| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Olawande Bamisi, Adesua Olukayode Oluwalabani, Tolulope Timothy Arogundade, Olayemi Joseph Olajid. Neuroinflammation and oxidative redox imbalance drive memory dysfunction in adolescent rats prenatally exposed to Datura Stramonium. Neurotoxicology and teratology. 2024-09-20. PMID:39303770. |
whereas increased expression of acetylcholinesterase and ldh was seen in adolescent rats prenatally infused d. stramonium, acetylcholine levels were downregulated in both hippocampal and pfc lysates, suggesting cholinergic and metabolic dysfunctions. |
2024-09-20 |
2024-09-23 |
rat |
| Chhatrapal Patel, Richa Patel, Anuradha Kesharwani, Laxmi Rao, Nishant Sudhir Jai. Central cholinergic transmission modulates endocannabinoid-induced marble-burying behavior in mice. Behavioural brain research. 2024-09-15. PMID:39278464. |
with various cholinergic agents like acetylcholine (ach), acetylcholinesterase inhibitor (achei), neostigmine, nicotine, machr antagonist, atropine, and nachr antagonist, mecamylamine. |
2024-09-15 |
2024-09-18 |
mouse |
| José Luis Gómez-Olivares, Rosa María López-Durán, Sergio Enríquez-Flores, Gabriel López-Velázquez, Ignacio De La Mora-De La Mora, Itzhel García-Torres, Rubí Viedma-Rodríguez, Rafael Valencia-Quintana, Mirta Milić, Luis Antonio Flores-Lópe. Preliminary exploration of the expression of acetylcholinesterase in normal human T lymphocytes and leukemic Jurkat T cells. Biomedical reports. vol 21. issue 5. 2024-09-14. PMID:39268406. |
the classic enzymatic function of acetylcholinesterase (ache) is the hydrolysis of acetylcholine (ach) in the neuronal synapse. |
2024-09-14 |
2024-09-16 |
human |
| Xueying Xu, Ximeng Ma, Jun Dou, Wenkai Chen, Jiying Chen, Mingsen Zhou, Anfu Shen, Xiangjiang Li. β-ionone inhibits the grazing of Daphnia sinensis by reducing the activity of acetylcholinesterase. Journal of hazardous materials. vol 479. 2024-09-10. PMID:39255669. |
transcriptomic analysis showed that β-ionone could significantly inhibit the expression of acetylcholinesterase (ache) mrna, while metabolomics further revealed that β-ionone could significantly increase the level of acetylcholine (ach) in d. sinensis. |
2024-09-10 |
2024-09-13 |
Not clear |
| Aditya Anand, Munesh Kumar, S K Tando. Organophosphorus poisoning causing haemorrhagic pancreatitis - a case series. The Medico-legal journal. 2024-09-10. PMID:39253837. |
organophosphorus is a nerve poison that causes irreversible inhibition of acetylcholinesterase, which leads to the accumulation of acetylcholine, resulting in excessive cholinergic stimulation of several organ systems. |
2024-09-10 |
2024-09-13 |
Not clear |
| Xingyi Zhao, Qiaoguan Hu, Xiaoqian Wang, Chunting Li, Xiao Chen, Dong Zhao, Yue Qiu, Haoyu Xu, Jiaqi Wang, Le Ren, Na Zhang, Shuang Li, Ping Gong, Yunlei Ho. Dual-target inhibitors based on acetylcholinesterase: Novel agents for Alzheimer's disease. European journal of medicinal chemistry. vol 279. 2024-09-07. PMID:39243456. |
acetylcholinesterase inhibitors (acheis) can delay the hydrolysis of acetylcholine (ach), which represents a key strategy for treating ad. |
2024-09-07 |
2024-09-10 |
Not clear |
| Elisabeth Wigenstam, Anders Bucht, Lina Thor. Cellular responses following ex vivo lung exposure to the nerve agent VX - potential for additional treatment targets? Chemico-biological interactions. 2024-09-05. PMID:39233266. |
nerve agent-induced lung injury is little investigated and the standard treatment for symptomatic relief targets the enzyme acetylcholinesterase and muscarinic acetylcholine and gabaergic receptors. |
