| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jamshed Iqbal, Muhammad S A Abbasi, Sumera Zaib, Saifullah Afridi, Norbert Furtmann, Jürgen Bajorath, Peter Lange. Identification of New Chromenone Derivatives as Cholinesterase Inhibitors and Molecular Docking Studies. Medicinal chemistry (Shariqah (United Arab Emirates)). vol 14. issue 8. 2019-03-05. PMID:29473519. |
this devastating disorder is generally associated with the gradual memory loss, specified by a decrease of acetylcholine level in the cortex hippocampus of the brain due to hyperactivation of cholinesterases (acetylcholinesterase (ache) and butyrylcholinesterase (bche)). |
2019-03-05 |
2023-08-13 |
Not clear |
| Adriana Ferreira Lopes Vilela, Cláudia Seidl, Juliana Maria Lima, Carmen Lúcia Cardos. An improved immobilized enzyme reactor-mass spectrometry-based label free assay for butyrylcholinesterase ligand screening. Analytical biochemistry. vol 549. 2019-03-05. PMID:29550345. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are key cholinesterase enzymes responsible for the hydrolysis of acetylcholine into choline and acetic acid, an essential process for the restoration of the cholinergic neuron. |
2019-03-05 |
2023-08-13 |
Not clear |
| Taiza H Figueiredo, James P Apland, Maria F M Braga, Ann M Marin. Acute and long-term consequences of exposure to organophosphate nerve agents in humans. Epilepsia. vol 59 Suppl 2. 2019-03-01. PMID:30159887. |
acetylcholinesterase inhibition results in the accumulation of excessive acetylcholine levels in synapses, leading to progression of toxic signs including hypersecretions, tremors, status epilepticus, respiratory distress, and death. |
2019-03-01 |
2023-08-13 |
Not clear |
| Yinghuan Wang, Yang Zhang, Wei Li, Yongtao Han, Baoyuan Gu. Study on neurotoxicity of dinotefuran, thiamethoxam and imidacloprid against Chinese lizards (Eremias argus). Chemosphere. vol 217. 2019-02-04. PMID:30419375. |
dinotefuran and thiamethoxam could directly increase the concentrations of acetylcholine in the brain and blood by up-regulating the expression of the ach gene, which in turn enhanced the binding of acetylcholine and acetylcholinesterase receptors, eventually causing the release of dopamine. |
2019-02-04 |
2023-08-13 |
Not clear |
| Xinhai Ye, Liwen Yang, David Stanley, Fei Li, Qi Fan. Two Bombyx mori acetylcholinesterase genes influence motor control and development in different ways. Scientific reports. vol 7. issue 1. 2019-02-01. PMID:28694460. |
among its other biological roles, acetylcholinesterase (ache, ec 3.1.1.7), encoded by two ace in most insects, catalyses the breakdown of acetylcholine, thereby terminating synaptic transmission. |
2019-02-01 |
2023-08-13 |
Not clear |
| Saida Haider, Zehra Batool, Saara Ahmad, Rafat Ali Siddiqui, Darakhshan Jabeen Halee. Walnut supplementation reverses the scopolamine-induced memory impairment by restoration of cholinergic function via mitigating oxidative stress in rats: a potential therapeutic intervention for age related neurodegenerative disorders. Metabolic brain disease. vol 33. issue 1. 2019-01-31. PMID:29027091. |
memory was assessed by elevated plus maze (epm), morris water maze (mwm), and novel object recognition task (nor) followed by estimation of regional acetylcholine levels and acetylcholinesterase activity. |
2019-01-31 |
2023-08-13 |
rat |
| Xin-Chen Wang, Yu-Min Xu, Hong-Ying Li, Chun-Ying Wu, Ting-Ting Xu, Na-Chuan Luo, Shi-Jie Zhang, Qi Wang, Shi-Jian Qua. Jiao-Tai-Wan Improves Cognitive Dysfunctions through Cholinergic Pathway in Scopolamine-Treated Mice. BioMed research international. vol 2018. 2019-01-08. PMID:30050927. |
