| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sangyun Lee, Ji-Hyun Kim, Sangyoub Le. Internal Diffusion-Controlled Enzyme Reaction: The Acetylcholinesterase Kinetics. Journal of chemical theory and computation. vol 8. issue 2. 2015-11-25. PMID:26596618. |
acetylcholinesterase is an enzyme with a very high turnover rate; it quenches the neurotransmitter, acetylcholine, at the synapse. |
2015-11-25 |
2023-08-13 |
Not clear |
| Tiziana Cappello, Maria Maisano, Alessia Giannetto, Vincenzo Parrino, Angela Mauceri, Salvatore Fasul. Neurotoxicological effects on marine mussel Mytilus galloprovincialis caged at petrochemical contaminated areas (eastern Sicily, Italy): ¹H NMR and immunohistochemical assays. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 169. 2015-11-17. PMID:25572855. |
acetylcholine, acetylcholinesterase, ache, and choline acetyltransferase, chat), and dopaminergic systems (i.e. |
2015-11-17 |
2023-08-13 |
Not clear |
| Da Xiao, Yan-Hui Lu, Qing-Li Shang, Dun-Lun Song, Xi-Wu Ga. Gene silencing of two acetylcholinesterases reveals their cholinergic and non-cholinergic functions in Rhopalosiphum padi and Sitobion avenae. Pest management science. vol 71. issue 4. 2015-11-16. PMID:24729410. |
the function of acetylcholinesterase (ache) is to terminate synaptic transmission by hydrolysing the neurotransmitter acetylcholine (ach) in the synaptic cleft, and thus it is an effective target for organophosphate (op) and carbamate (cb) insecticides. |
2015-11-16 |
2023-08-13 |
Not clear |
| Jing Liu, Carey Pop. The cannabinoid receptor antagonist AM251 increases paraoxon and chlorpyrifos oxon toxicity in rats. Neurotoxicology. vol 46. 2015-11-12. PMID:25447325. |
organophosphorus anticholinesterases (ops) elicit acute toxicity by inhibiting acetylcholinesterase (ache), leading to acetylcholine accumulation and overstimulation of cholinergic receptors. |
2015-11-12 |
2023-08-13 |
rat |
| Pablo Andrei Nogara, Rogério de Aquino Saraiva, Diones Caeran Bueno, Lílian Juliana Lissner, Cristiane Lenz Dalla Corte, Marcos M Braga, Denis Broock Rosemberg, João Batista Teixeira Roch. Virtual screening of acetylcholinesterase inhibitors using the Lipinski's rule of five and ZINC databank. BioMed research international. vol 2015. 2015-11-06. PMID:25685814. |
one of the methods used to treat ad is the increase of acetylcholine (ach) in the brain by using acetylcholinesterase inhibitors (acheis). |
2015-11-06 |
2023-08-13 |
Not clear |
| Eran Finkel, Alex Etlin, Meir Cherniak, Yoav Mor, Aharon Lev-Tov, Lili Angliste. Neuroanatomical basis for cholinergic modulation of locomotor networks by sacral relay neurons with ascending lumbar projections. The Journal of comparative neurology. vol 522. issue 15. 2015-11-02. PMID:24752570. |
histochemical and immunostaining of the sacral cord reveals expression of acetylcholinesterase activity, ability to synthesize acetylcholine, and/or innervation by cholinergic synaptic inputs in significant proportions of fluorescently back-labeled sacral vf neurons. |
2015-11-02 |
2023-08-13 |
rat |
| Eran Finkel, Alex Etlin, Meir Cherniak, Yoav Mor, Aharon Lev-Tov, Lili Angliste. Neuroanatomical basis for cholinergic modulation of locomotor networks by sacral relay neurons with ascending lumbar projections. The Journal of comparative neurology. vol 522. issue 15. 2015-11-02. PMID:24752570. |
moreover, the majority of the vf neurons express m2 muscarinic receptors, raising the possibility that the elevated acetylcholine levels resulting from inhibition of acetylcholinesterase act on such receptors. |
2015-11-02 |
2023-08-13 |
rat |