2024-09-05 |
2024-09-08 |
rat |
| Manikanta Nelakuditi, Sunil Kumar, Suhail M Shaikh, Avinash Parepalli, M Jayanth Kuma. A Narrative Review on Magnesium Sulfate as a Game Changer in Reducing ICU Stays in Organophosphate Poisoning Cases. Cureus. vol 16. issue 7. 2024-08-28. PMID:39188488. |
the toxic effects of op compounds arise from their inhibition of acetylcholinesterase, leading to an accumulation of acetylcholine and a subsequent cholinergic crisis, which can be fatal if not promptly treated. |
2024-08-28 |
2024-08-30 |
Not clear |
| Leonardo V F Ferreira, Taináh M R Santos, Camila A Tavares, Hassan Rasouli, Teodorico C Ramalh. Atomistic Origins of Resurrection of Aged Acetylcholinesterase by Quinone Methide Precursors. Molecules (Basel, Switzerland). vol 29. issue 15. 2024-08-10. PMID:39125089. |
nerve agents are organophosphates (ops) that act as potent inhibitors of acetylcholinesterase (ache), the enzyme responsible for the hydrolysis of acetylcholine. |
2024-08-10 |
2024-08-13 |
Not clear |
| Debashish Paramanick, Kagithala Naga Rani, Vijay Kumar Singh, Parakh Basist, Rahmuddin Khan, Jameel H Al-Tamimi, Omar M Noman, Mansour N Ibrahim, Abdulsalam Alhalm. Enhancement of Cognitive Function by Andrographolide-Loaded Lactose β-Cyclodextrin Nanoparticles: Synthesis, Optimization, and Behavioural Assessment. Pharmaceuticals (Basel, Switzerland). vol 17. issue 7. 2024-07-27. PMID:39065814. |
biochemical assays indicated a significant reduction in acetylcholinesterase activity and lipid peroxidation, suggesting increased acetylcholine levels and reduced oxidative stress. |
2024-07-27 |
2024-07-29 |
Not clear |
| Fatima Ezzahra Laghchioua, Carlos F M da Silva, Diana C G A Pinto, José A S Cavaleiro, Ricardo F Mendes, Filipe A Almeida Paz, Maria A F Faustino, El Mostapha Rakib, M Graça P M S Neves, Florbela Pereira, Nuno M M Mour. Design of Promising Thiazoloindazole-Based Acetylcholinesterase Inhibitors Guided by Molecular Docking and Experimental Insights. ACS chemical neuroscience. 2024-07-22. PMID:39037949. |
since acetylcholinesterase (ache) is a critical enzyme in the nervous system, responsible for breaking down the neurotransmitter acetylcholine, its inhibition holds a significant interest in the treatment of various neurological disorders. |
2024-07-22 |
2024-07-25 |
Not clear |
| Giovana R Oliveira, Matheus Gallas-Lopes, Rafael Chitolina, Leonardo M Bastos, Stefani M Portela, Thailana Stahlhofer-Buss, Darlan Gusso, Rosane Gomez, Angela T S Wyse, Ana P Herrmann, Angelo Piat. Evaluation of behavioral and neurochemical changes induced by carbofuran in zebrafish (Danio rerio). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2024-06-26. PMID:38925284. |
research has revealed that this pesticide acts as an inhibitor of acetylcholinesterase (ache), inducing an accumulation of acetylcholine in the brain. |
2024-06-26 |
2024-06-29 |
zebrafish |
| Behjat Pouramiri, Maryam Abbasi, Elahe Hadadianpou. Design, Green Synthesis and in silico Studies of New Substituted Naphtho[1,2-e][1,3]Oxazines as Potential Acetylcholinesterase Inhibitors. Chemistry & biodiversity. 2024-06-26. PMID:38923807. |
acetylcholinesterase (ache) inhibitors as the primary pharmacotherapy for numerous neurodegenerative conditions, leveraging their capacity to modulate acetylcholine levels crucial for cognitive function. |
2024-06-26 |
2024-06-29 |
Not clear |
