| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eun Kyoung Ryu, Xiaoyuan Che. Development of Alzheimer's disease imaging agents for clinical studies. Frontiers in bioscience : a journal and virtual library. vol 13. 2007-12-11. PMID:17981587. |
alzheimer's disease (ad) is a neurodegenerative disease characterized by a progressive loss of neurotransmitters, as well as acetylcholinesterase and nicotinic acetylcholine receptors in the central nervous system that leads to learning and memory deficits, among other problems. |
2007-12-11 |
2023-08-12 |
human |
| Mariapaola Piccardi, Donatella Congiu, Alessio Squassina, Francesca Manconi, Paolo Francesco Putzu, Rosa Maria Mereu, Caterina Chillotti, Maria Del Zomp. Alzheimer's disease: case-control association study of polymorphisms in ACHE, CHAT, and BCHE genes in a Sardinian sample. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 7. 2007-12-06. PMID:17503475. |
the resulting reduction in cholinergic activity is associated with decreased levels of the neurotransmitter acetylcholine (ach), decreased activity of acetylcholinesterase (ache), choline acetyltransferase (chat), and increased butyrylcholinesterase (bche) activity. |
2007-12-06 |
2023-08-12 |
human |
| Benzhuo Lu, Y C Zhou, Gary A Huber, Stephen D Bond, Michael J Holst, J Andrew McCammo. Electrodiffusion: a continuum modeling framework for biomolecular systems with realistic spatiotemporal resolution. The Journal of chemical physics. vol 127. issue 13. 2007-11-26. PMID:17919055. |
the second is a time-dependent diffusion process: the consumption of the neurotransmitter acetylcholine by acetylcholinesterase, determined by the se and a single uncoupled solution of the poisson-boltzmann equation. |
2007-11-26 |
2023-08-12 |
Not clear |
| Marcia D Howard, Nikita Mirajkar, Subramanya Karanth, Carey N Pop. Comparative effects of oral chlorpyrifos exposure on cholinesterase activity and muscarinic receptor binding in neonatal and adult rat heart. Toxicology. vol 238. issue 2-3. 2007-10-31. PMID:17644233. |
organophosphorus (op) pesticides elicit acute toxicity by inhibiting acetylcholinesterase (ache), the enzyme responsible for inactivating acetylcholine (ach) at cholinergic synapses. |
2007-10-31 |
2023-08-12 |
rat |
| N Tabe. Acetylcholinesterase inhibitors for Alzheimer's disease: anti-inflammatories in acetylcholine clothing! Age and ageing. vol 35. issue 4. 2007-10-19. PMID:16788077. |
acetylcholinesterase inhibitors for alzheimer's disease: anti-inflammatories in acetylcholine clothing! |
2007-10-19 |
2023-08-12 |
Not clear |
| Yoshihito X Fujii, Ayako Tashiro, Kumiko Arimoto, Hirofumi Fujigaya, Yasuhiro Moriwaki, Hidemi Misawa, Takeshi Fujii, Minoru Matsui, Tadashi Kasahara, Koichiro Kawashim. Diminished antigen-specific IgG1 and interleukin-6 production and acetylcholinesterase expression in combined M1 and M5 muscarinic acetylcholine receptor knockout mice. Journal of neuroimmunology. vol 188. issue 1-2. 2007-10-19. PMID:17586055. |
immunological activation of t cells enhances synthesis of acetylcholine (ach) and transcription of choline acetyltransferase (chat), m5 muscarinic ach receptor (machr) and acetylcholinesterase (ache). |
2007-10-19 |
2023-08-12 |
mouse |
| Fu Ai Ling, Dong Zhao Hui, Sun Man J. Protective effect of recombinant human somatotropin on amyloid beta-peptide induced learning and memory deficits in mice. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 17. issue 4. 2007-10-18. PMID:17596983. |
toxic effects of free radicals, damages of cholinergic neurons, and increased lipid peroxidation appeared in the cerebra of abeta-treated mice, manifesting an increase of malondialdehyde (mda) and decline of glutathione (gsh) level, an increment of choline acetyltransferase (chat) and acetylcholinesterase (ache) activities, and a reduction of the acetylcholine (ach) level. |
2007-10-18 |
2023-08-12 |
mouse |
| Isabel Martinez-Pena y Valenzuela, Mohammed Akaaboun. Acetylcholinesterase mobility and stability at the neuromuscular junction of living mice. Molecular biology of the cell. vol 18. issue 8. 2007-10-17. PMID:17538015. |
acetylcholinesterase (ache) is an enzyme that terminates acetylcholine neurotransmitter function at the synaptic cleft of cholinergic synapses. |
2007-10-17 |
2023-08-12 |
mouse |
| Ching-Yi Tsai, Carol H Y Wu, Samuel H H Chan, Alice Y W Chan. Muscarinic receptor-independent activation of cyclic adenosine monophosphate-dependent protein kinase in rostral ventrolateral medulla underlies the sympathoexcitatory phase of cardiovascular responses during mevinphos intoxication in the rat. Shock (Augusta, Ga.). vol 27. issue 5. 2007-09-20. PMID:17438462. |
as inhibitors of acetylcholinesterase, clinical presentations of poisoning from organophosphate compounds are generally believed to entail overstimulation by the accumulated acetylcholine on muscarinic receptors at peripheral and central synapses. |
2007-09-20 |
2023-08-12 |
rat |
| Carlos H T P da Silva, Ivone Carvalho, C A Taf. Virtual screening, molecular interaction field, molecular dynamics, docking, density functional, and ADMET properties of novel AChE inhibitors in Alzheimer's disease. Journal of biomolecular structure & dynamics. vol 24. issue 6. 2007-09-18. PMID:17508773. |
