| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hai Yan Zhang, Han Yan, Xi Can Tan. Non-cholinergic effects of huperzine A: beyond inhibition of acetylcholinesterase. Cellular and molecular neurobiology. vol 28. issue 2. 2008-07-30. PMID:17657601. |
the use of acetylcholinesterase inhibitors to decrease the breakdown of the neurotransmitter acetylcholine has been the main symptomatic therapy for mild to moderate alzheimer's patients, though the etiology of alzheimer's disease remains unclear and seems to involve multiple factors. |
2008-07-30 |
2023-08-12 |
Not clear |
| Joachim Hartmann, Cornelia Kiewert, Ellen G Duysen, Oksana Lockridge, Jochen Klei. Choline availability and acetylcholine synthesis in the hippocampus of acetylcholinesterase-deficient mice. Neurochemistry international. vol 52. issue 6. 2008-07-28. PMID:18023504. |
mice deficient for acetylcholinesterase (ache) have strongly increased extracellular levels of acetylcholine (ach) in the dorsal hippocampus [hartmann, j., kiewert, c., duysen, e.g., lockridge, o., greig, n.h., klein, j., 2007. |
2008-07-28 |
2023-08-12 |
mouse |
| Bozica Radić, Ana Lucić Vrdoljak, Davor Zeljezić, Nino Fuchs, Suzana Berend, Nevenka Kopja. Evaluation of HI-6 oxime: potential use in protection of human acetylcholinesterase inhibited by antineoplastic drug irinotecan and its cyto/genotoxicity in vitro. Acta biochimica Polonica. vol 54. issue 3. 2008-07-11. PMID:17713603. |
the function of acetylcholinesterase (ache) is the rapid hydrolysis of the neurotransmitter acetylcholine (ach), which is involved in the numerous cholinergic pathways in both the central and the peripheral nervous system. |
2008-07-11 |
2023-08-12 |
human |
| Gabriel Zimmerman, Marleisje Njunting, Sebastian Ivens, Else A Tolner, Elsa Tolner, Christoph J Behrens, Miriam Gross, Hermona Soreq, Uwe Heinemann, Alon Friedma. Acetylcholine-induced seizure-like activity and modified cholinergic gene expression in chronically epileptic rats. The European journal of neuroscience. vol 27. issue 4. 2008-07-08. PMID:18333967. |
we confirmed that while the total activity of the acetylcholine (ach)-hydrolysing enzyme, acetylcholinesterase (ache) was not altered, epileptic rats showed alternative splicing of ache pre-mrna transcripts, accompanied by a shift from membrane-bound ache tetramers to soluble monomers. |
2008-07-08 |
2023-08-12 |
rat |
| Rosane Souza da Silva, Stefânia Konrad Richetti, Vanessa Gass da Silveira, Ana Maria Oliveira Battastini, Mauricio Reis Bogo, Diogo R Lara, Carla Denise Bona. Maternal caffeine intake affects acetylcholinesterase in hippocampus of neonate rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 26. issue 3-4. 2008-06-30. PMID:18258404. |
we evaluated the effects of rat maternal caffeine intake (1g/l) on acetylcholine degradation and acetylcholinesterase expression from hippocampus of 7-, 14- and 21-day-old neonates in caffeine-treated and control groups. |
2008-06-30 |
2023-08-12 |
rat |
| Monica Rosa Loizzo, Rosa Tundis, Federica Menichini, Francesco Menichin. Natural products and their derivatives as cholinesterase inhibitors in the treatment of neurodegenerative disorders: an update. Current medicinal chemistry. vol 15. issue 12. 2008-06-30. PMID:18473814. |
ad and other forms of dementia could be treated by the use of agents which restore the level of acetylcholine through inhibition of both two major forms of cholinesterase: acetylcholinesterase (ache) and butyrylcholinesterase (bche). |
2008-06-30 |
2023-08-12 |
Not clear |
