| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yasumasa Yoshiyama, Ayako Kojima, Chieko Ishikawa, Kimihito Ara. Anti-inflammatory action of donepezil ameliorates tau pathology, synaptic loss, and neurodegeneration in a tauopathy mouse model. Journal of Alzheimer's disease : JAD. vol 22. issue 1. 2011-08-29. PMID:20847440. |
acetylcholinesterase inhibitors (acheis) are widely used to compensate for acetylcholine (ach) depletion in the alzheimer's disease (ad) brain. |
2011-08-29 |
2023-08-12 |
mouse |
| Kinji Ohn. [Genetic defects and disorders at the neuromuscular junction]. Brain and nerve = Shinkei kenkyu no shinpo. vol 63. issue 7. 2011-08-25. PMID:21747136. |
mutations identified to date include (i) muscle nicotinic acetylcholine receptor (achr) subunits, (ii) rapsyn that anchors and clusters achrs at the neuromuscular junction, (iii) agrin that is released from the nerve terminal and induces achr clustering by stimulating the downstream lrp4/musk/dok-7/rapsyn/achr pathway, (iv) muscle-specific kinase (musk) that transmits the achr-clustering signal from agrin/lrp4 to rapsyn/achr, (v) dok-7 that transmits the achr-clustering signal from agrin/lrp4/musk to rapsyn/achr, (vi) skeletal muscle sodium channel type 1.4 (nav1.4) that spreads the depolarization potential from the endplate throughout muscle fibers, (vii) collagen q that anchors acetylcholinesterase to the synaptic basal lamina, and (viii) choline acetyltransferase that resynthesizes acetylcholine from recycled choline at the nerve terminal. |
2011-08-25 |
2023-08-12 |
Not clear |
| b' Alberto Lle\\xc3\\xb. Current therapeutic options for Alzheimer\'s disease. Current genomics. vol 8. issue 8. 2011-07-14. PMID:19415128.' |
these compounds, known as acetylcholinesterase inhibitors (acheis), inhibit the cholinesterases and aim at improving the brain synaptic availability of acetylcholine. |
2011-07-14 |
2023-08-12 |
Not clear |
| K Yellamma, S Saraswathamma, B Nirmala Kumar. Cholinergic system under aluminium toxicity in rat brain. Toxicology international. vol 17. issue 2. 2011-07-14. PMID:21170257. |
acetylcholine and acetylcholinesterase were determined in selected regions of rat brain such as cerebral cortex, hippocampus, hypothalamus, cerebellum, and pons-medulla at selected time intervals/days under acute and chronic treatment with aluminium. |
2011-07-14 |
2023-08-12 |
rat |
| K Yellamma, S Saraswathamma, B Nirmala Kumar. Cholinergic system under aluminium toxicity in rat brain. Toxicology international. vol 17. issue 2. 2011-07-14. PMID:21170257. |
the results revealed that while acetylcholinesterase activity was inhibited, acetylcholine level was elevated differentially in all the above mentioned areas of brain under aluminium toxicity, exhibiting area-specific response. |
2011-07-14 |
2023-08-12 |
rat |
| A Gholamhoseinian, M N Moradi, F Sharifi-Fa. Screening the methanol extracts of some Iranian plants for acetylcholinesterase inhibitory activity. Research in pharmaceutical sciences. vol 4. issue 2. 2011-07-14. PMID:21589805. |
acetylcholinesterase (ache) is the main enzyme for the breakdown of acetylcholine. |
2011-07-14 |
2023-08-12 |
Not clear |
| Véronique Bernard, Emmanuelle Girard, Anna Hrabovska, Shelley Camp, Palmer Taylor, Benoit Plaud, Eric Krejc. Distinct localization of collagen Q and PRiMA forms of acetylcholinesterase at the neuromuscular junction. Molecular and cellular neurosciences. vol 46. issue 1. 2011-07-05. PMID:20883790. |
acetylcholinesterase (ache) terminates the action of acetylcholine at cholinergic synapses thereby preventing rebinding of acetylcholine to nicotinic postsynaptic receptors at the neuromuscular junction. |
2011-07-05 |
2023-08-12 |
mouse |
| Thomas Mülle. Rivastigmine in the treatment of patients with Alzheimer's disease. Neuropsychiatric disease and treatment. vol 3. issue 2. 2011-05-17. PMID:19300554. |
