| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alberto Halabe Buca. Donepezil (aricept) as a treatment for anorexia nervosa: a very feasible therapeutic possibility. Expert opinion on investigational drugs. vol 18. issue 5. 2010-01-11. PMID:19388874. |
donepezil is a drug that been proven to be effective in the treatment of dementia, including alzheimer's; it has been used for affective disorders and its mechanism of action is to inhibit the acetylcholinesterase enzyme to increase acetylcholine. |
2010-01-11 |
2023-08-12 |
Not clear |
| Joseph Yanai, Adi Pinkas, Frederic J Seidler, Ian T Ryde, Eddy A Van der Zee, Theodore A Slotki. Neurobehavioral teratogenicity of sarin in an avian model. Neurotoxicology and teratology. vol 31. issue 6. 2010-01-07. PMID:19660543. |
acetylcholinesterase and choline acetyltransferase were unaffected but sarin reduced the concentration of the high-affinity choline transporter, the rate-limiting factor in acetylcholine utilization. |
2010-01-07 |
2023-08-12 |
chicken |
| Seyed Khosrow Tayebati, Maria Antonietta Di Tullio, Alberto Ricci, Francesco Ament. Influence of dermal exposure to the pyrethroid insecticide deltamethrin on rat brain microanatomy and cholinergic/dopaminergic neurochemistry. Brain research. vol 1301. 2010-01-05. PMID:19748499. |
cholinergic neurotransmission markers investigated in frontal cortex, hippocampus and striatum were acetylcholine (ach), the synthesizing and catabolic enzymes choline acetyltransferase and acetylcholinesterase and the high affinity ach uptake system labeled with [(3)h]hemicholinium-3. |
2010-01-05 |
2023-08-12 |
rat |
| Mehmet Sofuoglu, Marc Moone. Cholinergic functioning in stimulant addiction: implications for medications development. CNS drugs. vol 23. issue 11. 2009-12-29. PMID:19845415. |
in human studies, acetylcholinesterase inhibitors, which increase synaptic acetylcholine levels, have shown promise for the treatment of stimulant addiction. |
2009-12-29 |
2023-08-12 |
human |
| Eu Vian Tan, Christopher R Low. Holographic enzyme inhibition assays for drug discovery. Analytical chemistry. vol 81. issue 18. 2009-12-21. PMID:19681618. |
this report describes an enzyme inhibition-based holographic sensor as a potential label-free detection system, using acetylcholinesterase (acetylcholine acetylhydrolase; ec 3.1.1.7; abbreviated herein ache) as the model enzyme. |
2009-12-21 |
2023-08-12 |
Not clear |
| Mireille Basselin, Henry N Nguyen, Lisa Chang, Jane M Bell, Stanley I Rapopor. Acute but not chronic donepezil increases muscarinic receptor-mediated signaling via arachidonic acid in unanesthetized rats. Journal of Alzheimer's disease : JAD. vol 17. issue 2. 2009-12-16. PMID:19363262. |
donepezil, an acetylcholinesterase (ache) inhibitor used for treating alzheimer's disease patients, is thought to act by increasing brain extracellular acetylcholine (ach), and ach binding to cholinergic receptors. |
2009-12-16 |
2023-08-12 |
rat |
| Giuseppina Martella, Annalisa Tassone, Giuseppe Sciamanna, Paola Platania, Dario Cuomo, Maria Teresa Viscomi, Paola Bonsi, Emanuele Cacci, Stefano Biagioni, Alessandro Usiello, Giorgio Bernardi, Nutan Sharma, David G Standaert, Antonio Pisan. Impairment of bidirectional synaptic plasticity in the striatum of a mouse model of DYT1 dystonia: role of endogenous acetylcholine. Brain : a journal of neurology. vol 132. issue Pt 9. 2009-12-14. PMID:19641103. |
