| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Machová, J Jakubík, P Michal, M Oksman, H Iivonen, H Tanila, V Doleza. Impairment of muscarinic transmission in transgenic APPswe/PS1dE9 mice. Neurobiology of aging. vol 29. issue 3. 2008-03-27. PMID:17140703. |
choline acetyltransferase and acetylcholinesterase activity declined age-dependently in both genotypes, whereas both age- and genotype-dependent decline was found in butyrylcholinesterase activity, vesicular acetylcholine transporter density, muscarinic receptors and carbachol stimulated binding of gtp gamma s in membranes as a functional indicator of muscarinic receptor coupling to g-proteins. |
2008-03-27 |
2023-08-12 |
mouse |
| O N Schuvailo, S V Dzyadevych, A V El'skaya, S Gautier-Sauvigné, E Csöregi, R Cespuglio, A P Soldatki. Carbon fibre-based microbiosensors for in vivo measurements of acetylcholine and choline. Biosensors & bioelectronics. vol 21. issue 1. 2008-03-05. PMID:15967355. |
this electrode was also modified through the co-immobilisation of acetylcholinesterase (ache) and/or choline oxidase (chox) in a bovine serum albumin (bsa) membrane for the development of a sensor for in vivo measurements of acetylcholine and choline. |
2008-03-05 |
2023-08-12 |
cattle |
| Kirsten Hoffmann, Andrea Wirmer, Michael Kunst, Daniela Gocht, Ralf Heinric. Muscarinic excitation in grasshopper song control circuits is limited by acetylcholinesterase activity. Zoological science. vol 24. issue 10. 2008-03-04. PMID:18088166. |
to demonstrate that endogenous acetylcholinesterase limits the activation of muscarinic receptors by synaptically released acetylcholine in the central body of chorthippus biguttulus, we investigated both its presence in the brain and effects on sound production resulting from inhibition of esterase activity. |
2008-03-04 |
2023-08-12 |
Not clear |
| Kirsten Hoffmann, Andrea Wirmer, Michael Kunst, Daniela Gocht, Ralf Heinric. Muscarinic excitation in grasshopper song control circuits is limited by acetylcholinesterase activity. Zoological science. vol 24. issue 10. 2008-03-04. PMID:18088166. |
eserine-mediated inhibition of acetylcholinesterase in the central body prolongs the presence of synaptically released acetylcholine at its postsynaptic receptors and increases its potency to activate muscarinic receptor-initiated signaling pathways acting to promote grasshopper sound production. |
2008-03-04 |
2023-08-12 |
Not clear |
| Chen-Chang Yang, Jou-Fang Den. Intermediate syndrome following organophosphate insecticide poisoning. Journal of the Chinese Medical Association : JCMA. vol 70. issue 11. 2008-02-26. PMID:18063499. |
previously proposed mechanisms of ims include different susceptibility of various cholinergic receptors, muscle necrosis, prolonged acetylcholinesterase inhibition, inadequate oxime therapy, downregulation or desensitization of postsynaptic acetylcholine receptors, failure of postsynaptic acetylcholine release, and oxidative stress-related myopathy. |
2008-02-26 |
2023-08-12 |
Not clear |
| Mercedes Villarroya, Antonio G García, José Marco-Contelles, Manuela G Lópe. An update on the pharmacology of galantamine. Expert opinion on investigational drugs. vol 16. issue 12. 2008-02-25. PMID:18042006. |
this review summarises the current state of the art concerning the pharmacology of galantamine, focusing on the most important details of its possibilities as an acetylcholinesterase inhibitor, an allosteric potentiator of neuronal nicotinic receptors for acetylcholine, a modulator of neurotransmitter release, and an agent causing neuroprotection through an antiapoptotic action. |
2008-02-25 |
2023-08-12 |
Not clear |
