| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laura E Paraoanu, Gunnar Steinert, Janine Klaczinski, Michaela Becker-Röck, Afrim Bytyqi, Paul G Laye. On functions of cholinesterases during embryonic development. Journal of molecular neuroscience : MN. vol 30. issue 1-2. 2007-02-23. PMID:17192676. |
this means that che functioning during development fits into the classical cholinergic neurotransmitter system: acetylcholine (ach), as a signal, binds to ach receptors and then is degraded by acetylcholinesterase (ache) as the terminating enzyme. |
2007-02-23 |
2023-08-12 |
Not clear |
| Laura Paleari, Sonya Trombino, Carla Falugi, Lorenzo Gallus, Sebastiano Carlone, Cristiano Angelini, Kristina Sepcic, Tom Turk, Marco Faimali, Douglas M Noonan, Adriana Albin. Marine sponge-derived polymeric alkylpyridinium salts as a novel tumor chemotherapeutic targeting the cholinergic system in lung tumors. International journal of oncology. vol 29. issue 6. 2007-02-22. PMID:17088975. |
cholino-acetyltransferase (chat), vesicular acetylcholine transporter (vacht) and acetylcholinesterase (ache) were observed in nsclc tumor biopsies and in nsclc cell lines. |
2007-02-22 |
2023-08-12 |
mouse |
| Ralph J Jense. Activation of group II metabotropic glutamate receptors reduces directional selectivity in retinal ganglion cells. Brain research. vol 1122. issue 1. 2007-01-30. PMID:17010323. |
to determine whether group ii mglurs modulate the release of the neurotransmitter acetylcholine from starburst amacrine cells, the effect of dcg-iv on on-off ds rgcs was examined in the presence of ambenonium, an acetylcholinesterase inhibitor. |
2007-01-30 |
2023-08-12 |
rabbit |
| Balasubramaniam Easwaramoorthy, Rama Pichika, Daphne Collins, Steven G Potkin, Frances M Leslie, Jogeshwar Mukherje. Effect of acetylcholinesterase inhibitors on the binding of nicotinic alpha4beta2 receptor PET radiotracer, (18)F-nifene: A measure of acetylcholine competition. Synapse (New York, N.Y.). vol 61. issue 1. 2007-01-26. PMID:17068780. |
effect of acetylcholinesterase inhibitors on the binding of nicotinic alpha4beta2 receptor pet radiotracer, (18)f-nifene: a measure of acetylcholine competition. |
2007-01-26 |
2023-08-12 |
rat |
| Balasubramaniam Easwaramoorthy, Rama Pichika, Daphne Collins, Steven G Potkin, Frances M Leslie, Jogeshwar Mukherje. Effect of acetylcholinesterase inhibitors on the binding of nicotinic alpha4beta2 receptor PET radiotracer, (18)F-nifene: A measure of acetylcholine competition. Synapse (New York, N.Y.). vol 61. issue 1. 2007-01-26. PMID:17068780. |
acetylcholinesterase inhibitors (achei's) are used to treat alzheimer's disease (ad), and the putative mode of action is to increase acetylcholine (ach) levels. |
2007-01-26 |
2023-08-12 |
rat |
| Gabriel Zimmerman, Hermona Sore. Termination and beyond: acetylcholinesterase as a modulator of synaptic transmission. Cell and tissue research. vol 326. issue 2. 2007-01-23. PMID:16802134. |
this unique termination mechanism makes acetylcholinesterase (ache), the enzyme in charge of executing acetylcholine breakdown, a key component of cholinergic signaling. |
2007-01-23 |
2023-08-12 |
Not clear |
| Xiu-Ling Ji, Gui-Wen Jin, Li-Ya Qu, Jin-Ping Cheng, Wen-Hua Wan. [Effect of chronic exposure by mercury contaminated rice on neurotransmitter level changes in rat brain]. Huan jing ke xue= Huanjing kexue. vol 27. issue 1. 2007-01-19. PMID:16599137. |
the changes of neurotransmitter acetylcholine (ach) and acetylcholinesterase (ache) in rat brain were examined at different times. |
2007-01-19 |
2023-08-12 |
rat |
| Aviad Hai, Deborah Ben-Haim, Nina Korbakov, Ariel Cohen, Joseph Shappir, Ruthi Oren, Micha E Spira, Shlomo Yitzchai. Acetylcholinesterase-ISFET based system for the detection of acetylcholine and acetylcholinesterase inhibitors. Biosensors & bioelectronics. vol 22. issue 5. 2007-01-17. PMID:16529923. |
acetylcholinesterase-isfet based system for the detection of acetylcholine and acetylcholinesterase inhibitors. |
2007-01-17 |
2023-08-12 |
Not clear |
| Martin J Hoogduijn, Zoltan Rakonczay, Paul G Geneve. The effects of anticholinergic insecticides on human mesenchymal stem cells. Toxicological sciences : an official journal of the Society of Toxicology. vol 94. issue 2. 2007-01-09. PMID:16960032. |
organophosphate (op) and carbamate pesticides, which are used in large amounts in agriculture to control insects, are designed to disrupt acetylcholine signaling by inhibiting the enzyme acetylcholinesterase (ache). |
2007-01-09 |
2023-08-12 |
human |
| Carlos H T P da Silva, Vanessa Leiria Campo, Ivone Carvalho, Carlton A Taf. Molecular modeling, docking and ADMET studies applied to the design of a novel hybrid for treatment of Alzheimer's disease. Journal of molecular graphics & modelling. vol 25. issue 2. 2007-01-08. PMID:16413803. |
it is achieved by acetylcholinesterase (ache) inhibition, the enzyme responsible for acetylcholine hydrolysis. |
2007-01-08 |
2023-08-12 |
human |
