| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M V K Reddy, K Y Rao, G Anusha, G M Kumar, A G Damu, Kakarla Raghava Reddy, Nagaraj P Shetti, Tejraj M Aminabhavi, Peddiahgari Vasu Govardhana Redd. In-vitro evaluation of antioxidant and anticholinesterase activities of novel pyridine, quinoxaline and s-triazine derivatives. Environmental research. vol 199. 2021-07-01. PMID:33991570. |
cholinesterase enzymes such as acetylcholinesterase (ache) and butyrylcholinesterase (buche) cause hydrolysis of acetylcholine (ach), a neurotransmitter responsible for the cognitive functions of the brain such as acquiring knowledge and comprehension. |
2021-07-01 |
2023-08-13 |
Not clear |
| Mohamed Ali Smach, Amira Zarrouk, Jawhar Hafsa, Henda Gaffrej, Jihen Ben Abdallah, Bassem Charfeddine, Khalifa Lime. Maillard Reaction Products and Phenolic Compounds from Roasted Peanut Flour Extracts Prevent Scopolamine-Induced Amnesia Via Cholinergic Modulation and Antioxidative Effects in Mice. Journal of medicinal food. vol 24. issue 6. 2021-06-25. PMID:33035147. |
brain tissues were collected to measure acetylcholine, acetylcholinesterase, and oxidative parameters (glutathione and malondialdehyde). |
2021-06-25 |
2023-08-13 |
mouse |
| Junyi Chen, Yadan Zhang, Yao Chai, Zhao Meng, Yahan Zhang, Longming Chen, Dongqin Quan, Yongan Wang, Qingbin Meng, Chunju L. Synergistic enhancement of the emergency treatment effect of organophosphate poisoning by a supramolecular strategy. Chemical science. vol 12. issue 14. 2021-06-25. PMID:34163757. |
these compounds irreversibly inhibit acetylcholinesterase (ache), resulting in the accumulation of acetylcholine (ach) and overstimulation of ach receptors. |
2021-06-25 |
2023-08-13 |
Not clear |
| Yaojie Liu, Ying Liu, Yatu Guo, Lin Xu, Hao Wan. Phlorizin exerts potent effects against aging induced by D-galactose in mice and PC12 cells. Food & function. vol 12. issue 5. 2021-06-22. PMID:33565551. |
on the other hand, phlorizin increased the levels of interleukin-2 (il-2) and acetylcholine (ach), reduced the release of interleukin-6 (il-6), aspartate aminotransferase (ast) and alanine aminotransferase (alt), and decreased the activity of acetylcholinesterase (ache) in the brain, improved the expression of antioxidant genes related to the nuclear factor e2-related factor 2 (nrf2) pathway, and reduced the occurrence of morphological lesions in the hippocampus and liver. |
2021-06-22 |
2023-08-13 |
mouse |
| Jonathan Hindmarsh, Paul Everett, Sharlene Hindmarsh, Mark Lee, Jonathan Pickar. Glycopyrrolate and the Management of "Death Rattle" in Patients with Myasthenia Gravis. Journal of palliative medicine. vol 23. issue 10. 2021-06-18. PMID:31976808. |
the condition is treated with acetylcholinesterase inhibitors, which potentiate the action of acetylcholine. |
2021-06-18 |
2023-08-13 |
Not clear |
| Junrong Zhang, Rui Liu, Dechen Zhang, Zhixian Zhang, Jinming Zhu, Li Xu, Yi Gu. Neuroprotective effects of maize tetrapeptide-anchored gold nanoparticles in Alzheimer's disease. Colloids and surfaces. B, Biointerfaces. vol 200. 2021-06-17. PMID:33508658. |
after 16 days of nanopeptide administration, the central cholinergic system function of acetylcholine and cholineacetyltransferase were enhanced, and the level of acetylcholinesterase was reduced. |
2021-06-17 |
2023-08-13 |
mouse |
