| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Drugs licensed for treating patients with alzheimer's disease. Nursing older people. vol 24. issue 6. 2019-11-20. PMID:27750512. |
cholinesterase inhibitors increase the availability of acetylcholine at the synaptic cleft between neurones by preventing its breakdown by the enzyme acetylcholinesterase. |
2019-11-20 |
2023-08-13 |
Not clear |
| Takeshi Fujii, Masato Mashimo, Yasuhiro Moriwaki, Hidemi Misawa, Shiro Ono, Kazuhide Horiguchi, Koichiro Kawashim. Expression and Function of the Cholinergic System in Immune Cells. Frontiers in immunology. vol 8. 2019-11-20. PMID:28932225. |
t and b cells express most cholinergic system components-e.g., acetylcholine (ach), choline acetyltransferase (chat), acetylcholinesterase, and both muscarinic and nicotinic ach receptors (machrs and nachrs, respectively). |
2019-11-20 |
2023-08-13 |
Not clear |
| Masahiro Tabuchi, Keiko Fujikura, Sakae Inou. Histochemistry of acetylcholine receptors and acetylcholinesterase during the formation of neuromuscular junctions in the urodele Hynobius nigrescens. Journal of morphology. vol 207. issue 1. 2019-11-20. PMID:29865493. |
histochemistry of acetylcholine receptors and acetylcholinesterase during the formation of neuromuscular junctions in the urodele hynobius nigrescens. |
2019-11-20 |
2023-08-13 |
Not clear |
| Masahiro Tabuchi, Keiko Fujikura, Sakae Inou. Histochemistry of acetylcholine receptors and acetylcholinesterase during the formation of neuromuscular junctions in the urodele Hynobius nigrescens. Journal of morphology. vol 207. issue 1. 2019-11-20. PMID:29865493. |
the development and structure of neuromuscular junctions (n-m-js) in stylopodia of forelimbs of larvae and adults of hynobius nigrescens were histochemically investigated for acetylcholine receptors (achrs) and acetylcholinesterase (ache) activity. |
2019-11-20 |
2023-08-13 |
Not clear |
| Masoud Soheili, Mahmoud Salam. Lavandula angustifolia biological characteristics: An in vitro study. Journal of cellular physiology. 2019-11-20. PMID:30784075. |
the accumulation of amyloid beta (aβ) plaques, reduction of acetylcholine due to hyperactivity of acetylcholinesterase, and glutamate neurotoxicity are known to be involved in decreased level of cognitive function. |
2019-11-20 |
2023-08-13 |
Not clear |
| Tania M Godoy-Reyes, Antoni Llopis-Lorente, Alba García-Fernández, Pablo Gaviña, Ana M Costero, Ramón Martínez-Máñez, Félix Sancenó. Acetylcholine-responsive cargo release using acetylcholinesterase-capped nanomaterials. Chemical communications (Cambridge, England). vol 55. issue 41. 2019-11-20. PMID:31041959. |
mesoporous silica nanoparticles capped with acetylcholinesterase, through boronic ester linkages, selectively release an entrapped cargo in the presence of acetylcholine. |
2019-11-20 |
2023-08-13 |
Not clear |
| Cecelia Jackson, Cherish Ardinger, Kristin M Winter, John H McDonough, Hilary S McCarre. Validating a model of benzodiazepine refractory nerve agent-induced status epilepticus by evaluating the anticonvulsant and neuroprotective effects of scopolamine, memantine, and phenobarbital. Journal of pharmacological and toxicological methods. vol 97. 2019-11-18. PMID:30790623. |
organophosphorus nerve agents (opnas) irreversibly block acetylcholinesterase activity, resulting in accumulation of excess acetylcholine at neural synapses, which can lead to a state of prolonged seizures known as status epilepticus (se). |
