| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ashwaq H Bataw. The International journal of neuroscience. vol 134. issue 1. 2024-01-16. PMID:35634646. |
alzheimer's disease (ad) appears as a result of an increase in the accumulation of amyloid beta peptide (aβ) and a decrease in neurotransmitters (acetylcholine) within the brain cells which may be due to increase in acetylcholinesterase (ache) activity and change in expression of apolipoprotein e4 (apoe4) and clusterin (clu) genes. |
2024-01-16 |
2024-01-19 |
Not clear |
| Géssica Oliveira Mendes, Moysés Fagundes de Araújo Neto, Deyse Brito Barbosa, Mayra Ramos do Bomfim, Lorena Silva Matos Andrade, Paulo Batista de Carvalho, Tiago Alves de Oliveira, Daniel Luciano Falkoski, Eduardo Habib Bechelane Maia, Marcelo Siqueira Valle, Laila Cristina Moreira Damázio, Alisson Marques da Silva, Alex Gutterres Taranto, Franco Henrique Andrade Leit. Identification of Potential Multitarget Compounds against Alzheimer's Disease through Pharmacophore-Based Virtual Screening. Pharmaceuticals (Basel, Switzerland). vol 16. issue 12. 2023-12-23. PMID:38139772. |
this study aims to present new multipurpose compounds capable of simultaneously inhibiting acetylcholinesterase (ache), butyrylcholinesterase (bche)-responsible for recycling acetylcholine in the synaptic cleft-and beta-secretase 1 (bace-1)-responsible for the generation of amyloid-β plaques. |
2023-12-23 |
2023-12-25 |
Not clear |
| Hussian Maanaki, Terry Xu, Guibing Chen, Xiuxia Du, Jun Wan. Development of integrated smartphone/resistive biosensor for on-site rapid environmental monitoring of organophosphate pesticides in food and water. Biosensors & bioelectronics: X. vol 15. 2023-12-21. PMID:38124900. |
the biosensor leverages the hydrolytic activity of acetylcholinesterase (ache) to its substrate, acetylcholine (ach), and unique transport properties of polyaniline nanofibers (pannfs) of chitosan/ache/pannf/carbon nanotube (cnt) nanocomposite film on a gold interdigitated electrode. |
2023-12-21 |
2023-12-23 |
Not clear |
| Bing Zhang, Yu Wang, Donghui Wu, Qilin Zhao, Yaoyao Chen, Yushu Li, Jian Sun, Xiurong Yan. Fluorescent assay for acetylcholinesterase activity and inhibitor screening based on lanthanide organic/inorganic hybrid materials. Analytical methods : advancing methods and applications. 2023-12-20. PMID:38116865. |
it is of great significance for the clinical diagnosis of alzheimer's disease (ad) to achieve the on-site activity evaluation of acetylcholinesterase (ache), the hydrolase of acetylcholine (ach). |
2023-12-20 |
2023-12-23 |
Not clear |
| Heba-Tallah Abd Elrahim Abd Elkader, Marium Marzoq Hussein, Nema A Mohammed, Heba M Abdo. The protective role of L-carnitine on oxidative stress, neurotransmitter perturbations, astrogliosis, and apoptosis induced by thiamethoxam in the brains of male rats. Naunyn-Schmiedeberg's archives of pharmacology. 2023-12-15. PMID:38099937. |
our results revealed marked serum lipid profile and electrolyte changes, declines in brain antioxidants and neurotransmitters (acetylcholine, dopamine, and serotonin levels) with elevations in thiobarbituric acid reactive substances and proinflammatory cytokine levels, as well as acetylcholinesterase and monoamine oxidase brain activity in tmx-treated rats. |
2023-12-15 |
2023-12-17 |
rat |
| João P C Veras, Victor L B França, Hernandes F Carvalho, Valder N Freir. Noncovalent binding of carbofuran to acetylcholinesterase from Homo sapiens, Danio rerio, Apis mellifera and Caenorhabditis elegans: Homology modelling, molecular docking and dynamics, and quantum biochemistry description. Chemico-biological interactions. 2023-12-15. PMID:38101596. |