| Kevin G McGarry, Kevin E Schill, Tyson P Winters, Erin E Lemmon, Carol L Sabourin, Jill A Harvilchuck, Robert A Moye. Characterization of Cholinesterases From Multiple Large Animal Species for Medical Countermeasure Development Against Chemical Warfare Nerve Agents. Toxicological sciences : an official journal of the Society of Toxicology. vol 174. issue 1. 2021-06-09. PMID:31879781. |
disruption of cholinergic function through the inhibition of acetylcholinesterase (ache) leads to the accumulation of the neurotransmitter acetylcholine. |
2021-06-09 |
2023-08-13 |
Not clear |
| Leila Sadeghi, Reza Yekta, Gholamreza Dehgha. The inhibitory effects of bile acids on catalytic and non‑catalytic functions of acetylcholinesterase as a therapeutic target in Alzheimer's disease. Acta neurobiologiae experimentalis. vol 80. issue 2. 2021-06-07. PMID:32602852. |
acetylcholine is a fast-acting neurotransmitter in synapses and neuromuscular junctions that is decreased in alzheimer's disease (ad) by hyper‑activation of acetylcholinesterase (ache), which leads to progressive loss of memory and neurobehavioral abnormalities. |
2021-06-07 |
2023-08-13 |
rat |
| Dan Wu, Xiaomeng Xu, Na Sun, Dongmei Li, Beiwei Zhu, Songyi Li. AGLPM and QMDDQ peptides exert a synergistic action on memory improvement against scopolamine-induced amnesiac mice. Food & function. vol 11. issue 12. 2021-06-07. PMID:33242042. |
furthermore, combination treatment with qmddq and aglpm could significantly reduce the acetylcholinesterase (ache) level and increase the acetylcholine (ach) level in the hippocampus, and noticeably improve the pathological morphology of the neuron cells in hippocampal regions ca1 and ca2 and dentate gyrus (dg). |
2021-06-07 |
2023-08-13 |
mouse |
| Yang Yang, Ming Zhao, Xi He, Qing Wu, Dong-Ling Li, Wei-Jin Zan. Pyridostigmine Protects Against Diabetic Cardiomyopathy by Regulating Vagal Activity, Gut Microbiota, and Branched-Chain Amino Acid Catabolism in Diabetic Mice. Frontiers in pharmacology. vol 12. 2021-06-05. PMID:34084135. |
these impairments were accompanied by reduction in vagal activity that manifested as increased acetylcholinesterase levels, decreased acetylcholine levels, and heart rate variability, which eventually led to cardiac damage. |
2021-06-05 |
2023-08-13 |
mouse |
| Lucas W Smedley, Dana B Foster, Colleen A Barthol, Reed Hall, G Christina Gutierre. Safety and Efficacy of Intermittent Bolus and Continuous Infusion Neostigmine for Acute Colonic Pseudo-Obstruction. Journal of intensive care medicine. vol 35. issue 10. 2021-06-01. PMID:30373445. |
neostigmine is an acetylcholinesterase inhibitor that increases frequency of smooth muscle contraction by increasing acetylcholine at autonomic nervous system synapses. |
2021-06-01 |
2023-08-13 |
Not clear |
| Shani Vaknine, Hermona Sore. Central and peripheral anti-inflammatory effects of acetylcholinesterase inhibitors. Neuropharmacology. vol 168. 2021-05-27. PMID:32143069. |
acetylcholinesterase (ache) inhibitors modulate acetylcholine hydrolysis and hence play a key role in determining the cholinergic tone and in implementing its impact on the cholinergic blockade of inflammatory processes. |
2021-05-27 |
2023-08-13 |
mouse |
| Yilei Song, Xiangyu Wang, Xingrong Wang, Jianze Wang, Qiulian Hao, Jifu Hao, Xueqin Ho. Osthole-Loaded Nanoemulsion Enhances Brain Target in the Treatment of Alzheimer's Disease via Intranasal Administration. Oxidative medicine and cellular longevity. vol 2021. 2021-05-18. PMID:33564364. |
ost-ne improved the spatial memory ability, increased the acetylcholine content in the cerebral cortex, and decreased the activity of acetylcholinesterase in the hippocampus of alzheimer's disease model mice. |
