and activity of choline acetyltransferase and increased the activity of acetylcholinesterase in rat hippocampus, pre-frontal cortex and amygdala. |
2021-07-28 |
2023-08-13 |
rat |
| Immacolata Vecchio, Luca Sorrentino, Annamaria Paoletti, Rosario Marra, Mariamena Arbitri. The State of The Art on Acetylcholinesterase Inhibitors in the Treatment of Alzheimer's Disease. Journal of central nervous system disease. vol 13. 2021-07-22. PMID:34285627. |
one of the causes leading to ad is the decrease of neurotransmitter acetylcholine (ach) levels in the brain, in part due to a higher activity of acetylcholinesterase (ache), the enzyme responsible for its degradation. |
2021-07-22 |
2023-08-13 |
Not clear |
| S Altaf, F Muhammad, B Aslam, M N Faisa. Cell membrane enveloped polymeric nanosponge for detoxification of chlorpyrifos poison: In vitro and in vivo studies. Human & experimental toxicology. vol 40. issue 8. 2021-07-21. PMID:33583223. |
organophosphates are highly toxic compounds as they are involved in irreversible inhibition of acetylcholinesterase, causing various neurotoxic effects via acetylcholine accumulation throughout the nervous system. |
2021-07-21 |
2023-08-13 |
Not clear |
| Jan Bures, Ilja Tacheci, Jaroslav Kvetina, Vera Radochova, Darina Kohoutova, Martin Valis, Stanislav Rejchrt, Veronika Knoblochova, Jana Zdarova Karasov. Dextran Sodium Sulphate-Induced Gastrointestinal Injury Further Aggravates the Impact of Galantamine on the Gastric Myoelectric Activity in Experimental Pigs. Pharmaceuticals (Basel, Switzerland). vol 14. issue 6. 2021-07-14. PMID:34207410. |
it has a unique, dual mode of action (inhibitor of acetylcholinesterase and allosteric modulator of nicotinic acetylcholine receptors). |
2021-07-14 |
2023-08-13 |
Not clear |
| Wansiri Innok, Asadhawut Hiranrat, Netnapa Chana, Thanyada Rungrotmongkol, Panita Kongsun. In silico and in vitro anti-AChE activity investigations of constituents from Mytragyna speciosa for Alzheimer's disease treatment. Journal of computer-aided molecular design. vol 35. issue 3. 2021-07-13. PMID:33439402. |
acetylcholinesterase (ache), one of the major therapeutic strategies for the treatment of alzheimer's disease (ad) is to increase the acetylcholine (ach) level in the brain by inhibiting the biological activity of ache. |
2021-07-13 |
2023-08-13 |
Not clear |
| Kiran Bagri, Ashwani Kumar, Manisha, Parvin Kuma. Computational Studies on Acetylcholinesterase Inhibitors: From Biochemistry to Chemistry. Mini reviews in medicinal chemistry. vol 20. issue 14. 2021-07-12. PMID:31884928. |
acetylcholinesterase inhibitors are the most promising therapeutics for alzheimer's disease treatment as these prevent the loss of acetylcholine and slows the progression of the disease. |
2021-07-12 |
2023-08-13 |
Not clear |
| Miroslav Pohank. Pharmacological Influencing of The Cholinergic Anti-inflammatory Pathway in Infectious Diseases and Inflammatory Pathologies. Mini reviews in medicinal chemistry. vol 21. issue 6. 2021-07-12. PMID:33208075. |
it consists of terminations of the vagal nerve into blood, acetylcholine released from the terminations, macrophages and other cells having α7 nicotinic acetylcholine receptor (α7 nachr), calcium ions crossing through the receptor and interacting with nuclear factors, and erythrocytes with acetylcholinesterase (ache) terminating the neurotransmission. |
2021-07-12 |
2023-08-13 |
Not clear |
| Prabhat Upadhyay, Rashmi Shukla, Kavindra Nath Tiwari, G P Dubey, Sunil Kumar Mishr. Neuroprotective effect of Reinwardtia indica against scopolamine induced memory-impairment in rat by attenuating oxidative stress. Metabolic brain disease. vol 35. issue 5. 2021-07-09. PMID:32026225. |
acetylcholine levels, acetylcholinesterase (ache), antioxidant enzymes (sod, cat & gsh), histopathology of the brain and biochemical test were also performed at the end of the treatment period. |
2021-07-09 |
2023-08-13 |
rat |
| Cong Lu, Rongjing Gao, Jingwei Lv, Ying Chen, Shuying Li, Lijing Zhang, Nana Zhang, Yongquan Wang, Bei Fan, Xinmin Liu, Fengzhong Wan. Neuroprotective effects of soy isoflavones on chronic ethanol-induced dementia in male ICR mice. Food & function. vol 11. issue 11. 2021-07-07. PMID:33124635. |
si administration significantly improved the cognitive performance in the mwm and pa tests, regulated the acetylcholinesterase (ache) activity and acetylcholine (ach) level, elevated the synaptic plasticity-related protein expressions and inhibited neuron apoptosis-related protein expressions in the cortex and hippocampus of mice. |
2021-07-07 |
2023-08-13 |
mouse |
| Koichiro Yoshimaru, Yusuke Yanagi, Satoshi Obata, Yoshiaki Takahashi, Keiko Irie, Atsuko Omori, Toshiharu Matsuura, Tomoaki Taguch. Acetylcholinesterase staining for the pathological diagnosis of Hirschsprung's disease. Surgery today. vol 51. issue 2. 2021-07-05. PMID:32577882. |
since then, the combination of rectal mucosal biopsy and rubeanic acid-amplificated ache staining has been brought about by the following milestones: the discovery that the submucosal plexus and the intermuscular plexus had the same level of nerve migration; the findings of research on acetylcholine (ach) and acetylcholinesterase (ache) in the intestinal tract; and the establishment of a rubeanic acid amplification method. |
2021-07-05 |
2023-08-13 |
Not clear |
| Andrea Castaneda, Ricardo Ferraz, Mónica Vieira, Isabel Cardoso, Vitor Vasconcelos, Rosário Martin. Bridging Cyanobacteria to Neurodegenerative Diseases: A New Potential Source of Bioactive Compounds against Alzheimer's Disease. Marine drugs. vol 19. issue 6. 2021-07-05. PMID:34208482. |
in this review, we aimed to compile the research works focused in the anti-ad potential of cyanobacteria, namely regarding the inhibition of the enzyme β-secretase (bace1) as a fundamental enzyme in the generation of β-amyloid (aβ), the inhibition of the enzyme acetylcholinesterase (ache) lead to an increase in the availability of the neurotransmitter acetylcholine in the synaptic cleft and the antioxidant and anti-inflammatory effects, as phenomena associated with neurodegeneration mechanisms. |
2021-07-05 |
2023-08-13 |
Not clear |