this pesticide is a potent inhibitor of acetylcholinesterase (ache), which acts by preventing the hydrolysis of acetylcholine (ach). |
2023-12-15 |
2023-12-18 |
human |
| Maciej Noga, Agata Michalska, Kamil Jurowsk. The prediction of acute toxicity (LD Archives of toxicology. 2023-12-05. PMID:38051368. |
the prediction of acute toxicity (ld nerve agents are organophosphate chemical warfare agents that exert their toxic effects by irreversibly inhibiting acetylcholinesterase, affecting the breakdown of the neurotransmitter acetylcholine in the synaptic cleft. |
2023-12-05 |
2023-12-10 |
Not clear |
| Jarrod A Gott, Sina Stücker, Philipp Kanske, Jan Haaker, Martin Dresle. Acetylcholine and metacognition during sleep. Consciousness and cognition. vol 117. 2023-12-02. PMID:38042119. |
while recent studies using acetylcholinesterase inhibitors suggest a potential role of acetylcholine in the occurrence of lucid dreaming, the underlying mechanisms by which this effect is produced remains un-modelled and unknown; with the causal link between cholinergic mechanisms and upstream psychological states being complex and elusive. |
2023-12-02 |
2023-12-10 |
Not clear |
| Tess L Blom, Thijs T Wingelaa. Current Perspectives on the Management of Patients Poisoned With Novichok: A Scoping Review. Military medicine. 2023-11-30. PMID:38035754. |
nerve agents have emerged as a global threat since their discovery in the 1930s, posing severe risks due to their inhibition of acetylcholinesterase and the subsequent accumulation of acetylcholine in nerve synapses. |
2023-11-30 |
2023-12-10 |
Not clear |
| Xiao Shi, Peng Liu, Yanyan Ma, Mingyuan Li, Zhenyu Zhang, Xinyue Zhang, Dahua Shi, Xinxin S. Identification of a 2-phenylthiazole derivative acetylcholinesterase modulator with in vitro antitumor activity in breast cancer cells. Chemical biology & drug design. 2023-11-27. PMID:38009562. |
acetylcholinesterase (ache) is a serine hydrolase with classical function to degrade acetylcholine and terminate neurotransmission. |
2023-11-27 |
2023-11-29 |
Not clear |
| Göksun Demirel, Sonia Sanajou, Anil Yirün, Deniz Arca Çakir, Aysel Berkkan, Terken Baydar, Pinar Erkekoğl. Evaluation of possible neuroprotective effects of virgin coconut oil on aluminum-induced neurotoxicity in an in vitro Alzheimer's disease model. Journal of applied toxicology : JAT. 2023-11-21. PMID:37989595. |
in addition, oxidative stress parameters (total antioxidant capacity, lipid peroxidase, protein carbonyl, and reactive oxygen species) and neurotransmitter-related parameters (dopamine, dopamine transporter acetylcholine, and synuclein alpha levels, acetylcholinesterase activity) were measured comparatively in the study groups. |
2023-11-21 |
2023-11-29 |
cattle |
| Showkat Ahmad Mir, Jamoliddin Razzokov, Vishwajeet Mukherjee, Iswar Baitharu, Binata Naya. An exploration of the binding prediction of anatoxin-a and atropine to acetylcholinesterase enzyme using multi-level computer simulations. Physical biology. 2023-11-14. PMID:37963412. |
acetylcholinesterase (ache) is crucial for the breakdown of acetylcholine to acetate and choline, while the inhibition of ache by anatoxin-a (atx-a) results in severe health complications. |
2023-11-14 |
2023-11-20 |
Not clear |
| Shehla Shoukat, Muhammad Amir Zia, Muhammad Uzair, Kotb A Attia, Asmaa M Abushady, Sajid Fiaz, Shaukat Ali, Seung Hwan Yang, Ghulam Muhammad Al. Heliyon. vol 9. issue 11. 2023-11-13. PMID:37954293. |
acetylcholinesterase breaks down the neurotransmitter acetylcholine, important for neural transmission. |
