| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Kre\\xc5\\xa1imir Baumann, Lorena Kordi\\xc4\\x87, Marko Mo\\xc4\\x8dibob, Goran \\xc5\\xa0inko, Sr\\xc4\\x91anka Tomi\\xc4\\x8. Synthesis and In Vitro Screening of Novel Heterocyclic \\xce\\xb2-d-Gluco- and \\xce\\xb2-d-Galactoconjugates as Butyrylcholinesterase Inhibitors. Molecules (Basel, Switzerland). vol 24. issue 15. 2020-01-14. PMID:31382668.' |
the development of selective butyrylcholinesterase (bche) inhibitors may improve the treatment of alzheimer's disease by increasing lower synaptic levels of the neurotransmitter acetylcholine, which is hydrolysed by acetylcholinesterase, as well as by overexpressed bche. |
2020-01-14 |
2023-08-13 |
Not clear |
| Thaddeus P Thomas, Amy Wegener, Tsung-Ming Shi. In Vivo Evaluation of A1 Adenosine Agonists as Novel Anticonvulsant Medical Countermeasures to Nerve Agent Intoxication in a Rat Soman Seizure Model. Neurotoxicity research. vol 36. issue 2. 2020-01-02. PMID:31069755. |
organophosphorus nerve agents (nas) irreversibly inhibit acetylcholinesterase, which results in the accumulation of acetylcholine and widespread excitotoxic seizure activity. |
2020-01-02 |
2023-08-13 |
rat |
| Eunjin Sohn, Hye-Sun Lim, Yu Jin Kim, Bu-Yeo Kim, Joo-Hwan Kim, Soo-Jin Jeon. Nutrients. vol 11. issue 6. 2019-12-30. PMID:31141948. |
acetylcholine (ach) levels and acetylcholinesterase (ache) activity were measured via an enzyme-linked immunosorbent assay (elisa). |
2019-12-30 |
2023-08-13 |
mouse |
| Yaghoub Pourshojaei, Khalil Eskandari, Ali Asadipou. Highly Significant Scaffolds to Design and Synthesis Cholinesterase Inhibitors as Anti-Alzheimer Agents. Mini reviews in medicinal chemistry. vol 19. issue 19. 2019-12-26. PMID:31538893. |
based on the cholinergic hypothesis, and xray crystallographic determination of the structure of acetylcholinesterase (ache) enzyme, the level of acetylcholine (ach, an important neurotransmitter associated with memory) in the hippocampus and cortex area of the brain has a direct effect on alzheimer. |
2019-12-26 |
2023-08-13 |
Not clear |
| Takayoshi Masuoka, Junsuke Uwada, Makiko Kudo, Hatsumi Yoshiki, Yuka Yamashita, Takanobu Taniguchi, Matomo Nishio, Takaharu Ishibashi, Ikunobu Muramats. Augmentation of Endogenous Acetylcholine Uptake and Cholinergic Facilitation of Hippocampal Long-Term Potentiation by Acetylcholinesterase Inhibition. Neuroscience. vol 404. 2019-12-24. PMID:30708046. |
augmentation of endogenous acetylcholine uptake and cholinergic facilitation of hippocampal long-term potentiation by acetylcholinesterase inhibition. |
2019-12-24 |
2023-08-13 |
Not clear |
| John A Bennett, Sara K Ture, Rachel A Schmidt, Michael A Mastrangelo, Scott J Cameron, Lara E Terry, David I Yule, Craig N Morrell, Charles J Lowenstei. Acetylcholine Inhibits Platelet Activation. The Journal of pharmacology and experimental therapeutics. vol 369. issue 2. 2019-12-20. PMID:30765424. |
furthermore, drugs inhibiting acetylcholinesterase, such as donepezil, also inhibit platelet activation, suggesting that platelets release acetylcholine. |
2019-12-20 |
2023-08-13 |
human |
| Zrinka Kovarik, Jarosław Kalisiak, Nikolina Maček Hrvat, Maja Katalinić, Tamara Zorbaz, Suzana Žunec, Carol Green, Zoran Radić, Valery V Fokin, K Barry Sharpless, Palmer Taylo. Reversal of Tabun Toxicity Enabled by a Triazole-Annulated Oxime Library-Reactivators of Acetylcholinesterase. Chemistry (Weinheim an der Bergstrasse, Germany). vol 25. issue 16. 2019-11-26. PMID:30458057. |
