| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meihua Li, Can Zheng, Toru Kawada, Masashi Inagaki, Kazunori Uemura, Toshiaki Shishido, Masaru Sugimach. Donepezil markedly improves long-term survival in rats with chronic heart failure after extensive myocardial infarction. Circulation journal : official journal of the Japanese Circulation Society. vol 77. issue 10. 2014-04-18. PMID:23832513. |
acetylcholinesterase inhibition increases synaptic acetylcholine, and can disproportionately increase vagal tone. |
2014-04-18 |
2023-08-12 |
rat |
| T R Anju, C S Paulos. Striatal cholinergic functional alterations in hypoxic neonatal rats: role of glucose, oxygen, and epinephrine resuscitation. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 91. issue 5. 2014-04-03. PMID:24032686. |
receptor binding and gene expression studies were done in the corpus striatum to analyse the changes in total muscarinic receptors, muscarinic m1, m2, m3 receptors, and the enzymes involved in acetylcholine metabolism, choline acetyltransferase and acetylcholinesterase. |
2014-04-03 |
2023-08-12 |
rat |
| Ana Zovko, Kristina Viktorsson, Rolf Lewensohn, Katja Kološa, Metka Filipič, Hong Xing, William R Kem, Laura Paleari, Tom Tur. APS8, a polymeric alkylpyridinium salt blocks α7 nAChR and induces apoptosis in non-small cell lung carcinoma. Marine drugs. vol 11. issue 7. 2014-04-01. PMID:23880932. |
aps8, an analog of poly-aps with defined alkyl chain length and molecular size, non-competitively inhibits α7 nicotinic acetylcholine receptors (nachrs) at nanomolar concentrations that are too low to be acetylcholinesterase (ache) inhibitory or generally cytotoxic. |
2014-04-01 |
2023-08-12 |
Not clear |
| A I Golovk. [Sobering up agents influencing toxicodynamics of ethanol]. Biomeditsinskaia khimiia. vol 59. issue 6. 2014-04-01. PMID:24511673. |
promising should be considered the agents, which modulate gaba-systems (partial reverse agonists of benzodiazepine receptors), glutamate (antagonists of metabotropic receptors mglur2/3), opioid neuropeptides (antagonists of opioid receptors), acetylcholine (reversible inhibitors of acetylcholinesterase and m-cholinoagonists), adenosine (selective antagonists of a(2a)-receptors). |
2014-04-01 |
2023-08-12 |
Not clear |
| Sibelle Feitosa da Cunha Xavier Soares, Andréia Aguiar Vieira, Reinaldo Teixeira Delfino, José Daniel Figueroa-Villa. NMR determination of Electrophorus electricus acetylcholinesterase inhibition and reactivation by neutral oximes. Bioorganic & medicinal chemistry. vol 21. issue 18. 2014-03-26. PMID:23916150. |
the main target of ops is the inhibition of acetylcholinesterase (ache), an enzyme necessary for the control of the neurotransmitter acetylcholine (ach). |
2014-03-26 |
2023-08-12 |
Not clear |
| Ansel T Hillmer, Dustin W Wooten, Mohammed Farhoud, Andrew T Higgins, Patrick J Lao, Todd E Barnhart, Jogeshwar Mukherjee, Bradley T Christia. PET imaging of acetylcholinesterase inhibitor-induced effects on α4β2 nicotinic acetylcholine receptor binding. Synapse (New York, N.Y.). vol 67. issue 12. 2014-03-25. PMID:23913347. |
acetylcholinesterase inhibitors (acheis) are drugs that increase synaptic acetylcholine (ach) concentrations and are under investigation as treatments for symptoms accompanying alzheimer's disease. |
2014-03-25 |
2023-08-12 |
human |
| Philippe Lestaevel, Hélène Bensoussan, Bernadette Dhieux, Olivia Delissen, Claire-Marie Vacher, Isabelle Dublineau, Philippe Voisin, Mohammed Taoui. Cerebral cortex and hippocampus respond differently after post-natal exposure to uranium. The Journal of toxicological sciences. vol 38. issue 5. 2014-03-25. PMID:24067729. |
