| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuzhen Liao, Yanan Qiao, Wenting Han, Zhaoxia Xie, Zhaoyang Wu, Guoli Shen, Ruqin Y. Acetylcholinesterase liquid crystal biosensor based on modulated growth of gold nanoparticles for amplified detection of acetylcholine and inhibitor. Analytical chemistry. vol 84. issue 1. 2012-05-01. PMID:22148672. |
a novel acetylcholinesterase (ache) liquid crystal (lc) biosensor based on enzymatic growth of gold nanoparticles (au nps) has been developed for amplified detection of acetylcholine (ach) and ache inhibitor. |
2012-05-01 |
2023-08-12 |
Not clear |
| Joseph S Zakhari, Isao Kinoyama, Mark S Hixon, Antonia Di Mola, Daniel Globisch, Kim D Jand. Formulating a new basis for the treatment against botulinum neurotoxin intoxication: 3,4-Diaminopyridine prodrug design and characterization. Bioorganic & medicinal chemistry. vol 19. issue 21. 2012-04-26. PMID:21975066. |
the carbamate prodrug is intended to be a slowly reversible inhibitor of acetylcholinesterase (ache) along the lines of the stigmines thereby allowing increased persistence of released acetylcholine within the synaptic cleft. |
2012-04-26 |
2023-08-12 |
Not clear |
| Manojkumar Valiyaveettil, Yonas Alamneh, Samuel Oguntayo, Yanling Wei, Ying Wang, Peethambaran Arun, Madhusoodana P Nambia. Regional specific alterations in brain acetylcholinesterase activity after repeated blast exposures in mice. Neuroscience letters. vol 506. issue 1. 2012-04-24. PMID:22079491. |
acetylcholinesterase (ache) which catalyzes the hydrolysis of the neurotransmitter acetylcholine has been recognized as one of the major regulators of stress responses after traumatic brain injury (tbi). |
2012-04-24 |
2023-08-12 |
mouse |
| Yan-Fang Xian, Zhi-Xiu Lin, Ming Zhao, Qing-Qiu Mao, Siu-Po Ip, Chun-Tao Ch. Uncaria rhynchophylla ameliorates cognitive deficits induced by D-galactose in mice. Planta medica. vol 77. issue 18. 2012-04-16. PMID:21858756. |
in addition, eur (200 or 400 mg/kg) significantly increased the levels of acetylcholine and glutathione and decreased the activity of acetylcholinesterase and the level of malondialdehyde in the brains of d-gal-treated mice. |
2012-04-16 |
2023-08-12 |
mouse |
| Lotta Berg, C David Andersson, Elisabet Artursson, Andreas Hörnberg, Anna-Karin Tunemalm, Anna Linusson, Fredrik Ekströ. Targeting acetylcholinesterase: identification of chemical leads by high throughput screening, structure determination and molecular modeling. PloS one. vol 6. issue 11. 2012-04-09. PMID:22140425. |
acetylcholinesterase (ache) is an essential enzyme that terminates cholinergic transmission by rapid hydrolysis of the neurotransmitter acetylcholine. |
2012-04-09 |
2023-08-12 |
mouse |
| Alessandra Giarola, Alessia Auber, Cristiano Chiamuler. Acetylcholinesterase inhibitors partially generalize to nicotine discriminative stimulus effect in rats. Behavioural pharmacology. vol 22. issue 1. 2012-04-06. PMID:21116174. |
acetylcholinesterase inhibitors (ache-is), galantamine, physostigmine and tacrine, enhance central levels of synaptic acetylcholine. |
2012-04-06 |
2023-08-12 |
rat |
| A Barelli, P M Soave, M Del Vicario, R Barell. New experimental Oximes in the management of organophosphorus pesticides poisoning. Minerva anestesiologica. vol 77. issue 12. 2012-04-04. PMID:21799476. |
the main toxic mechanism of opcs is the inhibition of the enzymes acetylcholinesterase (ache) and butyrylcholinesterase (buche), resulting in accumulation of acetylcholine (ach) at the synapse with cholinergic crisis and possible death. |
2012-04-04 |
2023-08-12 |
Not clear |