| J N Narendra Sharath Chandra, Manish Malviya, C T Sadashiva, M N Subhash, Kanchugarakoppal S Rangapp. Effect of novel arecoline thiazolidinones as muscarinic receptor 1 agonist in Alzheimer's dementia models. Neurochemistry international. vol 52. issue 3. 2008-06-20. PMID:17719699. |
among these are cholinergic agents, which include muscarinic agonists, acetylcholinesterase inhibitors, and acetylcholine releasing agents. |
2008-06-20 |
2023-08-12 |
rat |
| Mahdi Balali-Mood, Kia Balali-Moo. Neurotoxic disorders of organophosphorus compounds and their managements. Archives of Iranian medicine. vol 11. issue 1. 2008-06-03. PMID:18154426. |
the mechanism of toxicity of organophosphorus compounds is the inhibition of acetylcholinesterase, which results in accumulation of acetylcholine and the continued stimulation of acetylcholine receptors. |
2008-06-03 |
2023-08-12 |
Not clear |
| Renato Tavares dos Santos Pereira, Catarina Segreti Porto, Rosely Oliveira Godinho, Fernando Maurício Francis Abdall. Effects of estrogen on intracellular signaling pathways linked to activation of muscarinic acetylcholine receptors and on acetylcholinesterase activity in rat hippocampus. Biochemical pharmacology. vol 75. issue 9. 2008-05-27. PMID:18329631. |
effects of estrogen on intracellular signaling pathways linked to activation of muscarinic acetylcholine receptors and on acetylcholinesterase activity in rat hippocampus. |
2008-05-27 |
2023-08-12 |
rat |
| Alexander V Nemukhin, Sofia V Lushchekina, Anastasia V Bochenkova, Anna A Golubeva, Sergei D Varfolomee. Characterization of a complete cycle of acetylcholinesterase catalysis by ab initio QM/MM modeling. Journal of molecular modeling. vol 14. issue 5. 2008-05-22. PMID:18343962. |
the reaction mechanism of acetylcholine hydrolysis by acetylcholinesterase, including both acylation and deacylation stages from the enzyme-substrate (es) to the enzyme-product (ep) molecular complexes, is examined by using an ab initio type quantum mechanical - molecular mechanical (qm/mm) approach. |
2008-05-22 |
2023-08-12 |
Not clear |
| Jere R Virta, Tuula Tolvanen, Kjell Någren, Anna Brück, Anne Roivainen, Juha O Rinn. 1-11C-methyl-4-piperidinyl-N-butyrate radiation dosimetry in humans by dynamic organ-specific evaluation. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 49. issue 3. 2008-05-16. PMID:18287260. |
the neurotransmitter acetylcholine is hydrolyzed in the synaptic clefts by 2 enzymes, acetylcholinesterase (ache) and butyrylcholinesterase (buche). |
2008-05-16 |
2023-08-12 |
human |
| Ming-Cheng Lin, Mei-Ting Hwang, Han-Ging Chang, Chung-Sheng Lin, Gialih Li. Benzene-1,2-, 1,3-, and 1,4-di-N-substituted carbamates as conformationally constrained inhibitors of acetylcholinesterase. Journal of biochemical and molecular toxicology. vol 21. issue 6. 2008-05-09. PMID:17994573. |
benzene-1,2-, 1,3-, and 1,4-di-n-substituted carbamates (1-15) are synthesized as the conformationally constrained inhibitors of acetylcholinesterase and mimic gauche, eclipsed, and anti-conformations of acetylcholine, respectively. |
2008-05-09 |
2023-08-12 |
Not clear |
| Ming-Cheng Lin, Mei-Ting Hwang, Han-Ging Chang, Chung-Sheng Lin, Gialih Li. Benzene-1,2-, 1,3-, and 1,4-di-N-substituted carbamates as conformationally constrained inhibitors of acetylcholinesterase. Journal of biochemical and molecular toxicology. vol 21. issue 6. 2008-05-09. PMID:17994573. |
therefore, benzene-1,4-di-n-substituted carbamates (para compounds), with the angle of 180 degrees between two c(benzene)-o bonds, mimic the preferable anti c-o/c-n conformers of acetylcholine for the choline ethylene backbone in the acetylcholinesterase catalysis. |