the presence of an enhanced acetylcholine tone was confirmed by the observation that acetylcholinesterase activity was significantly increased in the striatum of mutant human torsina mice, as compared with both normal human torsina and nt littermates. |
2009-12-14 |
2023-08-12 |
mouse |
| Guo Wen, Wang Hui, Chen Dan, Wu Xiao-Qiong, Tong Jian-Bin, Li Chang-Qi, Lei De-Liang, Cai Wei-Jun, Li Zhi-Yuan, Luo Xue-Gan. The effects of exercise-induced fatigue on acetylcholinesterase expression and activity at rat neuromuscular junctions. Acta histochemica et cytochemica. vol 42. issue 5. 2009-12-11. PMID:19918322. |
acetylcholinesterase is the enzyme that terminates neurotransmission by hydrolyzing the acetylcholine released by the motoneurons at the neuromuscular junctions. |
2009-12-11 |
2023-08-12 |
rat |
| Maria Laura Bolognesi, Manuela Bartolini, Michela Rosini, Vincenza Andrisano, Carlo Melchiorr. Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action. Bioorganic & medicinal chemistry letters. vol 19. issue 15. 2009-12-07. PMID:19505825. |
the rr stereoisomer 2 resulted more effective than 1 in reverting two important effects mediated by acetylcholinesterase (ache), that is, acetylcholine hydrolysis and ache-induced amyloid-beta aggregation. |
2009-12-07 |
2023-08-12 |
Not clear |
| Muniswamy David, Vineetkumar K Patil, Sameer G Chebbi, Shambangouda R Marigoudar, Jagadeesh B Chittaragi, Ramesh Halapp. Gas-liquid chromatography for fenvalerate residue analysis: in vivo alterations in the acetylcholinesterase activity and acetylcholine in different tissues of the fish, Labeo rohita (Hamilton). Toxicology mechanisms and methods. vol 19. issue 6-7. 2009-12-04. PMID:19778241. |
gas-liquid chromatography for fenvalerate residue analysis: in vivo alterations in the acetylcholinesterase activity and acetylcholine in different tissues of the fish, labeo rohita (hamilton). |
2009-12-04 |
2023-08-12 |
Not clear |
| Yong Wang, Xin Ge, Xiao Fang Xu, Xiao Jing Wan. Acetylcholinesterase inhibitor is a potentially useful therapeutic agent for nicotine-induced periodontal disease. Medical hypotheses. vol 73. issue 4. 2009-11-16. PMID:19625132. |
these components include acetylcholine, choline acetyltransferase, acetylcholinesterase (ache) and nicotinic acetylcholine receptors. |
2009-11-16 |
2023-08-12 |
Not clear |
| Bin Wang, Xue Mei Wang, Hong Fu, Geng Xin Li. Protective effects of Wu-Zi-Yan-Zong-Fang on amyloid beta-induced damage in vivo and in vitro. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 129. issue 8. 2009-11-09. PMID:19652500. |
in vivo studies showed that wu-zi-yan-zong-fang significantly ameliorated the spatial memory and retention deficits, decreased acetylcholinesterase activity, and increased acetylcholine content caused by intracerebroventricular injection of amyloid-beta(25-35). |
2009-11-09 |
2023-08-12 |
rat |
| Alemayehu A Gorfe, Benzhuo Lu, Zeyun Yu, J Andrew McCammo. Enzymatic activity versus structural dynamics: the case of acetylcholinesterase tetramer. Biophysical journal. vol 97. issue 3. 2009-10-20. PMID:19651048. |
a classic example of a diffusion-controlled biological reaction catalyzed by an oligomeric enzyme is the hydrolysis of synaptic acetylcholine (ach) by tetrameric acetylcholinesterase (achet). |
2009-10-20 |
2023-08-12 |
Not clear |