in addition, the activity of acetylcholinesterase (ache) was effectively decreased; the activity of choline acetyltransferase (chat) and concentration of acetylcholine (ach) were improved after jtw treatment in both hippocampus and cortex of scop-treated mice. |
2019-01-08 |
2023-08-13 |
mouse |
| Hoda E Mohamed, Dina M Abo-ELmatty, Noha M Mesbah, Samy M Saleh, Abdel-Moniem A Ali, Amr T Sak. Raspberry ketone preserved cholinergic activity and antioxidant defense in obesity induced Alzheimer disease in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 107. 2019-01-03. PMID:30257330. |
it inhibited acetylcholinesterase enzyme (ache) and hence increased acetylcholine level (ach) in brain tissues of o-ad rats. |
2019-01-03 |
2023-08-13 |
rat |
| Si Cheng, Qiuhua Wu, He Xiao, Hao Che. Online Monitoring of Enzymatic Reactions Using Time-Resolved Desorption Electrospray Ionization Mass Spectrometry. Analytical chemistry. vol 89. issue 4. 2019-01-02. PMID:28192910. |
enzymatic reactions examined in this study include hydrolysis of 2-nitrophenyl-β-d-galactopyranoside by β-galactosidase and hydrolysis of acetylcholine by acetylcholinesterase. |
2019-01-02 |
2023-08-13 |
Not clear |
| Caio R D Assis, Amanda G Linhares, Mariana P Cabrera, Vagne M Oliveira, Kaline C C Silva, Marina Marcuschi, Elba V M Maciel Carvalho, Ranilson S Bezerra, Luiz B Carvalh. Erythrocyte acetylcholinesterase as biomarker of pesticide exposure: new and forgotten insights. Environmental science and pollution research international. vol 25. issue 19. 2018-12-20. PMID:29797194. |
acetylcholinesterase (ache) acts on the hydrolysis of acetylcholine, rapidly removing this neurotransmitter at cholinergic synapses and neuromuscular junctions as well as in neuronal growth and differentiation, modulation of cell adhesion ("electrotactins") and aryl-acylamidase activity (aaa). |
2018-12-20 |
2023-08-13 |
Not clear |
| Snezana Agatonovic-Kustrin, Christine Kettle, David W Morto. A molecular approach in drug development for Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 106. 2018-12-18. PMID:29990843. |
cholinergic signaling, which is important in cognition, is slowly lost in ad, so the first line therapy is to treat symptoms with acetylcholinesterase inhibitors to increase levels of acetylcholine. |
2018-12-18 |
2023-08-13 |
Not clear |
| Vivitri Prasasty, Muhammad Radifar, Enade Istyaston. Natural Peptides in Drug Discovery Targeting Acetylcholinesterase. Molecules (Basel, Switzerland). vol 23. issue 9. 2018-12-11. PMID:30217053. |
acetylcholinesterase-inhibitory peptide has gained much importance since it can inhibit acetylcholinesterase (ache) and increase the availability of acetylcholine in cholinergic synapses, enhancing cholinergic transmission in pharmacological treatment of alzheimer's disease (ad). |
2018-12-11 |
2023-08-13 |
Not clear |
| M Ender Avci, Ayse Gokce Keskus, Seniye Targen, M Efe Isilak, Mehmet Ozturk, Rengul Cetin Atalay, Michelle M Adams, Ozlen Kon. Development of a novel zebrafish xenograft model in ache mutants using liver cancer cell lines. Scientific reports. vol 8. issue 1. 2018-11-26. PMID:29371671. |
acetylcholinesterase (ache), an enzyme responsible for degradation of acetylcholine, has been identified as a prognostic marker in liver cancer. |
2018-11-26 |
2023-08-13 |
mouse |
| M D Baldissera, C F Souza, P H Doleski, K L S Moreira, M L da Veiga, M I U M da Rocha, R C V Santos, B Baldisserott. Involvement of cholinergic and adenosinergic systems on the branchial immune response of experimentally infected silver catfish with Streptococcus agalactiae. Journal of fish diseases. vol 41. issue 1. 2018-11-08. PMID:28699699. |
