| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sen-Zhi Zhu, Wei-Ping Huang, Lin-Qiang Huang, Yong-Li Han, Qian-Peng Han, Gao-Feng Zhu, Miao-Yun Wen, Yi-Yu Deng, Hong-Ke Zen. Huperzine A protects sepsis associated encephalopathy by promoting the deficient cholinergic nervous function. Neuroscience letters. vol 631. 2017-07-26. PMID:27400829. |
to elucidate the role of the cholinergic nervous system in sae, hippocampal choline acetyltransferase, muscarinic acetylcholine receptor-1, acetylcholinesterase and acetylcholine were evaluated in lps-induced sepsis rats. |
2017-07-26 |
2023-08-13 |
rat |
| Takeshi Fujii, Masato Mashimo, Yasuhiro Moriwaki, Hidemi Misawa, Shiro Ono, Kazuhide Horiguchi, Koichiro Kawashim. Physiological functions of the cholinergic system in immune cells. Journal of pharmacological sciences. vol 134. issue 1. 2017-07-13. PMID:28552584. |
this includes choline acetyltransferase (chat), muscarinic and nicotinic acetylcholine (ach) receptors (machrs and nachrs, respectively) and acetylcholinesterase (ache). |
2017-07-13 |
2023-08-13 |
Not clear |
| Shaffali Singla, Poonam Piplan. Coumarin derivatives as potential inhibitors of acetylcholinesterase: Synthesis, molecular docking and biological studies. Bioorganic & medicinal chemistry. vol 24. issue 19. 2017-07-11. PMID:27519464. |
a series of novel hybrids has been synthesized by linking coumarin moiety through an appropriate spacer to various substituted heterocyclic amines and evaluated as dual binding site acetylcholinesterase inhibitors for the treatment of cognitive dysfunction caused by increased hydrolysis of acetylcholine and scopolamine induced oxidative stress. |
2017-07-11 |
2023-08-13 |
Not clear |
| Xu Rui, Li Wenfang, Cheng Jing, Chen Meng, Ding Chengcheng, Xu Jiqu, Rong Shuan. Neuroprotective effects of phytosterol esters against high cholesterol-induced cognitive deficits in aged rat. Food & function. vol 8. issue 3. 2017-07-07. PMID:28256666. |
furthermore, pse improved cholinergic activities by restoring the acetylcholine (ach) content and decreasing acetylcholinesterase (ache) activity in the cerebral cortex, as well as by elevating choline acetyl transferase (chat) activity in the hippocampus and the cerebral cortex. |
2017-07-07 |
2023-08-13 |
rat |
| Alireza Basiri, Michelle Xiao, Alec McCarthy, Debashis Dutta, Siddappa N Byrareddy, Martin Conda-Sherida. Design and synthesis of new piperidone grafted acetylcholinesterase inhibitors. Bioorganic & medicinal chemistry letters. vol 27. issue 2. 2017-06-27. PMID:27914796. |
a common strategy to improve the well-being of ad patients consists on the inhibition of acetylcholinesterase with the concomitant increase of the neurotransmitter acetylcholine at cholinergic synapses. |
2017-06-27 |
2023-08-13 |
Not clear |
| Ritsuko Inoue, Takeo Suzuki, Kinya Nishimura, Masami Miur. Nicotinic acetylcholine receptor-mediated GABAergic inputs to cholinergic interneurons in the striosomes and the matrix compartments of the mouse striatum. Neuropharmacology. vol 105. 2017-06-22. PMID:26808315. |
the nicotinic receptor-mediated gabaergic responses were attenuated by continuous application of acetylcholine or the acetylcholinesterase inhibitor eserine and were enhanced by desformylflustrabromine, a positive allosteric modulator of the α4β2 subunit containing a nicotinic receptor. |
2017-06-22 |
2023-08-13 |
mouse |
| Matthew Udakis, Victoria Louise Wright, Susan Wonnacott, Christopher Philip Baile. Integration of inhibitory and excitatory effects of α7 nicotinic acetylcholine receptor activation in the prelimbic cortex regulates network activity and plasticity. Neuropharmacology. vol 105. 2017-06-21. PMID:26921769. |
