| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhiqing Pang, Che-Ming J Hu, Ronnie H Fang, Brian T Luk, Weiwei Gao, Fei Wang, Erdembileg Chuluun, Pavimol Angsantikul, Soracha Thamphiwatana, Weiyue Lu, Xinguo Jiang, Liangfang Zhan. Detoxification of Organophosphate Poisoning Using Nanoparticle Bioscavengers. ACS nano. vol 9. issue 6. 2016-05-16. PMID:26053868. |
organophosphate poisoning is highly lethal as organophosphates, which are commonly found in insecticides and nerve agents, cause irreversible phosphorylation and inactivation of acetylcholinesterase (ache), leading to neuromuscular disorders via accumulation of acetylcholine in the body. |
2016-05-16 |
2023-08-13 |
mouse |
| Avi Ring, Bjorn Oddvar Strom, Simon R Turner, Christopher M Timperley, Michael Bird, A Christopher Green, John E Chad, Franz Worek, John E H Tattersal. Bispyridinium Compounds Inhibit Both Muscle and Neuronal Nicotinic Acetylcholine Receptors in Human Cell Lines. PloS one. vol 10. issue 8. 2016-05-09. PMID:26274808. |
standard treatment of poisoning by organophosphorus anticholinesterases uses atropine to reduce the muscarinic effects of acetylcholine accumulation and oximes to reactivate acetylcholinesterase (the effectiveness of which depends on the specific anticholinesterase), but does not directly address the nicotinic effects of poisoning. |
2016-05-09 |
2023-08-13 |
human |
| Juliana O S Giacoppo, Tanos C C França, Kamil Kuča, Elaine F F da Cunha, Ruben Abagyan, Daiana T Mancini, Teodorico C Ramalh. Molecular modeling and in vitro reactivation study between the oxime BI-6 and acetylcholinesterase inhibited by different nerve agents. Journal of biomolecular structure & dynamics. vol 33. issue 9. 2016-04-19. PMID:25407587. |
nerve agents are organophosphates acting as potent inhibitors of acetylcholinesterase (ache), the enzyme responsible for the hydrolysis of acetylcholine and, consequently, the termination of the transmission of nerve impulses. |
2016-04-19 |
2023-08-13 |
Not clear |
| Maha A E Ahmed, Sally A El-Awda. Lipoic acid and pentoxifylline mitigate nandrolone decanoate-induced neurobehavioral perturbations in rats via re-balance of brain neurotransmitters, up-regulation of Nrf2/HO-1 pathway, and down-regulation of TNFR1 expression. Hormones and behavior. vol 73. 2016-03-28. PMID:26187709. |
these behavioral abnormalities were accompanied by several biochemical changes, including altered levels of brain monoamines, gaba, and acetylcholine, enhanced levels of malondialdehyde and tnf-α, elevated activity of acetylcholinesterase, and up-regulated expression of tnf-α receptor-1 (tnfr1). |
2016-03-28 |
2023-08-13 |
rat |
| Tatsuya Omotezako, Takeshi A Onuma, Hiroki Nishid. DNA interference: DNA-induced gene silencing in the appendicularian Oikopleura dioica. Proceedings. Biological sciences. vol 282. issue 1807. 2016-03-22. PMID:25904672. |
pcr products encoding zic-like1 and acetylcholine esterase also induced loss of sensory organ and muscle acetylcholinesterase activity, respectively. |
2016-03-22 |
2023-08-13 |
Not clear |
| Tran Manh Hung, Joo Sang Lee, Nguyen Ngoc Chuong, Jeong Ah Kim, Sang Ho Oh, Mi Hee Woo, Jae Sue Choi, Byung Sun Mi. Kinetics and molecular docking studies of cholinesterase inhibitors derived from water layer of Lycopodiella cernua (L.) Pic. Serm. (II). Chemico-biological interactions. vol 240. 2016-03-15. PMID:26297990. |
acetylcholinesterase (ache) inhibitors increase the availability of acetylcholine in central cholinergic synapses and are the most promising drugs currently available for the treatment of alzheimer's disease (ad). |
2016-03-15 |
2023-08-13 |
Not clear |
| Mahendra P Kashyap, Vivek Kumar, Abhishek K Singh, Vinay K Tripathi, Sadaf Jahan, Ankita Pandey, Ritesh K Srivastava, Vinay K Khanna, Aditya B Pan. Differentiating neurons derived from human umbilical cord blood stem cells work as a test system for developmental neurotoxicity. Molecular neurobiology. vol 51. issue 2. 2016-03-14. PMID:24859382. |
