| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S D Varfolomeev, V I Bykov, S B Tsybenov. Kinetics of Chemical Processes in the Human Brain. The Cholinergic Synapse-Mechanisms of Functioning and Control Methods. Doklady. Biochemistry and biophysics. vol 492. issue 1. 2021-01-29. PMID:32632593. |
the results of mathematical modeling of changes in the level of acetylcholine, induced ph impulse, the influence of the frequency of impulse transmission and inhibition of acetylcholinesterase are presented. |
2021-01-29 |
2023-08-13 |
human |
| Kevin B Temeyer, Kristie G Schlechte, Pia U Olafson, Barbara S Drolet, Jason P Tidwell, Weste L A Osbrink, Allan T Showler, Aaron D Gross, Adalberto A Pérez de Leó. Association of Salivary Cholinesterase With Arthropod Vectors of Disease. Journal of medical entomology. vol 57. issue 6. 2021-01-27. PMID:32459332. |
acetylcholinesterase (ache) was previously reported to be present in saliva of the southern cattle tick, rhipicephalus (boophilus) microplus (canestrini), with proposed potential functions to 1) reduce acetylcholine toxicity during rapid engorgement, 2) modulate host immune responses, and 3) to influence pathogen transmission and establishment in the host. |
2021-01-27 |
2023-08-13 |
cattle |
| Chun Wang, Zhaopeng Shen, Junhong Yu, Jieru Yang, Fei Meng, Xiaolu Jiang, Changliang Zh. Protective effects of enzyme degradation extract from The British journal of nutrition. vol 123. issue 9. 2021-01-25. PMID:31787131. |
the pyede also renewed the glutathione peroxidase (gsh-px), superoxide dismutase and total antioxidant capability activities, down-regulated the inducible nitric oxide synthase activity and nitric oxide levels, normalised the hippocampal neurons and modulated multiple neurotransmitter systems by inhibiting the activities of acetylcholinesterase and monoamine oxidase in the up-regulation of acetylcholine, dopamine and noradrenaline levels. |
2021-01-25 |
2023-08-13 |
mouse |
| Zhe Ying Ha, Shintu Mathew, Keng Yoon Yeon. Butyrylcholinesterase: A Multifaceted Pharmacological Target and Tool. Current protein & peptide science. vol 21. issue 1. 2021-01-22. PMID:31702488. |
unlike its sister enzyme acetylcholinesterase, butyrylcholinesterase has a broad substrate scope and lower acetylcholine catalytic efficiency. |
2021-01-22 |
2023-08-13 |
Not clear |
| Jayeong Hwang, Kumju Youn, Yeongseon Ji, Seonah Lee, Gyutae Lim, Jinhyuk Lee, Chi-Tang Ho, Sun-Hee Leem, Mira Ju. Biological and Computational Studies for Dual Cholinesterases Inhibitory Effect of Zerumbone. Nutrients. vol 12. issue 5. 2021-01-20. PMID:32344943. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) mediate the degradation of acetylcholine (ach), a primary neurotransmitter in the brain. |
2021-01-20 |
2023-08-13 |
Not clear |
| James J Sejva. Neurochemical and Neurobiological Weapons. Neurologic clinics. vol 38. issue 4. 2021-01-20. PMID:33040867. |
acetylcholinesterase inhibitors act by increasing the amount of acetylcholine in the neuromuscular junction, resulting in flaccid paralysis. |
2021-01-20 |
2023-08-13 |
Not clear |
| Mohamad Rima, Yara Lattouf, Maroun Abi Younes, Erika Bullier, Pascal Legendre, Jean-Marie Mangin, Elim Hon. Dynamic regulation of the cholinergic system in the spinal central nervous system. Scientific reports. vol 10. issue 1. 2021-01-19. PMID:32948826. |
in 1-day-old embryos, we show that spinal motoneurons express presynaptic cholinergic genes including choline acetyltransferase (chata), vesicular acetylcholine transporters (vachta, vachtb), high-affinity choline transporter (hacta) and acetylcholinesterase (ache), while nicotinic acetylcholine receptor (nachr) subunits are mainly expressed in interneurons. |
