| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Arjun Pitchai, Rajesh Kannan Rajaretinam, Rajasekar Mani, Nagasundaram Nagaraja. Molecular interaction of human acetylcholinesterase with Heliyon. vol 6. issue 9. 2020-10-02. PMID:32995619. |
acetylcholinesterase suppression is the common approach to enhance the well-being of ad patients by increasing the duration of acetylcholine in the cholinergic synapses. |
2020-10-02 |
2023-08-13 |
human |
| Dobrina Tsvetkova, Nikolai Danchev, Irina Nikolova, Danka Obreshkov. Pharmacological investigations of new galantamine peptide esters. Biotechnology, biotechnological equipment. vol 28. issue 1. 2020-10-01. PMID:26019502. |
galantamine hydrobromide (gal) is a reversible acetylcholinesterase inhibitor, with properties to increase the concentration of acetylcholine in several brain structures. |
2020-10-01 |
2023-08-13 |
mouse |
| Suman Chowdhury, Shivani, Suresh Kuma. In vitro anti-acetylcholinesterase activity of an aqueous extract of Unicaria tomentosa and in silico study of its active constituents. Bioinformation. vol 12. issue 3. 2020-10-01. PMID:28149044. |
enzyme acetylcholinesterase (ache) is responsible for destruction of acetylcholine (ach) in the brain. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jaymie R Voorhees, Diane S Rohlman, Pamela J Lein, Andrew A Piepe. Neurotoxicity in Preclinical Models of Occupational Exposure to Organophosphorus Compounds. Frontiers in neuroscience. vol 10. 2020-10-01. PMID:28149268. |
these compounds potently inhibit acetylcholinesterase (ache), the enzyme that inactivates acetylcholine at neuronal synapses, and acute exposure to high op levels can cause cholinergic crisis in humans and animals. |
2020-10-01 |
2023-08-13 |
Not clear |
| Lei Song, Xiaoping Li, Xiao-Xue Bai, Jian Gao, Chun-Yan Wan. Calycosin improves cognitive function in a transgenic mouse model of Alzheimer's disease by activating the protein kinase C pathway. Neural regeneration research. vol 12. issue 11. 2020-10-01. PMID:29239334. |
calycosin diminished hippocampal beta amyloid, tau protein, interleukin-1beta, tumor necrosis factor-alpha, acetylcholinesterase and malondialdehyde levels in a dose-dependent manner, and increased acetylcholine and glutathione activities. |
2020-10-01 |
2023-08-13 |
mouse |
| Stephen Brimijoin, Yang Gao, Liyi Geng, Vicky P Che. Treating Cocaine Addiction, Obesity, and Emotional Disorders by Viral Gene Transfer of Butyrylcholinesterase. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:29535625. |
butyrylcholinesterase (bche), a plasma enzyme that hydrolyses the neurotransmitter, acetylcholine relatively well, with far lower efficiency than acetylcholinesterase (ache) but with the capability to degrade a broad range of bioactive esters. |
2020-10-01 |
2023-08-13 |
mouse |
| Konstantin A Petrov, Evgeny E Nikolsky, Patrick Masso. Autoregulation of Acetylcholine Release and Micro-Pharmacodynamic Mechanisms at Neuromuscular Junction: Selective Acetylcholinesterase Inhibitors for Therapy of Myasthenic Syndromes. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:30050445. |
autoregulation of acetylcholine release and micro-pharmacodynamic mechanisms at neuromuscular junction: selective acetylcholinesterase inhibitors for therapy of myasthenic syndromes. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yu Wang, Jia Xia, Mengjun Shen, Yifan Zhou, Zhe Wu, Yuhuan Shi, Jianrong Xu, Lina Hou, Rui Zhang, Zhuibai Qiu, Qiong Xie, Hongzhuan Chen, Yongfang Zhang, Hao Wan. Effects of BIS-MEP on Reversing Amyloid Plaque Deposition and Spatial Learning and Memory Impairments in a Mouse Model of β-Amyloid Peptide- and Ibotenic Acid-Induced Alzheimer's Disease. Frontiers in aging neuroscience. vol 11. 2020-10-01. PMID:30723404. |
as classic drugs currently used in the clinic, acetylcholinesterase inhibitors (acheis) restore acetylcholine levels and relieve the symptoms of ad, but are insufficient at delaying the onset of ad. |
2020-10-01 |
2023-08-13 |
mouse |
| Azadeh Karami, Maria Eriksdotter, Ahmadul Kadir, Ove Almkvist, Agneta Nordberg, Taher Darreh-Shor. CSF Cholinergic Index, a New Biomeasure of Treatment Effect in Patients With Alzheimer's Disease. Frontiers in molecular neuroscience. vol 12. 2020-10-01. PMID:31680850. |
currently, three of four ad drugs act by inhibiting the acetylcholine (ach) degrading enzyme, acetylcholinesterase (ache). |
2020-10-01 |
2023-08-13 |
Not clear |
| Jin Ryul Hu, Yoon Seok Chun, Jong Kyu Kim, Il Je Cho, Sae Kwang K. Ginseng berry aqueous extract prevents scopolamine-induced memory impairment in mice. Experimental and therapeutic medicine. vol 18. issue 6. 2020-10-01. PMID:31772634. |
additionally, gbe prevented scp-induced reductions in acetylcholine by decreasing acetylcholinesterase activity and upregulating choline acetyltransferase mrna levels in the hippocampus. |
2020-10-01 |
2023-08-13 |