acetylcholine (ach) and acetylcholinesterase (ache) levels were evaluated in the entorhinal cortex and hippocampus. |
2014-03-25 |
2023-08-12 |
rat |
| Ling Huang, Tao Su, Xingshu L. Natural products as sources of new lead compounds for the treatment of Alzheimer's disease. Current topics in medicinal chemistry. vol 13. issue 15. 2014-03-10. PMID:23931437. |
one possible approach for the treatment of this disease is the restoration of the level of acetylcholine (ach) through the inhibition of acetylcholinesterase (ache) with reversible inhibitors. |
2014-03-10 |
2023-08-12 |
Not clear |
| K V Niessen, T Seeger, J E H Tattersall, C M Timperley, M Bird, C Green, H Thiermann, F Wore. Affinities of bispyridinium non-oxime compounds to [(3)H]epibatidine binding sites of Torpedo californica nicotinic acetylcholine receptors depend on linker length. Chemico-biological interactions. vol 206. issue 3. 2014-03-10. PMID:24157926. |
the toxicity of organophosphorus nerve agents or pesticides arises from accumulation of acetylcholine and overstimulation of both muscarinic and nicotinic acetylcholine receptors (machrs and nachrs) due to inhibition of acetylcholinesterase (ache). |
2014-03-10 |
2023-08-12 |
human |
| Miroslav Pohanka, Vojtech Adam, Rene Kize. An acetylcholinesterase-based chronoamperometric biosensor for fast and reliable assay of nerve agents. Sensors (Basel, Switzerland). vol 13. issue 9. 2014-02-27. PMID:23999806. |
the enzyme acetylcholinesterase (ache) is an important part of cholinergic nervous system, where it stops neurotransmission by hydrolysis of the neurotransmitter acetylcholine. |
2014-02-27 |
2023-08-12 |
Not clear |
| Saif M Al-Ghai. Acetylcholinesterase, glutathione and hepatosomatic index as potential biomarkers of sewage pollution and depuration in fish. Marine pollution bulletin. vol 74. issue 1. 2014-02-20. PMID:23911202. |
cellular biomarkers, cholinesterase activity using acetylcholine as a substrate (acetylcholinesterase ache) and reduced glutathione (gsh) and hepatosomatic index (hsi) were investigated in fresh water fish, tilapia, raised in a fish farm (group i/clean, as control), treated sewage water/tsw (group ii/sewage) and thereafter exposed to fresh water in an aquarium for 6 weeks (group iii/depurated) for depuration. |
2014-02-20 |
2023-08-12 |
Not clear |
| Xiomara A Perez, J Michael McIntosh, Maryka Qui. Long-term nicotine treatment down-regulates α6β2* nicotinic receptor expression and function in nucleus accumbens. Journal of neurochemistry. vol 127. issue 6. 2014-02-18. PMID:23992036. |
studies with an acetylcholinesterase inhibitor demonstrated that the response was also sensitive to increased endogenous acetylcholine. |
2014-02-18 |
2023-08-12 |
rat |
| Seok-Joo Park, Eun-Joo Shin, Sun Seek Min, Jihua An, Zhengyi Li, Yoon Hee Chung, Ji Hoon Jeong, Jae-Hyung Bach, Seung-Yeol Nah, Won-Ki Kim, Choon-Gon Jang, Yong-Sun Kim, Yo-Ichi Nabeshima, Toshitaka Nabeshima, Hyoung-Chun Ki. Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 8. 2014-02-13. PMID:23389690. |
cholinergic parameters (ie, acetylcholine (ach), choline acetyltransferase (chat), and acetylcholinesterase (ache)) and nmdar-dependent long-term potentiation (ltp) were significantly impaired in klotho mutant mice. |
2014-02-13 |
2023-08-12 |
mouse |
| Mary L Nowlan, Mary L Nolan, Lesley J Scot. Acotiamide: first global approval. Drugs. vol 73. issue 12. 2014-02-11. PMID:23881665. |
