| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hamid R Noori, Sarah Fliegel, Ines Brand, Rainer Spanage. The impact of acetylcholinesterase inhibitors on the extracellular acetylcholine concentrations in the adult rat brain: a meta-analysis. Synapse (New York, N.Y.). vol 66. issue 10. 2012-11-30. PMID:22733599. |
the impact of acetylcholinesterase inhibitors on the extracellular acetylcholine concentrations in the adult rat brain: a meta-analysis. |
2012-11-30 |
2023-08-12 |
rat |
| Hamid R Noori, Sarah Fliegel, Ines Brand, Rainer Spanage. The impact of acetylcholinesterase inhibitors on the extracellular acetylcholine concentrations in the adult rat brain: a meta-analysis. Synapse (New York, N.Y.). vol 66. issue 10. 2012-11-30. PMID:22733599. |
depending on the sensitivity of the analytical method applied for measuring acetylcholine levels in brain dialysates, acetylcholinesterase (ache) inhibitors are often used to increase the basal acetylcholine level up to a detectable magnitude. |
2012-11-30 |
2023-08-12 |
rat |
| Cristóbal de los Río. Cholinesterase inhibitors: a patent review (2007 - 2011). Expert opinion on therapeutic patents. vol 22. issue 8. 2012-11-27. PMID:22764681. |
cholinesterase inhibitors participate in the maintenance of the levels of the neurotransmitter acetylcholine by inhibiting the enzymes implicated in its degradation, namely, butyrylcholinesterase and acetylcholinesterase. |
2012-11-27 |
2023-08-12 |
Not clear |
| Jiří Lindovský, Konstantin Petrov, Jan Krůšek, Vladimir S Reznik, Eugeny E Nikolsky, František Vyskoči. Effect of tissue-specific acetylcholinesterase inhibitor C-547 on α3β4 and αβεδ acetylcholine receptors in COS cells. European journal of pharmacology. vol 688. issue 1-3. 2012-11-16. PMID:22634638. |
effect of tissue-specific acetylcholinesterase inhibitor c-547 on α3β4 and αβεδ acetylcholine receptors in cos cells. |
2012-11-16 |
2023-08-12 |
rat |
| P M Nagy, I Auber. Overexpression of the vesicular acetylcholine transporter increased acetylcholine release in the hippocampus. Neuroscience. vol 218. 2012-11-16. PMID:22641085. |
in addition to current strategies being developed, such as the use of acetylcholinesterase inhibitors, enhancing acetylcholine (ach) release may be critical for optimal cholinergic neurotransmission. |
2012-11-16 |
2023-08-12 |
mouse |
| Sahitya C Pandanaboina, Sangeetha L A Rajbanshi, Pavan N V Kunala, Saritha Pandanaboina, Murali M Pandanaboina, Visweswari Gopalreddy, Rajendra Wudayagir. Tramadol safety--cholinergic system of rat brain without nociception. Acta poloniae pharmaceutica. vol 69. issue 5. 2012-11-06. PMID:23061278. |
in the present investigation, changes in the levels of acetylcholinesterase (ache) activity, acetylcholine (ach) content, and the activity levels of plasma (pche) and erythrocyte (eche) cholinesterases as representatives of pseudocholinesterases were examined in different areas of the rat brain during the administration of the synthetic opioid analgesic drug tramadol (ultram) without induction of pain. |
2012-11-06 |
2023-08-12 |
rat |
| Vladimir Farar, Franziska Mohr, Marie Legrand, Boris Lamotte d'Incamps, Jan Cendelin, Jacqueline Leroy, Marc Abitbol, Veronique Bernard, Frédéric Baud, Vincent Fournet, Pascal Houze, Jochen Klein, Benoit Plaud, Jan Tuma, Martina Zimmermann, Philippe Ascher, Anna Hrabovska, Jaromir Myslivecek, Eric Krejc. Near-complete adaptation of the PRiMA knockout to the lack of central acetylcholinesterase. Journal of neurochemistry. vol 122. issue 5. 2012-10-31. PMID:22747514. |
acetylcholinesterase (ache) rapidly hydrolyzes acetylcholine. |
2012-10-31 |
2023-08-12 |
mouse |
| Takaaki Mori, Jun Maeda, Hitoshi Shimada, Makoto Higuchi, Hitoshi Shinotoh, Shu-ichi Ueno, Tetsuya Suhar. Molecular imaging of dementia. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society. vol 12. issue 2. 2012-10-29. PMID:22712644. |
meanwhile, brain cholinergic function can be estimated by measuring acetylcholinesterase activity in the brain with pet and radiolabeled acetylcholine analogues. |
2012-10-29 |
2023-08-12 |
mouse |
| Peng Song, Neil D Hershey, Omar S Mabrouk, Thomas R Slaney, Robert T Kenned. Mass spectrometry "sensor" for in vivo acetylcholine monitoring. Analytical chemistry. vol 84. issue 11. 2012-10-23. PMID:22616788. |
the detection limit of 5 nm was sufficient to monitor basal acetylcholine as well as dynamic changes elicited by microinjection of neostigmine, an inhibitor of acetylcholinesterase, that evoked rapid increases in acetycholine and tetrodotoxin, a blocker of na(+) channels, that lowered the acetylcholine concentration. |
2012-10-23 |
2023-08-12 |
rat |
| I Erdogan Orha. Current concepts on selected plant secondary metabolites with promising inhibitory effects against enzymes linked to Alzheimer's disease. Current medicinal chemistry. vol 19. issue 14. 2012-10-18. PMID:22414107. |