mouse |
| Zahiruddin Othman, Rahimah Zakaria, Nik Hazlina Nik Hussain, Asma' Hassan, Nazlahshaniza Shafin, Badriya Al-Rahbi, Asma Hayati Ahma. Potential Role of Honey in Learning and Memory. Medical sciences (Basel, Switzerland). vol 3. issue 2. 2020-09-30. PMID:29083387. |
these studies show that tualang honey improves morphology of memory-related brain areas, reduces brain oxidative stress, increases brain-derived neurotrophic factor (bdnf) and acetylcholine (ach) concentrations, and reduces acetylcholinesterase (ache) in the brain homogenates. |
2020-09-30 |
2023-08-13 |
human |
| Adriana M Dos Santos, Ariele C Moreira, Bianca Rebelo Lopes, Mariana F Fracola, Fernando G de Almeida, Odair C Bueno, Quezia B Cass, Dulce Helena F Souz. Acetylcholinesterases from Leaf-Cutting ant Enzyme research. vol 2019. 2020-09-30. PMID:31354985. |
acetylcholinesterases from leaf-cutting ant acetylcholinesterase (ache) is responsible for catalyzing the hydrolysis of the neurotransmitter acetylcholine (ach) leading to acetate and choline (ch) release. |
2020-09-30 |
2023-08-13 |
Not clear |
| Song-Hee Han, Sung-June Kim, Young Won Yun, Sang Yoon Nam, Hu-Jang Lee, Beom-Jun Le. Protective effects of cultured and fermented ginseng extracts against scopolamine-induced memory loss in a mouse model. Laboratory animal research. vol 34. issue 1. 2020-09-29. PMID:29628975. |
hljg0701-treated groups displayed significantly reduced acetylcholinesterase activity and increased acetylcholine level compared with the spl-administered group (spl-g) ( |
2020-09-29 |
2023-08-13 |
mouse |
| Rohit Pardeshi, Nityanand Bolshette, Kundlik Gadhave, Mohammad Arfeen, Sahabuddin Ahmed, Rohitash Jamwal, Bruce D Hammock, Mangala Lahkar, Sumanta Kumar Goswam. Docosahexaenoic Acid Increases the Potency of Soluble Epoxide Hydrolase Inhibitor in Alleviating Streptozotocin-Induced Alzheimer's Disease-Like Complications of Diabetes. Frontiers in pharmacology. vol 10. 2020-09-28. PMID:31068802. |
the activity of acetylcholinesterase (ache) which metabolizes acetylcholine was increased in the brain of diabetic rats. |
2020-09-28 |
2023-08-13 |
rat |
| Qing-Guang Liu, Qiang-Min Huang, Lin Liu, Thi-Tham Nguye. Structural and functional abnormalities of motor endplates in rat skeletal model of myofascial trigger spots. Neuroscience letters. vol 711. 2020-09-28. PMID:31398457. |
c1 and m1 were used for acetylcholine (ach) content measurement, while c2 and m2 were utilized for acetylcholinesterase (ache) staining. |
2020-09-28 |
2023-08-13 |
human |
| Valentina Gatta, Guadalupe Mengod, Marcella Reale, Ada Maria Tat. Possible Correlation between Cholinergic System Alterations and Neuro/Inflammation in Multiple Sclerosis. Biomedicines. vol 8. issue 6. 2020-09-28. PMID:32521719. |
the correlation between the increased activity of the cholinergic hydrolyzing enzymes acetylcholinesterase and butyrylcholinesterase, the reduced levels of acetylcholine and the increase of pro-inflammatory cytokines production were recently described in immune cells of ms patients. |
2020-09-28 |
2023-08-13 |
mouse |
| Jee Hyun Yi, Daniel J Whitcomb, Se Jin Park, Celia Martinez-Perez, Saviana A Barbati, Scott J Mitchell, Kwangwook Ch. M1 muscarinic acetylcholine receptor dysfunction in moderate Alzheimer's disease pathology. Brain communications. vol 2. issue 2. 2020-09-28. PMID:32766549. |
acetylcholinesterase inhibitors are one of the few treatment options for alzheimer's disease, where levels of available acetylcholine are enhanced to counteract the cholinergic loss. |
2020-09-28 |
2023-08-13 |
Not clear |
| Muhammad Niazi, Qasim Z Iqbal, Zeeshan Zia, Saud Bin Abdul Sattar, James Laffert. Rare Case of Iatrogenic Myocardial Infarction Induced by Use of Pyridostigmine. Cureus. vol 12. issue 8. 2020-09-28. PMID:32953356. |
treatment options include acetylcholinesterase medications that cause a wide range of side-effects by increasing the concentration of acetylcholine at the synaptic cleft. |
2020-09-28 |
2023-08-13 |
Not clear |
| Yameng Han, Zhongju Ye, Fuyan Wang, Tianyu Chen, Lin Wei, Langxing Chen, Lehui Xia. Single-particle enumeration-based ultrasensitive enzyme activity quantification with fluorescent polymer nanoparticles. Nanoscale. vol 11. issue 31. 2020-09-11. PMID:31353389. |
acetylcholinesterase (ache) plays a vital role in nerve conduction through rapidly hydrolyzing the neurotransmitter acetylcholine (ach) and is correlated with alzheimer's disease. |
2020-09-11 |
2023-08-13 |
human |
| Yijie Chen, Yue Zhang, Jia Zhuang, Joo Hee Lee, Licheng Wang, Ronnie H Fang, Weiwei Gao, Liangfang Zhan. Cell-Membrane-Cloaked Oil Nanosponges Enable Dual-Modal Detoxification. ACS nano. vol 13. issue 6. 2020-08-27. PMID:31117372. |
by inhibiting acetylcholinesterase, ops cause the accumulation of acetylcholine, which leads to neuromuscular disorders and even death. |
2020-08-27 |
2023-08-13 |
mouse |