| Liyuan Guo, Zelei Chang, Jianbo Tong, Peng Gao, Yakun Zhang, Yuan Liu, Yulu Yang, Chunying Wan. Design of vilazodone-donepezil chimeric derivatives as acetylcholinesterase inhibitors by QSAR, molecular docking and molecular dynamics simulations. Physical chemistry chemical physics : PCCP. 2024-06-19. PMID:38896464. |
acetylcholinesterase (ache) can increase acetylcholine concentrations and improve cognitive function in patients, and is a potential target to develop small molecule inhibitors for the treatment of alzheimer's disease (ad). |
2024-06-19 |
2024-06-21 |
Not clear |
| Leonardo F de Sousa, Diego F S Paschoal, Willian T G Novat. Molecular modeling of multi-target analogs of huperzine A and applications in Alzheimer's disease. Journal of molecular modeling. vol 30. issue 7. 2024-06-08. PMID:38850372. |
moreover, inhibiting acetylcholinesterase represents a pivotal strategy to enhance acetylcholine levels in the synaptic cleft. |
2024-06-08 |
2024-06-11 |
Not clear |
| Yashika Sarangle, Kiran Bamel, Ram Singh Purt. Role of acetylcholine and acetylcholinesterase in improving abiotic stress resistance/tolerance. Communicative & integrative biology. vol 17. issue 1. 2024-06-03. PMID:38827581. |
role of acetylcholine and acetylcholinesterase in improving abiotic stress resistance/tolerance. |
2024-06-03 |
2024-06-05 |
Not clear |
| Yashika Sarangle, Kiran Bamel, Ram Singh Purt. Role of acetylcholine and acetylcholinesterase in improving abiotic stress resistance/tolerance. Communicative & integrative biology. vol 17. issue 1. 2024-06-03. PMID:38827581. |
acetylcholine hydrolyzing enzyme acetylcholinesterase (ache) belongs to the gdsl lipase/acylhydrolase protein family and has been found in several plant species. |
2024-06-03 |
2024-06-05 |
Not clear |
| Haiyan Hao, Ailong Sh. Study on Anti-fatigue Effects and Mechanisms of Polysaccharide from Paris polyphylla. Doklady. Biochemistry and biophysics. vol 516. issue 1. 2024-05-25. PMID:38722403. |
the effects of pppm-1 on the contents of blood lactate, serum urea nitrogen, hepatic glycogen, muscle glycogen in the exercise fatigue model of mice, and acetylcholine (ach) content and acetylcholinesterase (ache) activity at the junction of the frog sciatic nerve-gastrocnemius under normal physiological, and na |
2024-05-25 |
2024-05-27 |
mouse |
| Tamara Bernauer, Valentin Nitsche, Jesko Kaiser, Christoph G W Gertzen, Georg Höfner, Karin V Niessen, Thomas Seeger, Dirk Steinritz, Franz Worek, Holger Gohlke, Klaus T Wanner, Franz F Paintne. Synthesis and Biological Evaluation of Novel MB327 Analogs as Resensitizers for Desensitized Nicotinic Acetylcholine Receptors after Intoxication with Nerve Agents. Toxicology letters. 2024-05-17. PMID:38759939. |
poisoning with organophosphorus compounds, which can lead to a cholinergic crisis due to the inhibition of acetylcholinesterase and the subsequent accumulation of acetylcholine (ach) in the synaptic cleft, is a serious problem for which treatment options are currently insufficient. |
2024-05-17 |
2024-05-27 |
rat |
| Yuxin Zhang, Xiaoqing Pei, Lingyang Jing, Qingyu Zhang, Hongfeng Zha. Lead induced cerebellar toxicology of developmental Japanese quail (Coturnix japonica) via oxidative stress-based Nrf2/Keap1 pathway inhibition and glutathione-mediated apoptosis signaling activation. Environmental pollution (Barking, Essex : 1987). vol 352. 2024-05-10. PMID:38718965. |
moreover, cerebellar neurotransmission was disturbed by pb with increasing acetylcholine (ach) and decreasing acetylcholinesterase (ache), dopamine (da), γ-aminobutyric acid (gaba) and na |
2024-05-10 |
2024-05-27 |
Not clear |