| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zaheer-ul-Haq, Sobia Ahsan Halim, Reaz Uddin, Jeffry D Madur. Benchmarking docking and scoring protocol for the identification of potential acetylcholinesterase inhibitors. Journal of molecular graphics & modelling. vol 28. issue 8. 2010-08-12. PMID:20447848. |
acetylcholinesterase (ache) plays a crucial role in nerve impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine (ach). |
2010-08-12 |
2023-08-12 |
Not clear |
| Markéta Kovárová, Karel Komers, Sárka Stepánková, Alexander Cega. Inhibition of acetylcholinesterase by 14 achiral and five chiral imidazole derivates. Bioresource technology. vol 101. issue 15. 2010-07-27. PMID:20335028. |
homological series of 14 achiral derivates and series of five chiral derivates of imidazole were tested in vitro as inhibitors of hydrolysis of acetylcholine using enzyme preparation of acetylcholinesterase from electric eel. |
2010-07-27 |
2023-08-12 |
Not clear |
| P F Zabrodskii, V F Kirichuk, V G Lim, I H Yafarova, A V Kuzmi. Role of cholinergic and cytokine regulation of T cell function in stimulation and inhibition of immune reactions in intoxication by organophosphorus compounds in different doses. Bulletin of experimental biology and medicine. vol 148. issue 3. 2010-07-26. PMID:20396698. |
acetylcholine and aceclidine stimulated activity of acetylcholinesterase in t cells, while dimethyl dichlorovinyl phosphate in a single dose of 0.5 ld50 inhibited it. |
2010-07-26 |
2023-08-12 |
rat |
| P F Zabrodskii, V F Kirichuk, V G Lim, I H Yafarova, A V Kuzmi. Role of cholinergic and cytokine regulation of T cell function in stimulation and inhibition of immune reactions in intoxication by organophosphorus compounds in different doses. Bulletin of experimental biology and medicine. vol 148. issue 3. 2010-07-26. PMID:20396698. |
during acute intoxication, the organophosphorus compound, depending on the dose, can stimulate (acetylcholine effect) and inhibit the immune reactions (acetylcholinesterase inhibition of t cells). |
2010-07-26 |
2023-08-12 |
rat |
| Pamela D Moore, Clement G Yedjou, Paul B Tchounwo. Malathion-induced oxidative stress, cytotoxicity, and genotoxicity in human liver carcinoma (HepG2) cells. Environmental toxicology. vol 25. issue 3. 2010-07-23. PMID:19399848. |
its toxicity has been associated with the inhibition of acetylcholinesterase activity, leading to the interference with the transmission of nerve impulse, accumulation of acetylcholine at synaptic junctions, and subsequent induction of adverse health effects including headache, dizziness, nausea, vomiting, bradycardia, and miosis. |
2010-07-23 |
2023-08-12 |
human |
| Yeon-Hwa Kim, Yunkyoung Lee, Dohee Kim, Min Whan Jung, Chang-Joong Le. Scopolamine-induced learning impairment reversed by physostigmine in zebrafish. Neuroscience research. vol 67. issue 2. 2010-07-13. PMID:20298728. |
in this study, the effects of scopolamine, an acetylcholine muscarinic receptor antagonist, and physostigmine, an acetylcholinesterase inhibitor, on the learning ability and memory of zebrafish were evaluated using a passive avoidance response test. |
2010-07-13 |
2023-08-12 |
zebrafish |
| T T Money, E Scarr, M Udawela, A S Gibbons, W J Jeon, M S Seo, B Dea. Treating schizophrenia: novel targets for the cholinergic system. CNS & neurological disorders drug targets. vol 9. issue 2. 2010-07-12. PMID:20053170. |
importantly, the demonstration that acetylcholinesterase inhibitors, which result in higher synaptic levels of acetylcholine, can reduce the cognitive deficits of schizophrenia suggested that under-stimulation of cholinoceptors could be associated with the cognitive deficits associated with this disorder. |
2010-07-12 |
2023-08-12 |
Not clear |
| J P Lopes de Almeida, C Saldanh. Nonneuronal cholinergic system in human erythrocytes: biological role and clinical relevance. The Journal of membrane biology. vol 234. issue 3. 2010-07-12. PMID:20352203. |
the widespread expression of nonneuronal acetylcholine is accompanied by the ubiquitous presence of acetylcholinesterase and nicotinic/muscarinic receptors. |
2010-07-12 |
2023-08-12 |
human |
| Sang-Hoon Lee, Jin-Sook Park, Se-Kwon Kim, Chang-Bum Ahn, Jae-Young J. Chitooligosaccharides suppress the level of protein expression and acetylcholinesterase activity induced by Abeta25-35 in PC12 cells. Bioorganic & medicinal chemistry letters. vol 19. issue 3. 2010-07-06. PMID:19097785. |
clinical applications of acetylcholinesterase (ache) inhibitors are widespread in alzheimer's sufferers in order to activate central cholinergic system and alleviate cognitive deficits by inhibiting the hydrolysis of acetylcholine. |
2010-07-06 |
2023-08-12 |
Not clear |
| Torsten Geissler, Wolfgang Brandt, Andrea Porzel, Dagmar Schlenzig, Astrid Kehlen, Ludger Wessjohann, Norbert Arnol. Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus. Bioorganic & medicinal chemistry. vol 18. issue 6. 2010-07-06. PMID:20176490. |
inhibition of acetylcholinesterase (ache) and therefore prevention of acetylcholine degradation is one of the most accepted therapy opportunities for alzheimer s disease (ad), today. |
