| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aliya Ahmad, Kalavathy Ramasamy, Siti Murnirah Jaafar, Abu Bakar Abdul Majeed, Vasudevan Man. Total isoflavones from soybean and tempeh reversed scopolamine-induced amnesia, improved cholinergic activities and reduced neuroinflammation in brain. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 65. 2014-10-28. PMID:24373829. |
significantly increased (p<0.001) acetylcholine and reduced acetylcholinesterase levels. |
2014-10-28 |
2023-08-12 |
rat |
| Sony Pandey, Ayinampudi Sree, Dipti Priya Sethi, Chityal Ganesh Kumar, Sudha Kakollu, Lipsa Chowdhury, Soumya Suchismita Das. A marine sponge associated strain of Bacillus subtilis and other marine bacteria can produce anticholinesterase compounds. Microbial cell factories. vol 13. issue 1. 2014-10-28. PMID:24528673. |
acetylcholinesterase (ache) inhibitors or anticholinesterases reduce the activity of enzyme acetylcholinesterase that degrades the neurotransmitter acetylcholine in the brain. |
2014-10-28 |
2023-08-12 |
Not clear |
| Fan Wang, Chonglei Li, Wei Liu, Yihe Ji. Potential mechanisms of neurobehavioral disturbances in mice caused by sub-chronic exposure to low-dose VOCs. Inhalation toxicology. vol 26. issue 4. 2014-10-14. PMID:24568580. |
the levels of reactive oxygen species (ros), malondialdehyde (mda) and glutamic acid (glu) were significantly increased, while the acetylcholinesterase (ache), choline acetyltransferase (chat) and acetylcholine (ach) levels, and the expression of nmda receptor were significantly decreased in vocs exposed groups. |
2014-10-14 |
2023-08-12 |
mouse |
| Golan Karvat, Tali Kimch. Acetylcholine elevation relieves cognitive rigidity and social deficiency in a mouse model of autism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 4. 2014-10-10. PMID:24096295. |
here we tested the hypothesis that augmentation of acetylcholine (ach) in the synaptic cleft by inhibiting acetylcholinesterase may ameliorate autistic phenotypes. |
2014-10-10 |
2023-08-12 |
mouse |
| Seung Ok Nam, Dong Hyun Park, Young Hun Lee, Jong Hoon Ryu, Yong Sup Le. Synthesis of aminoalkyl-substituted coumarin derivatives as acetylcholinesterase inhibitors. Bioorganic & medicinal chemistry. vol 22. issue 4. 2014-09-29. PMID:24485122. |
to date, the successful therapeutic strategy to treat ad is maintaining levels of acetylcholine by inhibiting acetylcholinesterase (ache). |
2014-09-29 |
2023-08-12 |
mouse |
| Cui-Ge Shi, Yi-Shu Yang, Hui Li, Ying Zhang, Ning Wang, Shang-Ming Wang, Jie-Dong Wang, Shu-Cheng Zhan. Tanshinol protects hippocampus and attenuates vascular dementia development. Journal of Asian natural products research. vol 16. issue 6. 2014-09-29. PMID:24957473. |
tsl remarkably increased acetylcholine level and decreased acetylcholinesterase activity in rats subjected to vd. |
2014-09-29 |
2023-08-13 |
rat |
| Hyo Geun Kim, Minho Moon, Jin Gyu Choi, Gunhyuk Park, Ae-Jung Kim, Jinyoung Hur, Kyung-Tae Lee, Myung Sook O. Donepezil inhibits the amyloid-beta oligomer-induced microglial activation in vitro and in vivo. Neurotoxicology. vol 40. 2014-09-19. PMID:24189446. |
donepezil is a well-known anti-dementia agent that increases acetylcholine levels through inhibition of acetylcholinesterase. |
2014-09-19 |
2023-08-12 |
mouse |
| Abby M Bailey, Stephanie N Baker, Regan A Baum, Hannah E Chandler, Kyle A Wean. Being prepared: emergency treatment following a nerve agent release. Advanced emergency nursing journal. vol 36. issue 1. 2014-09-10. PMID:24487260. |