the decreased acetylcholinesterase activity, dopaminergic, and cholinergic receptors and increased acetylcholine levels in the differentiating neuronal cells indicate the vulnerability of these cells towards mcp-induced neurotoxicity. |
2016-03-14 |
2023-08-13 |
human |
| Yan-Fang Xian, Siu-Po Ip, Qing-Qiu Mao, Zi-Ren Su, Jian-Nan Chen, Xiao-Ping Lai, Zhi-Xiu Li. Honokiol improves learning and memory impairments induced by scopolamine in mice. European journal of pharmacology. vol 760. 2016-03-08. PMID:25912802. |
in addition, treatment with honokiol significantly decreased the protein and mrna levels of interleukin (il)-1β and the activity of acetylcholinesterase (ache), while significantly increased the protein and mrna levels of il-10, and the level of acetylcholine (ach) in the brain of the scop-treated mice. |
2016-03-08 |
2023-08-13 |
mouse |
| Fen Liu, Yong Li, Rong Jiang, Cheng Nie, Zhenguo Zeng, Ning Zhao, Caixue Huang, Qiang Shao, Chengzhi Ding, Cheng Qing, Liang Xia, Erming Zeng, Kejian Qia. miR-132 inhibits lipopolysaccharide-induced inflammation in alveolar macrophages by the cholinergic anti-inflammatory pathway. Experimental lung research. vol 41. issue 5. 2016-02-26. PMID:26052826. |
we hypothesized that mir-132 attenuated lipopolysaccharide (lps)-induced inflammation of alveolar macrophages by targeting acetylcholinesterase (ache) and enhancing the acetylcholine (ach)-mediated cholinergic anti-inflammatory response. |
2016-02-26 |
2023-08-13 |
Not clear |
| Chen-Yi Ke, Yun-Tse Wu, Wei-Lung Tsen. Fluorescein-5-isothiocyanate-conjugated protein-directed synthesis of gold nanoclusters for fluorescent ratiometric sensing of an enzyme-substrate system. Biosensors & bioelectronics. vol 69. 2016-02-16. PMID:25703728. |
the effective fluorescence quenching of auncs by h2o2 enabled fitc/bsa-auncs to ratiometrically detect the h2o2 product-related enzyme system and its inhibition, including glucose oxidase-catalyzed oxidation of glucose, acetylcholinesterase/choline oxidase-mediated hydrolysis and oxidation of acetylcholine, and paraoxon-induced inhibition of acetylcholinesterase activity. |
2016-02-16 |
2023-08-13 |
cattle |
| Amy E Perkins, Jim R Fadel, Sandra J Kell. The effects of postnatal alcohol exposure and galantamine on the context pre-exposure facilitation effect and acetylcholine efflux using in vivo microdialysis. Alcohol (Fayetteville, N.Y.). vol 49. issue 3. 2016-01-28. PMID:25837482. |
et animals were not different at baseline, but had decreased k(+)/ca(2+)-induced acetylcholine efflux compared to nc animals and an enhanced acetylcholine response to galantamine (acetylcholinesterase inhibitor; 2.0 mg/kg) compared to both control groups. |
2016-01-28 |
2023-08-13 |
rat |
| Xue-Qin Hou, Lei Zhang, Cong Yang, Cui-Ping Rong, Wen-Qing He, Chun-Xia Zhang, Shi Li, Ru-Yu Su, Xiang Chang, Ji-Huan Qin, Yun-Bo Chen, Shao-Xiang Xian, Qi Wan. Alleviating effects of Bushen-Yizhi formula on ibotenic acid-induced cholinergic impairments in rat. Rejuvenation research. vol 18. issue 2. 2016-01-22. PMID:25482164. |
additionally, bsyz reversed ibo-induced disorders of acetylcholine (ach) levels, chat, and cholinesterase (che) in the cortex, which was consistent with the changes in mrna levels of chat and acetylcholinesterase (ache). |
2016-01-22 |
2023-08-13 |
rat |
| Elvis A F Martis, Rakesh C Chandarana, Mushtaque S Shaikh, Premlata K Ambre, Jacinta S D'Souza, Krishna R Iyer, Evans C Coutinho, Santosh R Nandan, Raghuvir R S Pissurlenka. Quantifying ligand-receptor interactions for gorge-spanning acetylcholinesterase inhibitors for the treatment of Alzheimer's disease. Journal of biomolecular structure & dynamics. vol 33. issue 5. 2016-01-15. PMID:24905476. |