2010-07-06 |
2023-08-12 |
Not clear |
| Gracielle Alves-Amaral, Marcelo Pires-Oliveira, Ana Luiza Andrade-Lopes, Tiago Chiavegatti, Rosely Oliveira Godinh. Gender-related differences in circadian rhythm of rat plasma acetyl- and butyrylcholinesterase: effects of sex hormone withdrawal. Chemico-biological interactions. vol 186. issue 1. 2010-07-01. PMID:20399201. |
the role of acetylcholinesterase (ache) in the termination of the cholinergic response through acetylcholine (ach) hydrolysis and the involvement of plasma butyrylcholinesterase (buche), mainly of hepatic origin, in the metabolism of xenobiotics with ester bonds is well known. |
2010-07-01 |
2023-08-12 |
rat |
| Chawanrat Somnuek, Chuta Boonphakdee, Voravit Cheevaporn, Keiichi Tanak. Gene expression of acetylcholinesterase in hybrid catfish (Clarias gariepinus X Clarias macrocephalus) exposed to chlorpyrifos and carbaryl. Journal of environmental biology. vol 30. issue 1. 2010-06-30. PMID:20112867. |
after serving as an eurotransmitter, acetylcholine is hydrolyzed by acetylcholinesterase (ache). |
2010-06-30 |
2023-08-12 |
Not clear |
| J P Changeux, T Podleski, J C Meunie. On Some Structural Analogies between Acetylcholinesterase and the Macromolecular Receptor of Acetylcholine. The Journal of general physiology. vol 54. issue 1. 2010-06-29. PMID:19873643. |
on some structural analogies between acetylcholinesterase and the macromolecular receptor of acetylcholine. |
2010-06-29 |
2023-08-12 |
Not clear |
| J P Changeux, T Podleski, J C Meunie. On Some Structural Analogies between Acetylcholinesterase and the Macromolecular Receptor of Acetylcholine. The Journal of general physiology. vol 54. issue 1. 2010-06-29. PMID:19873643. |
several properties of the enzyme acetylcholinesterase (ache) isolated in vitro are compared with those of the membrane receptor(s) of acetylcholine expressed by the in vivo electrical response of the electroplax membrane. |
2010-06-29 |
2023-08-12 |
Not clear |
| H G Mautne. Isologous oxygen, sulfur, and selenium compounds as probes of acetylcholine receptors. The Journal of general physiology. vol 54. issue 1. 2010-06-29. PMID:19873647. |
experiments with sulfur and selenium isologs of acetylcholine, choline, and local anesthetics suggest that the active sites of receptors of the electroplax and of electric eel acetylcholinesterase are different, but are compatible with the postulate that acetylcholine receptors of axonal and synaptic excitable membranes are similar. |
2010-06-29 |
2023-08-12 |
Not clear |
| A Karli. THE ASSOCIATION OF ACETYLCHOLINESTERASE AND MEMBRANE IN SUBCELLULAR FRACTIONS OF THE ELECTRIC TISSUE OF ELECTROPHORUS. The Journal of cell biology. vol 25. issue 2. 2010-06-22. PMID:19866659. |
the possible use of the peak fraction containing membranes rich in acetylcholinesterase for the investigation of other components of the acetylcholine system and of other properties of the membrane is discussed. |
2010-06-22 |
2023-08-12 |
Not clear |
| Kelvin Kin-Kwan Wong, Michelle Tsz-Wan Ho, Huang Quan Lin, Kwok-Fai Lau, John A Rudd, Ronald Chi-Kit Chung, Kwok-Pui Fung, Pang-Chui Shaw, David Chi-Cheong Wa. Cryptotanshinone, an acetylcholinesterase inhibitor from Salvia miltiorrhiza, ameliorates scopolamine-induced amnesia in Morris water maze task. Planta medica. vol 76. issue 3. 2010-06-18. PMID:19774505. |
the current therapeutic intervention for ad is primarily based on the inhibition of brain acetylcholinesterase (ache) to restore the brain acetylcholine level. |
2010-06-18 |
2023-08-12 |
human |
| A M Siebel, E P Rico, K M Capiotti, A L Piato, C T Cusinato, T M A Franco, M R Bogo, C D Bona. In vitro effects of antiepileptic drugs on acetylcholinesterase and ectonucleotidase activities in zebrafish (Danio rerio) brain. Toxicology in vitro : an international journal published in association with BIBRA. vol 24. issue 4. 2010-06-17. PMID:20362660. |
our findings have also shown that high cbz concentrations inhibit acetylcholinesterase activity, which can induce an increase of acetylcholine levels. |
2010-06-17 |
2023-08-12 |
zebrafish |
| Gopalreddygari Visweswari, Kanchi Siva Prasad, Pandanaboina Sahitya Chetan, Valluru Lokanatha, Wudayagiri Rajendr. Evaluation of the anticonvulsant effect of Centella asiatica (gotu kola) in pentylenetetrazol-induced seizures with respect to cholinergic neurotransmission. Epilepsy & behavior : E&B. vol 17. issue 3. 2010-06-08. PMID:20144879. |
increased acetylcholine content and decreased acetylcholinesterase activity were recorded in different brain regions during ptz-induced seizures. |
2010-06-08 |
2023-08-12 |
rat |
| Gopalreddygari Visweswari, Kanchi Siva Prasad, Pandanaboina Sahitya Chetan, Valluru Lokanatha, Wudayagiri Rajendr. Evaluation of the anticonvulsant effect of Centella asiatica (gotu kola) in pentylenetetrazol-induced seizures with respect to cholinergic neurotransmission. Epilepsy & behavior : E&B. vol 17. issue 3. 2010-06-08. PMID:20144879. |
pretreatment with c. asiatica extracts caused recovery of the levels of acetylcholine and acetylcholinesterase. |
2010-06-08 |
2023-08-12 |
rat |