it exerts its activity in the stomach via muscarinic receptor inhibition, resulting in enhanced acetylcholine release and inhibition of acetylcholinesterase activity. |
2014-02-11 |
2023-08-12 |
Not clear |
| Edward G Rowan, Alan L Harve. Snake toxins from mamba venoms: unique tools for the physiologist. Acta chimica Slovenica. vol 58. issue 4. 2014-02-10. PMID:24061116. |
despite their common 3d shape, these peptides can interfere selectively with different biological targets, including nicotinic and muscarinic acetylcholine receptors, acetylcholinesterase, ion channels, and cell membranes. |
2014-02-10 |
2023-08-12 |
Not clear |
| Javier Milara, Adela Serrano, Teresa Peiró, Enrique Artigues, Amadeu Gavaldà, Montse Miralpeix, Esteban J Morcillo, Julio Cortij. Aclidinium inhibits cigarette smoke-induced lung fibroblast-to-myofibroblast transition. The European respiratory journal. vol 41. issue 6. 2014-01-29. PMID:23018909. |
these effects could be reversed by treatment with the anticholinergic aclidinium bromide, by silencing the mrna of muscarinic receptors m1, m2 or m3, or by the depletion of extracellular acetylcholine by treatment with acetylcholinesterase. |
2014-01-29 |
2023-08-12 |
human |
| Hanaa H Ahmed, Selim F Estefan, Ehab M Mohamd, Abd El-Razik H Farrag, Rania S Sala. Does melatonin ameliorate neurological changes associated with Alzheimer's disease in ovariectomized rat model? Indian journal of clinical biochemistry : IJCB. vol 28. issue 4. 2014-01-15. PMID:24426241. |
hydrogen peroxide (h2o2), malondialdehyde (mda), total antioxidant capacity (tac), superoxide dismutase (sod), catalase (cat), b cell lymphoma 2 (bcl-2), brain derived neurotrophic factor (bdnf), acetylcholinesterase (ache) and acetylcholine (ach) were estimated in the brain tissues of the different groups. |
2014-01-15 |
2023-08-12 |
rat |
| Manickavasagom Alkondon, Edson X Albuquerque, Edna F R Pereir. Acetylcholinesterase inhibition reveals endogenous nicotinic modulation of glutamate inputs to CA1 stratum radiatum interneurons in hippocampal slices. Neurotoxicology. vol 36. 2014-01-13. PMID:23511125. |
the involvement of brain nicotinic acetylcholine receptors (nachrs) in the neurotoxicological effects of soman, a potent acetylcholinesterase (ache) inhibitor and a chemical warfare agent, is not clear. |
2014-01-13 |
2023-08-12 |
rat |
| Liang Guo, Xin Wang, Jin-yan Li, Hua-shan Liang, Yong Jiang, Shan-shan Chang, Yu-jing Song, Li Cheng, Jin-ping Zhen. [Effects of subchronic benzo[a]pyrene exposure on hippocampal cholinergic system in rats]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. vol 31. issue 2. 2014-01-09. PMID:23433211. |
to observe the effects of subchronic benzo[a]pyrene (b[a]p) exposure on the neurobehavior and hippocampal acetylcholine (ach) level, acetylcholinesterase (ache) activity, and mrna and protein expression of nicotinic acetylcholine receptor α7 subtype (nachr α7) in rats, and to investigate the neurotoxic mechanism of b[a]p. |
2014-01-09 |
2023-08-12 |
rat |
| Nichole M Neugebauer, Emily B Einstein, Maria B Lopez, Tristan D McClure-Begley, Yann S Mineur, Marina R Picciott. Morphine dependence and withdrawal induced changes in cholinergic signaling. Pharmacology, biochemistry, and behavior. vol 109. 2014-01-07. PMID:23651795. |
acetylcholinesterase (ache) activity and [³h]-epibatidine binding were evaluated in order to determine if morphine dependence and withdrawal induces alterations in cholinergic signaling or expression of high affinity nicotinic acetylcholine receptors (nachrs) in the midbrain (mb), medial habenula (mhb) and interpeduncular nucleus (ipn). |
2014-01-07 |
2023-08-12 |
mouse |