| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Minky Son, Chanin Park, Shailima Rampogu, Amir Zeb, Keun Woo Le. Discovery of Novel Acetylcholinesterase Inhibitors as Potential Candidates for the Treatment of Alzheimer's Disease. International journal of molecular sciences. vol 20. issue 4. 2019-07-17. PMID:30823604. |
acetylcholinesterase (ache) catalyzes the hydrolysis of neurotransmitter acetylcholine to acetate and choline in a synaptic cleft. |
2019-07-17 |
2023-08-13 |
human |
| Shibaji Ghosh, Kalyanashis Jana, Bishwajit Gangul. Revealing the mechanistic pathway of cholinergic inhibition of Alzheimer's disease by donepezil: a metadynamics simulation study. Physical chemistry chemical physics : PCCP. vol 21. issue 25. 2019-07-10. PMID:31173012. |
we report for the first time, the inhibition mechanism of ache by the donepezil drug molecule for the hydrolysis of acetylcholine (ach) with docking and well-tempered metadynamics (wtmtd) simulations with a human acetylcholinesterase (hache) crystal structure (). |
2019-07-10 |
2023-08-13 |
human |
| Kathleen M Carroll, Charla Nich, Elise E DeVito, Julia M Shi, Mehmet Sofuogl. Galantamine and Computerized Cognitive Behavioral Therapy for Cocaine Dependence: A Randomized Clinical Trial. The Journal of clinical psychiatry. vol 79. issue 1. 2019-07-01. PMID:29286595. |
to examine whether galantamine, a cognitive-enhancing medication that is both acetylcholinesterase inhibitor and agonist at nicotinic acetylcholine receptors, is effective at improving cocaine use outcomes and cognitive functioning, alone and in combination with computerized cognitive behavioral therapy (cbt). |
2019-07-01 |
2023-08-13 |
Not clear |
| Miranda L Xu, Wilson K W Luk, Cathy W C Bi, Etta Y L Liu, Kevin Q Y Wu, Ping Yao, Tina T X Dong, Karl W K Tsi. Erythropoietin regulates the expression of dimeric form of acetylcholinesterase during differentiation of erythroblast. Journal of neurochemistry. vol 146. issue 4. 2019-06-26. PMID:29675901. |
acetylcholinesterase (ache; ec 3.1.1.7) is known to hydrolyze acetylcholine at cholinergic synapses. |
2019-06-26 |
2023-08-13 |
Not clear |
| Agung Nugroho, Jong-Hyuk Park, Jae Sue Choi, Kyoung-Sik Park, Joon-Pyo Hong, Hee-Juhn Par. Structure determination and quantification of a new flavone glycoside with anti-acetylcholinesterase activity from the herbs of Elsholtzia ciliata. Natural product research. vol 33. issue 6. 2019-06-20. PMID:29224362. |
acetylcholinesterase (ache) inhibition activity was assayed to find anti-alzheimer's activity, since this enzyme increases the concentration of acetylcholine (ach), a neurotransmitter, responsible for brain's memory. |
2019-06-20 |
2023-08-13 |
Not clear |
| Rong-Rong Zhang, Ze-Xin Lin, Xin-Yi Lu, Xue Xia, Ren-Wang Jiang, Qu-Bo Che. CGY-1, a biflavonoid isolated from cardiocrinum giganteum seeds, improves memory deficits by modulating the cholinergic system in scopolamine-treated mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 111. 2019-06-17. PMID:30594789. |
in addition, cgy-1 decreased the activity of acetylcholinesterase and increased the activities of choline acetyltransferase and acetylcholine in the hippocampus. |
2019-06-17 |
2023-08-13 |
mouse |
| Jing Zhao, Dejun Hao, Liubin Xiao, Yongan Tan, Yiping Jiang, Lixin Bai, Kai Wan. Molecular and functional properties of two Spodoptera exigua acetylcholinesterase genes. Archives of insect biochemistry and physiology. vol 101. issue 3. 2019-06-06. PMID:31033012. |