2008-05-09 |
2023-08-12 |
Not clear |
| Antonio Contestabile, Elisabetta Ciani, Andrea Contestabil. The place of choline acetyltransferase activity measurement in the "cholinergic hypothesis" of neurodegenerative diseases. Neurochemical research. vol 33. issue 2. 2008-05-05. PMID:17940885. |
during the last few years, indeed, cholinergic replacement therapies, mainly based on the use of acetylcholinesterase inhibitors to increase synaptic availability of acetylcholine, have been exploited on the assumption that they could ameliorate the progression of the dementia from its initial stages. |
2008-05-05 |
2023-08-12 |
mouse |
| Dongren Yang, Angela Howard, Donald Bruun, Mispa Ajua-Alemanj, Cecile Pickart, Pamela J Lei. Chlorpyrifos and chlorpyrifos-oxon inhibit axonal growth by interfering with the morphogenic activity of acetylcholinesterase. Toxicology and applied pharmacology. vol 228. issue 1. 2008-04-28. PMID:18076960. |
a primary role of acetylcholinesterase (ache) is regulation of cholinergic neurotransmission by hydrolysis of synaptic acetylcholine. |
2008-04-28 |
2023-08-12 |
mouse |
| Glynis Johnson, Chrisna Swart, Samuel W Moor. Interaction of acetylcholinesterase with the G4 domain of the laminin alpha1-chain. The Biochemical journal. vol 411. issue 3. 2008-04-25. PMID:18215127. |
although the primary function of ache (acetylcholinesterase) is the synaptic hydrolysis of acetylcholine, it appears that the protein is also able to promote various non-cholinergic activities, including cell adhesion, neurite outgrowth and amyloidosis. |
2008-04-25 |
2023-08-12 |
mouse |
| Subramanya Karanth, Todd Holbrook, Charles MacAllister, Carey N Pop. Selective inhibition of butyrylcholinesterase in vivo in horses by the feed-through larvacide Equitrol. Regulatory toxicology and pharmacology : RTP. vol 50. issue 2. 2008-04-23. PMID:18166255. |
as with other organophosphates, tcvp elicits toxicity by inhibiting acetylcholinesterase, leading to accumulation of the neurotransmitter acetylcholine and cholinergic signs. |
2008-04-23 |
2023-08-12 |
Not clear |
| Undurti N Da. Acetylcholinesterase and butyrylcholinesterase as possible markers of low-grade systemic inflammation. Medical science monitor : international medical journal of experimental and clinical research. vol 13. issue 12. 2008-04-11. PMID:18049445. |
as a result of this increase in the activities of enzymes acetylcholinesterase and butyrylcholinesterase, the plasma and tissue levels of acetylcholine (ach) will be low. |
2008-04-11 |
2023-08-12 |
Not clear |
| Undurti N Da. Acetylcholinesterase and butyrylcholinesterase as possible markers of low-grade systemic inflammation. Medical science monitor : international medical journal of experimental and clinical research. vol 13. issue 12. 2008-04-11. PMID:18049445. |
hence, both acetylcholinesterase and butyrylcholinesterase by inactivating acetylcholine may enhance inflammation. |
2008-04-11 |
2023-08-12 |
Not clear |
| Hitoshi Shinoto. [Imaging of brain acetylcholinesterase activity in dementias and extrapyramidal disorders]. Rinsho shinkeigaku = Clinical neurology. vol 47. issue 11. 2008-04-04. PMID:18210807. |
carbon-11 labeled n-methylpiperidin-4-yl acetate ([11c]mp4a) and carbon-11 labeled n-methylpiperidin-4-yl propionate ([11c]mp4p) are acetylcholine analogues and have been successfully used for measurement of brain acetylcholinesterase (ache) activity in vivo in humans. |
2008-04-04 |
2023-08-12 |
Not clear |