| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Erik T Jansson, Maria T Dulay, Richard N Zar. Monitoring Enzymatic Reactions in Real Time Using Venturi Easy Ambient Sonic-Spray Ionization Mass Spectrometry. Analytical chemistry. vol 88. issue 12. 2018-08-17. PMID:27249533. |
the hydrolysis of acetylcholine by acetylcholinesterase into choline was monitored in real-time for a range of acetylcholine concentrations, fused-silica capillary geometries, and operating flow rates. |
2018-08-17 |
2023-08-13 |
Not clear |
| Konstanze Plaschke, Thuc Quyen Monica Do, Florian Uhle, Thorsten Brenner, Markus A Weigand, Jürgen Kopit. Ablation of the Right Cardiac Vagus Nerve Reduces Acetylcholine Content without Changing the Inflammatory Response during Endotoxemia. International journal of molecular sciences. vol 19. issue 2. 2018-08-13. PMID:29389905. |
right cardiac vagus nerve resection (vgx) led to a marked decrease in heart acetylcholine concentration and an increase in cardiac acetylcholinesterase activity. |
2018-08-13 |
2023-08-13 |
rat |
| Alsu R Mukhametshina, Svetlana V Fedorenko, Alexey M Petrov, Guzel F Zakyrjanova, Konstantin A Petrov, Leniz F Nurullin, Irek R Nizameev, Asiya R Mustafina, Oleg G Sinyashi. Targeted Nanoparticles for Selective Marking of Neuromuscular Junctions and ex Vivo Monitoring of Endogenous Acetylcholine Hydrolysis. ACS applied materials & interfaces. vol 10. issue 17. 2018-07-31. PMID:29652477. |
the present work for the first time introduces nanosensors for luminescent monitoring of acetylcholinesterase (ache)-catalyzed hydrolysis of endogenous acetylcholine (ach) released in neuromuscular junctions of isolated muscles. |
2018-07-31 |
2023-08-13 |
Not clear |
| Terrone L Rosenberry, Xavier Brazzolotto, Ian R Macdonald, Marielle Wandhammer, Marie Trovaslet-Leroy, Sultan Darvesh, Florian Nacho. Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study. Molecules (Basel, Switzerland). vol 22. issue 12. 2018-07-17. PMID:29186056. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) hydrolyze the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic neurotransmission. |
2018-07-17 |
2023-08-13 |
human |
| Yue Wang, Qing Tian, En-Jie Liu, Li Zhao, Jie Song, Xin-An Liu, Qing-Guo Ren, Xia Jiang, Juan Zeng, Yu-Tao Yang, Jian-Zhi Wan. Activation of GSK-3 disrupts cholinergic homoeostasis in nucleus basalis of Meynert and frontal cortex of rats. Journal of cellular and molecular medicine. vol 21. issue 12. 2018-07-11. PMID:28656644. |
we activated gsk-3 by lateral ventricular infusion of wortmannin (wt) and gf-109203x (gfx), the inhibitors of phosphoinositol-3 kinase (pi3-k) and protein kinase c (pkc), respectively, and significantly decreased the acetylcholine (ach) level via inhibiting choline acetyl transferase (chat) rather than regulating acetylcholinesterase (ache). |
2018-07-11 |
2023-08-13 |
rat |
| Aniélen D Silva, Nathieli B Bottari, Guilherme M do Carmo, Matheus D Baldissera, Carine F Souza, Vanessa S Machado, Vera M Morsch, Maria Rosa C Schetinger, Ricardo E Mendes, Silvia G Monteiro, Aleksandro S Da Silv. Chagas disease: modulation of the inflammatory response by acetylcholinesterase in hematological cells and brain tissue. Molecular and cellular biochemistry. vol 438. issue 1-2. 2018-07-09. PMID:28766165. |
thus, the aim of this study was to investigate whether trypanosoma cruzi infection can alter the activity of acetylcholinesterase and acetylcholine levels in mice, and whether these alterations are linked to the inflammatory cholinergic signaling pathway. |
2018-07-09 |
2023-08-13 |
mouse |
| Carlos Roca, Carlos Requena, Víctor Sebastián-Pérez, Sony Malhotra, Chris Radoux, Concepción Pérez, Ana Martinez, Juan Antonio Páez, Tom L Blundell, Nuria E Campill. Identification of new allosteric sites and modulators of AChE through computational and experimental tools. Journal of enzyme inhibition and medicinal chemistry. vol 33. issue 1. 2018-07-05. PMID:29873262. |
