| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Martina Zimmermann, Martin S Westwell, Susan A Greenfiel. Impact of detergents on the activity of acetylcholinesterase and on the effectiveness of its inhibitors. Biological chemistry. vol 390. issue 1. 2009-03-12. PMID:19007306. |
acetylcholinesterase (ache) plays a central role in the development of alzheimer's disease: ache inhibition for preventing the characteristic dwindling of acetylcholine levels constitutes the current standard treatment for the disorder. |
2009-03-12 |
2023-08-12 |
Not clear |
| H Kalonia, M Bishnoi, A Kuma. Possible mechanism involved in sleep deprivation-induced memory dysfunction. Methods and findings in experimental and clinical pharmacology. vol 30. issue 7. 2009-02-23. PMID:18985181. |
in addition, increased levels of acetylcholinesterase (ache; the enzyme responsible for the degradation of acetylcholine) and reduction in norepinephrine and dopamine levels were seen in 72-h sleep-deprived animals. |
2009-02-23 |
2023-08-12 |
rat |
| S K Tayebati, M A Di Tullio, F Ament. Vesicular acetylcholine transporter (VAChT) in the brain of spontaneously hypertensive rats (SHR): effect of treatment with an acetylcholinesterase inhibitor. Clinical and experimental hypertension (New York, N.Y. : 1993). vol 30. issue 8. 2009-02-06. PMID:19021024. |
vesicular acetylcholine transporter (vacht) in the brain of spontaneously hypertensive rats (shr): effect of treatment with an acetylcholinesterase inhibitor. |
2009-02-06 |
2023-08-12 |
rat |
| Manuel Iván Girón-Pérez, Galina Zaitseva, Josefina Casas-Solis, Anne Santerr. Effects of diazinon and diazoxon on the lymphoproliferation rate of splenocytes from Nile tilapia (Oreochromis niloticus): the immunosuppresive effect could involve an increase in acetylcholine levels. Fish & shellfish immunology. vol 25. issue 5. 2009-01-29. PMID:18674623. |
conversely, ex vivo assays showed that spleen from fish exposed to diazinon presented a lower acetylcholinesterase activity and a higher acetylcholine concentration than non-exposed controls. |
2009-01-29 |
2023-08-12 |
Not clear |
| Jennifer M Bui, J Andrew McCammo. Intrinsic conformational flexibility of acetylcholinesterase. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18452905. |
to understand the dynamical properties of acetylcholinesterase (ache) in rapid termination of cationic neurotransmitter, acetylcholine at neurosynaptic junctions, multiple molecular dynamics (md) trajectories of ache in the presence and absence of its inhibitors [j.m. |
2008-12-10 |
2023-08-12 |
Not clear |
| Wei Su, Jun Wu, Wei-Yuan Ye, Xue-Jun Zhan. A monoclonal antibody against synaptic AChE: a useful tool for detecting apoptotic cells. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18538755. |
the classical function of acetylcholinesterase (ache) is to terminate synaptic transmission at cholinergic synapses by rapidly hydrolyzing the neurotransmitter acetylcholine (ach). |
2008-12-10 |
2023-08-12 |
Not clear |
| Christelle Bertrand, Beatrice Bonafos, Maud Tremblay, Arnaud Ferry, Arnaud Chatonne. Effect of fluoxetine on neuromuscular function in acetylcholinesterase (AChE) knockout mice. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18550043. |
the slow channel myasthenic syndrome (slow-channel-cms) results in a marked prolongation of channel opening in stimulated receptors (nachr) and the end plate acetylcholinesterase (ache) deficiency congenital myasthenic syndrome (colq-cms) results in an increased action of acetylcholine (ach) at the synapse. |
2008-12-10 |
2023-08-12 |
mouse |
| Jure Stoja. Kinetic evaluation of multiple initial rate data by simultaneous analysis with two equations. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18579127. |
during the acetylcholinesterase catalytic process, the acetylcholine substrate attaches to the peripheral anionic site and then slides to the catalytic site situated in the center of the enzyme, at the bottom of a deep and narrow active gorge. |
2008-12-10 |
2023-08-12 |
Not clear |
| Israel Silman, Joel L Sussma. Acetylcholinesterase: how is structure related to function? Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18586019. |
in accordance with its biological role, termination of neurotransmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter, acetylcholine, acetylcholinesterase is one of nature's most efficient enzymes. |
2008-12-10 |
2023-08-12 |
Not clear |
| Brian R Coleman, Ruthie H Ratcliffe, Samuel A Oguntayo, Xuerong Shi, Bhupendra P Doctor, Richard K Gordon, Madhusoodana P Nambia. [+]-Huperzine A treatment protects against N-methyl-D-aspartate-induced seizure/status epilepticus in rats. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18588864. |
the toxicity of organophosphorous (op) nerve agents is attributed to their irreversible inhibition of acetylcholinesterase (ache), which leads to excessive accumulation of acetylcholine (ach) and is followed by the release of excitatory amino acids (eaa). |
2008-12-10 |
2023-08-12 |
rat |
