| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hardeep Sandhu, Rajaram Naresh Kumar, Prabha Gar. Machine learning-based modeling to predict inhibitors of acetylcholinesterase. Molecular diversity. 2021-04-23. PMID:33891263. |
acetylcholinesterase enzyme is responsible for the degradation of acetylcholine and is an important drug target for the treatment of alzheimer's disease. |
2021-04-23 |
2023-08-13 |
Not clear |
| Megan Andrews, Babak Tousi, Marwan N Sabbag. 5HT6 Antagonists in the Treatment of Alzheimer's Dementia: Current Progress. Neurology and therapy. vol 7. issue 1. 2021-04-21. PMID:29728891. |
because they are pro-cholinergic, these medications are to be used as adjuncts to acetylcholinesterase inhibitors (such as donepezil), further increasing acetylcholine in the central nervous system (cns). |
2021-04-21 |
2023-08-13 |
Not clear |
| Theodore A Alsto. Eponymous plot of Richard J. Kitz and Irwin B. Wilson in biochemistry. Journal of anesthesia history. vol 6. issue 4. 2021-04-20. PMID:33674029. |
irwin b. wilson and anesthesiologist richard j. kitz found the enzyme acetylcholinesterase to be inactivated in two steps by covalently acting molecules resembling acetylcholine in structure. |
2021-04-20 |
2023-08-13 |
Not clear |
| Brenda M Marrero-Rosado, Michael F Stone, Marcio de Araujo Furtado, Caroline R Schultz, C Linn Cadieux, Lucille A Lumle. Novel Genetically Modified Mouse Model to Assess Soman-Induced Toxicity and Medical Countermeasure Efficacy: Human Acetylcholinesterase Knock-in Serum Carboxylesterase Knockout Mice. International journal of molecular sciences. vol 22. issue 4. 2021-04-19. PMID:33672922. |
cwnas bind to acetylcholinesterase and prevent the catalysis of acetylcholine, causing a plethora of peripheral and central physiologic manifestations, including seizure. |
2021-04-19 |
2023-08-13 |
mouse |
| Ana Matošević, Andreja Radman Kastelic, Ana Mikelić, Antonio Zandona, Maja Katalinić, Ines Primožič, Anita Bosak, Tomica Hrena. Quinuclidine-Based Carbamates as Potential CNS Active Compounds. Pharmaceutics. vol 13. issue 3. 2021-04-13. PMID:33804719. |
the treatment of central nervous system (cns) diseases related to the decrease of neurotransmitter acetylcholine in neurons is based on compounds that prevent or disrupt the action of acetylcholinesterase and butyrylcholinesterase. |
2021-04-13 |
2023-08-13 |
human |
| Laura Montali, Maria Maddalena Calabretta, Antonia Lopreside, Marcello D'Elia, Massimo Guardigli, Elisa Michelin. Multienzyme chemiluminescent foldable biosensor for on-site detection of acetylcholinesterase inhibitors. Biosensors & bioelectronics. vol 162. 2021-04-05. PMID:32452394. |
the rapid hydrolysis of acetylcholine (ach), one of the key neurotransmitters in the human body, by the enzyme acetylcholinesterase (ache) is fundamental for the termination of ach impulse transmission. |
2021-04-05 |
2023-08-13 |
human |
| Wen-Jun Gan, Chen-Lin Gao, Wen-Qian Zhang, Jun-Ling Gu, Ting-Ting Zhao, Heng-Li Guo, Hua Zhou, Yong Xu, Li-Li Yu, Li-Fang Li, Ding-Kun Gui, You-Hua X. Kuwanon G protects HT22 cells from advanced glycation end product-induced damage. Experimental and therapeutic medicine. vol 21. issue 5. 2021-03-23. PMID:33747164. |
both intracellular and extracellular levels of acetylcholine and choline acetyltransferase were significantly elevated after kwg administration in comparison with controls whilethe level of acetylcholinesterase decreased. |
2021-03-23 |
2023-08-13 |
mouse |