shortage of the neurotransmitters, acetylcholine and butyrylcholine has been demonstrated, and therefore, inhibition of the enzymes; acetylcholinesterase (ache) and butyrylcholinesterase (bche) that break down acetylcholine and butyrylcholine has become a standard approach for ad treatment. |
2012-10-18 |
2023-08-12 |
human |
| D Qujeq, T Roushan, A Norouzy, M Habibi-Rezaei, M Mehdinejad-Shan. Effects of dichlorvos and carbaryl on the activity of free and immobilized acetylcholinesterase. Toxicology and industrial health. vol 28. issue 4. 2012-10-17. PMID:21937528. |
acetylcholinesterase (ache) is responsible for the rapid hydrolytic degradation of the neurotransmitter acetylcholine into inactive products choline and acetic acid. |
2012-10-17 |
2023-08-12 |
Not clear |
| George D Geromichalos, Fotini N Lamari, Magdalini A Papandreou, Dimitrios T Trafalis, Marigoula Margarity, Athanasios Papageorgiou, Zacharias Sinako. Saffron as a source of novel acetylcholinesterase inhibitors: molecular docking and in vitro enzymatic studies. Journal of agricultural and food chemistry. vol 60. issue 24. 2012-10-10. PMID:22655699. |
inhibitors of acetylcholine breakdown by acetylcholinesterase (ache) constitute the main therapeutic modality for alzheimer's disease. |
2012-10-10 |
2023-08-12 |
Not clear |
| Xavier Brazzolotto, Marielle Wandhammer, Cyril Ronco, Marie Trovaslet, Ludovic Jean, Oksana Lockridge, Pierre-Yves Renard, Florian Nacho. Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure. The FEBS journal. vol 279. issue 16. 2012-10-09. PMID:22726956. |
it can accommodate larger substrates or inhibitors than acetylcholinesterase (ache), the enzyme responsible for hydrolysis of the neurotransmitter acetylcholine in the central nervous system and neuromuscular junctions. |
2012-10-09 |
2023-08-12 |
human |
| R E Gyurcsányi, Z Fehér, G Nag. Study of the determination of acetylcholine after enzymatic hydrolysis by triangle programmed coulometric flow titration. Talanta. vol 47. issue 4. 2012-10-02. PMID:18967406. |
the limit of detection for the determination of acetylcholine was found to be 8x10(-5) m. the method described could be advantageously used for indirect determination of acetylcholinesterase inhibitors. |
2012-10-02 |
2023-08-12 |
Not clear |
| N C Inestrosa, H L Fernánde. Is there a correspondence between half-lives of motor endplate acetylcholinesterase and junctional acetylcholine receptors? Neuroscience letters. vol 5. issue 1-2. 2012-10-02. PMID:19604976. |
is there a correspondence between half-lives of motor endplate acetylcholinesterase and junctional acetylcholine receptors? |
2012-10-02 |
2023-08-12 |
Not clear |
| Kosuke Yamamoto, Yoshie S Momonok. Subcellular localization of overexpressed maize AChE gene in rice plant. Plant signaling & behavior. vol 3. issue 8. 2012-10-02. PMID:19704473. |
the ach-mediated system consisting of acetylcholine (ach), acetylcholine receptor (achr) and acetylcholinesterase (ache) is fundamental for nervous system function in animals and insects. |
2012-10-02 |
2023-08-12 |
Not clear |
| Takafumi Tezuka, Isamu Akita, Natsuko Yoshin. Self-incompatibility involved in the level of acetylcholine and cAMP. Plant signaling & behavior. vol 2. issue 6. 2012-10-02. PMID:19704589. |
a potent inhibitor (neostigmine) of acetylcholinesterase (ache) as well as acetylcholine also promoted the elongation. |
2012-10-02 |
2023-08-12 |
Not clear |
| Lauren Meredith Willis, Barbara Shukitt-Hale, James A Josep. Dietary polyunsaturated fatty acids improve cholinergic transmission in the aged brain. Genes & nutrition. vol 4. issue 4. 2012-10-02. PMID:19727886. |
despite years of research, pharmacological interventions to treat or forestall the development of alzheimer's disease have primarily focused on enhancing cholinergic transmission, either through increasing acetylcholine (ach) synthesis or inhibition of the acetylcholinesterase enzyme responsible for ach hydrolysis. |
2012-10-02 |
2023-08-12 |
Not clear |
| Janet R Wetherell, Stuart J Armstrong, Robert W Read, Geraldine F Cloug. VX Penetration Following Percutaneous Poisoning: A Dermal Microdialysis Study in the Guinea Pig. Toxicology mechanisms and methods. vol 18. issue 4. 2012-10-02. PMID:20020896. |
abstract vx, a potent organophosphorus compound, acts primarily by irreversibly inhibiting acetylcholinesterase resulting in an accumulation of acetylcholine, which produces the characteristic signs of nerve agent poisoning. |
2012-10-02 |
2023-08-12 |
Not clear |
| E Neuman. Chemical representation of ion flux gating in excitable biomembranes. Neurochemistry international. vol 2C. 2012-10-02. PMID:20487768. |
basic electrophysiological data are discussed in terms of recent relaxation kinetic results on isolated acetylcholine receptor-lipid complexes and on acetylcholinesterase from electric fish. |
2012-10-02 |
2023-08-12 |
Not clear |