| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marloes J A Joosen, Herman P M van Helde. Correlations between acetylcholinesterase inhibition, acetylcholine levels and EEG changes during perfusion with neostigmine and N6-cyclopentyladenosine in rat brain. European journal of pharmacology. vol 555. issue 2-3. 2007-04-04. PMID:17113068. |
acetylcholinesterase activity and acetylcholine levels were measured by microdialysis, and eeg signals were recorded from an electrode placed near the microdialysis probe. |
2007-04-04 |
2023-08-12 |
rat |
| Marloes J A Joosen, Herman P M van Helde. Correlations between acetylcholinesterase inhibition, acetylcholine levels and EEG changes during perfusion with neostigmine and N6-cyclopentyladenosine in rat brain. European journal of pharmacology. vol 555. issue 2-3. 2007-04-04. PMID:17113068. |
a non-linear relationship between the acetylcholinesterase activity and the extracellular amount of acetylcholine was found, the latter being approximately three times higher in the striatum than in the hippocampus upon infusion with 10(-4) m neostigmine. |
2007-04-04 |
2023-08-12 |
rat |
| Haruo Kobayashi, Tadahiko Suzuki, Maki Sakamoto, Wataru Hashimoto, Keiko Kashiwada, Itaru Sato, Fumiaki Akahori, Tetsuo Sato. Brain regional acetylcholinesterase activity and muscarinic acetylcholine receptors in rats after repeated administration of cholinesterase inhibitors and its withdrawal. Toxicology and applied pharmacology. vol 219. issue 2-3. 2007-03-29. PMID:17188317. |
brain regional acetylcholinesterase activity and muscarinic acetylcholine receptors in rats after repeated administration of cholinesterase inhibitors and its withdrawal. |
2007-03-29 |
2023-08-12 |
rat |
| Bernd Kallmünzer, Björn Sörensen, Winfried L Neuhuber, Jürgen Wör. Heterogeneity of neuromuscular junctions in striated muscle of human esophagus demonstrated by triple staining for the vesicular acetylcholine transporter, alpha-bungarotoxin, and acetylcholinesterase. Cell and tissue research. vol 324. issue 2. 2007-03-28. PMID:16437206. |
heterogeneity of neuromuscular junctions in striated muscle of human esophagus demonstrated by triple staining for the vesicular acetylcholine transporter, alpha-bungarotoxin, and acetylcholinesterase. |
2007-03-28 |
2023-08-12 |
human |
| Bernd Kallmünzer, Björn Sörensen, Winfried L Neuhuber, Jürgen Wör. Heterogeneity of neuromuscular junctions in striated muscle of human esophagus demonstrated by triple staining for the vesicular acetylcholine transporter, alpha-bungarotoxin, and acetylcholinesterase. Cell and tissue research. vol 324. issue 2. 2007-03-28. PMID:16437206. |
during studies on enteric co-innervation in the human esophagus, we found that not all acetylcholinesterase (ache)-positive motor endplates stained for alpha-bungarotoxin (alpha-bt) and the vesicular acetylcholine transporter (vacht), respectively. |
2007-03-28 |
2023-08-12 |
human |
| Ulrike Holzgrabe, Petra Kapková, Vildan Alptüzün, Josef Scheiber, Eva Kugelman. Targeting acetylcholinesterase to treat neurodegeneration. Expert opinion on therapeutic targets. vol 11. issue 2. 2007-03-22. PMID:17227232. |
thus, the aim of many treatment regimens is to support this system either by means of muscarinic agonists or by inhibitors of acetylcholinesterase (ache), the latter being able to increase the concentration of acetylcholine. |
2007-03-22 |
2023-08-12 |
Not clear |
| Slawomir Gralewic. [Possible consequences of acetylcholinesterase inhibition in organophosphate poisoning. Discussion continued]. Medycyna pracy. vol 57. issue 3. 2007-03-20. PMID:17125036. |