there is a need for continued development of acetylcholinesterase (ache) inhibitors that could prolong the life of acetylcholine in the synaptic cleft and also prevent the aggregation of amyloid peptides associated with alzheimer's disease. |
2016-01-15 |
2023-08-13 |
Not clear |
| J O Hollnagel, R Ul Haq, C J Behrens, A Maslarova, I Mody, U Heineman. No evidence for role of extracellular choline-acetyltransferase in generation of gamma oscillations in rat hippocampal slices in vitro. Neuroscience. vol 284. 2016-01-04. PMID:25453770. |
acetylcholine (ach) is well known to induce persistent γ-oscillations in the hippocampus when applied together with physostigmine, an inhibitor of the ach degrading enzyme acetylcholinesterase (ache). |
2016-01-04 |
2023-08-13 |
rat |
| Sihua Qian, Hengwei Li. Colorimetric sensor array for detection and identification of organophosphorus and carbamate pesticides. Analytical chemistry. vol 87. issue 10. 2015-12-23. PMID:25913282. |
the sensing mechanism of this array is based on the irreversible inhibition capability of ops and carbamates to the activity of acetylcholinesterase (ache), preventing production of thiocholine and h2o2 from s-acetylthiocholine and acetylcholine and thus resulting in decreased or no color reactions to thiocholine and h2o2 sensitive indicators. |
2015-12-23 |
2023-08-13 |
Not clear |
| Zongming Ren, Xu Zhang, Xiaoguang Wang, Pingping Qi, Biao Zhang, Yang Zeng, Rongshu Fu, Mingsheng Mia. AChE inhibition: one dominant factor for swimming behavior changes of Daphnia magna under DDVP exposure. Chemosphere. vol 120. 2015-12-18. PMID:25112705. |
as a key enzyme that hydrolyzes the neurotransmitter acetylcholine in cholinergic synapses of both vertebrates and invertebrates, acetylcholinesterase (ache) is strongly inhibited by organophosphates. |
2015-12-18 |
2023-08-13 |
Not clear |
| E D Farfán-García, M C Castillo-Hernández, R Pinto-Almazán, S Rivas-Arancibia, J M Gallardo, C Guerra-Araiz. Tibolone prevents oxidation and ameliorates cholinergic deficit induced by ozone exposure in the male rat hippocampus. Neurochemical research. vol 39. issue 9. 2015-12-15. PMID:25052429. |
in this work, we analyzed the effect of chronic tibolone (tib) administration in central nervous system, specifically the content of choline acetyltransferase, acetylcholinesterase, acetylcholine and oxidative stress markers in the hippocampus of male rats exposed to ozone. |
2015-12-15 |
2023-08-13 |
rat |
| Alžběta Kračmarová, Lucie Drtinová, Miroslav Pohank. Possibility of Acetylcholinesterase Overexpression in Alzheimer Disease Patients after Therapy with Acetylcholinesterase Inhibitors. Acta medica (Hradec Kralove). vol 58. issue 2. 2015-12-09. PMID:26455564. |
acetylcholinesterase is an enzyme responsible for termination of excitatory transmission at cholinergic synapses by the hydrolyzing of a neurotransmitter acetylcholine. |
2015-12-09 |
2023-08-13 |
Not clear |
| Robert Zdanowski, Małgorzata Krzyżowska, Dominika Ujazdowska, Aneta Lewicka, Sławomir Lewick. Role of α7 nicotinic receptor in the immune system and intracellular signaling pathways. Central-European journal of immunology. vol 40. issue 3. 2015-12-09. PMID:26648784. |
the non-neuronal acetylcholine is accompanied by the expression of acetylcholinesterase and nicotinic/muscarinic acetylcholine receptors. |
2015-12-09 |
2023-08-13 |
Not clear |
| Kosuke Yamamoto, Satoshi Shida, Yoshihiro Honda, Mariko Shono, Hiroshi Miyake, Suguru Oguri, Hikaru Sakamoto, Yoshie S Momonok. Overexpression of acetylcholinesterase gene in rice results in enhancement of shoot gravitropism. Biochemical and biophysical research communications. vol 465. issue 3. 2015-11-27. PMID:26277389. |
acetylcholine (ach), a known neurotransmitter in animals and acetylcholinesterase (ache) exists widely in plants, although its role in plant signal transduction is unclear. |
2015-11-27 |
2023-08-13 |
Not clear |