| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jason M Kinchen, Robert P Mohney, Kirk L Pappa. Long-Chain Acylcholines Link Butyrylcholinesterase to Regulation of Non-neuronal Cholinergic Signaling. Journal of proteome research. 2021-11-11. PMID:34758617. |
bche provides reserve capacity to hydrolyze acetylcholine, but its importance is arguable given acetylcholinesterase is the most catalytically efficient enzyme characterized to date. |
2021-11-11 |
2023-08-13 |
Not clear |
| Sean M Mooney-Leber, Dana Zeid, Prescilla Garcia-Trevizo, Laurel R Seemiller, Molly A Bogue, Stephen C Grubb, Gary Peltz, Thomas J Goul. Genetic Differences in Dorsal Hippocampus Acetylcholinesterase Activity Predict Contextual Fear Learning Across Inbred Mouse Strains. Frontiers in psychiatry. vol 12. 2021-11-05. PMID:34733190. |
since cholinergic signaling is affected by genetic background, we examined the genetic relationship between activity levels of acetylcholinesterase (ache), the primary enzyme involved in the acetylcholine metabolism, and learning using a panel of 20 inbred mouse strains. |
2021-11-05 |
2023-08-13 |
mouse |
| Anna Loftén, Louise Adermark, Mia Ericson, Bo Söderpal. An acetylcholine-dopamine interaction in the nucleus accumbens and its involvement in ethanol's dopamine-releasing effect. Addiction biology. vol 26. issue 3. 2021-11-01. PMID:32789970. |
using reversed in vivo microdialysis, the acetylcholinesterase inhibitor physostigmine was administered locally in the nac followed by addition of either the muscarinic acetylcholine (ach) receptor antagonist scopolamine or the nicotinic ach receptor antagonist mecamylamine. |
2021-11-01 |
2023-08-13 |
rat |
| Pedro M Rodríguez Cruz, Imelda Hughes, Adnan Manzur, Pinki Munot, Sithara Ramdas, Ronnie Wright, Catherine Breen, Mathew Pitt, Alistair T Pagnamenta, Jenny C Taylor, Jacqueline Palace, David Beeso. Presynaptic congenital myasthenic syndrome due to three novel mutations in SLC5A7 encoding the sodium-dependant high-affinity choline transporter. Neuromuscular disorders : NMD. vol 31. issue 1. 2021-10-26. PMID:33250374. |
slc5a7 encodes the presynaptic sodium-dependant high-affinity choline transporter 1 (cht), which uptakes choline to the presynaptic nerve terminal following the breakdown of acetylcholine by the acetylcholinesterase within the synaptic cleft. |
2021-10-26 |
2023-08-13 |
Not clear |
| Hanan A Edres, Nabil M Taha, Mohamed A Lebda, Mohamed S Elfek. The potential neuroprotective effect of allicin and melatonin in acrylamide-induced brain damage in rats. Environmental science and pollution research international. vol 28. issue 41. 2021-10-26. PMID:34120280. |
the obvious brain oxidative injuries contributed to distinct brain dysfunction that was assured by alteration of brain neurotransmitters (serotonin, dopamine, acetylcholine, and acetylcholinesterase) and pathological brain lesions. |
2021-10-26 |
2023-08-13 |
rat |
| Zackary A Cope, Maria L Lavadia, Aniek J M Joosen, Chuck J A van de Cappelle, Joseph C Lara, Alexandra Huval, Molly K Kwiatkowski, Marina R Picciotto, Yann S Mineur, Davide Dulcis, Jared W Youn. Converging evidence that short-active photoperiod increases acetylcholine signaling in the hippocampus. Cognitive, affective & behavioral neuroscience. vol 20. issue 6. 2021-10-25. PMID:32794101. |
elevating acetylcholine with the acetylcholinesterase inhibitor physostigmine induces depression symptoms in people and increases fst immobility in mice. |
2021-10-25 |
2023-08-13 |
mouse |
| Edward C Meek, Russell L Carr, Janice E Chamber. In vitro age-related differences in rats to organophosphates. Toxicology in vitro : an international journal published in association with BIBRA. vol 72. 2021-10-22. PMID:33497710. |
