| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Feifei Xu, Xinyang Li, Chen Chen, Zhigang Liang, Guanhong Xu, Fangdi Wei, Jing Yang, Qin Hu, Yao Ce. A dual-emission ratiometric fluorescence strategy with enzyme-based inhibition for organophosphorus pesticides determination. Mikrochimica acta. vol 190. issue 8. 2023-07-29. PMID:37516685. |
the substrate acetylcholine was catalyzed by acetylcholinesterase (ache) to produce thiocholine (tch). |
2023-07-29 |
2023-08-14 |
Not clear |
| Hongyi Xian, Zhiming Li, Rongyi Ye, Mingzhu Dai, Yu Feng, Ruobing Bai, Jie Guo, Xiliang Yan, Xingfen Yang, Da Chen, Zhenlie Huan. 4-Methylbenzylidene camphor triggers estrogenic effects via the brain-liver-gonad axis in zebrafish larvae. Environmental pollution (Barking, Essex : 1987). 2023-07-28. PMID:37506809. |
this may have been associated with the disruption of acetylcholinesterase and acetylcholine activities. |
2023-07-28 |
2023-08-14 |
zebrafish |
| Keyvan Mehri, Zohreh Zavvari Oskuye, Ehsan Nassireslami, Esmail Karami, Mohammad Reza Parviz. Rivastigmine ameliorates botulinum-induced hippocampal damage and spatial memory impairment in male rats. Neurotoxicology. 2023-07-28. PMID:37507053. |
furthermore, in the botox groups, the level of acetylcholine decreased, while the level of the acetylcholinesterase enzyme increased significantly in the hippocampus. |
2023-07-28 |
2023-08-14 |
rat |
| Linlin Song, Qian Zhang, Lei Min, Xinyu Guo, Wenqiang Gao, Lin Cui, Chun-Yang Zhan. Electrochemiluminescence enhanced by isolating ACQphores in imine-linked covalent organic framework for organophosphorus pesticide assay. Talanta. vol 266. issue Pt 1. 2023-07-23. PMID:37481885. |
acetylcholinesterase (ache) can enzymatically hydrolyze acetylcholine (ach) to generate acetic acid. |
2023-07-23 |
2023-08-14 |
Not clear |
| Alexandru Graur, Patricia Sinclair, Amanda K Schneeweis, Daniel T Pak, Nadine Kabban. The human acetylcholinesterase C-terminal T30 peptide activates neuronal growth through alpha 7 nicotinic acetylcholine receptors and the mTOR pathway. Scientific reports. vol 13. issue 1. 2023-07-15. PMID:37454238. |
the human acetylcholinesterase c-terminal t30 peptide activates neuronal growth through alpha 7 nicotinic acetylcholine receptors and the mtor pathway. |
2023-07-15 |
2023-08-14 |
human |
| Alexandru Graur, Patricia Sinclair, Amanda K Schneeweis, Daniel T Pak, Nadine Kabban. The human acetylcholinesterase C-terminal T30 peptide activates neuronal growth through alpha 7 nicotinic acetylcholine receptors and the mTOR pathway. Scientific reports. vol 13. issue 1. 2023-07-15. PMID:37454238. |
acetylcholinesterase (ache) is a highly conserved enzyme responsible for the regulation of acetylcholine signaling within the brain and periphery. |
2023-07-15 |
2023-08-14 |
human |
| Ana Matošević, Dejan M Opsenica, Marta Spasić, Nikola Maraković, Antonio Zandona, Suzana Žunec, Marija Bartolić, Zrinka Kovarik, Anita Bosa. Evaluation of 4-aminoquinoline derivatives with an n-octylamino spacer as potential multi-targeting ligands for the treatment of Alzheimer's disease. Chemico-biological interactions. 2023-07-05. PMID:37406982. |
the most successful therapeutic strategy in the treatment of alzheimer's disease (ad) is directed toward increasing levels of the neurotransmitter acetylcholine (ach) by inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche), the enzymes responsible for its hydrolysis. |