inhibition of the breakdown of acetylcholine by blocking the enzymes acetylcholinesterase and butyrylcholinesterase with rivastigmine improves this cholinergic depletion. |
2011-05-17 |
2023-08-12 |
Not clear |
| Greg J Norman, John S Morris, Kate Karelina, Zachary M Weil, Ning Zhang, Yousef Al-Abed, Holly M Brothers, Gary L Wenk, Valentin A Pavlov, Kevin J Tracey, A Courtney Devrie. Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic α7 nicotinic receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 9. 2011-05-13. PMID:21368056. |
cardiac arrest also induces alterations in numerous cellular components of central cholinergic signaling, including a reduction in choline acetyltransferase enzymatic activity and the number of choline acetyltransferase-positive neurons, as well as, reduced acetylcholinesterase and vesicular acetylcholine transporter mrna. |
2011-05-13 |
2023-08-12 |
Not clear |
| Alvin V Terry, Jerry J Buccafusco, Elizabeth J Herman, Patrick M Callahan, Wayne D Beck, Samantha Warner, Leah Vandenhuerk, Kristy Bouchard, Gary M Schwarz, Jie Gao, James M Chapma. The prototypical ranitidine analog JWS-USC-75-IX improves information processing and cognitive function in animal models. The Journal of pharmacology and experimental therapeutics. vol 336. issue 3. 2011-04-21. PMID:21106907. |
jws was previously found to inhibit acetylcholinesterase (ache) activity, serve as a potent ligand at muscarinic m₂ acetylcholine receptors, and elicit positive effects on spatial learning, passive avoidance, and working memory in rodents. |
2011-04-21 |
2023-08-12 |
rat |
| S Armenta, M Blanc. Ion mobility spectrometry: a valuable tool for kinetic studies in enzymology. Analytica chimica acta. vol 685. issue 1. 2011-04-04. PMID:21168544. |
the capability of ims in the determination of enzyme kinetics and inhibition studies by the analysis of substrate depletion and/or product formation using only a few microliters of solution has been successfully demonstrated on the example of acetylcholine hydrolysis catalyzed by acetylcholinesterase (ache) and inhibited by neostigmine and galanthamine. |
2011-04-04 |
2023-08-12 |
Not clear |
| Paulo R Bueno, Ailton M Watanabe, Ronaldo C Faria, Márcio L Santos, Carla S Riccard. Electrogravimetric real-time and in situ michaelis-menten enzymatic kinetics: progress curve of acetylcholinesterase hydrolysis. The journal of physical chemistry. B. vol 114. issue 49. 2011-04-01. PMID:21082796. |
in this paper, acetylcholinesterase was used as the enzymatic model and acetylcholine as substrate. |
2011-04-01 |
2023-08-12 |
Not clear |
| Yechun Xu, Jacques-Philippe Colletier, Martin Weik, Guangrong Qin, Hualiang Jiang, Israel Silman, Joel L Sussma. Long route or shortcut? A molecular dynamics study of traffic of thiocholine within the active-site gorge of acetylcholinesterase. Biophysical journal. vol 99. issue 12. 2011-03-28. PMID:21156143. |
the principal role of acetylcholinesterase is termination of nerve impulse transmission at cholinergic synapses, by rapid hydrolysis of the neurotransmitter acetylcholine to acetate and choline. |
2011-03-28 |
2023-08-12 |
Not clear |
| Yukihiro Noda, Akihiro Mouri, Yu Ando, Yukari Waki, Shin-Nosuke Yamada, Akira Yoshimi, Kiyofumi Yamada, Norio Ozaki, Dayong Wang, Toshitaka Nabeshim. Galantamine ameliorates the impairment of recognition memory in mice repeatedly treated with methamphetamine: involvement of allosteric potentiation of nicotinic acetylcholine receptors and dopaminergic-ERK1/2 systems. The international journal of neuropsychopharmacology. vol 13. issue 10. 2011-03-18. PMID:20219155. |
galantamine, a drug used to treat alzheimer's disease, inhibits acetylcholinesterase (ache) and allosterically modulates nicotinic acetylcholine receptors (nachrs) resulting in stimulation of catecholamine neurotransmission. |