| Eran Finkel, Alex Etlin, Meir Cherniak, Yoav Mor, Aharon Lev-Tov, Lili Angliste. Neuroanatomical basis for cholinergic modulation of locomotor networks by sacral relay neurons with ascending lumbar projections. The Journal of comparative neurology. vol 522. issue 15. 2015-11-02. PMID:24752570. |
we suggest that variations in the sacral level of acetylcholine modulate the sca-induced locomotor rhythm via muscarinic receptor-dependent mechanisms and that the modified activity of sacral vf neurons in the presence of an acetylcholinesterase inhibitor can be partially ascribed to the cholinergic components associated with them. |
2015-11-02 |
2023-08-13 |
rat |
| Tarou Ogurusu, Kazumi Sakata, Tokumitsu Wakabayashi, Yutaro Shimizu, Ryuzo Shinga. The Caenorhabditis elegans R13A5.9 gene plays a role in synaptic vesicle exocytosis. Biochemical and biophysical research communications. vol 463. issue 4. 2015-11-02. PMID:26079877. |
r13a5.9 mutant worms exhibited low sensitivity to aldicarb (an acetylcholinesterase inhibitor), which suggested that vesicular loading or release, or acetylcholine synthesis, was disrupted in these organisms. |
2015-11-02 |
2023-08-13 |
caenorhabditis_elegans |
| Yi Xie, Binbin Wang, Fanchi Li, Lie Ma, Min Ni, Weide Shen, Fashui Hong, Bing L. Molecular mechanisms of reduced nerve toxicity by titanium dioxide nanoparticles in the phoxim-exposed brain of Bombyx mori. PloS one. vol 9. issue 6. 2015-10-28. PMID:24971466. |
the treatments also relieved the phoxim-induced increases in the contents of acetylcholine (ach), glutamate (glu) and nitric oxide (no) and the phoxim-induced decreases in the contents of norepinephrine (ne), dopamine (da), and 5-hydroxytryptamine (5-ht), and reduced the inhibition of acetylcholinesterase (ache), na+/k+-atpase, ca2+-atpase, and ca2+/mg2+-atpase activities and the activation of total nitric oxide synthase (tnos) in the brain. |
2015-10-28 |
2023-08-13 |
Not clear |
| Young Hun Lee, Min Cheol Shin, Yong Don Yun, Seo Young Shin, Jong Min Kim, Jeong Moo Seo, Nam-Jung Kim, Jong Hoon Ryu, Yong Sup Le. Synthesis of aminoalkyl-substituted aurone derivatives as acetylcholinesterase inhibitors. Bioorganic & medicinal chemistry. vol 23. issue 1. 2015-10-22. PMID:25468034. |
to date, the successful therapeutic strategy to treat ad is maintaining the levels of acetylcholine by inhibiting acetylcholinesterase (ache). |
2015-10-22 |
2023-08-13 |
mouse |
| Lucas H Hess, Alina Lyuleeva, Benno M Blaschke, Matthias Sachsenhauser, Max Seifert, Jose A Garrido, Frank Deube. Graphene transistors with multifunctional polymer brushes for biosensing applications. ACS applied materials & interfaces. vol 6. issue 12. 2015-10-16. PMID:24866105. |
to demonstrate the potential of this polymer brush functionalization scaffold, we modified solution-gated graphene field-effect transistors with the enzyme acetylcholinesterase and a transducing group, allowing the detection of the neurotransmitter acetylcholine. |
2015-10-16 |
2023-08-13 |
Not clear |
| b' Dragan Hrn\\xc4\\x8di\\xc4\\x87, Aleksandra Ra\\xc5\\xa1i\\xc4\\x87-Markovi\\xc4\\x87, Tihomir Stojkovi\\xc4\\x87, Milica Velimirovi\\xc4\\x87, Nela Pu\\xc5\\xa1ka\\xc5\\xa1, Radmila Obrenovi\\xc4\\x87, Djuro Macut, Veselinka Su\\xc5\\xa1i\\xc4\\x87, Vladimir Jakovljevi\\xc4\\x87, Dragan Djuric, Nata\\xc5\\xa1a Petronijevi\\xc4\\x87, Olivera Stanojlovi\\xc4\\x8. Hyperhomocysteinemia induced by methionine dietary nutritional overload modulates acetylcholinesterase activity in the rat brain. Molecular and cellular biochemistry. vol 396. issue 1-2. 2015-10-06. PMID:25052005.' |
acetylcholinesterase is a serine protease that rapidly hydrolyzes neurotransmitter acetylcholine. |
2015-10-06 |
2023-08-13 |
rat |
| Ying Li, Shan Hai, Yan Zhou, Bi Rong Don. Cholinesterase inhibitors for rarer dementias associated with neurological conditions. The Cochrane database of systematic reviews. issue 3. 2015-10-02. PMID:25734590. |
