| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Letícia A Nascimento, Érica C M Nascimento, João B L Martin. In silico study of tacrine and acetylcholine binding profile with human acetylcholinesterase: docking and electronic structure. Journal of molecular modeling. vol 28. issue 9. 2022-08-10. PMID:35947248. |
in silico study of tacrine and acetylcholine binding profile with human acetylcholinesterase: docking and electronic structure. |
2022-08-10 |
2023-08-14 |
human |
| Letícia A Nascimento, Érica C M Nascimento, João B L Martin. In silico study of tacrine and acetylcholine binding profile with human acetylcholinesterase: docking and electronic structure. Journal of molecular modeling. vol 28. issue 9. 2022-08-10. PMID:35947248. |
in this way, we performed a set of theoretical tests of tacrine ligand and acetylcholine neurotransmitter against the human acetylcholinesterase enzyme. |
2022-08-10 |
2023-08-14 |
human |
| Ariel A Batallán Burrowes, Olayemi Joseph Olajide, Isabella A Iasenza, Waqqas M Shams, Francis Carter, C Andrew Chapma. Ovariectomy reduces cholinergic modulation of excitatory synaptic transmission in the rat entorhinal cortex. PloS one. vol 17. issue 8. 2022-08-08. PMID:35939438. |
ovariectomy was conducted at pd63, and tissue was obtained on pd84 to 89 to quantify changes in the degradative enzyme acetylcholinesterase, the vesicular acetylcholine transporter, and muscarinic m1 receptor protein. |
2022-08-08 |
2023-08-14 |
rat |
| Ariel A Batallán Burrowes, Olayemi Joseph Olajide, Isabella A Iasenza, Waqqas M Shams, Francis Carter, C Andrew Chapma. Ovariectomy reduces cholinergic modulation of excitatory synaptic transmission in the rat entorhinal cortex. PloS one. vol 17. issue 8. 2022-08-08. PMID:35939438. |
although the vesicular acetylcholine transporter was unaffected, ovariectomy reduced both acetylcholinesterase and m1 receptor protein, and these reductions were prevented by chronic replacement of 17β-estradiol following ovariectomy. |
2022-08-08 |
2023-08-14 |
rat |
| Brandon M Togioka, Katie J Schennin. Optimizing Reversal of Neuromuscular Block in Older Adults: Sugammadex or Neostigmine. Drugs & aging. 2022-08-07. PMID:35934764. |
neostigmine, an acetylcholinesterase inhibitor, increases the concentration of acetylcholine at the neuromuscular junction, providing competitive antagonism of neuromuscular blocking drug and facilitating muscle contraction. |
2022-08-07 |
2023-08-14 |
Not clear |
| Sílvia Moreira, Ricardo Silva, David F Carrageta, Marco G Alves, Vicente Seco-Rovira, Pedro F Oliveira, Maria de Lourdes Pereir. Carbamate Pesticides: Shedding Light on Their Impact on the Male Reproductive System. International journal of molecular sciences. vol 23. issue 15. 2022-07-28. PMID:35897782. |
this class of chemicals is classified as acetylcholinesterase inhibitors, blocking acetylcholine hydrolyzation in a reversible manner. |
2022-07-28 |
2023-08-14 |
Not clear |
| Betül Danışman, Güven Akçay, Çiğdem Gökçek-Saraç, Deniz Kantar, Mutay Aslan, Narin Deri. The Role of Acetylcholine on the Effects of Different Doses of Sulfite in Learning and Memory. Neurochemical research. 2022-07-27. PMID:35895153. |
acetylcholinesterase activity, choline acetyltransferase activity, acetylcholine level as well as arc and synapsin 1 expressions were analyzed on the hippocampi. |
2022-07-27 |
2023-08-14 |
rat |
