| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christopher D Ruark, C Eric Hack, Peter J Robinson, Paul E Anderson, Jeffery M Gearhar. Quantitative structure-activity relationships for organophosphates binding to acetylcholinesterase. Archives of toxicology. vol 87. issue 2. 2013-07-02. PMID:22990135. |
organophosphates are a group of pesticides and chemical warfare nerve agents that inhibit acetylcholinesterase, the enzyme responsible for hydrolysis of the excitatory neurotransmitter acetylcholine. |
2013-07-02 |
2023-08-12 |
human |
| Miroslav Pohanka, Oto Pavlis, Jiri Pikul. Galantamine effect on tularemia pathogenesis in a BALB/c mouse model. Iranian biomedical journal. vol 16. issue 3. 2013-06-28. PMID:23023217. |
it is an inhibitor of acetylcholinesterase; however, interaction with nicotinic acetylcholine receptors has also been reported. |
2013-06-28 |
2023-08-12 |
mouse |
| Konstantin A Petrov, Artem I Malomouzh, Irina V Kovyazina, Eric Krejci, Alexandra D Nikitashina, Svetlana E Proskurina, Vladimir V Zobov, Evgeny E Nikolsk. Regulation of acetylcholinesterase activity by nitric oxide in rat neuromuscular junction via N-methyl-D-aspartate receptor activation. The European journal of neuroscience. vol 37. issue 2. 2013-06-27. PMID:23121214. |
acetylcholinesterase (ache) is an enzyme that hydrolyses the neurotransmitter acetylcholine, thereby limiting spillover and duration of action. |
2013-06-27 |
2023-08-12 |
rat |
| Vaneet Aggarwal, Xin Deng, Atac Tuli, Kean S Go. Diazinon-chemistry and environmental fate: a California perspective. Reviews of environmental contamination and toxicology. vol 223. 2013-06-24. PMID:23149814. |
diazinon is very highly to moderately toxic aquatic arganisms, diazinon inhibits the enzyme acetylcholinesterase, which hydrolyzes the neurotransmitter acetylcholine and leads to a suite of intermediate syndromes including anorexia, diarrhea, generalized weakness, muscle tremors, abnormal posturing and behavior, depression, and health. |
2013-06-24 |
2023-08-12 |
Not clear |
| Wei Wang, Yan Deng, Song Li, Hongna Liu, Zhuoxuan Lu, Liming Zhang, Lin Lin, Lijian X. A novel acetylcholine bioensor and its electrochemical behavior. Journal of biomedical nanotechnology. vol 9. issue 4. 2013-06-17. PMID:23621036. |
a novel type of acetylcholine electrochemical biosensor was successfully fabricated by dropping beta-cyclodextrin solution, acetylcholinesterase solution and nafion-methanol solution to the homemade nano-porous pseudo carbon paste electrode (nano-ppcpe) as working electrode, and then the electrochemical behavior of the as-prepared biosensor was studied through the acetylthiocholine iodide (atchi). |
2013-06-17 |
2023-08-12 |
Not clear |
| Lianguo Chen, Changjiang Huang, Chenyan Hu, Ke Yu, Lihua Yang, Bingsheng Zho. Acute exposure to DE-71: effects on locomotor behavior and developmental neurotoxicity in zebrafish larvae. Environmental toxicology and chemistry. vol 31. issue 10. 2013-06-10. PMID:22833361. |
in the cholinergic system, acetylcholinesterase activity significantly increased (10.7 and 12.4%) in the 68.7 and 227.6 µg/l exposure groups, respectively, and acetylcholine concentration accordingly decreased (60.5%) in the 227.6 µg/l exposure group. |
2013-06-10 |
2023-08-12 |
zebrafish |
| Jun-Ying Wang, Fan-Ying Meng, Shu-Ping Chen, Yong-Hui Gao, Jun-Ling Li. Analysis on interrelation between electroacupuncture-induced cumulative analgesic effect and hypothalamic cholinergic activities in chronic neuropathic pain rats. Chinese journal of integrative medicine. vol 18. issue 9. 2013-05-28. PMID:22936324. |