these actions were distinguished by their differential dependence on local acetylcholine (ach): potentiation of endogenous cholinergic signalling with the positive allosteric modulator, pnu-120596, enhanced spontaneous excitatory events, an effect that was further increased by inhibition of acetylcholinesterase. |
2017-06-21 |
2023-08-13 |
mouse |
| Kjartan F Herrik, Arne Mørk, Nelly Richard, Christoffer Bundgaard, Jesper F Bastlund, Inge E M de Jon. The 5-HT6 receptor antagonist idalopirdine potentiates the effects of acetylcholinesterase inhibition on neuronal network oscillations and extracellular acetylcholine levels in the rat dorsal hippocampus. Neuropharmacology. vol 107. 2017-06-19. PMID:27039041. |
the 5-ht6 receptor antagonist idalopirdine potentiates the effects of acetylcholinesterase inhibition on neuronal network oscillations and extracellular acetylcholine levels in the rat dorsal hippocampus. |
2017-06-19 |
2023-08-13 |
rat |
| Jong Min Kim, Chang Hyeon Park, Seon Kyeong Park, Tae Wan Seung, Jin Yong Kang, Jeong Su Ha, Du Sang Lee, Uk Lee, Dae-Ok Kim, Ho Jin He. Ginsenoside Re Ameliorates Brain Insulin Resistance and Cognitive Dysfunction in High Fat Diet-Induced C57BL/6 Mice. Journal of agricultural and food chemistry. vol 65. issue 13. 2017-06-05. PMID:28314104. |
g re regulated acetylcholine (ach), acetylcholinesterase (ache), malondialdehyde (mda), superoxide dismutase (sod), and oxidized glutathione (gsh)/total gsh by regulating the c-jun n-terminal protein kinase (jnk) pathway. |
2017-06-05 |
2023-08-13 |
mouse |
| Kei M Lau, Amy G W Gong, Miranda L Xu, Candy T W Lam, Laura M L Zhang, Cathy W C Bi, D Cui, Anthony W M Cheng, Tina T X Dong, Karl W K Tsim, Huangquan Li. Transcriptional activity of acetylcholinesterase gene is regulated by DNA methylation during C2C12 myogenesis. Brain research. vol 1642. 2017-05-22. PMID:27021952. |
the expression of acetylcholinesterase (ache), an enzyme hydrolyzes neurotransmitter acetylcholine at vertebrate neuromuscular junction, is regulated during myogenesis, indicating the significance of muscle intrinsic factors in controlling the enzyme expression. |
2017-05-22 |
2023-08-13 |
mouse |
| Hao Liu, Wei Ye, Hai-Feng Che. Positive cooperative regulation of double binding sites for human acetylcholinesterase. Chemical biology & drug design. vol 89. issue 5. 2017-05-09. PMID:27779818. |
acetylcholinesterase is a potent enzyme that regulates neurotransmission by rapidly hydrolyzing the neurotransmitter acetylcholine in synapses of the nervous system. |
2017-05-09 |
2023-08-13 |
human |
| Xiaochun Jin, Megan M McCollum, Allison L Germann, Gustav Akk, Joe Henry Steinbac. The E Loop of the Transmitter Binding Site Is a Key Determinant of the Modulatory Effects of Physostigmine on Neuronal Nicotinic α4β2 Receptors. Molecular pharmacology. vol 91. issue 2. 2017-05-09. PMID:27895161. |
physostigmine is a well known inhibitor of acetylcholinesterase, which can also activate, potentiate, and inhibit acetylcholine receptors, including neuronal nicotinic receptors comprising α4 and β2 subunits. |
2017-05-09 |
2023-08-13 |
Not clear |
| Zhou-Yi Lai, Hai-Bo Wang, Rui-Ling Lv, Qiu-Chan Tan, Zhi-Qin Deng, Yuan Wang, Xiao-Xue Sun, Jia-Bao Wu, Lin-Yan Zhu, Lei Wang, Li-Xin Chen, Wen-Cai Ye, Li-Wei Wan. [Role of acetylcholine in gelsenicine-induced death in mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 68. issue 3. 2017-05-01. PMID:27350197. |
the acetylcholine concentration and acetylcholinesterase activity in the blood were measured by the testing kits, and the mortality was calculated and analyzed. |
2017-05-01 |
2023-08-13 |
mouse |