cholinesterase inhibitors are hypothesised to work by inhibiting the enzyme acetylcholinesterase (ache) which breaks down the neurotransmitter acetylcholine. |
2015-10-02 |
2023-08-13 |
Not clear |
| Ryota Matsuo, Suguru Kobayashi, Kyoko Wakiya, Miki Yamagishi, Masayuki Fukuoka, Etsuro It. The cholinergic system in the olfactory center of the terrestrial slug Limax. The Journal of comparative neurology. vol 522. issue 13. 2015-09-22. PMID:24523205. |
here we cloned the cdnas of choline acetyltransferase (chat), acetylcholinesterase, vesicular acetylcholine transporter, and several nicotinic acetylcholine receptors (nachrs), and investigated their localization in the brain of limax. |
2015-09-22 |
2023-08-12 |
Not clear |
| Q Zou, S W S Leung, P M Vanhoutt. Transient Receptor Potential Channel Opening Releases Endogenous Acetylcholine, which Contributes to Endothelium-Dependent Relaxation Induced by Mild Hypothermia in Spontaneously Hypertensive Rat but Not Wistar-Kyoto Rat Arteries. The Journal of pharmacology and experimental therapeutics. vol 354. issue 2. 2015-09-15. PMID:26060231. |
the responses in shr aortae were also reduced by acetylcholinesterase (the enzyme responsible for acetylcholine degradation), bromoacetylcholine (inhibitor of acetylcholine synthesis), hemicholinium-3 (inhibitor of choline uptake), and vesamicol (inhibitor of acetylcholine release). |
2015-09-15 |
2023-08-13 |
rat |
| Q Zou, S W S Leung, P M Vanhoutt. Transient Receptor Potential Channel Opening Releases Endogenous Acetylcholine, which Contributes to Endothelium-Dependent Relaxation Induced by Mild Hypothermia in Spontaneously Hypertensive Rat but Not Wistar-Kyoto Rat Arteries. The Journal of pharmacology and experimental therapeutics. vol 354. issue 2. 2015-09-15. PMID:26060231. |
compared with wky rats, the shr preparations expressed similar levels of acetylcholinesterase and choline acetyltransferase, but a lesser amount of vesicular acetylcholine transporter, located mainly in the endothelium. |
2015-09-15 |
2023-08-13 |
rat |
| Z Ming, G Sawicki, L K Beka. Acute systemic LPS-mediated inflammation induces lasting changes in mouse cortical neuromodulation and behavior. Neuroscience letters. vol 590. 2015-09-14. PMID:25650524. |
as increased acetylcholinesterase activity is associated with reduced acetylcholine signaling and impaired cognitive ability, these studies demonstrate the potential for a single inflammatory event to initiate processes that may lead to long-term neurodegeneration. |
2015-09-14 |
2023-08-13 |
mouse |
| Franciele Martini, César Augusto Bruning, Suelen Mendonca Soares, Cristina Wayne Nogueira, Gilson Zen. Inhibitory effect of ebselen on cerebral acetylcholinesterase activity in vitro: kinetics and reversibility of inhibition. Current pharmaceutical design. vol 21. issue 7. 2015-09-11. PMID:25312723. |
there is evidence that ebselen inhibits acetylcholinesterase (ache) activity, an enzyme that plays a key role in the cholinergic system by hydrolyzing acetylcholine (ach), in vitro and ex vivo. |
2015-09-11 |
2023-08-13 |
Not clear |
| Xiangling Ren, Jianfei Wei, Jun Ren, Li Qiang, Fangqiong Tang, Xianwei Men. A sensitive biosensor for the fluorescence detection of the acetylcholinesterase reaction system based on carbon dots. Colloids and surfaces. B, Biointerfaces. vol 125. 2015-09-07. PMID:25500325. |
specifically, the proposed fluorescent biosensor was successfully applied to detect the concentration of choline (in the range from 0.025 to 50 μm) and acetylcholine (in the range from 0.050 to 50 μm), and the activity of choline oxidase (in the range from 1 to 75 u/l) and acetylcholinesterase (1 to 80 u/l). |
2015-09-07 |
2023-08-13 |
Not clear |