2019-11-18 |
2023-08-13 |
rat |
| Xin Yuan, Xiao Teng, Yin Wang, Yuntai Ya. Recipient treatment with acetylcholinesterase inhibitor donepezil attenuates primary graft failure in rats through inhibiting post-transplantational donor heart ischaemia/reperfusion injury. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. vol 53. issue 2. 2019-11-15. PMID:28950359. |
we hypothesize that donepezil (do), a reversible acetylcholinesterase inhibitor that increases cholinergic receptor activation, may protect the transplanted heart through increasing the level of acetylcholine, which in turn inhibits systemic inflammation in the recipients. |
2019-11-15 |
2023-08-13 |
rat |
| Eng Leng Saw, Yoshihiko Kakinuma, Martin Fronius, Rajesh Katar. The non-neuronal cholinergic system in the heart: A comprehensive review. Journal of molecular and cellular cardiology. vol 125. 2019-10-28. PMID:30343172. |
the existence of cardiac nncs has been confirmed by the presence of cholinergic markers in the cardiomyocytes, which are crucial for synthesis (choline acetyltransferase, chat), storage (vesicular acetylcholine transporter, vacht), reuptake of choline for synthesis (high-affinity choline transporter, cht1) and degradation (acetylcholinesterase, ache) of acetylcholine (ach). |
2019-10-28 |
2023-08-13 |
Not clear |
| C David Andersson, Nicolas Martinez, Dominik Zeller, Anders Allgardsson, Michael M Koza, Bernhard Frick, Fredrik Ekström, Judith Peters, Anna Linusso. Influence of Enantiomeric Inhibitors on the Dynamics of Acetylcholinesterase Measured by Elastic Incoherent Neutron Scattering. The journal of physical chemistry. B. vol 122. issue 36. 2019-10-11. PMID:30110543. |
the enzyme acetylcholinesterase (ache) is essential in humans and animals because it catalyzes the breakdown of the nerve-signaling substance acetylcholine. |
2019-10-11 |
2023-08-13 |
Not clear |
| Ji Eun Kim, Ji Won Park, Mi Ju Kang, Hyeon Jun Choi, Su Ji Bae, Yusang Choi, Young Ju Lee, Sungbaek Seo, Jin Tae Hong, Dae Youn Hwan. Laxative Effect of Spicatoside A by Cholinergic Regulation of Enteric Nerve in Loperamide-Induced Constipation: ICR Mice Model. Molecules (Basel, Switzerland). vol 24. issue 5. 2019-10-07. PMID:30836659. |
furthermore, significant improvements were observed in the acetylcholinesterase (ache) activity and acetylcholine receptors' (achrs) downstream signaling pathway after treatment of spia. |
2019-10-07 |
2023-08-13 |
mouse |
| Robert Josef Nachlinger, Vivien Kauschke, Katja Trinkaus, Thaqif El Khassawna, Christian Heiss, Katrin Susanne Lip. Application of donepezil increased collagen 1 expression in mesenchymal stroma cells of an ovine osteoporosis model. Journal of musculoskeletal & neuronal interactions. vol 18. issue 3. 2019-09-30. PMID:30179213. |
donepezil inhibits the acetylcholine degradation molecule acetylcholinesterase (ache). |
2019-09-30 |
2023-08-13 |
Not clear |
| Fatma M Abdel Bar, Diaaeldin M Elimam, Amira S Mira, Fardous F El-Senduny, Farid A Badri. Derivatization, molecular docking and Natural product research. vol 33. issue 18. 2019-09-20. PMID:29656653. |
derivatization, molecular docking and acetylcholinesterase inhibitors (ache-is) increase both level and duration of action of acetylcholine (ach); thus, alleviate symptoms of alzheimer's disease (ad). |
2019-09-20 |
2023-08-13 |
Not clear |