| Betül Danışman, Güven Akçay, Çiğdem Gökçek-Saraç, Deniz Kantar, Mutay Aslan, Narin Deri. The Role of Acetylcholine on the Effects of Different Doses of Sulfite in Learning and Memory. Neurochemical research. 2022-07-27. PMID:35895153. |
acetylcholine levels and choline acetyltransferase activity were also increased in the sulfite groups, while acetylcholinesterase activity was decreased compared to controls. |
2022-07-27 |
2023-08-14 |
rat |
| Huilin Yu, Junhui Zhang, Yinghong Chen, Juan Chen, Yang Qiu, Yan Zhao, Honghao Li, Shengyao Xia, Shiguo Chen, Jiajin Zh. The adverse effects of fluxapyroxad on the neurodevelopment of zebrafish embryos. Chemosphere. 2022-07-21. PMID:35863420. |
flu at a concentration of 1 mg/l significantly decreased dopamine level and notably altered acetylcholinesterase (ache) activity and acetylcholine (ach) content. |
2022-07-21 |
2023-08-14 |
zebrafish |
| Vasudevan Mani, Minhajul Arfeen, Hamdoon A Mohammed, Hossam A Elsisi, Sultan Sajid, Yasser Almogbel, Maha Aldubayan, Muralikrishnan Dhanasekaran, Ahmad Alhowai. Sukkari dates seed improves type-2 diabetes mellitus-induced memory impairment by reducing blood glucose levels and enhancing brain cholinergic transmission: Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. vol 30. issue 6. 2022-07-11. PMID:35812141. |
glucose and insulin levels in the blood and acetylcholine, acetylcholinesterase brain homogenates were estimated. |
2022-07-11 |
2023-08-14 |
rat |
| Keyu Xiang, Zhiyu He, Jianxin Fu, Guoqing Wang, Hongyan Li, Yu Zhang, Shicui Zhang, Lingxin Che. Microplastics exposure as an emerging threat to ancient lineage: A contaminant of concern for abnormal bending of amphioxus via neurotoxicity. Journal of hazardous materials. vol 438. 2022-07-08. PMID:35803186. |
mechanistic insight reveals that microplastics can bring about histological damages in gill, intestine and hepatic cecum; in-depth assay of relevant biomarkers including superoxide dismutase, catalase, glutathione, pyruvic acid and total cholesterol indicates the occurrence of oxidative damage and metabolic disorder; further, microplastics exposure depresses the activity of acetylcholinesterase while allowing the level of acetylcholine to rise in muscle, suggesting the emergence of neurotoxicity. |
2022-07-08 |
2023-08-14 |
human |
| Jingyi Wu, Yaw-Syan Fu, Kaihuang Lin, Xin Huang, Yi-Jing Chen, Dong Lai, Ning Kang, Liyue Huang, Ching-Feng Wen. A narrative review: The pharmaceutical evolution of phenolic syringaldehyde. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 153. 2022-07-05. PMID:35780614. |
moreover, sa nicely docked with dipeptidyl peptidase-iv, glucagon-like peptide 1 receptor, peroxisome proliferator-activated receptor, acetylcholine m2 receptor, and acetylcholinesterase in anti-diabetes investigations. |
2022-07-05 |
2023-08-14 |
Not clear |
| Nancy D Asen, Rotimi E Aluk. Acetylcholinesterase and butyrylcholinesterase inhibitory activities of antioxidant peptides obtained from enzymatic pea protein hydrolysates and their ultrafiltration peptide fractions. Journal of food biochemistry. 2022-06-27. PMID:35758753. |
practical applications: alzheimer's disease (ad) has multiple pathological pathways in addition to the loss of acetylcholine (ach) catalyzed by acetylcholinesterase (ache) and butyrylcholinesterase (buche). |
2022-06-27 |
2023-08-14 |
Not clear |
| Grażyna Budryn, Iwona Majak, Joanna Grzelczyk, Dominik Szwajgier, Alejandro Rodríguez-Martínez, Horacio Pérez-Sánche. Hydroxybenzoic Acids as Acetylcholinesterase Inhibitors: Calorimetric and Docking Simulation Studies. Nutrients. vol 14. issue 12. 2022-06-24. PMID:35745206. |