acetylcholinesterase (ache) is a vital enzyme that hydrolyzes acetylcholine. |
2019-06-06 |
2023-08-13 |
Not clear |
| Zafer Sahin, Merve Ertas, Ceysu Bender, Emre F Bülbül, Barkin Berk, Sevde N Biltekin, Leyla Yurttaş, Şeref Demiraya. Thiazole-substituted benzoylpiperazine derivatives as acetylcholinesterase inhibitors. Drug development research. vol 79. issue 8. 2019-06-05. PMID:30343499. |
hit, lead & candidate discovery after acetylcholine is released into the synaptic cleft, it is reabsorbed or deactivated by acetylcholinesterase (ache). |
2019-06-05 |
2023-08-13 |
Not clear |
| Debapriya Garabadu, Mahima Sharm. Eugenol Attenuates Scopolamine-Induced Hippocampal Cholinergic, Glutamatergic, and Mitochondrial Toxicity in Experimental Rats. Neurotoxicity research. vol 35. issue 4. 2019-05-23. PMID:30737653. |
additionally, eugenol attenuated scopolamine-induced hippocampal cholinergic dysfunction (decrease in acetylcholine level, increase in acetylcholinesterase activity, and decrease in density and affinity of m |
2019-05-23 |
2023-08-13 |
rat |
| Chunyue Wang, Xueying Cai, Wenji Hu, Zhiping Li, Fange Kong, Xia Chen, Di Wan. Investigation of the neuroprotective effects of crocin via antioxidant activities in HT22 cells and in mice with Alzheimer's disease. International journal of molecular medicine. vol 43. issue 2. 2019-05-20. PMID:30569175. |
biochemical analysis confirmed that crocin was able to reduce the aβ1‑42 content in the mouse brains, increase the levels of glutathione peroxidase, superoxide dismutase, acetylcholine and choline acetyltransferase, and reduce the levels of ros and acetylcholinesterase in the serum, cerebral cortex and hypothalamus compared with untreated mice. |
2019-05-20 |
2023-08-13 |
mouse |
| Xiuxia Song, Maohua Miao, Xiaoyu Zhou, Dekun Li, Youping Tian, Hong Liang, Runsheng Li, Wei Yua. Bisphenol A Exposure and Sperm ACHE Hydroxymethylation in Men. International journal of environmental research and public health. vol 16. issue 1. 2019-05-08. PMID:30626059. |
the acetylcholinesterase (ache) gene is a sperm-expressed gene encoding the acetylcholine hydrolyzing enzyme acetylcholinesterase and participates in the apoptosis of cells, including sperm. |
2019-05-08 |
2023-08-13 |
human |
| Niko Amend, Horst Thiermann, Franz Worek, Timo Will. The arrhythmogenic potential of nerve agents and a cardiac safety profile of antidotes - A proof-of-concept study using human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CM). Toxicology letters. vol 308. 2019-04-25. PMID:30858091. |
the directly acting cholinergic compounds acetylcholine and carbachol and the irreversible acetylcholinesterase inhibitor cyclosarin - a highly toxic nerve agent - were assessed. |
2019-04-25 |
2023-08-13 |
human |
| Mridula Saxena, Ragini Dube. Target Enzyme in Alzheimer's Disease: Acetylcholinesterase Inhibitors. Current topics in medicinal chemistry. vol 19. issue 4. 2019-04-24. PMID:30706815. |
the enzyme acetylcholinesterase enzyme (ache) is the key enzyme in the hydrolysis of the neurotransmitter acetylcholine and is also the target of most of the clinically used drugs for the treatment of ad but these drugs provide only symptomatic treatment and have the limitation of loss of therapeutic efficacy with time. |
2019-04-24 |
2023-08-13 |
Not clear |
