| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Theodosia Vallianatou, Mohammadreza Shariatgorji, Anna Nilsson, Elva Fridjonsdottir, Patrik Källback, Nicoletta Schintu, Per Svenningsson, Per E André. Molecular imaging identifies age-related attenuation of acetylcholine in retrosplenial cortex in response to acetylcholinesterase inhibition. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 12. 2020-07-10. PMID:31009936. |
molecular imaging identifies age-related attenuation of acetylcholine in retrosplenial cortex in response to acetylcholinesterase inhibition. |
2020-07-10 |
2023-08-13 |
mouse |
| Theodosia Vallianatou, Mohammadreza Shariatgorji, Anna Nilsson, Elva Fridjonsdottir, Patrik Källback, Nicoletta Schintu, Per Svenningsson, Per E André. Molecular imaging identifies age-related attenuation of acetylcholine in retrosplenial cortex in response to acetylcholinesterase inhibition. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 12. 2020-07-10. PMID:31009936. |
here, we present age-related alterations of acetylcholine levels after administration of the acetylcholinesterase inhibitor drug tacrine in normal mice. |
2020-07-10 |
2023-08-13 |
mouse |
| Michael Eddlesto. Novel Clinical Toxicology and Pharmacology of Organophosphorus Insecticide Self-Poisoning. Annual review of pharmacology and toxicology. vol 59. 2020-07-08. PMID:30230960. |
current treatment is modestly effective, aiming only to reactivate acetylcholinesterase and counter the effects of excess acetylcholine at muscarinic receptors. |
2020-07-08 |
2023-08-13 |
Not clear |
| Huan Xu, Lingke Chen, Xiao Zhang, Xuliang Jiang, Weitian Tian, Weifeng Yu, Xiangrui Wang, Jie Tian, Diansan S. Central cholinergic neuronal degeneration promotes the development of postoperative cognitive dysfunction. Laboratory investigation; a journal of technical methods and pathology. vol 99. issue 7. 2020-06-25. PMID:30626892. |
the impact of anesthesia/surgery (appendectomy) on learning and memory and the levels of choline acetyltransferase (chat), acetylcholinesterase (ache), vesicular acetylcholine transporter (vacht), and choline transporter (cht) in adult and aged mice were measured. |
2020-06-25 |
2023-08-13 |
mouse |
| Fereshteh Shiri, Somayeh Pirhadi, Jahan B Ghasem. Dynamic structure based pharmacophore modeling of the Acetylcholinesterase reveals several potential inhibitors. Journal of biomolecular structure & dynamics. vol 37. issue 7. 2020-06-02. PMID:29695192. |
acetylcholinesterase is a critical enzyme that regulates neurotransmission by catalyzing the breakdown of neurotransmitter acetylcholine in synapses of the nervous system. |
2020-06-02 |
2023-08-13 |
Not clear |
| Hua Fang, Hua-Feng Li, Miao Yang, Ren Liao, Ru-Rong Wang, Quan-Yun Wang, Peng-Cheng Zheng, Fang-Xiang Zhang, Jian-Ping Zhan. NF-κB signaling pathway inhibition suppresses hippocampal neuronal apoptosis and cognitive impairment via RCAN1 in neonatal rats with hypoxic-ischemic brain damage. Cell cycle (Georgetown, Tex.). vol 18. issue 9. 2020-05-27. PMID:30990350. |
expression of rcan1, nf-κb signaling pathway-related genes and glial fibrillary acidic protein (gfap), s-100β and acetylcholine (ach) level, and acetylcholinesterase (ache) activity were determined with neuron apoptosis detected to further explore the function of nf-κb signaling pathway. |
2020-05-27 |
2023-08-13 |
rat |
| Azime Berna Özçelik, Zeynep Özdemir, Suat Sari, Semra Utku, Mehtap Uysa. A new series of pyridazinone derivatives as cholinesterases inhibitors: Synthesis, in vitro activity and molecular modeling studies. Pharmacological reports : PR. vol 71. issue 6. 2020-04-27. PMID:31675671. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are known to be serine hydrolase enzymes responsible for the hydrolysis of acetylcholine (ach). |
2020-04-27 |
2023-08-13 |
Not clear |
| Christoph Fenzl, Christa Genslein, Alexander Zöpfl, Antje J Baeumner, Thomas Hirsc. A photonic crystal based sensing scheme for acetylcholine and acetylcholinesterase inhibitors. Journal of materials chemistry. B. vol 3. issue 10. 2020-04-08. PMID:32262377. |
a photonic crystal based sensing scheme for acetylcholine and acetylcholinesterase inhibitors. |
2020-04-08 |
2023-08-13 |
human |
| Christoph Fenzl, Christa Genslein, Alexander Zöpfl, Antje J Baeumner, Thomas Hirsc. A photonic crystal based sensing scheme for acetylcholine and acetylcholinesterase inhibitors. Journal of materials chemistry. B. vol 3. issue 10. 2020-04-08. PMID:32262377. |
we demonstrate this unique combination by successfully detecting acetylcholine (ach) and acetylcholinesterase (ache) inhibitors. |
2020-04-08 |
2023-08-13 |
human |
| Li Su, Xinai Yu, Wenjie Qin, Wenpei Dong, Chengke Wu, Yan Zhang, Guojiang Mao, Suling Fen. One-step analysis of glucose and acetylcholine in water based on the intrinsic peroxidase-like activity of Ni/Co LDHs microspheres. Journal of materials chemistry. B. vol 5. issue 1. 2020-04-08. PMID:32263440. |
we also extended the one-step method to detect acetylcholine (ach) by taking advantage of the specific catalytic reaction of acetylcholinesterase (ache) and choline oxidase (chox). |