2021-01-19 |
2023-08-13 |
zebrafish |
| Shumon I Dhar, Nogah Nativ-Zeltzer, Omid B Mehdizadeh, Apoorva T Ramaswamy, Yuval Nachalon, Peter C Belafsk. Effects of Pyridostigmine on Esophageal and Pharyngeal Motility in Dysphagic Patients Undergoing High-Resolution Manometry. Dysphagia. 2021-01-16. PMID:33452552. |
pyridostigmine is an acetylcholinesterase inhibitor which increases effective concentrations of acetylcholine at the neuromuscular junction of both striated and smooth muscle cells. |
2021-01-16 |
2023-08-13 |
Not clear |
| Dan Wu, Shuyu Zhang, Na Sun, Beiwei Zhu, Songyi Li. Neuroprotective Function of a Novel Hexapeptide QMDDQ from Shrimp via Activation of the PKA/CREB/BNDF Signaling Pathway and Its Structure-Activity Relationship. Journal of agricultural and food chemistry. vol 68. issue 24. 2021-01-13. PMID:32452680. |
biochemical results revealed that both peptides exhibited neuroprotective effects by increasing acetylcholine (ach) content and inhibiting acetylcholinesterase (ache) activity in pc12 cells; qmddq was more active than kmddq. |
2021-01-13 |
2023-08-13 |
mouse |
| Yu Wu, Jiabin Wu, Lei Jiao, Weiqing Xu, Hengjia Wang, Xiaoqian Wei, Wenling Gu, Guoxi Ren, Nian Zhang, Qinghua Zhang, Liang Huang, Lin Gu, Chengzhou Zh. Cascade Reaction System Integrating Single-Atom Nanozymes with Abundant Cu Sites for Enhanced Biosensing. Analytical chemistry. vol 92. issue 4. 2020-12-30. PMID:31941278. |
integrating cu-n-c sazymes with natural acetylcholinesterase and choline oxidase, three-enzyme-based cascade reaction system was constructed for the colorimetric detection of acetylcholine and organophosphorus pesticides. |
2020-12-30 |
2023-08-13 |
Not clear |
| Eun-A Jang, Tae-Young Kim, Eu-Gene Jung, Seongtae Jeong, Hong-Beom Bae, Seongheon Le. Donepezil-related inadequate neuromuscular blockade during laparoscopic surgery: A case report. World journal of clinical cases. vol 8. issue 21. 2020-12-30. PMID:33269268. |
donepezil is an acetylcholinesterase inhibitor used to improve cognition and delay disease progression in dementia patients by increasing acetylcholine levels. |
2020-12-30 |
2023-08-13 |
Not clear |
| Wildson Max Barbosa da Silva, Solange de Oliveira Pinheiro, Daniela Ribeiro Alves, Jane Eire Silva Alencar de Menezes, Francisco Ernani Alves Magalhães, Francisca Crislândia Oliveira Silva, Jacilene Silva, Emmanuel Silva Marinho, Selene Maia de Morai. Synthesis of Quercetin-Metal Complexes, In Vitro and In Silico Anticholinesterase and Antioxidant Evaluation, and In Vivo Toxicological and Anxiolitic Activities. Neurotoxicity research. vol 37. issue 4. 2020-12-21. PMID:31853730. |
the level of acetylcholine, a neurotransmitter essential for processing memory and learning, is lower in the brains of patients with alzheimer's disease due to the higher concentration of the enzyme acetylcholinesterase. |
2020-12-21 |
2023-08-13 |
Not clear |
| Ewa Baranowska-Wójcik, Dominik Szwajgier, Anna Winiarska-Miecza. Regardless of the Brewing Conditions, Various Types of Tea are a Source of Acetylcholinesterase Inhibitors. Nutrients. vol 12. issue 3. 2020-12-21. PMID:32155927. |
acetylcholinesterase (ache) plays a significant role in the process through hydrolysis of the acetylcholine neurotransmitter. |
2020-12-21 |
2023-08-13 |
Not clear |
| Arnavaz Hajizadeh Barfejani, Mahbod Jafarvand, Seyed Mohammad Seyedsaadat, Roozbeh Tarighati Rasekh. Donepezil in the treatment of ischemic stroke: Review and future perspective. Life sciences. vol 263. 2020-12-15. PMID:33058916. |