| Mousumi Patra, Milon Banik, Pathikrit Bandopadhyay, Debanjan Dutta, Riya Mukherjee, Sreeparna Das, Naznin Ara Begum, Tarakdas Bas. Nanonization of a chemically synthesized flavone HMDF (3-hydroxy-3',4'-methylenedioxyflavone) by entrapping within calcium phosphate nanoparticles and exploring its antioxidant role on neural cells in vitro and zebrafish in vivo. Nanotechnology. vol 32. issue 23. 2021-03-16. PMID:33724928. |
hmdf-cpnps, but not hmdf alone, inhibited the in vitro activity of acetylcholinesterase enzymes to break down the major neurotransmitter compound acetylcholine. |
2021-03-16 |
2023-08-13 |
mouse |
| Jason Kho, Adam Ioannou, Amit K J Mandal, Constantinos G Missouri. Donepezil induces ventricular arrhythmias by delayed repolarisation. Naunyn-Schmiedeberg's archives of pharmacology. vol 394. issue 3. 2021-03-11. PMID:33230575. |
acetylcholinesterase inhibitors such as donepezil delay the progression of alzheimer's dementia by increasing acetylcholine concentrations in the central nervous system. |
2021-03-11 |
2023-08-13 |
Not clear |
| A R Salem, P Martínez Pulido, F Sanchez, Y Sanchez, A J Español, M E Sale. Effect of low dose metronomic therapy on MCF-7 tumor cells growth and angiogenesis. Role of muscarinic acetylcholine receptors. International immunopharmacology. vol 84. 2021-03-10. PMID:32311671. |
the non-neuronal cholinergic system refers to the presence of acetylcholine, choline acetyltransferase, acetylcholinesterase and cholinergic receptors, nicotinic and muscarinic (machrs) expressed in non-neuronal cells. |
2021-03-10 |
2023-08-13 |
mouse |
| Wei Sun, Peidong Liu, Chunzhi Tang, Lei A. Melamine Disrupts Acetylcholine-Mediated Neural Information Flow in the Hippocampal CA3-CA1 Pathway. Frontiers in behavioral neuroscience. vol 15. 2021-03-10. PMID:33679339. |
the levels of acetylcholine (ach) and its esterolytic protease, acetylcholinesterase (ache), were detected in the hippocampus (hpc) following the behavioral test. |
2021-03-10 |
2023-08-13 |
rat |
| Dingkun Wang, Yanlin Ren, Wei Sun, Jing Gong, Xin Zou, Hui Dong, Lijun Xu, Kaifu Wang, Fuer L. Berberine Ameliorates Glucose Metabolism in Diabetic Rats through the alpha7 Nicotinic Acetylcholine Receptor-Related Cholinergic Anti-Inflammatory Pathway. Planta medica. 2021-03-08. PMID:33682914. |
treatment with berberine inhibited acetylcholinesterase activity, and upregulated acetylcholine levels in the serum and alpha7 nicotinic acetylcholine receptor gene expression in the liver tissue. |
2021-03-08 |
2023-08-13 |
rat |
| Hui Li, Wenhua Xu, Xuying Liu, Junli Ye, Peijie Li, Fangfang Shang, Xiaoling Y. Curcumin Alleviates the Side Effects of Cisplatin on Gastric Emptying of Mice by Inhibiting the Signal Changes of Acetylcholine and Interstitial Cells of Cajal. Journal of medicinal food. vol 23. issue 9. 2021-03-05. PMID:32833554. |
furthermore, cisplatin reduced acetylcholine (ach) concentration and the messenger rna (mrna) level of ach receptor (achr) as well as acetylcholinesterase activity in the stomach of mice; caused ultrastructural damage to interstitial cells of cajal (icc); and altered the expression of c-kit/stem cell factor and the gap junction protein connexin 43 in icc. |
2021-03-05 |
2023-08-13 |
mouse |
| Qiyun Wu, Yiteng Xia, Kun Dai, Panzhu Bai, Kenneth K L Kwan, Maggie S S Guo, Tina T X Dong, Karl W K Tsi. Solar light induces the release of acetylcholine from skin keratinocytes affecting melanogenesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 7. 2021-03-01. PMID:32519787. |