acetylcholinesterase (ache), which is most widely known for the hydrolysis of the neurotransmitter acetylcholine, has a peripheral allosteric subsite responsible for amyloidosis in alzheimer's disease through interaction with amyloid β-peptide. |
2018-07-05 |
2023-08-13 |
Not clear |
| Liangqia Guo, Zhihong Li, Huan Chen, Yarong Wu, Ling Chen, Zhiping Song, Tianran Li. Colorimetric biosensor for the assay of paraoxon in environmental water samples based on the iodine-starch color reaction. Analytica chimica acta. vol 967. 2018-06-15. PMID:28390486. |
in the presence of acetylcholine chloride, acetylcholinesterase (ache) and choline oxidase (cho) catalyzed the formation of h |
2018-06-15 |
2023-08-13 |
Not clear |
| Corinna Scheffel, Karin V Niessen, Sebastian Rappenglück, Klaus T Wanner, Horst Thiermann, Franz Worek, Thomas Seege. Electrophysiological investigation of the effect of structurally different bispyridinium non-oxime compounds on human α7-nicotinic acetylcholine receptor activity-An in vitro structure-activity analysis. Toxicology letters. vol 293. 2018-06-04. PMID:29191791. |
organophosphorus compounds, including nerve agents and pesticides, exert their toxicity through irreversible inhibition of acetylcholinesterase (ache) resulting in an accumulation of acetylcholine and functional impairment of muscarinic and nicotinic acetylcholine receptors. |
2018-06-04 |
2023-08-13 |
human |
| Corinna Scheffel, Karin V Niessen, Sebastian Rappenglück, Klaus T Wanner, Horst Thiermann, Franz Worek, Thomas Seege. Counteracting desensitization of human α7-nicotinic acetylcholine receptors with bispyridinium compounds as an approach against organophosphorus poisoning. Toxicology letters. vol 293. 2018-06-04. PMID:29248576. |
irreversible inhibition of acetylcholinesterase (ache) resulting in accumulation of acetylcholine and overstimulation of muscarinic and nicotinic receptors accounts for the acute toxicity of organophosphorus compounds (op). |
2018-06-04 |
2023-08-13 |
human |
| Volker Strauss, Maria Cecilia Rey Moreno, Jeanette Vogt, Martina Dammann, Steffen Schneider, Sibylle Gröters, Bennard van Ravenzwaa. Acetylcholinesterase measurement in various brain regions and muscles of juvenile, adolescent, and adult rats. Toxicology mechanisms and methods. vol 27. issue 9. 2018-05-23. PMID:28671028. |
several insecticides, chemicals, and drugs are known to inhibit acetylcholinesterase (ache) activity, responsible for the cleavage of the neurotransmitter acetylcholine. |
2018-05-23 |
2023-08-13 |
rat |
| Reed B Jacob, Kenan C Michaels, Cathy J Anderson, James M Fay, Nikolay V Dokholya. Harnessing Nature's Diversity: Discovering organophosphate bioscavenger characteristics among low molecular weight proteins. Scientific reports. vol 6. 2018-05-16. PMID:27845442. |
this exposure inhibits acetylcholinesterase resulting in increased acetylcholine levels within the synaptic cleft causing loss of muscle control, seizures, and death. |
2018-05-16 |
2023-08-13 |
Not clear |
| Anders Allgardsson, C David Andersson, Christine Akfur, Franz Worek, Anna Linusson, Fredrik Ekströ. An Unusual Dimeric Inhibitor of Acetylcholinesterase: Cooperative Binding of Crystal Violet. Molecules (Basel, Switzerland). vol 22. issue 9. 2018-05-08. PMID:28867801. |
acetylcholinesterase (ache) is an essential enzyme that terminates cholinergic transmission by a rapid hydrolysis of the neurotransmitter acetylcholine. |
2018-05-08 |
2023-08-13 |
Not clear |
| Paula Rayane de Souza, Kelma Sirleide de Souza, Caio Rodrigo Dias de Assis, Marlyete Chagas de Araújo, Kaline Catiely Campos Silva, Juliett de Fátima Xavier da Silva, Andreia Cybelle Marques Ferreira, Valdir Luna da Silva, Mônica Lúcia Adam, Luiz Bezerra de Carvalho, Ranilson de Souza Bezerr. Acetylcholinesterase of mangrove oyster Crassostrea rhizophorae: A highly thermostable enzyme with promising features for estuarine biomonitoring. Aquatic toxicology (Amsterdam, Netherlands). vol 197. 2018-05-07. PMID:29462762. |