to observe the effects of repeated electroacupuncture (ea) of zusanli (st36)- yanglingquan (gb34) on hypothalamic acetylcholinesterase (ache) and vesicular acetylcholine (ach) transporter (vacht) activities and choline acetyltransferase (chat) mrna and muscarinic m1 receptor (m1r) mrna expression in chronic constrictive injury (cci) and/or ovariectomy (ovx) rats so as to reveal its underlying mechanism in cumulative analgesia. |
2013-05-28 |
2023-08-12 |
rat |
| Zrinka Kovarik, Nikolina Maček, Rakesh K Sit, Zoran Radić, Valery V Fokin, K Barry Sharpless, Palmer Taylo. Centrally acting oximes in reactivation of tabun-phosphoramidated AChE. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:22960624. |
organophosphates (op) inhibit acetylcholinesterase (ache, ec 3.1.1.7), both in peripheral tissues and central nervous system (cns), causing adverse and sometimes fatal effects due to the accumulation of neurotransmitter acetylcholine (ach). |
2013-05-28 |
2023-08-12 |
Not clear |
| Alexander V Nemukhin, Bella L Grigorenko, Dmitry I Morozov, Mikhail S Kochetov, Sofya V Lushchekina, Sergei D Varfolomee. On quantum mechanical--molecular mechanical (QM/MM) approaches to model hydrolysis of acetylcholine by acetylcholinesterase. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:22982775. |
on quantum mechanical--molecular mechanical (qm/mm) approaches to model hydrolysis of acetylcholine by acetylcholinesterase. |
2013-05-28 |
2023-08-12 |
Not clear |
| Alexander V Nemukhin, Bella L Grigorenko, Dmitry I Morozov, Mikhail S Kochetov, Sofya V Lushchekina, Sergei D Varfolomee. On quantum mechanical--molecular mechanical (QM/MM) approaches to model hydrolysis of acetylcholine by acetylcholinesterase. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:22982775. |
we re-visited the results of quantum mechanics--molecular mechanics (qm/mm) approaches aiming to construct the reaction energy profile for the acylation stage of acetylcholine hydrolysis by acetylcholinesterase. |
2013-05-28 |
2023-08-12 |
Not clear |
| Marcio de Araujo Furtado, Franco Rossetti, Soma Chanda, Debra Youric. Exposure to nerve agents: from status epilepticus to neuroinflammation, brain damage, neurogenesis and epilepsy. Neurotoxicology. vol 33. issue 6. 2013-05-28. PMID:23000013. |
se induced by soman is a result of cholinergic system hyperactivity caused by the irreversible inhibition of acetylcholinesterase, and the subsequent increase in the amount of the neurotransmitter acetylcholine at central and peripheral sites. |
2013-05-28 |
2023-08-12 |
Not clear |
| David A Hicks, Natalia Z Makova, Natalia N Nalivaeva, Anthony J Turne. Characterisation of acetylcholinesterase release from neuronal cells. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:23047022. |
although acetylcholinesterase (ache) is primarily a hydrolytic enzyme, metabolising the neurotransmitter acetylcholine in cholinergic synapses, it also has some non-catalytic functions in the brain which are far less well characterised. |
2013-05-28 |
2023-08-12 |
mouse |
| Veena Beri, Jeffrey T Auletta, Ghulam M Maharvi, Juanita F Wood, Abdul H Fauq, Terrone L Rosenberr. Hydrolysis of low concentrations of the acetylthiocholine analogs acetyl(homo)thiocholine and acetyl(nor)thiocholine by acetylcholinesterase may be limited by selective gating at the enzyme peripheral site. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:23047027. |
hydrolysis of acetylcholine by acetylcholinesterase (ache) is extremely rapid, with a second-order hydrolysis rate constant k(e) (often denoted k(cat)/k(m)) that approaches 10(8) m(-1) s(-1). |
2013-05-28 |
2023-08-12 |