2020-04-08 |
2023-08-13 |
Not clear |
| Raul Riquelme, Freddy Ruz, Artur Mayerhofer, Hernán E Lar. Role of ovarian sympathetic nerves and cholinergic local system during cold stress. The Journal of endocrinology. vol 242. issue 2. 2020-04-06. PMID:31176305. |
in contrast, increased follicular development and improved fertility in rats were found after pharmacological inhibition of acetylcholinesterase, which increased intraovarian acetylcholine (ach). |
2020-04-06 |
2023-08-13 |
rat |
| Xiao Hu, Cerasela Zoica Din. Nanoporous gold electrode for ultrasensitive detection of neurotoxin fasciculin. Analytica chimica acta. vol 1085. 2020-03-16. PMID:31522735. |
acetylcholinesterase (ache), an efficient biocatalyst known to hydrolyze the neurotransmitter acetylcholine, could be inactivated in the presence of insecticides, nerve agents or other drug inhibitors to thus result in disrupted neurotransmission. |
2020-03-16 |
2023-08-13 |
Not clear |
| Lilai Yuan, Le Qian, Yu Qian, Jia Liu, Ke Yang, Ying Huang, Chengju Wang, Yingren Li, Xiyan M. Bisphenol F-Induced Neurotoxicity toward Zebrafish Embryos. Environmental science & technology. vol 53. issue 24. 2020-03-16. PMID:31702913. |
additionally, no significant change was found in neurotransmitter levels (5-hydroxytryptamine, dopamine, and acetylcholine) or acetylcholinesterase (ache) enzyme activity after bpf exposure, indicating that bpf may not affect neurotransmission. |
2020-03-16 |
2023-08-13 |
zebrafish |
| Lilly Toker, Israel Silman, Tzviya Zeev-Ben-Mordehai, Joel L Sussman, Lawrence M Schopfer, Oksana Lockridg. Polyproline-rich peptides associated with Torpedo californica acetylcholinesterase tetramers. Chemico-biological interactions. vol 319. 2020-03-16. PMID:32087110. |
acetylcholinesterase (ache) terminates cholinergic neurotransmission by hydrolyzing acetylcholine. |
2020-03-16 |
2023-08-13 |
Not clear |
| Messele Fentabil, Mulu Gebremedhin, John Barry, John Mikler, Laura Cochran. In vivo efficacy of the Reactive Skin Decontamination Lotion (RSDL®) kit against organophosphate and carbamate pesticides. Chemico-biological interactions. vol 318. 2020-03-10. PMID:32044340. |
the pesticides inhibit acetylcholinesterase (ache) leading to signs and symptoms of hyperactivity of organs due to accumulation of acetylcholine. |
2020-03-10 |
2023-08-13 |
Not clear |
| Jamie R Friedman, Stephen D Richbart, Justin C Merritt, Kathleen C Brown, Nicholas A Nolan, Austin T Akers, Jamie K Lau, Zachary R Robateau, Sarah L Miles, Piyali Dasgupt. Acetylcholine signaling system in progression of lung cancers. Pharmacology & therapeutics. vol 194. 2020-02-28. PMID:30291908. |
several lines of evidence show that lung cancer cells express all of the proteins required for the uptake of choline (choline transporter 1, choline transporter-like proteins) synthesis of ach (choline acetyltransferase, carnitine acetyltransferase), transport of ach (vesicular acetylcholine transport, octs, octns) and degradation of ach (acetylcholinesterase, butyrylcholinesterase). |
2020-02-28 |
2023-08-13 |
human |
| Pablo Zambrano, Mario Suwalsky, Malgorzata Jemiola-Rzeminska, Kazimierz Strzalka, Benjamin Sepúlveda, María J Gallardo, Luis F Aguila. The acetylcholinesterase (AChE) inhibitor and anti-Alzheimer drug donepezil interacts with human erythrocytes. Biochimica et biophysica acta. Biomembranes. vol 1861. issue 6. 2020-02-14. PMID:30904408. |
this drug is a specific inhibitor of the enzyme acetylcholinesterase (ache), whose main physiological function is to hydrolyze the neurotransmitter acetylcholine. |
2020-02-14 |
2023-08-13 |
human |
| James T Brewster, Simone Dell'Acqua, Danny Q Thach, Jonathan L Sessle. Classics in Chemical Neuroscience: Donepezil. ACS chemical neuroscience. vol 10. issue 1. 2020-02-06. PMID:30372021. |
the discovery of acetylcholine and acetylcholinesterase provided the first insight into the intricacies of chemical signal transduction and neuronal communication. |
2020-02-06 |
2023-08-13 |
Not clear |
| Jonas Jarczyk, Benito A Yard, Simone Hoege. The Cholinergic Anti-Inflammatory Pathway as a Conceptual Framework to Treat Inflammation-Mediated Renal Injury. Kidney & blood pressure research. vol 44. issue 4. 2020-01-29. PMID:31307039. |
importantly, immune cells in the spleen express most cholinergic system components such as acetylcholine (ach), choline acetyltransferase, acetylcholinesterase, and both muscarinic and nicotinic ach receptors, making communication between both systems possible. |
2020-01-29 |
2023-08-13 |
Not clear |
| Charlotte Whitmore, Christopher D Lindsay, Mike Bird, Samuel J Gore, Helen Rice, Rebecca L Williams, Christopher M Timperley, A Christopher Gree. Assessment of false transmitters as treatments for nerve agent poisoning. Toxicology letters. vol 321. 2020-01-27. PMID:31830555. |
nerve agents inhibit acetylcholinesterase (ache), leading to a build-up of acetylcholine (ach) and overstimulation at cholinergic synapses. |
2020-01-27 |
2023-08-13 |
human |