donepezil, an acetylcholinesterase inhibitor, improves cognition and global function in patients with alzheimer's and vascular dementia via modulation of acetylcholine receptors and downstream inflammatory response. |
2020-12-15 |
2023-08-13 |
Not clear |
| Jennifer N Pearson-Smith, Manisha Pate. Antioxidant drug therapy as a neuroprotective countermeasure of nerve agent toxicity. Neurobiology of disease. vol 133. 2020-12-14. PMID:31028872. |
nerve agents initiate neurotoxicity by the irreversible inhibition of acetylcholinesterase and resultant accumulation of acetylcholine in excitable tissues. |
2020-12-14 |
2023-08-13 |
Not clear |
| Khalid Bashir Dar, Aashiq Hussain Bhat, Shajrul Amin, Bilal Ahmad Reshi, Mohammad Afzal Zargar, Akbar Masood, Showkat Ahmad Gani. Elucidating Critical Proteinopathic Mechanisms and Potential Drug Targets in Neurodegeneration. Cellular and molecular neurobiology. vol 40. issue 3. 2020-12-07. PMID:31584139. |
we explicate the role of key neuroproteomic drug targets notably aβ, tau, alpha synuclein, prions, secretases, acetylcholinesterase (ache), lrrk2, molecular chaperones, a2a receptors, muscarinic acetylcholine receptors (machr), n-methyl-d-aspartate receptor (nmdar), glial cell line-derived neurotrophic factor (gdnf) family ligands (gfls) and mitochondrial/oxidative stress-related proteins for combating neurodegeneration and associated cognitive and motor impairment. |
2020-12-07 |
2023-08-13 |
Not clear |
| Ye Lu, Min Wei, Chenchen Wang, Wei Wei, Yong Li. Enhancing hydrogel-based long-lasting chemiluminescence by a platinum-metal organic framework and its application in array detection of pesticides and d-amino acids. Nanoscale. vol 12. issue 8. 2020-12-04. PMID:32053129. |
under the catalysis of acetylcholinesterase (ache) and choline oxidase (cho), h2o2 was produced by using acetylcholine chloride (ach) as a substrate, which was sensitive to the proposed cl system. |
2020-12-04 |
2023-08-13 |
human |
| Rui Sha, Yangsheng Chen, Yijing Wang, Yali Luo, Yiyun Liu, Yongchao Ma, Yunping Li, Li Xu, Heidi Qunhui Xie, Bin Zha. Gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice: Neurobehavioral effects on female offspring. The Science of the total environment. vol 752. 2020-11-18. PMID:32889265. |
in accordance with the potential enhancement of cholinergic neurotransmission due to the gene upregulations, the enzymatic activity of acetylcholinesterase was decreased, which might lead to excess acetylcholine and consequent hyper-excitation at the synapses. |
2020-11-18 |
2023-08-13 |
mouse |
| J B Greer, J T Magnuson, K Hester, M Giroux, C Pope, T Anderson, J Liu, V Dang, N D Denslow, D Schlen. Effects of Chlorpyrifos on Cholinesterase and Serine Lipase Activities and Lipid Metabolism in Brains of Rainbow Trout (Oncorhynchus mykiss). Toxicological sciences : an official journal of the Society of Toxicology. 2020-11-01. PMID:31359069. |
chlorpyrifos is an organophosphorus insecticide that elicits acute toxicity through inhibition of acetylcholinesterase (ache), leading to acetylcholine accumulation and prolonged stimulation of cholinergic receptors throughout the central and peripheral nervous systems. |
2020-11-01 |
2023-08-13 |
Not clear |
| Si Chen, Zhengdong Lin, Kai-Leng Tan, Risheng Chen, Wenfang Su, Haishan Zhao, Qiwen Tan, Wen Ta. Enhanced Contextual Fear Memory and Elevated Astroglial Glutamate Synthase Activity in Hippocampal CA1 BChE shRNA Knockdown Mice. Frontiers in psychiatry. vol 11. 2020-10-22. PMID:33061920. |
butyrylcholinesterase (bche) efficiently hydrolyzes acetylcholine (ach) at high concentrations when acetylcholinesterase (ache) is substrate-inhibited. |
2020-10-22 |
2023-08-13 |
mouse |