acetylcholinesterase (ache; ec 3.1.1.7) is an enzyme of the group of serine esterases that acts on the hydrolysis of the neurotransmitter acetylcholine allowing the intermittence of the nerve impulses responsible for the neuronal communication. |
2018-05-07 |
2023-08-13 |
Not clear |
| Taibi Ben Hadda, Oualid Talhi, Artur S M Silva, Fatma Sezer Senol, Ilkay Erdogan Orhan, Abdur Rauf, Yahia N Mabkhot, Khaldoun Bachari, Ismail Warad, Thoraya A Farghaly, Ismail I Althagafi, Mohammad S Mubara. Cholinesterase Inhibitory Activity of Some semi-Rigid Spiro Heterocycles: POM Analyses and Crystalline Structure of Pharmacophore Site. Mini reviews in medicinal chemistry. vol 18. issue 8. 2018-05-04. PMID:28714400. |
cholinesterase family consists of two sister enzymes; acetylcholinesterase (ache) and butyrylcholinesterase (bche) which hydrolyze acetylcholine. |
2018-05-04 |
2023-08-13 |
Not clear |
| Javier Urra, Jan Blohberger, Michelle Tiszavari, Artur Mayerhofer, Hernan E Lar. In vivo blockade of acetylcholinesterase increases intraovarian acetylcholine and enhances follicular development and fertility in the rat. Scientific reports. vol 6. 2018-05-02. PMID:27440195. |
in vivo blockade of acetylcholinesterase increases intraovarian acetylcholine and enhances follicular development and fertility in the rat. |
2018-05-02 |
2023-08-13 |
rat |
| Junli Zhen, Yanjing Qian, Jian Fu, Ruijun Su, Haiting An, Wei Wang, Yan Zheng, Xiaomin Wan. Deep Brain Magnetic Stimulation Promotes Neurogenesis and Restores Cholinergic Activity in a Transgenic Mouse Model of Alzheimer's Disease. Frontiers in neural circuits. vol 11. 2018-05-02. PMID:28713248. |
in addition, dms significantly raised the level of acetylcholine and prevented the increase in acetylcholinesterase activity as well as the decrease in acetyltransferase activity in the hippocampus of 5xfad mice. |
2018-05-02 |
2023-08-13 |
mouse |
| Irini Doytchinova, Mariyana Atanasova, Iva Valkova, Georgi Stavrakov, Irena Philipova, Zvetanka Zhivkova, Dimitrina Zheleva-Dimitrova, Spiro Konstantinov, Ivan Dimitro. Novel hits for acetylcholinesterase inhibition derived by docking-based screening on ZINC database. Journal of enzyme inhibition and medicinal chemistry. vol 33. issue 1. 2018-05-01. PMID:29651876. |
the inhibition of the enzyme acetylcholinesterase (ache) increases the levels of the neurotransmitter acetylcholine and symptomatically improves the affected cognitive function. |
2018-05-01 |
2023-08-13 |
Not clear |
| Yi Lu, Ming Zhao, Jin-Jun Liu, Xi He, Xiao-Jiang Yu, Long-Zhu Liu, Lei Sun, Li-Na Chen, Wei-Jin Zan. Long-term administration of pyridostigmine attenuates pressure overload-induced cardiac hypertrophy by inhibiting calcineurin signalling. Journal of cellular and molecular medicine. vol 21. issue 9. 2018-04-30. PMID:28296184. |
pyridostigmine increased the acetylcholine levels by inhibiting acetylcholinesterase in rats with pressure overload. |
2018-04-30 |
2023-08-13 |
rat |
| Yi Lu, Ming Zhao, Jin-Jun Liu, Xi He, Xiao-Jiang Yu, Long-Zhu Liu, Lei Sun, Li-Na Chen, Wei-Jin Zan. Long-term administration of pyridostigmine attenuates pressure overload-induced cardiac hypertrophy by inhibiting calcineurin signalling. Journal of cellular and molecular medicine. vol 21. issue 9. 2018-04-30. PMID:28296184. |
pyridostigmine attenuated cardiac hypertrophy and improved cardiac function, which was related to improved cholinergic transmission efficiency (decreased acetylcholinesterase and increased acetylcholine), inhibition of the can/nfat3/gata4 pathway and suppression of the interaction of orai1/stim1. |
2018-04-30 |
2023-08-13 |
rat |