the expression levels of choline acetyltransferase (chat), acetylcholinesterase (ache), vesicular acetylcholine transporter (vacht), and synaptophysin, were upregulated during differentiation of keratinocytes. |
2021-03-01 |
2023-08-13 |
human |
| Max Epstein, Karan Bali, Thomas J Piggot, A Christopher Green, Christopher M Timperley, Mike Bird, John E H Tattersall, Isabel Bermudez, Philip C Biggi. Molecular determinants of binding of non-oxime bispyridinium nerve agent antidote compounds to the adult muscle nAChR. Toxicology letters. vol 340. 2021-02-22. PMID:33482275. |
they covalently modify acetylcholinesterase, preventing the breakdown of acetylcholine (ach) with subsequent loss of synaptic transmission, which can result in death. |
2021-02-22 |
2023-08-13 |
Not clear |
| Sebastian Oddsson, Natalia M Kowal, Philip K Ahring, Elin S Olafsdottir, Thomas Ball. Structure-Based Discovery of Dual-Target Hits for Acetylcholinesterase and the α7 Nicotinic Acetylcholine Receptors: In Silico Studies and In Vitro Confirmation. Molecules (Basel, Switzerland). vol 25. issue 12. 2021-02-17. PMID:32580406. |
structure-based discovery of dual-target hits for acetylcholinesterase and the α7 nicotinic acetylcholine receptors: in silico studies and in vitro confirmation. |
2021-02-17 |
2023-08-13 |
Not clear |
| Xiaohe Luo, Marianne Lauwers, Paul G Layer, Chunyi We. Non-neuronal Role of Acetylcholinesterase in Bone Development and Degeneration. Frontiers in cell and developmental biology. vol 8. 2021-02-16. PMID:33585459. |
acetylcholinesterase (ache), an enzyme catalyzing the degradation of acetylcholine, plays an important suppressive role in the cholinergic regulation by terminating the action of acetylcholine. |
2021-02-16 |
2023-08-13 |
Not clear |
| Sukesh Narayan Sinha, Kumpati Rajesh Kumar, Ramakrishna Ungarala, Dileshwar Kumar, Abhijeet Deshpande, K Vasudev, Naveen Kumar Boiroju, Amrisha Singh, R Pandu Naik, Sunil Pokharaka. Toxicokinetic analysis of commonly used pesticides using data on acute poisoning cases from Hyderabad, South India. Chemosphere. vol 268. 2021-02-10. PMID:33485672. |
organophosphorus pesticides (ops) interfere with the activity of acetylcholinesterase (ache), a vital enzyme that regulates the functioning of the nervous system, resulting in acetylcholine (ach) accumulation at the synapses and myoneural junctions. |
2021-02-10 |
2023-08-13 |
human |
| İrem Bozbey, Zeynep Özdemir, Harun Uslu, Azime Berna Özçelik, Fatma Sezer Şenol, İlkay Erdoğan Orhan, Mehtap Uysa. A Series of New Hydrazone Derivatives: Synthesis, Molecular Docking and Anticholinesterase Activity Studies. Mini reviews in medicinal chemistry. vol 20. issue 11. 2021-02-02. PMID:31660824. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are known to be serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ach), which is a significant neurotransmitter for regulation of cognition in animals. |
2021-02-02 |
2023-08-13 |
Not clear |
| Tomoyo Horio, Aisa Ozawa, Junichi Kamiie, Motoharu Sakau. Immunohistochemical analysis for acetylcholinesterase and choline acetyltransferase in mouse cerebral cortex after traumatic brain injury. The Journal of veterinary medical science. vol 82. issue 6. 2021-02-02. PMID:32321871. |
acetylcholine (ach), a neurotransmitter synthesized and hydrolyzed by choline acetyltransferase (chat) and acetylcholinesterase (ache), respectively, in the central nervous system, has the potential to regulate glial cells' states, i.e., non-reactive and reactive states. |
2021-02-02 |
2023-08-13 |
mouse |