numerous toxicologists still believe that the only function of acetylcholinesterase (ache) is to catalyse the hydrolysis of acetylcholine (ach), and that the toxicity of organophosphorous pesticides (op) results from their ability to switch this function off. |
2007-03-20 |
2023-08-12 |
Not clear |
| Osamu Yasuhara, Akinori Matsuo, Jean-Pierre Bellier, Yoshinari Aim. Demonstration of choline acetyltransferase of a peripheral type in the rat heart. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 55. issue 3. 2007-03-20. PMID:17142806. |
cholinergic innervation of the heart has been analyzed using cholinergic markers including acetylcholinesterase, choline acetyltransferase (chat), and vesicular acetylcholine transporter (vacht). |
2007-03-20 |
2023-08-12 |
rat |
| Xilong Zhao, William Marszalec, Peter T Toth, Joseph Huang, Jay Z Yeh, Toshio Narahash. In vitro galantamine-memantine co-application: mechanism of beneficial action. Neuropharmacology. vol 51. issue 7-8. 2007-03-09. PMID:17011596. |
since alzheimer's disease is known to be associated with down-regulation of the cholinergic and n-methyl-d-aspartate (nmda) systems, most of these drugs inhibit acetylcholinesterase, potentiate the activity of nicotinic acetylcholine receptors (nachrs), or modulate nmda receptors. |
2007-03-09 |
2023-08-12 |
rat |
| Amir Dori, Hermona Sore. Neuromuscular therapeutics by RNA-targeted suppression of ACHE gene expression. Annals of the New York Academy of Sciences. vol 1082. 2007-03-05. PMID:17145929. |
here, we report the use of monarsen, a 20-mer acetylcholinesterase-targeted antisense agent with three 3'-2'o-methyl-protected nucleotides, for selectively attenuating the stress-induced accumulation of the normally rare, soluble "readthrough" acetylcholinesterase variant ache-r. acetylcholine hydrolysis by ache-r may cause muscle fatigue and moreover, limit the cholinergic anti-inflammatory blockade, yielding inflammation-associated pathology. |
2007-03-05 |
2023-08-12 |
human |
| Patrick Lippiello, Sharon R Letchworth, Gregory J Gatto, Vincent M Traina, Merouane Bencheri. Ispronicline: a novel alpha4beta2 nicotinic acetylcholine receptor-selective agonist with cognition-enhancing and neuroprotective properties. Journal of molecular neuroscience : MN. vol 30. issue 1-2. 2007-02-23. PMID:17192610. |
to date, the primary treatments for alzheimer's disease with proven efficacy have been acetylcholinesterase inhibitors that prevent the hydrolysis of acetylcholine (ach) in the synaptic cleft, thereby prolonging its activity. |
2007-02-23 |
2023-08-12 |
Not clear |
| b' Emmanuelle Girard, V\\xc3\\xa9ronique Bernard, Shelley Camp, Palmer Taylor, Eric Krejci, Jordi Molg\\xc3\\xb. Remodeling of the neuromuscular junction in mice with deleted exons 5 and 6 of acetylcholinesterase. Journal of molecular neuroscience : MN. vol 30. issue 1-2. 2007-02-23. PMID:17192646.' |
at the vertebrate skeletal neuromuscular junction (nmj), two closely related enzymes can hydrolyze acetylcholine (ach): acetylcholinesterase (ache) and butyrylcholinesterase (bche). |
2007-02-23 |
2023-08-12 |
mouse |
| Laura E Paraoanu, Gunnar Steinert, Janine Klaczinski, Michaela Becker-Röck, Afrim Bytyqi, Paul G Laye. On functions of cholinesterases during embryonic development. Journal of molecular neuroscience : MN. vol 30. issue 1-2. 2007-02-23. PMID:17192676. |
this means that che functioning during development fits into the classical cholinergic neurotransmitter system: acetylcholine (ach), as a signal, binds to ach receptors and then is degraded by acetylcholinesterase (ache) as the terminating enzyme. |