cat |
| Wei Cui, Shengquan Hu, Hugh H N Chan, Jialie Luo, Wenming Li, Shinghung Mak, Tony Chunglit Choi, Jianhui Rong, Paul R Carlier, Yifan Ha. Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:23085120. |
bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/akt cascade. |
2013-05-28 |
2023-08-12 |
Not clear |
| Elizabeth N Schock, Windsor C Ford, Kirsten J Midgley, Joseph G Fader, Michael N Giavasis, Michelle L McWhorte. The effects of carbaryl on the development of zebrafish (Danio rerio) embryos. Zebrafish. vol 9. issue 4. 2013-05-28. PMID:23094693. |
the active ingredient in sevin(™), carbaryl (1-napthyl-n-methylcarbamate), is a known acetylcholinesterase (ache) inhibitor that prevents the breakdown of acetylcholine to acetate and choline at the synapse. |
2013-05-28 |
2023-08-12 |
zebrafish |
| Pran Kishore Deb, Anuradha Sharma, Poonam Piplani, Raghuram Rao Akkinepall. Molecular docking and receptor-specific 3D-QSAR studies of acetylcholinesterase inhibitors. Molecular diversity. vol 16. issue 4. 2013-05-16. PMID:22996404. |
the reversible inhibition of acetylcholinesterase (ache) has become a promising target for the treatment of alzheimer's disease (ad) which is mainly associated with low in vivo levels of acetylcholine (ach). |
2013-05-16 |
2023-08-12 |
Not clear |
| Yann S Mineur, Adetokunbo Obayemi, Mattis B Wigestrand, Gianna M Fote, Cali A Calarco, Alice M Li, Marina R Picciott. Cholinergic signaling in the hippocampus regulates social stress resilience and anxiety- and depression-like behavior. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 9. 2013-05-02. PMID:23401542. |
symptoms of depression can be induced in humans through blockade of acetylcholinesterase (ache) whereas antidepressant-like effects can be produced in animal models and some clinical trials by limiting activity of acetylcholine (ach) receptors. |
2013-05-02 |
2023-08-12 |
mouse |
| G Lou, Q Zhang, F Xiao, Q Xiang, Z Su, L Zhang, P Yang, Y Yang, Q Zheng, Y Huan. Intranasal administration of TAT-haFGF(₁₄₋₁₅₄) attenuates disease progression in a mouse model of Alzheimer's disease. Neuroscience. vol 223. 2013-05-01. PMID:22885230. |
importantly, tat-hafgf(14-154) improved the learning and memory abilities of samp8 mice in the behavioral test, and promoted the function of cholinergic system by measuring the relevant biomarkers (acetylcholine (ach) level, acetylcholinesterase (ache) and choline acetyltransferase (chat) activities). |
2013-05-01 |
2023-08-12 |
mouse |
| Abdelfatteh El Omri, Junkyu Han, Kiyokazu Kawada, Manef Ben Abdrabbah, Hiroko Isod. Luteolin enhances cholinergic activities in PC12 cells through ERK1/2 and PI3K/Akt pathways. Brain research. vol 1437. 2013-04-30. PMID:22226506. |
our findings showed that luteolin treatment significantly induced neurite outgrowth extension, enhanced acetylcholinesterase (ache) activity, known as neuronal differentiation marker, and increased the level of total choline and acetylcholine in pc12 cells. |
2013-04-30 |
2023-08-12 |
Not clear |
| Vasudevan Mani, Kalavathy Ramasamy, Aliya Ahmad, Siti Norshazwani Wahab, Siti Murnirah Jaafar, Teh Lay Kek, Mohd Zaki Salleh, Abu Bakar Abdul Majee. Effects of the total alkaloidal extract of Murraya koenigii leaf on oxidative stress and cholinergic transmission in aged mice. Phytotherapy research : PTR. vol 27. issue 1. 2013-04-26. PMID:22447662. |
interestingly, significant progress was noted with the supplementation of mka by an improvement of the acetylcholine (ach) levels and a reduction in the acetylcholinesterase (ache) activity in aged mouse brain. |
2013-04-26 |
2023-08-12 |
mouse |