the mechanism of toxic action for organophosphates (ops) is the persistent inhibition of acetylcholinesterase (ache) resulting in accumulation of acetylcholine and subsequent hyperstimulation of the nervous system. |
2021-10-22 |
2023-08-13 |
rat |
| Y Cheng, P Kekenes-Huskey, Je Hake, Mj Holst, Ja McCammon, Ap Michailov. Multi-Scale Continuum Modeling of Biological Processes: From Molecular Electro-Diffusion to Sub-Cellular Signaling Transduction. Computational science & discovery. vol 5. issue 1. 2021-10-21. PMID:23505398. |
at the molecular scale, smol has yielded experimentally-validated estimates of the diffusion-limited association rates for the binding of acetylcholine to mouse acetylcholinesterase using crystallographic structural data. |
2021-10-21 |
2023-08-12 |
mouse |
| Qiyun Wu, Panzhu Bai, Yingjie Xia, Queenie W S Lai, Maggie S S Guo, Kun Dai, Zhongyu Zheng, Christine S J Ling, Tina T X Dong, Rongbiao Pi, Karl W K Tsi. Solar light induces expression of acetylcholinesterase in skin keratinocytes: Signalling mediated by activator protein 1 transcription factor. Neurochemistry international. vol 141. 2021-10-18. PMID:33038610. |
acetylcholinesterase (ache) hydrolyses acetylcholine to choline and acetate, playing an important role in terminating the neurotransmission in brain and muscle. |
2021-10-18 |
2023-08-13 |
Not clear |
| Namrita Halder, Girdhari La. Cholinergic System and Its Therapeutic Importance in Inflammation and Autoimmunity. Frontiers in immunology. vol 12. 2021-10-14. PMID:33936095. |
the cholinergic system includes the neurotransmitter\ molecule, acetylcholine (ach), cholinergic receptors (achrs), choline acetyltransferase (chat) enzyme, and acetylcholinesterase (ache) enzyme. |
2021-10-14 |
2023-08-13 |
Not clear |
| Eng Leng Saw, James T Pearson, Daryl O Schwenke, Pujika Emani Munasinghe, Hirotsugu Tsuchimochi, Shruti Rawal, Sean Coffey, Philip Davis, Richard Bunton, Isabelle Van Hout, Yuko Kai, Michael J A Williams, Yoshihiko Kakinuma, Martin Fronius, Rajesh Katar. Activation of the cardiac non-neuronal cholinergic system prevents the development of diabetes-associated cardiovascular complications. Cardiovascular diabetology. vol 20. issue 1. 2021-10-05. PMID:33618724. |
recent evidence suggests that cardiomyocytes possess a non-neuronal cholinergic system (nncs) that comprises of choline acetyltransferase (chat), choline transporter 1 (cht1), vesicular acetylcholine transporter (vacht), acetylcholinesterase (ache) and type-2 muscarinic ach receptors (m |
2021-10-05 |
2023-08-13 |
Not clear |
| Donald A Godfrey, Lissette Carlson, Jami L Park, C David Ros. Enzymes of acetylcholine metabolism in the rat inferior colliculus. Brain research. vol 1766. 2021-09-21. PMID:33991492. |
we have used microdissection of freeze-dried sections combined with radiometric assays to map the distributions in the rat inferior colliculus of the activities of choline acetyltransferase (chat), which catalyzes synthesis of acetylcholine, and acetylcholinesterase (ache), which catalyzes its breakdown by hydrolysis. |
2021-09-21 |
2023-08-13 |
rat |
| Amber N Edinoff, Joseph S Fitz-Gerald, Krisha Andrea A Holland, Johnnie G Reed, Sarah E Murnane, Sarah G Minter, Aaron J Kaye, Elyse M Cornett, Farnad Imani, Seyed-Hossein Khademi, Adam M Kaye, Richard D Urman, Alan D Kay. Adjuvant Drugs for Peripheral Nerve Blocks: The Role of NMDA Antagonists, Neostigmine, Epinephrine, and Sodium Bicarbonate. Anesthesiology and pain medicine. vol 11. issue 3. 2021-09-21. PMID:34540646. |
neostigmine is a cholinesterase inhibitor that exerts its effect by competitively binding at the active site of acetylcholinesterase, which prevents the hydrolysis of acetylcholine and subsequently retaining acetylcholine at the nerve terminal. |