| Michal Alon, Fishel Alon, Ralf Nauen, Shai Mori. Organophosphates' resistance in the B-biotype of Bemisia tabaci (Hemiptera: Aleyrodidae) is associated with a point mutation in an ace1-type acetylcholinesterase and overexpression of carboxylesterase. Insect biochemistry and molecular biology. vol 38. issue 10. 2008-12-10. PMID:18721883. |
organophosphate (op) insecticides are inhibitors of the enzyme acetylcholinesterase (ache), which terminates nerve impulses by catalyzing the hydrolysis of the neurotransmitter acetylcholine. |
2008-12-10 |
2023-08-12 |
Not clear |
| Jessica J Roland, Katherine Mark, Ryan P Vetreno, Lisa M Savag. Increasing hippocampal acetylcholine levels enhance behavioral performance in an animal model of diencephalic amnesia. Brain research. vol 1234. 2008-12-08. PMID:18706897. |
systemic (experiment 1) and intrahippocampal (experiment 2) injections of the acetylcholinesterase inhibitor physostigmine were administered to determine if increasing acetylcholine levels would eliminate the behavioral impairment produced by ptd. |
2008-12-08 |
2023-08-12 |
rat |
| Nikita Mirajkar, Carey N Pop. In vitro sensitivity of cholinesterases and [3H]oxotremorine-M binding in heart and brain of adult and aging rats to organophosphorus anticholinesterases. Biochemical pharmacology. vol 76. issue 8. 2008-11-18. PMID:18761328. |
organophosphorus (op) insecticides elicit toxicity via acetylcholinesterase inhibition, allowing acetylcholine accumulation and excessive stimulation of cholinergic receptors. |
2008-11-18 |
2023-08-12 |
rat |
| Rick L Williams, Gary J Mihlan, Abraham J Tobi. Modeling cholinesterase activity for human dietary risk assessment of carbamate insecticides. Risk analysis : an official publication of the Society for Risk Analysis. vol 28. issue 4. 2008-11-14. PMID:18631301. |
carbamates are a class of chemicals that inhibit the activity of acetylcholinesterase in humans, an enzyme involved in the regulation of the neurotransmitter acetylcholine. |
2008-11-14 |
2023-08-12 |
human |
| Deanna L Kelly, Robert P McMahon, Elaine Weiner, Douglas L Boggs, Dwight Dickinson, Robert R Conley, Robert W Buchana. Lack of beneficial galantamine effect for smoking behavior: a double-blind randomized trial in people with schizophrenia. Schizophrenia research. vol 103. issue 1-3. 2008-09-26. PMID:18550339. |
galantamine is an acetylcholinesterase inhibitor that acts as a positive allosteric modulator of nicotine acetylcholine receptors including both the alpha4beta2 and alpha7 subunits. |
2008-09-26 |
2023-08-12 |
human |
| Marko Zivin, Peter Pregel. Prolonged treatment with donepezil increases acetylcholinesterase expression in the central nervous system. Psychiatria Danubina. vol 20. issue 2. 2008-09-26. PMID:18587286. |
acetylcholinesterase (ache), an enzyme catalysing rapid hydrolysis of acetylcholine is the major enzyme in the metabolism of this neurotransmitter in the central nervous system and in the skeletal and smooth muscles. |
2008-09-26 |
2023-08-12 |
Not clear |
| Edgar Buhl, Klaus Schildberger, Paul A Stevenso. A muscarinic cholinergic mechanism underlies activation of the central pattern generator for locust flight. The Journal of experimental biology. vol 211. issue Pt 14. 2008-09-25. PMID:18587129. |
in deafferented locusts, fictive flight was initiated by bath application of the muscarinic agonist pilocarpine, the acetylcholine analogue carbachol, and the acetylcholinesterase blocker eserine, but not by nicotine. |
2008-09-25 |
2023-08-12 |
Not clear |
| Michal Harel, Leilani K Sonoda, Israel Silman, Joel L Sussman, Terrone L Rosenberr. Crystal structure of thioflavin T bound to the peripheral site of Torpedo californica acetylcholinesterase reveals how thioflavin T acts as a sensitive fluorescent reporter of ligand binding to the acylation site. Journal of the American Chemical Society. vol 130. issue 25. 2008-09-15. PMID:18512913. |
acetylcholinesterase plays a key role in cholinergic synaptic transmission by hydrolyzing the neurotransmitter acetylcholine with one of the highest known catalytic rate constants. |
2008-09-15 |
2023-08-12 |
Not clear |
| Chiara Giuliano, Vinay Parikh, Josh R Ward, Christian Chiamulera, Martin Sarte. Increases in cholinergic neurotransmission measured by using choline-sensitive microelectrodes: enhanced detection by hydrolysis of acetylcholine on recording sites? Neurochemistry international. vol 52. issue 7. 2008-08-08. PMID:18346819. |
previous experiments demonstrated that second-based transient increases in choline concentrations measured by electrodes coated with choline oxidase (chox) and the amperometric detection of hydrogen peroxide validly indicate the depolarization-dependent release of acetylcholine (ach) and its hydrolysis by endogenous acetylcholinesterase (ache). |
2008-08-08 |
2023-08-12 |
Not clear |
| S Cellek, R Thangiah, E M Jarvie, S Vivekanandan, O Lalude, G J Sange. Synergy between 5-HT4 receptor activation and acetylcholinesterase inhibition in human colon and rat forestomach. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 20. issue 5. 2008-08-06. PMID:18194150. |
5-hydroxytryptamine (5-ht4) receptor agonists increase gastrointestinal (gi) motility by enhancing enteric acetylcholine release which is then metabolized by acetylcholinesterase (ache) to inactive metabolites. |
2008-08-06 |
2023-08-12 |
human |