| Patrik Danielson, Håkan Alfredson, Sture Forsgre. Immunohistochemical and histochemical findings favoring the occurrence of autocrine/paracrine as well as nerve-related cholinergic effects in chronic painful patellar tendon tendinosis. Microscopy research and technique. vol 69. issue 10. 2006-12-29. PMID:16830327. |
antibodies against the m(2) receptor, choline acetyltransferase (chat), and vesicular acetylcholine transporter (vacht) were applied, and staining for demonstration of activity of acetylcholinesterase (ache) was also utilized. |
2006-12-29 |
2023-08-12 |
human |
| Laurent P Lacroix, Laura Ceolin, Alessandro Zocchi, Giorgia Varnier, Marco Garzotti, Ornella Curcuruto, Christian A Heidbrede. Selective dopamine D3 receptor antagonists enhance cortical acetylcholine levels measured with high-performance liquid chromatography/tandem mass spectrometry without anti-cholinesterases. Journal of neuroscience methods. vol 157. issue 1. 2006-12-14. PMID:16697046. |
on extracellular levels of acetylcholine (ach) in the rat medial prefrontal cortex (mpfc) by using a lc/ms-ms analytical method that permitted the detection of ach without the necessity of adding acetylcholinesterase inhibitors to the perfusate. |
2006-12-14 |
2023-08-12 |
rat |
| Yuki Takada-Takatori, Toshiaki Kume, Mitsuhiro Sugimoto, Hiroshi Katsuki, Hachiro Sugimoto, Akinori Akaik. Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade. Neuropharmacology. vol 51. issue 3. 2006-12-14. PMID:16762377. |
acetylcholinesterase inhibitors used in treatment of alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade. |
2006-12-14 |
2023-08-12 |
Not clear |
| Anuradha Nallapaneni, Jing Liu, Subramanya Karanth, Carey Pop. Modulation of paraoxon toxicity by the cannabinoid receptor agonist WIN 55,212-2. Toxicology. vol 227. issue 1-2. 2006-11-29. PMID:16956707. |
organophosphorus insecticides elicit toxicity by inhibiting acetylcholinesterase and thereby increasing synaptic acetylcholine levels. |
2006-11-29 |
2023-08-12 |
rat |
| Yves Bourne, Zoran Radic, Gerlind Sulzenbacher, Esther Kim, Palmer Taylor, Pascale Marcho. Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding. The Journal of biological chemistry. vol 281. issue 39. 2006-11-27. PMID:16837465. |
hydrolysis of acetylcholine catalyzed by acetylcholinesterase (ache), one of the most efficient enzymes in nature, occurs at the base of a deep and narrow active center gorge. |
2006-11-27 |
2023-08-12 |
mouse |
| Naoko Kaneko, Hideyuki Okano, Kazunobu Sawamot. Role of the cholinergic system in regulating survival of newborn neurons in the adult mouse dentate gyrus and olfactory bulb. Genes to cells : devoted to molecular & cellular mechanisms. vol 11. issue 10. 2006-11-08. PMID:16999735. |
to examine the function of acetylcholine in neurogenesis, we used donepezil (aricept), a potent and selective acetylcholinesterase inhibitor that improves cognitive impairment in alzheimer's disease. |
2006-11-08 |
2023-08-12 |
mouse |
| Pavla Zdrazilová, Sárka Stĕpánková, Alena Komersová, Martina Vránová, Karel Komers, Alexander Cega. Kinetics of 13 new cholinesterase inhibitors. Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 61. issue 7-8. 2006-11-07. PMID:16989325. |
kinetics of hydrolysis of acetylcholine and acetylthiocholine by two types of acetylcholinesterase and butyrylcholinesterase inhibited by 13 new inhibitors (5 carbamates and 8 carbazates--hydrazinium derivatives) was measured in vitro in a batch reactor at 25 degrees c, ph 8, ionic strength 0.11 m and enzyme activity 3.5 u by four nondependent analytical methods. |
2006-11-07 |
2023-08-12 |
cattle |
| Pavla Zdrazilová, Sárka Stĕpánková, Alena Komersová, Martina Vránová, Karel Komers, Alexander Cega. Kinetics of 13 new cholinesterase inhibitors. Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 61. issue 7-8. 2006-11-07. PMID:16989325. |
physiologically important hydrolyses of acetylcholine catalyzed by acetylcholinesterase from electric eel or bovine erythrocytes and butyrylcholinesterase from horse plasma can be most quickly inhibited by carbamoylation of the mentioned enzymes by the 3-n,n-diethylaminophenyl-n'-(1-alkyl) carbamates 4 and 5. |
2006-11-07 |
2023-08-12 |
cattle |
| Ai-Ling Fu, Zhao-Hui Dong, Man-Ji Su. Protective effect of N-acetyl-L-cysteine on amyloid beta-peptide-induced learning and memory deficits in mice. Brain research. vol 1109. issue 1. 2006-10-31. PMID:16872586. |
there was also an increase in acetylcholinesterase (ache) activity and a reduction in the choline acetyltransferase (chat) activity and acetylcholine (ach) levels. |
2006-10-31 |
2023-08-12 |
mouse |
| Deqiang Zhang, J Andrew McCammo. The association of tetrameric acetylcholinesterase with ColQ tail: a block normal mode analysis. PLoS computational biology. vol 1. issue 6. 2006-09-29. PMID:16299589. |
acetylcholinesterase (ache) rapidly hydrolyzes acetylcholine in the neuromuscular junctions and other cholinergic synapses to terminate the neuronal signal. |
2006-09-29 |
2023-08-12 |
mouse |