| John C O'Donnell, John H McDonough, Tsung-Ming Shi. In vivo microdialysis and electroencephalographic activity in freely moving guinea pigs exposed to organophosphorus nerve agents sarin and VX: analysis of acetylcholine and glutamate. Archives of toxicology. vol 85. issue 12. 2012-03-22. PMID:21695469. |
organophosphorus nerve agents such as sarin (gb) and vx irreversibly inhibit acetylcholinesterase, causing a buildup of acetylcholine (ach) in synapses and neuromuscular junctions, which leads to excess bronchial secretions, convulsions, seizures, coma, and death. |
2012-03-22 |
2023-08-12 |
human |
| Sangu Muthuraju, Panchanan Maiti, Soumya Pati, Preeti Solanki, Alpesh Kumar Sharma, Shashi Bala Singh, Dipti Prasad, Govindasamy Ilavazhaga. Role of cholinergic markers on memory function of rats exposed to hypobaric hypoxia. European journal of pharmacology. vol 672. issue 1-3. 2012-03-07. PMID:21924263. |
cholinergic markers such as acetylcholine, acetylcholinesterase, choline acetyltransferase, α-7-nicotinic acetylcholine receptor and m(1) muscarinic acetylcholine receptor were also evaluated along with neuronal morphology and dna fragmentation. |
2012-03-07 |
2023-08-12 |
rat |
| Sangu Muthuraju, Panchanan Maiti, Soumya Pati, Preeti Solanki, Alpesh Kumar Sharma, Shashi Bala Singh, Dipti Prasad, Govindasamy Ilavazhaga. Role of cholinergic markers on memory function of rats exposed to hypobaric hypoxia. European journal of pharmacology. vol 672. issue 1-3. 2012-03-07. PMID:21924263. |
we found impairment in memory function along with a decrease in acetylcholine levels, increase in acetylcholinesterase activity, down regulation of choline acetyltransferase, α-7-nicotinic acetylcholine receptor and m(1) muscarinic acetylcholine receptor. |
2012-03-07 |
2023-08-12 |
rat |
| Sangu Muthuraju, Panchanan Maiti, Soumya Pati, Preeti Solanki, Alpesh Kumar Sharma, Shashi Bala Singh, Dipti Prasad, Govindasamy Ilavazhaga. Role of cholinergic markers on memory function of rats exposed to hypobaric hypoxia. European journal of pharmacology. vol 672. issue 1-3. 2012-03-07. PMID:21924263. |
it improved acetylcholine level, decreased acetylcholinesterase activity and increased the synthesis of acetylcholine by increasing choline acetyltransferase activity. |
2012-03-07 |
2023-08-12 |
rat |
| Kimberly D Spradling, Lucille A Lumley, Christopher L Robison, James L Meyerhoff, James F Dillma. Transcriptional analysis of rat piriform cortex following exposure to the organophosphonate anticholinesterase sarin and induction of seizures. Journal of neuroinflammation. vol 8. 2012-02-23. PMID:21777429. |
organophosphorus nerve agents irreversibly inhibit acetylcholinesterase, causing a toxic buildup of acetylcholine at muscarinic and nicotinic receptors. |
2012-02-23 |
2023-08-12 |
rat |
| Jouni Ihalainen, Timo Sarajärvi, Doug Rasmusson, Susanna Kemppainen, Pekka Keski-Rahkonen, Marko Lehtonen, Pradeep K Banerjee, Kazue Semba, Heikki Tanil. Effects of memantine and donepezil on cortical and hippocampal acetylcholine levels and object recognition memory in rats. Neuropharmacology. vol 61. issue 5-6. 2012-02-16. PMID:21704049. |
this preclinical study investigated the ability of memantine (mem) to stimulate brain acetylcholine (ach) release, potentially acting synergistically with donepezil (don, an acetylcholinesterase inhibitor). |
2012-02-16 |
2023-08-12 |
rat |
| Douglas A Caruana, E Clea Warburton, Zafar I Bashi. Induction of activity-dependent LTD requires muscarinic receptor activation in medial prefrontal cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 50. 2012-02-09. PMID:22171048. |
synaptic stimulation that was subthreshold for producing ltd did, however, result in ltd when acetylcholine levels were enhanced by inhibition of acetylcholinesterase or when delivered in the presence of the m(1)-selective positive allosteric modulator bqca. |