2011-03-18 |
2023-08-12 |
mouse |
| Qingfeng Liu, Xiayan Shao, Jie Chen, Yehong Shen, Chengcheng Feng, Xiaoling Gao, Yue Zhao, Jingwei Li, Qizhi Zhang, Xinguo Jian. In vivo toxicity and immunogenicity of wheat germ agglutinin conjugated poly(ethylene glycol)-poly(lactic acid) nanoparticles for intranasal delivery to the brain. Toxicology and applied pharmacology. vol 251. issue 1. 2011-02-24. PMID:21163285. |
amino acid neurotransmitters, lactate dehydrogenase (ldh) activity, reduced glutathione (gsh), acetylcholine, acetylcholinesterase activity, tumor necrosis factor α (tnf-α) and interleukin-8 (il-8) in rat olfactory bulb (ob) and brain were measured to estimate the in vivo toxicity of wga-np. |
2011-02-24 |
2023-08-12 |
mouse |
| Qingfeng Liu, Xiayan Shao, Jie Chen, Yehong Shen, Chengcheng Feng, Xiaoling Gao, Yue Zhao, Jingwei Li, Qizhi Zhang, Xinguo Jian. In vivo toxicity and immunogenicity of wheat germ agglutinin conjugated poly(ethylene glycol)-poly(lactic acid) nanoparticles for intranasal delivery to the brain. Toxicology and applied pharmacology. vol 251. issue 1. 2011-02-24. PMID:21163285. |
no significant changes in acetylcholine level, acetylcholinesterase activity, gsh level, tnf-α level and il-8 level were observed in rat ob and brain for the wga-np group. |
2011-02-24 |
2023-08-12 |
mouse |
| Qiong Wang, Li-Hua Sun, William Jia, Xin-Min Liu, Hai-Xia Dang, Wen-Li Mai, Ning Wang, Andre Steinmetz, Yu-Qin Wang, Chang-Jiang X. Comparison of ginsenosides Rg1 and Rb1 for their effects on improving scopolamine-induced learning and memory impairment in mice. Phytotherapy research : PTR. vol 24. issue 12. 2011-02-17. PMID:20564503. |
after 6 and 12 mg/kg of rg1 and rb1 intraperitoneal administration to mice for 7 days, their effects were assessed using the step-down passive avoidance (sd) and the morris water maze (mwm) tests, the acetylcholinesterase (ache) activity, acetylcholine (ach) content and serotonin (5-ht) level in the hippocampus were analysed after sd and mwm tests. |
2011-02-17 |
2023-08-12 |
mouse |
| John C O'Donnell, Cindy Acon-Chen, John H McDonough, Tsung-Ming Shi. Comparison of extracellular striatal acetylcholine and brain seizure activity following acute exposure to the nerve agents cyclosarin and tabun in freely moving guinea pigs. Toxicology mechanisms and methods. vol 20. issue 9. 2011-02-02. PMID:20919801. |
the inhibition of acetylcholinesterase, which is responsible for breaking down acetylcholine (ach) at the synapse and neuromuscular junction, leads to a build-up of extracellular ach and a series of toxic consequences including hypersecretion, tremor, convulsion/seizure, respiratory distress, coma, and death. |
2011-02-02 |
2023-08-12 |
human |
| b' Momcilo Dordevi\\xc4\\x87, Predrag Sazdanovi\\xc4\\x87, Gordana Dordevi\\xc4\\x87, Bozidar Jovanovi\\xc4\\x8. [Morbidity in newborns exposed to organophosphorus pesticides]. Medicinski pregled. vol 63. issue 5-6. 2011-01-19. PMID:21186557.' |
this group of compounds make substances whose activity mechanism is based on the inhibition of acetylcholinesterase in nerve synapsis, thus producing holynergic syndrome, resulting from the accumulation of acetylcholine which developed due to the absence of decomposition under the influence of cholinesterase. |
2011-01-19 |
2023-08-12 |
Not clear |
| Mohammad A Kamal, M Reale, Abdulaziz A Al-Jafar. Multiple approaches to analyse the data for rat brain acetylcholinesterase inhibition by cyclophosphamide. Neurochemical research. vol 35. issue 10. 2011-01-18. PMID:20652634. |
acetylcholinesterase (ache) is an externally oriented membrane-bound enzyme and its main physiological role is termination of chemical transmission at cholinergic synapses and secretory organs by rapid hydrolysis of the neurotransmitter acetylcholine (ach). |
2011-01-18 |
2023-08-12 |
rat |