| Alexandra A Anderson, Dmitry S Ushakov, Michael A Ferenczi, Ryoichi Mori, Paul Martin, Jane L Saffel. Morphoregulation by acetylcholinesterase in fibroblasts and astrocytes. Journal of cellular physiology. vol 215. issue 1. 2008-02-19. PMID:17948252. |
acetylcholinesterase (ache) terminates neurotransmission at cholinergic synapses by hydrolysing acetylcholine, but also has non-enzymatic morphoregulatory effects on neurons such as stimulation of neurite outgrowth. |
2008-02-19 |
2023-08-12 |
mouse |
| Y C Zhou, Benzhuo Lu, Gary A Huber, Michael J Holst, J Andrew McCammo. Continuum simulations of acetylcholine consumption by acetylcholinesterase: a Poisson-Nernst-Planck approach. The journal of physical chemistry. B. vol 112. issue 2. 2008-02-15. PMID:18052268. |
continuum simulations of acetylcholine consumption by acetylcholinesterase: a poisson-nernst-planck approach. |
2008-02-15 |
2023-08-12 |
Not clear |
| Y C Zhou, Benzhuo Lu, Gary A Huber, Michael J Holst, J Andrew McCammo. Continuum simulations of acetylcholine consumption by acetylcholinesterase: a Poisson-Nernst-Planck approach. The journal of physical chemistry. B. vol 112. issue 2. 2008-02-15. PMID:18052268. |
the poisson-nernst-planck (pnp) equation provides a continuum description of electrostatic-driven diffusion and is used here to model the diffusion and reaction of acetylcholine (ach) with acetylcholinesterase (ache) enzymes. |
2008-02-15 |
2023-08-12 |
Not clear |
| Alemayehu A Gorfe, Chia-en A Chang, Ivaylo Ivanov, J Andrew McCammo. Dynamics of the acetylcholinesterase tetramer. Biophysical journal. vol 94. issue 4. 2008-02-11. PMID:17921202. |
acetylcholinesterase rapidly hydrolyzes the neurotransmitter acetylcholine in cholinergic synapses, including the neuromuscular junction. |
2008-02-11 |
2023-08-12 |
Not clear |
| Jaromir Myslivecek, Ellen G Duysen, Oksana Lockridg. Adaptation to excess acetylcholine by downregulation of adrenoceptors and muscarinic receptors in lungs of acetylcholinesterase knockout mice. Naunyn-Schmiedeberg's archives of pharmacology. vol 376. issue 1-2. 2008-01-17. PMID:17805515. |
adaptation to excess acetylcholine by downregulation of adrenoceptors and muscarinic receptors in lungs of acetylcholinesterase knockout mice. |
2008-01-17 |
2023-08-12 |
mouse |
| Jaromir Myslivecek, Ellen G Duysen, Oksana Lockridg. Adaptation to excess acetylcholine by downregulation of adrenoceptors and muscarinic receptors in lungs of acetylcholinesterase knockout mice. Naunyn-Schmiedeberg's archives of pharmacology. vol 376. issue 1-2. 2008-01-17. PMID:17805515. |
the acetylcholinesterase knockout mouse has elevated acetylcholine levels due to the complete absence of acetylcholinesterase. |
2008-01-17 |
2023-08-12 |
mouse |
| Francesca Cerbai, Maria Grazia Giovannini, Claudia Melani, Albert Enz, Giancarlo Pepe. N1phenethyl-norcymserine, a selective butyrylcholinesterase inhibitor, increases acetylcholine release in rat cerebral cortex: a comparison with donepezil and rivastigmine. European journal of pharmacology. vol 572. issue 2-3. 2008-01-14. PMID:17643410. |
acetylcholine extracellular levels were measured by microdialysis coupled with hplc; acetylcholinesterase and butyrylcholinesterase activity were measured with colorimetric and radiometric methods. |
2008-01-14 |
2023-08-12 |
rat |
| Francesca Cerbai, Maria Grazia Giovannini, Claudia Melani, Albert Enz, Giancarlo Pepe. N1phenethyl-norcymserine, a selective butyrylcholinesterase inhibitor, increases acetylcholine release in rat cerebral cortex: a comparison with donepezil and rivastigmine. European journal of pharmacology. vol 572. issue 2-3. 2008-01-14. PMID:17643410. |