2012-02-09 |
2023-08-12 |
rat |
| Kasim Abass Askar, A Caleb Kudi, A John Mood. Purification of soluble acetylcholinesterase from sheep liver by affinity chromatography. Applied biochemistry and biotechnology. vol 165. issue 1. 2012-02-02. PMID:21499785. |
the purpose of this study was to develop a protocol for the purification of acetylcholinesterase (ache, acetylcholine acetylhydrolase, e.c.3.1.1.7) enzyme and to extend a purification method for further enzyme characterization. |
2012-02-02 |
2023-08-12 |
Not clear |
| M Sánchez-Guerra, N Pérez-Herrera, B Quintanilla-Veg. Organophosphorous pesticides research in Mexico: epidemiological and experimental approaches. Toxicology mechanisms and methods. vol 21. issue 9. 2012-01-30. PMID:22003926. |
studies in agricultural workers from several regions of the country reported moderate to severe cholinergic symptoms, including decreased acetylcholinesterase (ache) activity (the main acute op toxic effect that causes an over accumulation of the neurotransmitter acetylcholine), revealing the potential risk of intoxication of mexican farmers. |
2012-01-30 |
2023-08-12 |
human |
| Yinyin Xia, Shuqun Cheng, Junlin He, Xueqing Liu, Yan Tang, Haiyan Yuan, Lijun He, Tao Lu, Baijie Tu, Yingxiong Wan. Effects of subchronic exposure to benzo[a]pyrene (B[a]P) on learning and memory, and neurotransmitters in male Sprague-Dawley rat. Neurotoxicology. vol 32. issue 2. 2012-01-25. PMID:21216261. |
b[a]p treatment decreased the levels of malondialdehyde (mda), nitric oxide (no), nitric oxide synthase (nos), superoxide dismutase (sod), acetylcholine (ach), choline acetyltransferase (chat), and increased the activity of acetylcholinesterase (ache). |
2012-01-25 |
2023-08-12 |
rat |
| Yushan Wang, Lidong Liu, Tracy Weiss, Christine Stewart, John Mikle. Effect of acute soman exposure on GABA(A) receptors in rat hippocampal slices and cultured hippocampal neurons. Neurotoxicity research. vol 20. issue 4. 2012-01-25. PMID:21643853. |
the effect of soman on gaba(a)r endocytosis was not due to inhibition of acetylcholinesterase (ache) because (1) the acetylcholine muscarinic receptor antagonist atropine did not block soman-induced gaba(a)r endocytosis; and (2) physostigmine, at concentrations that completely inhibit ache activity, did not cause gaba(a)r endocytosis. |
2012-01-25 |
2023-08-12 |
rat |
| Vijayasree Vayalanellore Giridharan, Rajarajan Amirthalingam Thandavarayan, Tetsuya Konish. Amelioration of scopolamine induced cognitive dysfunction and oxidative stress by Inonotus obliquus - a medicinal mushroom. Food & function. vol 2. issue 6. 2012-01-24. PMID:21779570. |
to elucidate the mechanism of the cognitive enhancing activity of mec, the activities of acetylcholinesterase (ache), anti-oxidant enzymes, the levels of acetylcholine (ach) and nitrite of mice brain homogenates were evaluated. |
2012-01-24 |
2023-08-12 |
mouse |
| Tanvisith Charoenying, Tawit Suriyo, Apinya Thiantanawat, Sansanee C Chaiyaroj, Preeda Parkpian, Jutamaad Satayaviva. Effects of paraoxon on neuronal and lymphocytic cholinergic systems. Environmental toxicology and pharmacology. vol 31. issue 1. 2012-01-23. PMID:21787676. |
further, the paraoxon-induced modulatory effects were comparable despite different cell types, including over-expression of n-terminus acetylcholinesterase (n-ache) protein, a marker of apoptosis, down-regulations of mrna encoding m1, m2, and m3 muscarinic acetylcholine receptors (machrs), and induction in expression of c-fos gene, an indication of certain machr subtype(s) activation. |
2012-01-23 |
2023-08-12 |
human |