2021-05-18 |
2023-08-13 |
mouse |
| Afreen Jahan Rahman, Deepti Sharma, Deepanshu Kumar, Mallika Pathak, Anju Singh, Vinod Kumar, Raman Chawla, Himanshu Ojh. Spectroscopic and molecular modelling study of binding mechanism of bovine serum albumin with phosmet. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. vol 244. 2021-05-14. PMID:32829155. |
phosmet exerts its neurotoxicity by inhibiting acetylcholinesterase that catalyzes the degradation of acetylcholine (a neurotransmitter). |
2021-05-14 |
2023-08-13 |
cattle |
| Roland Blumer, Johannes Streicher, Génova Carrero-Rojas, Paula M Calvo, Rosa R de la Cruz, Angel M Pasto. Palisade Endings Have an Exocytotic Machinery But Lack Acetylcholine Receptors and Distinct Acetylcholinesterase Activity. Investigative ophthalmology & visual science. vol 61. issue 14. 2021-05-12. PMID:33369640. |
palisade endings have an exocytotic machinery but lack acetylcholine receptors and distinct acetylcholinesterase activity. |
2021-05-12 |
2023-08-13 |
Not clear |
| E Wigenstam, E Forsberg, A Bucht, L Thor. Efficacy of atropine and scopolamine on airway contractions following exposure to the nerve agent VX. Toxicology and applied pharmacology. vol 419. 2021-05-11. PMID:33785355. |
nerve agents are highly toxic organophosphorus compounds that inhibit acetylcholinesterase resulting in rapid accumulation of the neurotransmitter acetylcholine (ach) causing a cholinergic syndrome including respiratory failure. |
2021-05-11 |
2023-08-13 |
rat |
| Kristy L Meads, Thaddeus P Thomas, Jeffrey L Langston, Todd M Myers, Tsung-Ming Shi. Evaluation of adenosine A1 receptor agonists as neuroprotective countermeasures against Soman intoxication in rats. Toxicology and applied pharmacology. vol 416. 2021-05-10. PMID:33631229. |
soman, an organophosphorus (op) compound, disrupts nervous system function through inactivation of acetylcholinesterase (ache), the enzyme that breaks down acetylcholine at synapses. |
2021-05-10 |
2023-08-13 |
rat |
| Petek Piner Benli, Mehmet Çeli. In Vivo Effects of Neonicotinoid-Sulfoximine Insecticide Sulfoxaflor on Acetylcholinesterase Activity in the Tissues of Zebrafish ( Toxics. vol 9. issue 4. 2021-05-02. PMID:33916113. |
in vivo effects of neonicotinoid-sulfoximine insecticide sulfoxaflor on acetylcholinesterase activity in the tissues of zebrafish ( sulfoxaflor is the first member of the neonicotinoid-sulfoximine insecticides that acts as an agonist of nicotinic acetylcholine receptors (nachrs). |
2021-05-02 |
2023-08-13 |
zebrafish |
| Jayeong Hwang, Kumju Youn, Gyutae Lim, Jinhyuk Lee, Dong Hyun Kim, Mira Ju. Discovery of Natural Inhibitors of Cholinesterases from Nutrients. vol 13. issue 1. 2021-04-27. PMID:33477276. |
the loss of cognitive functions is mostly characterized by the rapid hydrolysis of acetylcholine by cholinesterases including acetylcholinesterase (ache) and butyrylcholinesterase (bche). |
2021-04-27 |
2023-08-13 |
Not clear |
| Zhanwen Wang, Yang Chen, Han Xiao, Shengcan Li, Tao Zhang, Jianzhong Hu, Hongbin Lu, Hui Xi. The Enhancement Effect of Acetylcholine and Pyridostigmine on Bone-Tendon Interface Healing in a Murine Rotator Cuff Model. The American journal of sports medicine. vol 49. issue 4. 2021-04-27. PMID:33592162. |
little is known about the effect of the parasympathetic transmitter acetylcholine (ach) and the acetylcholinesterase inhibitor pyridostigmine (pyr), both of which have anti-inflammatory properties, in the healing process of rotator cuff injury. |
2021-04-27 |
2023-08-13 |
Not clear |