| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ludise Malkova, Alan P Kozikowski, Karen Gal. The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques. Neuropharmacology. vol 60. issue 7-8. 2012-01-18. PMID:21185313. |
huperzine a is a reversible acetylcholinesterase (ache) inhibitor, its administration results in regionally specific increases in acetylcholine levels in the brain. |
2012-01-18 |
2023-08-12 |
human |
| Shuang Hu, Tony Pawson, Robert M Steve. UNC-73/trio RhoGEF-2 activity modulates Caenorhabditis elegans motility through changes in neurotransmitter signaling upstream of the GSA-1/Galphas pathway. Genetics. vol 189. issue 1. 2012-01-17. PMID:21750262. |
although unc-73 rhogef-2 mutants have grossly normal synaptic morphology and weak resistance to the acetylcholinesterase inhibitor aldicarb, they are significantly hypersensitive to the acetylcholine receptor agonist levamisole, indicating alterations in acetylcholine neurotransmitter signaling. |
2012-01-17 |
2023-08-12 |
caenorhabditis_elegans |
| Evert-Jan Kooi, Marloes Prins, Natasha Bajic, Jeroen A M Beliën, Wouter H Gerritsen, Jack van Horssen, Eleonora Aronica, Anne-Marie van Dam, Jeroen J M Hoozemans, Paul T Francis, Paul van der Valk, Jeroen J G Geurt. Cholinergic imbalance in the multiple sclerosis hippocampus. Acta neuropathologica. vol 122. issue 3. 2012-01-10. PMID:21691765. |
in ms hippocampus, activity and protein expression of choline acetyltransferase (chat), the acetylcholine synthesizing enzyme, was decreased, while the activity and protein expression of acetylcholinesterase (ache), the acetylcholine degrading enzyme, was found to be unaltered. |
2012-01-10 |
2023-08-12 |
Not clear |
| Adone Baroni, Elisabetta Buommino, Eleonora Ruocco, Marcella Petrazzuolo, Anna De Filippis, Rocco Alfredo Satriano, Vincenzo Ruocco, Valentina Cozza, Maria Antonietta Tufan. Captopril modulates acetylcholinesterase in human keratinocytes. Archives of dermatological research. vol 303. issue 7. 2011-12-12. PMID:21286734. |
the keratinocyte acetylcholine axis is composed of the enzymes mediating acetylcholine synthesis (acetyltransferase) and degradation (acetylcholinesterase), and two classes of acetylcholine receptors. |
2011-12-12 |
2023-08-12 |
human |
| Adone Baroni, Elisabetta Buommino, Eleonora Ruocco, Marcella Petrazzuolo, Anna De Filippis, Rocco Alfredo Satriano, Vincenzo Ruocco, Valentina Cozza, Maria Antonietta Tufan. Captopril modulates acetylcholinesterase in human keratinocytes. Archives of dermatological research. vol 303. issue 7. 2011-12-12. PMID:21286734. |
in this study we investigated the effect of captopril, an ace-inhibitor, on acetylcholinesterase and acetylcholine secretion in human keratinocytes. |
2011-12-12 |
2023-08-12 |
human |
| Julia Radosa, Wilhelm Dyck, Sergij Goerdt, Hjalmar Kurze. The cholinergic system in guttate psoriasis with special reference to mast cells. Experimental dermatology. vol 20. issue 8. 2011-12-06. PMID:21521372. |
both in vivo and in vitro, mast cells lacked expression of cholinacetyl transferase, vesicular acetylcholine transporter and choline transporter-1 but contained high levels of acetylcholinesterase and different nicotinic and muscarinic acetylcholine receptor (achr). |
2011-12-06 |
2023-08-12 |
Not clear |
| Michael Adler, Richard E Sweeney, Tracey A Hamilton, Oksana Lockridge, Ellen G Duysen, Angela L Purcell, Sharad S Deshpand. Role of acetylcholinesterase on the structure and function of cholinergic synapses: insights gained from studies on knockout mice. Cellular and molecular neurobiology. vol 31. issue 6. 2011-11-30. PMID:21538119. |