2021-09-21 |
2023-08-13 |
Not clear |
| Oksana Gerlits, Matthew P Blakeley, David A Keen, Zoran Radić, Andrey Kovalevsk. Room temperature crystallography of human acetylcholinesterase bound to a substrate analogue 4K-TMA: Towards a neutron structure. Current research in structural biology. vol 3. 2021-09-21. PMID:34541552. |
acetylcholinesterase (ache) catalyzes hydrolysis of acetylcholine thereby terminating cholinergic nerve impulses for efficient neurotransmission. |
2021-09-21 |
2023-08-13 |
human |
| Motahareh Hassanzadeh, Farshid Hassanzadeh, Ghadam Ali Khodarahmi, Mahbobe Rostami, Fateme Azimi, Hamid Nadri, Farshad Homayouni Moghada. Design, synthesis, and bio-evaluation of new isoindoline-1,3-dione derivatives as possible inhibitors of acetylcholinesterase. Research in pharmaceutical sciences. vol 16. issue 5. 2021-09-16. PMID:34522196. |
a significant decrease in acetylcholine level in the brain is common in most patients with alzheimer's disease, therefore acetylcholinesterase (ache) inhibitors such as donepezil and rivastigmine are widely used for patients with limited therapeutic results and major side effects. |
2021-09-16 |
2023-08-13 |
Not clear |
| Stephen D Richbart, Justin C Merritt, Nicholas A Nolan, Piyali Dasgupt. Acetylcholinesterase and human cancers. Advances in cancer research. vol 152. 2021-09-13. PMID:34353435. |
the enzyme acetylcholinesterase (ache) is a serine hydrolase whose primary function is to degrade acetylcholine (ach) and terminate neurotransmission. |
2021-09-13 |
2023-08-13 |
human |
| Lebin Weng, Ting-Hsu Chen, Qingyan Zheng, Wei-Hao Weng, Liyue Huang, Dong Lai, Yaw-Syan Fu, Ching-Feng Wen. Syringaldehyde promoting intestinal motility with suppressing α-amylase hinders starch digestion in diabetic mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 141. 2021-09-08. PMID:34246193. |
by performing virtual screening with molecular docking, the data showed that syringaldehyde nicely interacted with glucagon-like peptide 1 receptor (glp-1r), peroxisome proliferator-activated receptor (ppar), dipeptidyl peptidase-iv (dpp-4), acetylcholine m2 receptor, and acetylcholinesterase. |
2021-09-08 |
2023-08-13 |
mouse |
| Yue Zhao, Yifei Dong, Qi Ge, Pengbo Cui, Na Sun, Songyi Li. Neuroprotective effects of NDEELNK from sea cucumber ovum against scopolamine-induced PC12 cell damage through enhancing energy metabolism and upregulation of the PKA/BDNF/NGF signaling pathway. Food & function. vol 12. issue 17. 2021-09-02. PMID:34259275. |
ndeelnk exerted the neuroprotective effect by improving the acetylcholine (ach) level and reducing the acetylcholinesterase (ache) activity in pc12 cells. |
2021-09-02 |
2023-08-13 |
Not clear |
| Qianqian Sun, Cen Liu, Kunxiu Jiang, Yongsheng Fang, Chuchu Kong, Jin Fu, Yonggang Li. A preliminary study on the neurotoxic mechanism of harmine in Caenorhabditis elegans. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 245. 2021-08-31. PMID:33794375. |
above all, harmine can directly inhibit the activity of acetylcholinesterase, leading to excessive accumulation of acetylcholine, which may be one of the harmine neurotoxicity mechanisms. |
2021-08-31 |
2023-08-13 |
caenorhabditis_elegans |
| Nikolina Maček Hrvat, Zrinka Kovari. Counteracting poisoning with chemical warfare nerve agents. Arhiv za higijenu rada i toksikologiju. vol 71. issue 4. 2021-08-30. PMID:33410774. |
phosphylation of the pivotal enzyme acetylcholinesterase (ache) by nerve agents (nas) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter acetylcholine, which induces cholinergic crisis, that is, overstimulation of muscarinic and nicotinic membrane receptors in the central and peripheral nervous system. |
2021-08-30 |
2023-08-13 |
Not clear |