acetylcholinesterase (ache), an enzyme that degrades the neurotransmitter acetylcholine, when covalently inhibited by organophosphorus compounds (ops), such as nerve agents and pesticides, can be reactivated by oximes. |
2019-11-26 |
2023-08-13 |
mouse |
| Doretti, Ferrara, Lora, Schiavon, Verones. Acetylcholine biosensor involving entrapment of acetylcholinesterase and poly(ethylene glycol)-modified choline oxidase in a poly(vinyl alcohol) cryogel membrane. Enzyme and microbial technology. vol 27. issue 3-5. 2019-11-20. PMID:10899554. |
acetylcholine biosensor involving entrapment of acetylcholinesterase and poly(ethylene glycol)-modified choline oxidase in a poly(vinyl alcohol) cryogel membrane. |
2019-11-20 |
2023-08-12 |
Not clear |
| Doretti, Ferrara, Lora, Schiavon, Verones. Acetylcholine biosensor involving entrapment of acetylcholinesterase and poly(ethylene glycol)-modified choline oxidase in a poly(vinyl alcohol) cryogel membrane. Enzyme and microbial technology. vol 27. issue 3-5. 2019-11-20. PMID:10899554. |
a bienzymatic sensor for the determination of acetylcholine was prepared by physical coimmobilization of acetylcholinesterase and poly(ethylene glycol)-modified choline oxidase in a poly(vinyl alcohol) cryogel membrane obtained by a cyclic freezing-thawing process. |
2019-11-20 |
2023-08-12 |
Not clear |
| J -P. Changeux, W Leuzinger, M Huche. Specific binding of acetylcholine to acetylcholinesterase in the presence of eserine. FEBS letters. vol 2. issue 2. 2019-11-20. PMID:11946273. |
specific binding of acetylcholine to acetylcholinesterase in the presence of eserine. |
2019-11-20 |
2023-08-12 |
Not clear |
| b' Matej Ku\\xc4\\x8dera, Anna Hrabovsk\\xc3\\xa. [Cholinergic system of the heart]. Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti. vol 63. issue 6. 2019-11-20. PMID:26837871.' |
the effect of acetylcholine in the heart is terminated by cholinesterases acetylcholinesterase and butyrylcholinesterase. |
2019-11-20 |
2023-08-13 |
Not clear |
| Takao Hashimoto, Bo Yang, Yuri Okazaki, Ikumi Yoshizawa, Kaori Kajihara, Norihisa Kato, Masanobu Wada, Noriyuki Yanak. Time Course Analysis of Skeletal Muscle Pathology of GDE5 Transgenic Mouse. PloS one. vol 11. issue 9. 2019-11-20. PMID:27658304. |
this study also demonstrated compensatory mrna expression of neuromuscular junction (nmj) components, including nicotinic acetylcholine receptors (α1, γ, and ε subunits) and acetylcholinesterase in type ii fiber-rich quadriceps muscles in gde5dc471 mice. |
2019-11-20 |
2023-08-13 |
mouse |
| Drugs licensed for treating patients with alzheimer's disease. Nursing older people. vol 24. issue 6. 2019-11-20. PMID:27750512. |
cholinesterase inhibitors increase the availability of acetylcholine at the synaptic cleft between neurones by preventing its breakdown by the enzyme acetylcholinesterase. |
2019-11-20 |
2023-08-13 |
Not clear |
| Takeshi Fujii, Masato Mashimo, Yasuhiro Moriwaki, Hidemi Misawa, Shiro Ono, Kazuhide Horiguchi, Koichiro Kawashim. Expression and Function of the Cholinergic System in Immune Cells. Frontiers in immunology. vol 8. 2019-11-20. PMID:28932225. |
t and b cells express most cholinergic system components-e.g., acetylcholine (ach), choline acetyltransferase (chat), acetylcholinesterase, and both muscarinic and nicotinic ach receptors (machrs and nachrs, respectively). |