2023-07-05 |
2023-08-14 |
human |
| Anushree Chandrashekhar Gade, Manikanta Murahari, Parasuraman Pavadai, Maushmi Shailesh Kuma. Virtual Screening of a Marine Natural Product Database for In Silico Identification of a Potential Acetylcholinesterase Inhibitor. Life (Basel, Switzerland). vol 13. issue 6. 2023-06-28. PMID:37374081. |
acetylcholinesterase (ache) hydrolyses acetylcholine and induces amyloid-beta aggregation. |
2023-06-28 |
2023-08-14 |
Not clear |
| Jonathan Godinez, Catherine Y Lee, Jason P Schwan. Synthesis and Evaluation of Fmoc-Amino Esters and Amides Bearing a Substrate Like Quaternary Ammonium Group as Selective Butyrylcholinesterase Inhibitors. Bioorganic & medicinal chemistry letters. 2023-06-26. PMID:37364726. |
for the two major cholinesterases, butyrylcholinesterase (bche) and acetylcholinesterase (ache), increased bche activity observed in individuals with ad has been suggested to deplete acetylcholine levels. |
2023-06-26 |
2023-08-14 |
Not clear |
| Shangfu Li, Dian Teguh, Depeng Wu, Lesong Liu, Chaofeng Hu, Jinbo Yuan, Charles A Inderjeeth, Jiake X. Antidementia medication acetylcholinesterase inhibitors have therapeutic benefits on osteoporotic bone by attenuating osteoclastogenesis and bone resorption. Journal of cellular physiology. 2023-06-19. PMID:37334837. |
this study was designed to determine whether the use of acetylcholinesterase inhibitors (acheis), a group of drugs that stimulate acetylcholine receptors and are used to treat alzheimer's disease (ad), is associated with osteoporosis protection and inhibition of osteoclast differentiation and function. |
2023-06-19 |
2023-08-14 |
mouse |
| Abhinav Anand, Navneet Khurana, Satinder Kaur, Nemat Ali, Abdullah F AlAsmari, Mohammad Waseem, Muzaffar Iqbal, Faris M Alzahrani, Neha Sharm. The multifactorial role of vanillin in amelioration of aluminium chloride and D-galactose induced Alzheimer's disease in mice. European journal of pharmacology. 2023-06-17. PMID:37329974. |
these include oxidative stress, overexpression of acetylcholinesterase (ache), depletion of acetylcholine levels, increased beta-secretase mediated conversion of amyloid precursor protein (app) to amyloid beta (abeta), accumulation of abeta oligomers, decrease in brain derived neurotrophic factor (bdnf) and accelerated neuronal apoptosis due to elevated levels of caspase-3. |
2023-06-17 |
2023-08-14 |
mouse |
| Richard A Fluc. ACETYLCHOLINE AND ACETYLCHOLINESTERASE ACTIVITY IN EARLY EMBRYOS OF THE MEDAKA ORYZIAS LATIPES, A TELEOST. Development, growth & differentiation. vol 20. issue 1. 2023-06-07. PMID:37281839. |
acetylcholine and acetylcholinesterase activity in early embryos of the medaka oryzias latipes, a teleost. |
2023-06-07 |
2023-08-14 |
chicken |
| Lenka Pulkrabkova, Lubica Muckova, Martina Hrabinova, Ales Sorf, Tereza Kobrlova, Petr Jost, Dagmar Bezdekova, Jan Korabecny, Daniel Jun, Ondrej Souku. Differentiated SH-SY5Y neuroblastoma cells as a model for evaluation of nerve agent-associated neurotoxicity. Archives of toxicology. 2023-05-23. PMID:37221426. |
despite a clear mechanism of their lethality caused by the irreversible inhibition of acetylcholinesterase (ache) and manifested via overstimulation of peripheral nicotinic and muscarinic acetylcholine (ach) receptors, the mechanism for central neurotoxicity responsible for acute or delayed symptoms of the poisoning has not been thoroughly uncovered. |