one of the symptoms of alzheimer's disease (ad) is low acetylcholine level due to high acetylcholinesterase (ache) activity. |
2022-06-24 |
2023-08-14 |
Not clear |
| Martina Bortolami, Fabiana Pandolfi, Valeria Tudino, Antonella Messore, Valentina Noemi Madia, Daniela De Vita, Roberto Di Santo, Roberta Costi, Isabella Romeo, Stefano Alcaro, Marisa Colone, Annarita Stringaro, Alba Espargaró, Raimon Sabatè, Luigi Scipion. Design, Synthesis, and In Vitro, In Silico and In Cellulo Evaluation of New Pyrimidine and Pyridine Amide and Carbamate Derivatives as Multi-Functional Cholinesterase Inhibitors. Pharmaceuticals (Basel, Switzerland). vol 15. issue 6. 2022-06-24. PMID:35745594. |
the standard approach is represented by the cholinesterase inhibitors (cheis) that restore the levels of acetylcholine (ach) by inhibiting the acetylcholinesterase (ache). |
2022-06-24 |
2023-08-14 |
Not clear |
| Tess Puopolo, Chang Liu, Hang Ma, Navindra P Seera. Inhibitory Effects of Cannabinoids on Acetylcholinesterase and Butyrylcholinesterase Enzyme Activities. Medical cannabis and cannabinoids. vol 5. issue 1. 2022-06-15. PMID:35702400. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are two cholinergic enzymes catalyzing the reaction of cleaving acetylcholine into acetate and choline at the neuromuscular junction. |
2022-06-15 |
2023-08-14 |
Not clear |
| Nupur Vasdev, Mayank Handa, Prashant Kesharwani, Rahul Shukl. Rosemary oil low energy nanoemulsion: Optimization, µrheology, Journal of biomaterials science. Polymer edition. 2022-06-10. PMID:35686513. |
acetylcholinesterase (ache) inhibitors prevent the lysis of acetylcholine in the brain and prevent dementia. |
2022-06-10 |
2023-08-14 |
human |
| Yan-Ling Su, Dong Liu, Yao-Jie Liu, Yang-Lin Ji, Gui-Shan Liu, Ji-Li-Te Wang, Biao Wang, Hao Wan. Phlorizin alleviates cholinergic memory impairment and regulates gut microbiota in d-galactose induced mice. Experimental gerontology. 2022-06-06. PMID:35660419. |
furthermore, a neurotransmitter of acetylcholine (ach) was enhanced, while acetylcholinesterase (ache) activity was inhibited by phlorizin administration. |
2022-06-06 |
2023-08-14 |
mouse |
| Jatinder Dhaliwal, Navneet Dhaliwal, Ansab Akhtar, Anurag Kuhad, Kanwaljit Chopr. Tetramethylpyrazine Attenuates Cognitive Impairment Via Suppressing Oxidative Stress, Neuroinflammation, and Apoptosis in Type 2 Diabetic Rats. Neurochemical research. 2022-06-06. PMID:35665448. |
acetylcholinesterase (ache) and choline acetytransferase (chat) activity, acetylcholine (ach) levels, oxidative stress, apoptotic (bcl-2, bax, caspase-3), and inflammatory markers (tnf-α, il-1β, and nf-kβ) were assessed. |
2022-06-06 |
2023-08-14 |
rat |
| Masato Mashimo, Koichiro Kawashima, Takeshi Fuji. Non-neuronal Cholinergic Muscarinic Acetylcholine Receptors in the Regulation of Immune Function. Biological & pharmaceutical bulletin. vol 45. issue 6. 2022-06-01. PMID:35650095. |
immune cells such as t and b cells, monocytes and macrophages all express most of the cholinergic components of the nervous system, including acetylcholine (ach), choline acetyltransferase (chat), high affinity choline transporter, muscarinic and nicotinic ach receptors (machrs and nachrs, respectively), and acetylcholinesterase (ache). |
2022-06-01 |
2023-08-13 |
Not clear |