2023-11-13 |
2023-11-20 |
Not clear |
| Omyma Rabie, Heba A S El-Nashar, Mina Y George, Taghreed A Majrashi, Tarfah Al-Warhi, Fatma E Hassan, Wagdy M Eldehna, Nada M Mostaf. Phytochemical profiling and neuroprotective activity of Callistemon subulatus leaves against cyclophosphamide-induced chemobrain. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 167. 2023-10-05. PMID:37797461. |
in addition, cse counteracted the effect of cpa on hippocampal acetylcholinesterase (ache) activity enhancing the level of acetylcholine. |
2023-10-05 |
2023-10-07 |
rat |
| Benjamín Pérez-Aguilar, Jens U Marquardt, Encarnación Muñoz-Delgado, Rosa María López-Durán, María Concepción Gutiérrez-Ruiz, Luis E Gomez-Quiroz, José Luis Gómez-Olivare. Changes in the Acetylcholinesterase Enzymatic Activity in Tumor Development and Progression. Cancers. vol 15. issue 18. 2023-09-28. PMID:37760598. |
acetylcholinesterase is a well-known protein because of the relevance of its enzymatic activity in the hydrolysis of acetylcholine in nerve transmission. |
2023-09-28 |
2023-10-07 |
Not clear |
| Jordi Olloquequi, Miren Ettcheto, Amanda Cano, Ana Fortuna, Joana Bicker, Elena Sánchez-Lopez, Cristian Paz, Jesús Ureña, Ester Verdaguer, Carme Auladell, Antoni Camin. Licochalcone A: A Potential Multitarget Drug for Alzheimer's Disease Treatment. International journal of molecular sciences. vol 24. issue 18. 2023-09-28. PMID:37762479. |
lico-a also acts as an acetylcholinesterase inhibitor, leading to increased levels of the neurotransmitter acetylcholine (ach) in the brain. |
2023-09-28 |
2023-10-07 |
Not clear |
| Zainabu Majid, Qi Zhang, Zhansen Yang, Huilian Che, Nan Chen. A Multi-Enzyme Cascade Response for the Colorimetric Recognition of Organophosphorus Pesticides Utilizing Core-Shell Pd@Pt Nanoparticles with High Peroxidase-like Activity. Foods (Basel, Switzerland). vol 12. issue 17. 2023-09-09. PMID:37685251. |
their limits are closely monitored since their residual hinders the capability of acetylcholinesterase (ache) and brings out a threatening accumulation of the neurotransmitter acetylcholine (ach), which affects human well-being. |
2023-09-09 |
2023-10-07 |
human |
| Aleksandar R Zivkovic, Karsten Schmidt, Stefan Hofer, Thorsten Brenner, Markus A Weigand, Sebastian O Decke. Non-Neuronal Acetylcholinesterase Activity Shows Limited Utility for Early Detection of Sepsis. Biomedicines. vol 11. issue 8. 2023-08-26. PMID:37626609. |
acetylcholinesterase (ache), an enzyme primarily responsible for the hydrolysis of acetylcholine, has been proposed as a potential early indicator of sepsis onset. |
2023-08-26 |
2023-09-07 |
Not clear |
| Shohda A El-Maraghy, Aya Reda, Reham M Essam, Mona A Korta. The citrus flavonoid "Nobiletin" impedes STZ-induced Alzheimer's disease in a mouse model through regulating autophagy mastered by SIRT1/FoxO3a mechanism. Inflammopharmacology. 2023-08-19. PMID:37598127. |
moreover, nobiletin de-escalated hippocampal acetylcholinesterase (ache) activity and enhanced acetylcholine level while halting bace1 and amyloid-β levels. |
2023-08-19 |
2023-09-07 |
mouse |
| Dane Sands, Andrew Davis, Scott Banfield, Ian R Pottie, Sultan Darves. Solvents and detergents compatible with enzyme kinetic studies of cholinesterases. Chemico-biological interactions. 2023-08-14. PMID:37579937. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that serve a wide range of physiological functions including the hydrolysis of the neurotransmitter acetylcholine and several other xenobiotics. |
2023-08-14 |
2023-09-07 |
Not clear |