2023-05-23 |
2023-08-14 |
Not clear |
| Jie Chen, Kai-Chun Lin, Shalini Prasad, David W Schmidtk. Label free impedance based acetylcholinesterase enzymatic biosensors for the detection of acetylcholine. Biosensors & bioelectronics. vol 235. 2023-05-22. PMID:37216844. |
label free impedance based acetylcholinesterase enzymatic biosensors for the detection of acetylcholine. |
2023-05-22 |
2023-08-14 |
rat |
| Hongyan Pei, Lei He, Meiling Shi, Xiangjuan Guo, Weijia Chen, Jianming Li, Zhongmei He, Rui D. PI3K-Akt signaling pathway based on network pharmacology for the anti-Alzheimer's disease effect of licorice stem flavonoids. Aging. vol 15. 2023-05-11. PMID:37166431. |
results: of brain homogenate supernatant assay demonstrated that glycyrrhiza glabra stem and leaf flavonoids had a significant effect on the levels of oxidative indicators superoxide dismutase (sod), catalase (cat), malonaldehyde (mda), acetylcholine (ach), acetylcholinesterase (ache), caspase-3, caspase-9 and serum inflammatory factors tnf-α, il-6 and il-1β. |
2023-05-11 |
2023-08-14 |
mouse |
| Jagpreet S Sidhu, Kalpana Rajendran, Abraham B Mathew, Tabish Iqbal, Deepak K Saini, Debasis Da. Acetylcholine Structure-Based Small Activatable Fluorogenic Probe for Specific Detection of Acetylcholinesterase. Analytical chemistry. 2023-05-03. PMID:37132509. |
acetylcholine structure-based small activatable fluorogenic probe for specific detection of acetylcholinesterase. |
2023-05-03 |
2023-08-14 |
Not clear |
| Muslum Gok, Cigdem Cicek, Ebru Bodu. Butyrylcholinesterase in lipid metabolism: A new outlook. Journal of neurochemistry. 2023-05-02. PMID:37129444. |
cholinesterase enzymes acetylcholinesterase (ache) and butyrylcholinesterase (bche) are traditionally associated with the termination of acetylcholine mediated neural signaling. |
2023-05-02 |
2023-08-14 |
Not clear |
| Sanghyeon Kim, Keon Mook Seong, Si Hyeock Le. Acetylcholine titre regulation by non-neuronal acetylcholinesterase 1 and its putative roles in honey bee physiology. Insect molecular biology. 2023-05-02. PMID:37130064. |
acetylcholine titre regulation by non-neuronal acetylcholinesterase 1 and its putative roles in honey bee physiology. |
2023-05-02 |
2023-08-14 |
bee |
| Yuting Xue, Haotian Zhong, Bin Liu, Shuo Qin, Zhengbo Chen, Kai Li, Lirong Zheng, Xia Zu. Colorimetric identification of multiple terpenoids based on bimetallic FeCu/NPCs nanozymes. Analytical biochemistry. 2023-04-27. PMID:37105389. |
terpenoids act as inhibitors of acetylcholinesterase (ache) and reduce the hydrolysis of acetylcholine (atch), providing insight into establishing a simple and distinct assay for terpenoids. |
2023-04-27 |
2023-08-14 |
Not clear |
| Patricia G Izquierdo, Claude L Charvet, Cedric Neveu, A Christopher Green, John E H Tattersall, Lindy Holden-Dye, Vincent O'Conno. Modelling organophosphate intoxication in C. elegans highlights nicotinic acetylcholine receptor determinants that mitigate poisoning. PloS one. vol 18. issue 4. 2023-04-21. PMID:37083685. |
organophosphate intoxication via acetylcholinesterase inhibition executes neurotoxicity via hyper stimulation of acetylcholine receptors. |
2023-04-21 |
2023-08-14 |
caenorhabditis_elegans |