| Natalia M Kowal, Dinesh C Indurthi, Philip K Ahring, Mary Chebib, Elin S Olafsdottir, Thomas Ball. Novel Approach for the Search for Chemical Scaffolds with Dual Activity with Acetylcholinesterase and the α7 Nicotinic Acetylcholine Receptor-A Perspective for the Treatment of Neurodegenerative Disorders. Molecules (Basel, Switzerland). vol 24. issue 3. 2019-04-23. PMID:30691196. |
novel approach for the search for chemical scaffolds with dual activity with acetylcholinesterase and the α7 nicotinic acetylcholine receptor-a perspective for the treatment of neurodegenerative disorders. |
2019-04-23 |
2023-08-13 |
Not clear |
| Lixue Fan, Jiapeng Wang, Fanrong Meng, Yuan Luo, Xin Sui, Baoquan Zhao, Wanhua Li, Dongqin Quan, Jun Yang, Yongan Wan. Delivering the Acetylcholine Neurotransmitter by Nanodrugs as an Effective Treatment for Alzheimer's Disease. Journal of biomedical nanotechnology. vol 14. issue 12. 2019-04-16. PMID:30305214. |
the current clinical symptomatic therapy for alzheimer's disease involves increasing acetylcholine levels in the brain by inhibiting acetylcholinesterase. |
2019-04-16 |
2023-08-13 |
mouse |
| Qiyun Wu, Aster H Y Fung, Miranda L Xu, Kaman Poon, Etta Y L Liu, Xiang P Kong, Ping Yao, Qing P Xiong, Tina T X Dong, Karl W K Tsi. Microphthalmia-associated transcription factor up-regulates acetylcholinesterase expression during melanogenesis of murine melanoma cells. The Journal of biological chemistry. vol 293. issue 37. 2019-04-09. PMID:30076217. |
acetylcholinesterase (ache) hydrolyzes the neurotransmitter acetylcholine in neurons. |
2019-04-09 |
2023-08-13 |
Not clear |
| Thomas Wein, Klaus T Wanner, Sebastian Rappenglück, Sonja Sichler, Karin V Niessen, Thomas Seeger, Franz Worek, Horst Thierman. New Resensitizers for the Nicotinic Acetylcholine Receptor by Ligand-Based Pharmacophore Modeling. Current computer-aided drug design. vol 15. issue 1. 2019-04-08. PMID:29968541. |
irreversible inhibition of the acetylcholinesterase upon intoxication with organophosphorus compounds leads to an accumulation of acetylcholine in the synaptic cleft and a subsequent desensitization of nicotinic acetylcholine receptors which may ultimately result in respiratory failure. |
2019-04-08 |
2023-08-13 |
Not clear |
| Simranjeet Kaur, Neha Singla, D K Dhawa. Neuro-protective potential of quercetin during chlorpyrifos induced neurotoxicity in rats. Drug and chemical toxicology. vol 42. issue 2. 2019-04-08. PMID:30747009. |
further, cpf treatment caused a significant inhibition in the enzyme activities of acetylcholinesterase and choline acetyltransferase, but caused an increase in the levels of acetylcholine in the brain. |
2019-04-08 |
2023-08-13 |
rat |
| Hong You, Chang Liu, Xiaofeng Du, Donald P McManu. Acetylcholinesterase and Nicotinic Acetylcholine Receptors in Schistosomes and Other Parasitic Helminths. Molecules (Basel, Switzerland). vol 22. issue 9. 2019-04-05. PMID:28906438. |
acetylcholinesterase and nicotinic acetylcholine receptors in schistosomes and other parasitic helminths. |
2019-04-05 |
2023-08-13 |
Not clear |
| Yao-Guo Han, Xiong Qin, Tao Zhang, Ming Lei, Fang-Yuan Sun, Jing-Jing Sun, Wei-Fang Yua. Electroacupuncture prevents cognitive impairment induced by lipopolysaccharide via inhibition of oxidative stress and neuroinflammation. Neuroscience letters. vol 683. 2019-03-11. PMID:29885447. |
ea prevented lps-induced decrease of α7nachr protein, acetylcholine (ach) content and choline acetyltransferase (chat) activity, and prevented lps-induced increase of acetylcholinesterase (ache) activity (p < 0.05). |
2019-03-11 |
2023-08-13 |
mouse |