| Cheng Chen, Lin-Fei He, Jia-Nan Zhang, Yi Zhan. Effect of acetylcholine in rat brain in promoting early recovery of spinal cord injury by inhibiting monoamine oxidase enzyme: A pre-clinical evidence. Pakistan journal of pharmaceutical sciences. vol 31. issue 6(Special). 2019-09-03. PMID:30630780. |
acetylcholine inhibited acetylcholinesterase enzyme and mao isoform (mao-a or -b) in the cerebral cortex. |
2019-09-03 |
2023-08-13 |
rat |
| Muhammed Khairujjaman Mazumder, Shuvasish Choudhur. Tea polyphenols as multi-target therapeutics for Alzheimer's disease: An in silico study. Medical hypotheses. vol 125. 2019-08-27. PMID:30902161. |
with neurodegeneration, the level of the neurotransmitter acetylcholine (ach), as well as acetylcholinesterase (ache), decreases in the synaptic cleft, called cholinergic deficiency. |
2019-08-27 |
2023-08-13 |
Not clear |
| Alena Komersová, Markéta Kovářová, Karel Komers, Václav Lochař, Alexander Čega. Why is the hydrolytic activity of acetylcholinesterase pH dependent? Kinetic study of acetylcholine and acetylthiocholine hydrolysis catalyzed by acetylcholinesterase from electric eel. Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 73. issue 9-10. 2019-08-19. PMID:29936491. |
kinetic study of acetylcholine and acetylthiocholine hydrolysis catalyzed by acetylcholinesterase from electric eel. |
2019-08-19 |
2023-08-13 |
Not clear |
| b' Maja D Vitorovi\\xc4\\x87-Todorovi\\xc4\\x87, Franz Worek, Andrej Perdih, Sonja \\xc4\\x90 Bauk, Tamara B Vujatovi\\xc4\\x87, Ilija N Cvijeti\\xc4\\x8. The in vitro protective effects of the three novel nanomolar reversible inhibitors of human cholinesterases against irreversible inhibition by organophosphorous chemical warfare agents. Chemico-biological interactions. vol 309. 2019-08-19. PMID:31228470.' |
acetylcholinesterase (ache) is an enzyme which terminates the cholinergic neurotransmission, by hydrolyzing acetylcholine at the nerve and nerve-muscle junctions. |
2019-08-19 |
2023-08-13 |
human |
| Nashwa H Ashmawy, Abdulrahman A Almehizia, Teraze A Youssef, Abd El-Galil E Amr, Mohamed A Al-Omar, Ayman H Kame. Novel Carbon/PEDOT/PSS-Based Screen-Printed Biosensors for Acetylcholine Neurotransmitter and Acetylcholinesterase Detection in Human Serum. Molecules (Basel, Switzerland). vol 24. issue 8. 2019-08-12. PMID:31003551. |
novel carbon/pedot/pss-based screen-printed biosensors for acetylcholine neurotransmitter and acetylcholinesterase detection in human serum. |
2019-08-12 |
2023-08-13 |
human |
| Rosa Purgatorio, Modesto de Candia, Marco Catto, Antonio Carrieri, Leonardo Pisani, Annalisa De Palma, Maddalena Toma, Olga A Ivanova, Leonid G Voskressensky, Cosimo D Altomar. Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease. European journal of medicinal chemistry. vol 177. 2019-07-25. PMID:31158754. |
due to the role of butyrylcholinesterase (bche) in acetylcholine hydrolysis in the late stages of the alzheimer's disease (ad), inhibitors of butyrylcholinesterase (bche) have been recently envisaged, besides acetylcholinesterase (ache) inhibitors, as candidates for treating mild-to-moderate ad. |
2019-07-25 |
2023-08-13 |
Not clear |
| Miranda L Xu, Wilson K W Luk, Etta Y L Liu, Xiang P Kong, Qi Y Wu, Ying J Xia, Tina T X Dong, Karl W K Tsi. Differentiation of erythroblast requires the dimeric form of acetylcholinesterase: Interference with erythropoietin receptor. Chemico-biological interactions. vol 308. 2019-07-22. PMID:31170385. |
acetylcholinesterase (ache) hydrolyzes acetylcholine at cholinergic synapses, and which has various isoforms of ache, i.e. |
2019-07-22 |
2023-08-13 |
Not clear |