electrophysiological and ultrastructural studies were performed on phrenic nerve-hemidiaphragm preparations isolated from wild-type and acetylcholinesterase (ache) knockout (ko) mice to determine the compensatory mechanisms manifested by the neuromuscular junction to excess acetylcholine (ach). |
2011-11-30 |
2023-08-12 |
mouse |
| Pamela D Moore, Anita K Patlolla, Paul B Tchounwo. Cytogenetic evaluation of malathion-induced toxicity in Sprague-Dawley rats. Mutation research. vol 725. issue 1-2. 2011-11-15. PMID:21835262. |
its toxicity has been attributed primarily to the accumulation of acetylcholine (ach) at nerve junctions, due to the inhibition of acetylcholinesterase (ache), and consequently overstimulation of the nicotinic and muscarinic receptors. |
2011-11-15 |
2023-08-12 |
rat |
| Daniela Galimberti, Elio Scarpin. Disease-modifying treatments for Alzheimer's disease. Therapeutic advances in neurological disorders. vol 4. issue 4. 2011-11-10. PMID:21765871. |
the first drugs developed for alzheimer's disease (ad), acetylcholinesterase inhibitors (achei), increase acetylcholine levels, previously demonstrated to be reduced in ad. |
2011-11-10 |
2023-08-12 |
Not clear |
| Francisco J Carvajal, Nibaldo C Inestros. Interactions of AChE with Aβ Aggregates in Alzheimer's Brain: Therapeutic Relevance of IDN 5706. Frontiers in molecular neuroscience. vol 4. 2011-11-10. PMID:21949501. |
acetylcholinesterase (ache; ec 3.1.1.7) plays a crucial role in the rapid hydrolysis of the neurotransmitter acetylcholine, in the central and peripheral nervous system and might also participate in non-cholinergic mechanism related to neurodegenerative diseases. |
2011-11-10 |
2023-08-12 |
mouse |
| Vicky P Chen, Wilson K W Luk, Wallace K B Chan, K Wing Leung, Ava J Y Guo, Gallant K L Chan, Sherry L Xu, Roy C Y Choi, Karl W K Tsi. Molecular Assembly and Biosynthesis of Acetylcholinesterase in Brain and Muscle: the Roles of t-peptide, FHB Domain, and N-linked Glycosylation. Frontiers in molecular neuroscience. vol 4. 2011-11-10. PMID:22046147. |
acetylcholinesterase (ache) is responsible for the hydrolysis of the neurotransmitter, acetylcholine, in the nervous system. |
2011-11-10 |
2023-08-12 |
chicken |
| Tanja Klein-Rodewald, Thomas Seeger, Mathias Dutschmann, Franz Worek, Michael Mörsche. Central respiratory effects on motor nerve activities after organophosphate exposure in a working heart brainstem preparation of the rat. Toxicology letters. vol 206. issue 1. 2011-10-28. PMID:21767620. |
the impact of organophosphorus compound (op) intoxication on the activity of central respiratory circuitry, causing acetylcholinesterase (ache) inhibition and accumulation of acetylcholine in the respiratory brainstem circuits, is not understood. |
2011-10-28 |
2023-08-12 |
rat |
| Derek S Wilkinson, Thomas J Goul. The effects of galantamine on nicotine withdrawal-induced deficits in contextual fear conditioning in C57BL/6 mice. Behavioural brain research. vol 223. issue 1. 2011-10-18. PMID:21514327. |
galantamine is an acetylcholinesterase inhibitor and allosteric modulator of nicotinic acetylcholine receptors (nachrs) with cognitive enhancing effects that may alleviate cognitive deficits associated with nicotine withdrawal. |
2011-10-18 |
2023-08-12 |
mouse |