2019-11-20 |
2023-08-13 |
Not clear |
| Masahiro Tabuchi, Keiko Fujikura, Sakae Inou. Histochemistry of acetylcholine receptors and acetylcholinesterase during the formation of neuromuscular junctions in the urodele Hynobius nigrescens. Journal of morphology. vol 207. issue 1. 2019-11-20. PMID:29865493. |
histochemistry of acetylcholine receptors and acetylcholinesterase during the formation of neuromuscular junctions in the urodele hynobius nigrescens. |
2019-11-20 |
2023-08-13 |
Not clear |
| Masahiro Tabuchi, Keiko Fujikura, Sakae Inou. Histochemistry of acetylcholine receptors and acetylcholinesterase during the formation of neuromuscular junctions in the urodele Hynobius nigrescens. Journal of morphology. vol 207. issue 1. 2019-11-20. PMID:29865493. |
the development and structure of neuromuscular junctions (n-m-js) in stylopodia of forelimbs of larvae and adults of hynobius nigrescens were histochemically investigated for acetylcholine receptors (achrs) and acetylcholinesterase (ache) activity. |
2019-11-20 |
2023-08-13 |
Not clear |
| Masoud Soheili, Mahmoud Salam. Lavandula angustifolia biological characteristics: An in vitro study. Journal of cellular physiology. 2019-11-20. PMID:30784075. |
the accumulation of amyloid beta (aβ) plaques, reduction of acetylcholine due to hyperactivity of acetylcholinesterase, and glutamate neurotoxicity are known to be involved in decreased level of cognitive function. |
2019-11-20 |
2023-08-13 |
Not clear |
| Tania M Godoy-Reyes, Antoni Llopis-Lorente, Alba García-Fernández, Pablo Gaviña, Ana M Costero, Ramón Martínez-Máñez, Félix Sancenó. Acetylcholine-responsive cargo release using acetylcholinesterase-capped nanomaterials. Chemical communications (Cambridge, England). vol 55. issue 41. 2019-11-20. PMID:31041959. |
mesoporous silica nanoparticles capped with acetylcholinesterase, through boronic ester linkages, selectively release an entrapped cargo in the presence of acetylcholine. |
2019-11-20 |
2023-08-13 |
Not clear |
| Cecelia Jackson, Cherish Ardinger, Kristin M Winter, John H McDonough, Hilary S McCarre. Validating a model of benzodiazepine refractory nerve agent-induced status epilepticus by evaluating the anticonvulsant and neuroprotective effects of scopolamine, memantine, and phenobarbital. Journal of pharmacological and toxicological methods. vol 97. 2019-11-18. PMID:30790623. |
organophosphorus nerve agents (opnas) irreversibly block acetylcholinesterase activity, resulting in accumulation of excess acetylcholine at neural synapses, which can lead to a state of prolonged seizures known as status epilepticus (se). |
2019-11-18 |
2023-08-13 |
rat |
| Xin Yuan, Xiao Teng, Yin Wang, Yuntai Ya. Recipient treatment with acetylcholinesterase inhibitor donepezil attenuates primary graft failure in rats through inhibiting post-transplantational donor heart ischaemia/reperfusion injury. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. vol 53. issue 2. 2019-11-15. PMID:28950359. |
we hypothesize that donepezil (do), a reversible acetylcholinesterase inhibitor that increases cholinergic receptor activation, may protect the transplanted heart through increasing the level of acetylcholine, which in turn inhibits systemic inflammation in the recipients. |
2019-11-15 |
2023-08-13 |
rat |