it has been recognized that the cholinergic and adenosinergic systems have an essential role in immune and inflammatory responses during bacterial fish pathogens, such as the enzymes acetylcholinesterase (ache) and adenosine deaminase (ada), which are responsible for catalysis of the anti-inflammatory molecules acetylcholine (ach) and adenosine (ado) respectively. |
2018-11-08 |
2023-08-13 |
Not clear |
| Yongfeng Zhang, Jiaqi Wang, Chunyue Wang, Zhiping Li, Xin Liu, Jun Zhang, Jiahui Lu, Di Wan. Pharmacological Basis for the Use of Evodiamine in Alzheimer's Disease: Antioxidation and Antiapoptosis. International journal of molecular sciences. vol 19. issue 5. 2018-10-15. PMID:29883380. |
in the central cholinergic system of ad mice, evo significantly increased the serum levels of acetylcholine and choline acetyltransferase and decreased the level of acetylcholinesterase in the serum, hypothalamus, and brain. |
2018-10-15 |
2023-08-13 |
mouse |
| Xiaochun Guo, Shengnan Zhang, Shaoyong Lu, Binghui Zheng, Ping Xie, Jun Chen, Guangyu Li, Chunsheng Liu, Qin Wu, Houcheng Cheng, Nan San. Perfluorododecanoic acid exposure induced developmental neurotoxicity in zebrafish embryos. Environmental pollution (Barking, Essex : 1987). vol 241. 2018-10-05. PMID:30029309. |
additionally, the acetylcholine (ach) content as well as acetylcholinesterase (ache) activity were determined to be significantly downregulated in pfdoa treatment groups. |
2018-10-05 |
2023-08-13 |
zebrafish |
| Jeong Su Ha, Jong Min Kim, Seon Kyeong Park, Jin Yong Kang, Du Sang Lee, Uk Lee, Dae-Ok Kim, Sung-Gil Choi, Ho Jin He. Anti-amyloidogenic properties of an ethyl acetate fraction from Actinidia arguta in Aβ Food & function. vol 9. issue 6. 2018-10-01. PMID:29786737. |
furthermore, efaa showed the ameliorating effect of cholinergic functions by increasing acetylcholine (ach) levels and decreasing acetylcholinesterase (ache) activity, and protected antioxidant systems by increasing superoxide dismutase (sod) and decreasing the oxidized glutathione (gsh)/total gsh and malondialdehyde (mda) in the brain. |
2018-10-01 |
2023-08-13 |
mouse |
| Berthold Drexler, Thomas Seeger, Franz Worek, Horst Thiermann, Bernd Antkowiak, Christian Grasshof. Midazolam is effective to reduce cortical network activity in organotypic cultures during severe cholinergic overstimulation with soman. Toxicology letters. vol 297. 2018-09-24. PMID:30165091. |
extensive cholinergic overstimulation was induced by increasing acetylcholine levels and simultaneously treating the slices with soman to block acetylcholinesterase activity. |
2018-09-24 |
2023-08-13 |
Not clear |
| Yonglai Zhang, Rui Sha, Kaiguo Wang, Hao Li, Bo Yan, Naibao Zho. Protective effects of tetrahydropalmatine against ketamine-induced learning and memory injury via antioxidative, anti-inflammatory and anti-apoptotic mechanisms in mice. Molecular medicine reports. vol 17. issue 5. 2018-09-21. PMID:29512789. |
in addition, tetrahydropalmatine significantly inhibited oxidative stress, inflammation and acetylcholinesterase activity, and decreased acetylcholine levels in ketamine‑induced mice. |
2018-09-21 |
2023-08-13 |
mouse |
| Yechun Xu, Shanmei Cheng, Joel L Sussman, Israel Silman, Hualiang Jian. Computational Studies on Acetylcholinesterases. Molecules (Basel, Switzerland). vol 22. issue 8. 2018-09-13. PMID:28796192. |
the catalytic triad of acetylcholinesterase is located at the bottom of a long and narrow gorge, but it catalyzes the extremely rapid hydrolysis of the neurotransmitter, acetylcholine, with a reaction rate close to the diffusion-controlled limit. |
2018-09-13 |
2023-08-13 |
Not clear |