these agents work through altering the transmission and breakdown of acetylcholine by binding to, and inactivating, acetylcholinesterase. |
2014-09-10 |
2023-08-12 |
human |
| Eduardo Luis Konrath, Carolina dos Santos Passos, Luiz Carlos Klein, Amélia T Henrique. Alkaloids as a source of potential anticholinesterase inhibitors for the treatment of Alzheimer's disease. The Journal of pharmacy and pharmacology. vol 65. issue 12. 2014-09-05. PMID:24236981. |
the inhibition of acetylcholinesterase (ache), the key enzyme in the breakdown of acetylcholine, is currently the main pharmacological strategy available for alzheimer's disease (ad). |
2014-09-05 |
2023-08-12 |
Not clear |
| Yinhui Yi, Gangbing Zhu, Chang Liu, Yan Huang, Youyu Zhang, Haitao Li, Jiangna Zhao, Shouzhuo Ya. A label-free silicon quantum dots-based photoluminescence sensor for ultrasensitive detection of pesticides. Analytical chemistry. vol 85. issue 23. 2014-08-28. PMID:24160846. |
this sensing strategy involves the reaction of acetylcholine chloride (ach) with acetylcholinesterase (ache) to form choline that is in turn catalytically oxidized by choline oxidase (chox) to produce betaine and h2o2 which can quench the photoluminescence (pl) of siqds. |
2014-08-28 |
2023-08-12 |
Not clear |
| Athina A Strilakou, Stylianos T Tsakiris, Konstantinos G Kalafatakis, Aikaterini T Stylianaki, Petros L Karkalousos, Andreas V Koulouris, Iordanis S Mourouzis, Charis A Liap. Carnitine modulates crucial myocardial adenosine triphosphatases and acetylcholinesterase enzyme activities in choline-deprived rats. Canadian journal of physiology and pharmacology. vol 92. issue 1. 2014-07-25. PMID:24383876. |
choline is also the precursor of acetylcholine (cholinergic component of the heart's autonomic nervous system), whose levels are regulated by acetylcholinesterase (ache). |
2014-07-25 |
2023-08-12 |
rat |
| Donghoon Kwon, Jinmyoung Joo, Sanghee Lee, Sangmin Jeo. Facile and sensitive method for detecting cardiac markers using ubiquitous pH meters. Analytical chemistry. vol 85. issue 24. 2014-07-15. PMID:24229314. |
these complexes were subsequently conjugated to polyclonal antibody-functionalized acetylcholinesterase (ache) and dispersed in acetylcholine (ach) solution. |
2014-07-15 |
2023-08-12 |
human |
| Gaizka Garai-Ibabe, Laura Saa, Valeri Pavlo. Thiocholine mediated stabilization of in situ produced CdS quantum dots: application for the detection of acetylcholinesterase activity and inhibitors. The Analyst. vol 139. issue 1. 2014-07-14. PMID:24225492. |
the high toxicity of these compounds arises from their ability to inhibit acetylcholinesterase from degrading acetylcholine (ach), which could affect the physiology of the nervous system with serious or fatal consequences. |
2014-07-14 |
2023-08-12 |
human |
| Karyn G Robinson, Matthew J Viereck, Megan V Margiotta, Karen W Gripp, Omar A Abdul-Rahman, Robert E Akin. Neuromotor synapses in Escobar syndrome. American journal of medical genetics. Part A. vol 161A. issue 12. 2014-07-02. PMID:24038971. |
compared to spinalis muscle from control patients with idiopathic scoliosis or cerebral palsy (cp), the patient with escobar syndrome had a significantly higher degree of acetylcholine receptor present outside acetylcholinesterase and significantly less acetylcholinesterase outside acetylcholine receptors. |