at the peak of acetylcholine increase, a 27% acetylcholinesterase inhibition and no butyrylcholinesterase inhibition was found after donepezil (1 mg/kg, i.p) administration. |
2008-01-14 |
2023-08-12 |
rat |
| Francesca Cerbai, Maria Grazia Giovannini, Claudia Melani, Albert Enz, Giancarlo Pepe. N1phenethyl-norcymserine, a selective butyrylcholinesterase inhibitor, increases acetylcholine release in rat cerebral cortex: a comparison with donepezil and rivastigmine. European journal of pharmacology. vol 572. issue 2-3. 2008-01-14. PMID:17643410. |
since in the present study it was also confirmed that in the brain butyrylcholinesterase activity is only about 10% of acetylcholinesterase activity, it is surprising that its partial inhibition is sufficient to increase extracellular acetylcholine levels. |
2008-01-14 |
2023-08-12 |
rat |
| Paul W Elsinghorst, Julia S Cieslik, Klaus Mohr, Christian Tränkle, Michael Gütscho. First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor. Journal of medicinal chemistry. vol 50. issue 23. 2008-01-08. PMID:17944454. |
gallamine and tacrine are allosteric antagonists at muscarinic m2 acetylcholine receptors and inhibitors of acetylcholinesterase. |
2008-01-08 |
2023-08-12 |
Not clear |
| Allam A Rao, Gumpeny R Sridhar, Undurti N Da. Elevated butyrylcholinesterase and acetylcholinesterase may predict the development of type 2 diabetes mellitus and Alzheimer's disease. Medical hypotheses. vol 69. issue 6. 2008-01-03. PMID:17553629. |
hence, elevated butyrylcholinesterase and acetylcholinesterase concentrations will lead to a decrease in the levels of acetylcholine that could trigger the onset of low-grade systemic inflammation seen in type 2 diabetes and alzheimer's disease. |
2008-01-03 |
2023-08-12 |
Not clear |
| Mohamed B Abou-Donia, Larry B Goldstein, Sarah Bullman, T Tu, Wasi A Khan, Ankelika M Dechkovskaia, Ali A Abdel-Rahma. Imidacloprid induces neurobehavioral deficits and increases expression of glial fibrillary acidic protein in the motor cortex and hippocampus in offspring rats following in utero exposure. Journal of toxicology and environmental health. Part A. vol 71. issue 2. 2008-01-03. PMID:18080902. |
on postnatal day (pnd) 30, all male and female offspring were evaluated for (a) acetylcholinesterase (ache) and butyrylcholinesterase (buche) activity, (b) ligand binding for nicotinic acetylcholine receptors (nachr) and muscarinic acetylcholine receptors (m2 machr), (c) sensorimotor performance (inclined plane, beam-walking, and forepaw grip), and (d) pathological alterations in the brain (using cresyl violet and glial fibrillary acidic protein [gfap] immunostaining). |
2008-01-03 |
2023-08-12 |
human |
| Yoram Finkelstein, Dejan Milatovic, Michael Aschne. Modulation of cholinergic systems by manganese. Neurotoxicology. vol 28. issue 5. 2007-12-26. PMID:17920128. |
in fact, a number of cholinergic synaptic mechanisms are putative targets for manganese activity: presynaptic choline uptake, quantal release of acetylcholine into the synaptic cleft, postsynaptic binding of acetylcholine to receptors and its synaptic degradation by acetylcholinesterase. |
2007-12-26 |
2023-08-12 |
Not clear |
| A Baydin, D Aygun, M Yazici, A Karatas, T Deniz, T Yarda. Is there a relationship between the blood cholinesterase and QTc interval in the patients with acute organophosphate poisoning? International journal of clinical practice. vol 61. issue 6. 2007-12-17. PMID:17504354. |
organophosphates cause poisoning as a result of the excessive accumulation of acetylcholine at the cholinergic synapses due to inhibition of acetylcholinesterase (che). |
2007-12-17 |
2023-08-12 |
Not clear |