many drugs currently used for the treatment of the ad are based on the improvement of cholinergic neurotransmission achieved by acetylcholinesterase (ache) inhibition, the enzyme responsible for acetylcholine hydrolysis. |
2007-09-18 |
2023-08-12 |
Not clear |
| Samira S Valvassori, Jucélia J Fortunato, Karin M Gomes, Gislaine Z Réus, Márcio R Martins, Elaine C Gavioli, Maria Rosa C Schetinger, Felipe Dal-Pizzol, João Queved. Acute and subacute exposure to malathion impairs aversive but not non-associative memory in rats. Neurotoxicity research. vol 12. issue 1. 2007-09-18. PMID:17513201. |
this pesticide affects the central nervous system by inhibiting acetylcholinesterase, leading to an increase of acetylcholine in the synaptic cleft, and subsequent activation of cholinergic muscarinic and nicotinic receptors. |
2007-09-18 |
2023-08-12 |
rat |
| C C Lin, Michelle N Y Hui, S H Chen. Toxicity and cardiac effects of carbaryl in early developing zebrafish (Danio rerio) embryos. Toxicology and applied pharmacology. vol 222. issue 2. 2007-09-17. PMID:17559897. |
our chronic exposure data also demonstrated carbaryl-induced bradycardia, which is a common effect of acetylcholinesterase inhibitors due to the accumulation of acetylcholine, in embryos from 1 day post-fertilization (dpf) to 5 dpf. |
2007-09-17 |
2023-08-12 |
zebrafish |
| C C Lin, Michelle N Y Hui, S H Chen. Toxicity and cardiac effects of carbaryl in early developing zebrafish (Danio rerio) embryos. Toxicology and applied pharmacology. vol 222. issue 2. 2007-09-17. PMID:17559897. |
the novel observation of carbaryl-induced bradycardia in 1- and 2-dpf embryos suggested that carbaryl affected cardiac function possibly through an alternative mechanism other than acetylcholinesterase inhibition such as inhibition of calcium ion channels, since acetylcholine receptors in zebrafish are not functional until 3 dpf. |
2007-09-17 |
2023-08-12 |
zebrafish |
| Dan Grisaru, Ran Keidar, Letizia Schreiber, Joseph B Lessing, Varda Deutsc. The effect of the readthrough acetylcholinesterase variant (AChE-R) on uterine muscle and leiomyomas. Molecular human reproduction. vol 13. issue 5. 2007-09-13. PMID:17350961. |
acetylcholine signaling and acetylcholinesterase (ache) function(s) are pivotal elements in muscle development. |
2007-09-13 |
2023-08-12 |
human |
| J B Matthews, O Lazari, A J Davidson, S Warren, M E Selkir. A tryptophan amphiphilic tetramerization domain-containing acetylcholinesterase from the bovine lungworm, Dictyocaulus viviparus. Parasitology. vol 133. issue Pt 3. 2007-09-10. PMID:16719958. |
acetylcholine (ach) is one of an array of neurotransmitters used by invertebrates and, analogous to vertebrate nervous systems, acetylcholinesterase (ache) regulates synaptic levels of this transmitter. |
2007-09-10 |
2023-08-12 |
cattle |
| Laure Ginestet, Juan E Ferrario, Rita Raisman-Vozari, Etienne C Hirsch, Thomas Debei. Donepezil induces a cholinergic sprouting in basocortical degeneration. Journal of neurochemistry. vol 102. issue 2. 2007-09-07. PMID:17394553. |
one of the few currently approved therapies for alzheimer's disease (ad) consists in the administration of acetylcholinesterase inhibitors, which enhances the lifetime of the neurotransmitter acetylcholine. |
2007-09-07 |
2023-08-12 |
rat |
| Tsung-Ming Shih, Oscar U Scremin, Margareth Roch, Ly Huynh, Wei Sun, Donald J Jende. Cerebral acetylcholine and choline contents and turnover following low-dose acetylcholinesterase inhibitors treatment in rats. Archives of toxicology. vol 80. issue 11. 2007-08-30. PMID:16628397. |
cerebral acetylcholine and choline contents and turnover following low-dose acetylcholinesterase inhibitors treatment in rats. |
2007-08-30 |
2023-08-12 |
rat |
| Anton Bom, Ola Epemolu, Frank Hope, Samantha Rutherford, Karen Thomso. Selective relaxant binding agents for reversal of neuromuscular blockade. Current opinion in pharmacology. vol 7. issue 3. 2007-08-21. PMID:17368102. |
traditionally, reversal of neuromuscular blockade during anaesthesia was achieved by increasing the acetylcholine concentration in the neuromuscular junction using acetylcholinesterase inhibitors. |
2007-08-21 |
2023-08-12 |
human |
| M Perayre Badia, E Leiva Badosa, L Pastó Cardona, R Jódar Massané. [Intermediate syndrome after organophosphate poisoning despite continuous infusion of pralidoxime]. Anales de medicina interna (Madrid, Spain : 1984). vol 24. issue 3. 2007-08-21. PMID:17590134. |
acute organophosphate poisoning leads to a cholinergic crisis secondary to an acetylcholine rise, developed by an acetylcholinesterase inhibition. |
2007-08-21 |
2023-08-12 |
Not clear |
| Jean-Pierre Bellier, Hiroshi Kimur. Acetylcholine synthesis by choline acetyltransferase of a peripheral type as demonstrated in adult rat dorsal root ganglion. Journal of neurochemistry. vol 101. issue 6. 2007-08-16. PMID:17542812. |
our detailed analysis further showed that, despite low enzyme activities of both choline acetyltransferase and acetylcholinesterase, the level of acetylcholine in the ganglion was as high as to that in various brain regions receiving cholinergic innervation. |
2007-08-16 |
2023-08-12 |
rat |