| Yoshihiko Kakinuma, Tsuyoshi Akiyama, Takayuki Sat. Cholinoceptive and cholinergic properties of cardiomyocytes involving an amplification mechanism for vagal efferent effects in sparsely innervated ventricular myocardium. The FEBS journal. vol 276. issue 18. 2009-09-15. PMID:19674111. |
our recent studies have shown that, as indicated by vagal stimulation, an acetylcholinesterase inhibitor donepezil, an anti-alzheimer's disease drug, prevents progression of heart failure in rats with myocardial infarction, and activates a common cell survival signal shared by acetylcholine (ach) in vitro. |
2009-09-15 |
2023-08-12 |
mouse |
| Sangu Muthuraju, Panchanan Maiti, Preeti Solanki, Alpesh Kumar Sharma, Amitabh, Shashi Bala Singh, Dipti Prasad, Govindasamy Ilavazhaga. Acetylcholinesterase inhibitors enhance cognitive functions in rats following hypobaric hypoxia. Behavioural brain research. vol 203. issue 1. 2009-08-31. PMID:19446892. |
cholinergic markers like acetylcholine (ach) and acetylcholinesterase (ache) were evaluated in hippocampus and cortex of rats. |
2009-08-31 |
2023-08-12 |
rat |
| Bomi Lee, Kangsik Jung, Dong-Hyun Ki. Timosaponin AIII, a saponin isolated from Anemarrhena asphodeloides, ameliorates learning and memory deficits in mice. Pharmacology, biochemistry, and behavior. vol 93. issue 2. 2009-08-28. PMID:19426756. |
ta3 also increased hippocampal acetylcholine levels in scopolamine-treated mice and dose-dependently inhibited acetylcholinesterase (ache) activity (ic(50) value, 35.4 microm). |
2009-08-28 |
2023-08-12 |
mouse |
| Turgut Emrah Bozkurt, Inci Sahin-Erdeml. M(1) and M(3) muscarinic receptors are involved in the release of urinary bladder-derived relaxant factor. Pharmacological research. vol 59. issue 5. 2009-08-26. PMID:19416629. |
in addition, mcn-a-343, by activating the facilitatory m(1) receptors and physostigmine by inhibiting the acetylcholinesterase may induce the release of this factor through endogenous acetylcholine in the coaxial bioassay system. |
2009-08-26 |
2023-08-12 |
Not clear |
| Jeffrey B Eells, Timothy Brow. Repeated developmental exposure to chlorpyrifos and methyl parathion causes persistent alterations in nicotinic acetylcholine subunit mRNA expression with chlorpyrifos altering dopamine metabolite levels. Neurotoxicology and teratology. vol 31. issue 2. 2009-08-20. PMID:18977431. |
organophosphates (ops), commonly used as insecticides, inhibit acetylcholinesterase, the enzyme responsible for the inactivation of synaptic acetylcholine, which results in elevated acetylcholine neurotransmission. |
2009-08-20 |
2023-08-12 |
rat |
| Filomena A Carvalho, José Pedro Almeida, Isabel O Fernandes, Teresa Freitas-Santos, Carlota Saldanh. Non-neuronal cholinergic system and signal transduction pathways mediated by band 3 in red blood cells. Clinical hemorheology and microcirculation. vol 40. issue 3. 2009-08-18. PMID:19029645. |
non-neuronal acetylcholine (ach) and acetylcholinesterase (ache) have been recognized in the past. |
2009-08-18 |
2023-08-12 |
Not clear |
| Łukasz Górski, Monika Mroczkiewicz, Mariusz Pietrzak, Elzbieta Malinowsk. Metalloporphyrin-based acetate-selective electrodes as detectors for enzymatic acetylcholine determination in flow-injection analysis system. Analytica chimica acta. vol 644. issue 1-2. 2009-08-05. PMID:19463558. |
enzymatic hydrolysis was used to generate acetate ions from acetylcholine, employing acetylcholinesterase immobilized on amberlite. |
2009-08-05 |
2023-08-12 |
Not clear |