2007-02-23 |
2023-08-12 |
Not clear |
| Laura Paleari, Sonya Trombino, Carla Falugi, Lorenzo Gallus, Sebastiano Carlone, Cristiano Angelini, Kristina Sepcic, Tom Turk, Marco Faimali, Douglas M Noonan, Adriana Albin. Marine sponge-derived polymeric alkylpyridinium salts as a novel tumor chemotherapeutic targeting the cholinergic system in lung tumors. International journal of oncology. vol 29. issue 6. 2007-02-22. PMID:17088975. |
cholino-acetyltransferase (chat), vesicular acetylcholine transporter (vacht) and acetylcholinesterase (ache) were observed in nsclc tumor biopsies and in nsclc cell lines. |
2007-02-22 |
2023-08-12 |
mouse |
| Ralph J Jense. Activation of group II metabotropic glutamate receptors reduces directional selectivity in retinal ganglion cells. Brain research. vol 1122. issue 1. 2007-01-30. PMID:17010323. |
to determine whether group ii mglurs modulate the release of the neurotransmitter acetylcholine from starburst amacrine cells, the effect of dcg-iv on on-off ds rgcs was examined in the presence of ambenonium, an acetylcholinesterase inhibitor. |
2007-01-30 |
2023-08-12 |
rabbit |
| Balasubramaniam Easwaramoorthy, Rama Pichika, Daphne Collins, Steven G Potkin, Frances M Leslie, Jogeshwar Mukherje. Effect of acetylcholinesterase inhibitors on the binding of nicotinic alpha4beta2 receptor PET radiotracer, (18)F-nifene: A measure of acetylcholine competition. Synapse (New York, N.Y.). vol 61. issue 1. 2007-01-26. PMID:17068780. |
effect of acetylcholinesterase inhibitors on the binding of nicotinic alpha4beta2 receptor pet radiotracer, (18)f-nifene: a measure of acetylcholine competition. |
2007-01-26 |
2023-08-12 |
rat |
| Balasubramaniam Easwaramoorthy, Rama Pichika, Daphne Collins, Steven G Potkin, Frances M Leslie, Jogeshwar Mukherje. Effect of acetylcholinesterase inhibitors on the binding of nicotinic alpha4beta2 receptor PET radiotracer, (18)F-nifene: A measure of acetylcholine competition. Synapse (New York, N.Y.). vol 61. issue 1. 2007-01-26. PMID:17068780. |
acetylcholinesterase inhibitors (achei's) are used to treat alzheimer's disease (ad), and the putative mode of action is to increase acetylcholine (ach) levels. |
2007-01-26 |
2023-08-12 |
rat |
| Gabriel Zimmerman, Hermona Sore. Termination and beyond: acetylcholinesterase as a modulator of synaptic transmission. Cell and tissue research. vol 326. issue 2. 2007-01-23. PMID:16802134. |
this unique termination mechanism makes acetylcholinesterase (ache), the enzyme in charge of executing acetylcholine breakdown, a key component of cholinergic signaling. |
2007-01-23 |
2023-08-12 |
Not clear |
| Xiu-Ling Ji, Gui-Wen Jin, Li-Ya Qu, Jin-Ping Cheng, Wen-Hua Wan. [Effect of chronic exposure by mercury contaminated rice on neurotransmitter level changes in rat brain]. Huan jing ke xue= Huanjing kexue. vol 27. issue 1. 2007-01-19. PMID:16599137. |
the changes of neurotransmitter acetylcholine (ach) and acetylcholinesterase (ache) in rat brain were examined at different times. |
2007-01-19 |
2023-08-12 |
rat |
| Aviad Hai, Deborah Ben-Haim, Nina Korbakov, Ariel Cohen, Joseph Shappir, Ruthi Oren, Micha E Spira, Shlomo Yitzchai. Acetylcholinesterase-ISFET based system for the detection of acetylcholine and acetylcholinesterase inhibitors. Biosensors & bioelectronics. vol 22. issue 5. 2007-01-17. PMID:16529923. |
acetylcholinesterase-isfet based system for the detection of acetylcholine and acetylcholinesterase inhibitors. |
2007-01-17 |
2023-08-12 |
Not clear |