| Zhou-Yi Lai, Hai-Bo Wang, Rui-Ling Lv, Qiu-Chan Tan, Zhi-Qin Deng, Yuan Wang, Xiao-Xue Sun, Jia-Bao Wu, Lin-Yan Zhu, Lei Wang, Li-Xin Chen, Wen-Cai Ye, Li-Wei Wan. [Role of acetylcholine in gelsenicine-induced death in mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 68. issue 3. 2017-05-01. PMID:27350197. |
the results showed that half lethal dose of gelsenicine (0.15 mg/kg) reduced the acetylcholinesterase activity and increased the blood acetylcholine concentration. |
2017-05-01 |
2023-08-13 |
mouse |
| Zhou-Yi Lai, Hai-Bo Wang, Rui-Ling Lv, Qiu-Chan Tan, Zhi-Qin Deng, Yuan Wang, Xiao-Xue Sun, Jia-Bao Wu, Lin-Yan Zhu, Lei Wang, Li-Xin Chen, Wen-Cai Ye, Li-Wei Wan. [Role of acetylcholine in gelsenicine-induced death in mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 68. issue 3. 2017-05-01. PMID:27350197. |
these results suggest that gelsenicine can inhibit acetylcholinesterase activity and increase blood acetylcholine concentration, but the accumulation of acetylcholine may not be the only or main cause of the death induced by gelsenicine in mice. |
2017-05-01 |
2023-08-13 |
mouse |
| Cindy Acon-Chen, Jeffrey A Koenig, Garrett R Smith, Amber R Truitt, Thaddeus P Thomas, Tsung-Ming Shi. Evaluation of acetylcholine, seizure activity and neuropathology following high-dose nerve agent exposure and delayed neuroprotective treatment drugs in freely moving rats. Toxicology mechanisms and methods. vol 26. issue 5. 2017-03-24. PMID:27329284. |
organophosphorus nerve agents such as soman (gd) inhibit acetylcholinesterase, producing an excess of acetylcholine (ach), which results in respiratory distress, convulsions and status epilepticus that leads to neuropathology. |
2017-03-24 |
2023-08-13 |
rat |
| Stanton F McHardy, Hua-Yu Leo Wang, Shelby V McCowen, Matthew C Valde. Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015). Expert opinion on therapeutic patents. vol 27. issue 4. 2017-03-22. PMID:27967267. |
acetylcholinesterase (ache) is the major enzyme that hydrolyzes acetylcholine, a key neurotransmitter for synaptic transmission, into acetic acid and choline. |
2017-03-22 |
2023-08-13 |
Not clear |
| Daniela Galimberti, Elio Scarpin. Old and new acetylcholinesterase inhibitors for Alzheimer's disease. Expert opinion on investigational drugs. vol 25. issue 10. 2017-03-10. PMID:27459153. |
acheis reversibly inhibit acetylcholinesterase (ache), thus increasing the availability of acetylcholine in cholinergic synapses, enhancing cholinergic transmission. |
2017-03-10 |
2023-08-13 |
Not clear |
| Nidhi Chauhan, Sheetal Chawla, C S Pundir, Utkarsh Jai. An electrochemical sensor for detection of neurotransmitter-acetylcholine using metal nanoparticles, 2D material and conducting polymer modified electrode. Biosensors & bioelectronics. vol 89. issue Pt 1. 2017-03-01. PMID:27342368. |
an essential biological sensor for acetylcholine (ach) detection is constructed by immobilizing enzymes, acetylcholinesterase (ache) and choline oxidase (cho), on the surface of iron oxide nanoparticles (fe |
2017-03-01 |
2023-08-13 |
Not clear |
| Roman Roy, Flavia Niccolini, Gennaro Pagano, Marios Politi. Cholinergic imaging in dementia spectrum disorders. European journal of nuclear medicine and molecular imaging. vol 43. issue 7. 2017-02-24. PMID:26984612. |
spect and pet studies using selective radioligands for cholinergic markers, such as [(11)c]mp4a and [(11)c]pmp pet for acetylcholinesterase (ache), [(123)i]5ia spect for the α4β2 nicotinic acetylcholine receptor and [(123)i]ibvm spect for the vesicular acetylcholine transporter, have been developed in an attempt to clarify those aspects of the diseases that remain unclear. |
2017-02-24 |
2023-08-13 |
Not clear |