| Derek S Wilkinson, Thomas J Goul. The effects of galantamine on nicotine withdrawal-induced deficits in contextual fear conditioning in C57BL/6 mice. Behavioural brain research. vol 223. issue 1. 2011-10-18. PMID:21514327. |
the ability of galantamine to reverse nicotine withdrawal-deficits in contextual conditioning is likely mediated through enhanced levels of acetylcholine via inhibition of acetylcholinesterase, potentiation of hippocampal α4β2* nachrs, or both. |
2011-10-18 |
2023-08-12 |
mouse |
| Vinicius Barreto da Silva, Peterson de Andrade, Daniel Fábio Kawano, Pedro Alves Bezerra Morais, Jonathan Resende de Almeida, Ivone Carvalho, Carlton Anthony Taft, Carlos Henrique Tomich de Paula da Silv. In silico design and search for acetylcholinesterase inhibitors in Alzheimer's disease with a suitable pharmacokinetic profile and low toxicity. Future medicinal chemistry. vol 3. issue 8. 2011-10-12. PMID:21707398. |
one pharmacological approach is to restore acetylcholine level by inhibiting acetylcholinesterase (ache) with reversible inhibitors, such as galanthamine, thus helping to improve the cognitive symptoms of the disease. |
2011-10-12 |
2023-08-12 |
Not clear |
| Ia Iu Bagrov, N B Manusov. [Effect of acetylcholine and acetylcholinesterase on the activity of contractile vacuole of Amoeba proteus]. Tsitologiia. vol 53. issue 6. 2011-09-30. PMID:21870511. |
[effect of acetylcholine and acetylcholinesterase on the activity of contractile vacuole of amoeba proteus]. |
2011-09-30 |
2023-08-12 |
Not clear |
| Yael Abreu-Villaça, Cláudio C Filgueiras, Alex C Manhãe. Developmental aspects of the cholinergic system. Behavioural brain research. vol 221. issue 2. 2011-09-09. PMID:20060019. |
in the current review, we focus on the developmental aspects associated with major components of the cholinergic system: acetylcholine, choline acetyltransferase, vesicular acetylcholine transporter, high-affinity choline transporter, acetylcholinesterase, nicotinic and muscarinic receptors. |
2011-09-09 |
2023-08-12 |
mouse |
| Andrea Wever. Localisation of pre- and postsynaptic cholinergic markers in the human brain. Behavioural brain research. vol 221. issue 2. 2011-09-09. PMID:20170687. |
on the cholinergic site data based on the distribution of choline acetyltransferase-immunoreactive structures are in the focus, complemented by data from acetylcholinesterase and vesicular acetylcholine transporter studies. |
2011-09-09 |
2023-08-12 |
human |
| Reinhard Schliebs, Thomas Arend. The cholinergic system in aging and neuronal degeneration. Behavioural brain research. vol 221. issue 2. 2011-09-09. PMID:21145918. |
indeed, there is abundant evidence that β-amyloid may trigger cholinergic dysfunction through action on α7 nicotinic acetylcholine receptors, affecting ngf signaling, mediating tau phosphorylation, interacting with acetylcholinesterase, and specifically affecting the proteome in cholinergic neurons. |
2011-09-09 |
2023-08-12 |
Not clear |
| Vijayasree V Giridharan, Rajarajan A Thandavarayan, Tetsuya Konish. Effect of Shengmai-san on cognitive performance and cerebral oxidative damage in BALB/c mice. Journal of medicinal food. vol 14. issue 6. 2011-08-30. PMID:21554136. |
to elucidate the mechanism of its cognitive-enhancing activity, the effects of sms (2, 4, or 8 g/kg) on activities of acetylcholinesterase (ache) and antioxidant enzymes and levels of acetylcholine (ach) and nitrite were evaluated in brain homogenate. |
2011-08-30 |
2023-08-12 |
mouse |