2014-07-02 |
2023-08-12 |
Not clear |
| Faiyaz Ahmed, Raza Murad Ghalib, P Sasikala, K K Mueen Ahme. Cholinesterase inhibitors from botanicals. Pharmacognosy reviews. vol 7. issue 14. 2014-06-24. PMID:24347920. |
decreased concentration of the neurotransmitter, acetylcholine (ach), appears to be critical element in the development of dementia, and the most appropriate therapeutic approach to treat ad and other form of dementia is to restore acetylcholine levels by inhibiting both major form of cholinesterase: acetylcholinesterase (ache) and butyrylcholinesterase (bche). |
2014-06-24 |
2023-08-12 |
Not clear |
| Amy Easton, Sethu Sankaranarayanan, An Tanghe, Dick Terwel, Alan X Lin, Nina Hoque, Clotilde Bourin, Huidong Gu, Michael Ahlijanian, Linda Bristo. Effects of sub-chronic donepezil on brain Abeta and cognition in a mouse model of Alzheimer's disease. Psychopharmacology. vol 230. issue 2. 2014-06-23. PMID:23783773. |
acetylcholinesterase inhibitors (acheis) are approved to treat the symptoms of mild to moderate alzheimer's disease by restoring acetylcholine levels at synapses where the neurotransmitter has been depleted due to neurodegeneration. |
2014-06-23 |
2023-08-12 |
mouse |
| Jonah Cheung, Ebony N Gary, Kazuro Shiomi, Terrone L Rosenberr. Structures of human acetylcholinesterase bound to dihydrotanshinone I and territrem B show peripheral site flexibility. ACS medicinal chemistry letters. vol 4. issue 11. 2014-06-05. PMID:24900610. |
acetylcholinesterase is a critical enzyme that regulates neurotransmission by degrading the neurotransmitter acetylcholine in synapses of the nervous system. |
2014-06-05 |
2023-08-13 |
human |
| Jennifer L Carey, Courtney Dunn, Romolo J Gaspar. Central respiratory failure during acute organophosphate poisoning. Respiratory physiology & neurobiology. vol 189. issue 2. 2014-06-02. PMID:23933009. |
ops affect neuronal signaling through acetylcholine (ach) neurotransmission via inhibition of acetylcholinesterase (ache), leading to accumulation of ach at the synaptic cleft and excessive stimulation at post-synaptic receptors. |
2014-06-02 |
2023-08-12 |
Not clear |
| Sebastian Aguiar, Thomas Borowsk. Neuropharmacological review of the nootropic herb Bacopa monnieri. Rejuvenation research. vol 16. issue 4. 2014-05-05. PMID:23772955. |
current evidence suggests bm acts via the following mechanisms-anti-oxidant neuroprotection (via redox and enzyme induction), acetylcholinesterase inhibition and/or choline acetyltransferase activation, β-amyloid reduction, increased cerebral blood flow, and neurotransmitter modulation (acetylcholine [ach], 5-hydroxytryptamine [5-ht], dopamine [da]). |
2014-05-05 |
2023-08-12 |
Not clear |
| Alicja Tomaszek, Liliana Kiczak, Jacek Bania, Paweł Krupa, Urszula Pasławska, Maciej Zacharski, Adrian Janiszewski, Tadeusz Stefaniak, Dorota Zyśko, Hossein Ardehali, Ewa A Jankowska, Piotr Ponikowsk. Changes in parasympathetic system in medulla oblongata in male pigs in the course of tachycardia-induced cardiomyopathy. Autonomic neuroscience : basic & clinical. vol 177. issue 2. 2014-04-29. PMID:23891249. |
α7 nicotinic acetylcholine receptor (α7nachr) and enzymes metabolizing acetylcholine (acetylcholinesterase, ache, choline acetyltransferase, chat) in medulla oblongata (mo) of male pigs with chronic tachycardia-induced cardiomyopathy. |
2014-04-29 |
2023-08-12 |
Not clear |