| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dean M Robinson, Greg L Ploske. Galantamine extended release. CNS drugs. vol 20. issue 8. 2006-09-19. PMID:16863272. |
galantamine inhibits acetylcholinesterase (ache) to slow acetylcholine hydrolysis, and may also modulate presynaptic nicotinic receptor activation, thereby increasing neurotransmitter concentrations in the synaptic cleft.black triangle once-daily galantamine extended release (er) 24 mg and twice-daily galantamine immediate release (ir) 12 mg are bioequivalent in terms of the area under the plasma concentration-time curve from time 0 to 24 hours and steady-state minimum plasma concentration.black triangle primary endpoints indicated a significantly greater effect of galantamine er on cognitive performance than placebo, with efficacy similar to galantamine ir, in a randomised, double-blind trial. |
2006-09-19 |
2023-08-12 |
Not clear |
| Ivan S Uroukov, Mingwen Ma, Larry Bull, Wendy M Purcel. Electrophysiological measurements in three-dimensional in vivo-mimetic organotypic cell cultures: preliminary studies with hen embryo brain spheroids. Neuroscience letters. vol 404. issue 1-2. 2006-09-18. PMID:16750879. |
basic biochemical functionality was also determined and acetylcholinesterase measured, indicating the activity of acetylcholine receptors. |
2006-09-18 |
2023-08-12 |
Not clear |
| Bjørnar Hasse. Nicotinic mechanisms contribute to soman-induced symptoms and lethality. Neurotoxicology. vol 27. issue 4. 2006-09-08. PMID:16500708. |
the symptoms and lethality of intoxication with the acetylcholinesterase inactivator soman are attributed primarily to excessive activation of muscarinic acetylcholine receptors; nicotinic activation is considered of less importance, a notion that may rely on studies that have used nicotinic antagonists at low doses. |
2006-09-08 |
2023-08-12 |
mouse |
| Carlos Mauricio R Sant'Anna, Andrea dos Santos Viana, Nailton Monteiro do Nascimento Junio. A semiempirical study of acetylcholine hydrolysis catalyzed by Drosophila melanogaster acetylcholinesterase. Bioorganic chemistry. vol 34. issue 2. 2006-08-30. PMID:16540146. |
a semiempirical study of acetylcholine hydrolysis catalyzed by drosophila melanogaster acetylcholinesterase. |
2006-08-30 |
2023-08-12 |
drosophila_melanogaster |
| Carlos Mauricio R Sant'Anna, Andrea dos Santos Viana, Nailton Monteiro do Nascimento Junio. A semiempirical study of acetylcholine hydrolysis catalyzed by Drosophila melanogaster acetylcholinesterase. Bioorganic chemistry. vol 34. issue 2. 2006-08-30. PMID:16540146. |
the enzymatic mechanism of acetylcholine hydrolysis was evaluated by semiempirical molecular orbital calculations with a model constructed with the coordinates of sixteen amino acids and four water molecules from the crystallographic structure of drosophila melanogaster acetylcholinesterase (ache, entry 1qo9 in the protein data bank). |
2006-08-30 |
2023-08-12 |
drosophila_melanogaster |
| Zoraide R Ramos, Jucélia J Fortunato, Fabiano R Agostinho, Márcio R Martins, Maísa Correa, Maria Rosa C Schetinger, Felipe Dal-Pizzol, João Queved. Influence of malathion on acetylcholinesterase activity in rats submitted to a forced swimming test. Neurotoxicity research. vol 9. issue 4. 2006-08-23. PMID:16782587. |
classically, this toxicity is attributed mainly to the accumulation of acetylcholine (ach), due to inhibition of acetylcholinesterase (ache), and consequently overstimulation of the nicotinic and muscarinic receptors. |
2006-08-23 |
2023-08-12 |
human |
| Manickavasagom Alkondon, Edson X Albuquerqu. Subtype-specific inhibition of nicotinic acetylcholine receptors by choline: a regulatory pathway. The Journal of pharmacology and experimental therapeutics. vol 318. issue 1. 2006-08-14. PMID:16565162. |
choline is an essential nutrient and a precursor of neurotransmitter acetylcholine (ach) and is produced at synapses during depolarization, upon hydrolysis of ach via acetylcholinesterase, and under conditions of injury and trauma. |
2006-08-14 |
2023-08-12 |
rat |
| Pavla Zdrazilová, Sárka Stepánková, Martina Vránová, Karel Komers, Alena Komersová, Alexander Cega. Kinetics of total enzymatic hydrolysis of acetylcholine and acetylthiocholine. Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 61. issue 3-4. 2006-08-11. PMID:16729592. |
up to the exhaustion of substrate) of acetylcholine and acetylthiocholine by acetylcholinesterase and butyrylcholinesterase were studied in vitro in a batch reactor at 25 degrees c, ph 8 and ionic strength of 0.11 m. every hydrolysis was monitored by 2-3 independent analytical methods. |
2006-08-11 |
2023-08-12 |
Not clear |
| K-I Hayashida, T Bynum, M Vincler, J C Eisenac. Inhibitory M2 muscarinic receptors are upregulated in both axotomized and intact small diameter dorsal root ganglion cells after peripheral nerve injury. Neuroscience. vol 140. issue 1. 2006-08-10. PMID:16580144. |
acetylcholine reduces nociceptive input in part by activating inhibitory m2 muscarinic receptors on primary sensory neurons, and acetylcholinesterase inhibitors and muscarinic agonists produce analgesia in humans and animals. |
2006-08-10 |
2023-08-12 |
rat |
| Bin Zhao, Shabbir M Moochhala, Jia Lu, Donna Tan, Mui Hoon La. Determination of pyridostigmine bromide and its metabolites in biological samples. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. vol 9. issue 1. 2006-08-10. PMID:16849010. |
pyridostigmine bromide (pb) is a quartenary ammonium compound that inhibits the hydrolysis of acetylcholine by competitive reversible binding to acetylcholinesterase. |
2006-08-10 |
2023-08-12 |
Not clear |
| Jacques-Philippe Colletier, Didier Fournier, Harry M Greenblatt, Jure Stojan, Joel L Sussman, Giuseppe Zaccai, Israel Silman, Martin Wei. Structural insights into substrate traffic and inhibition in acetylcholinesterase. The EMBO journal. vol 25. issue 12. 2006-08-03. PMID:16763558. |
acetylcholinesterase (ache) terminates nerve-impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter, acetylcholine. |
2006-08-03 |
2023-08-12 |
Not clear |
| Goksel Doganay, Bereha Khodr, George Georgiou, Zeinab Khali. Pharmacological manipulation of the vasoconstrictive effects of amyloid-beta peptides by donepezil and rivastigmine. Current Alzheimer research. vol 3. issue 2. 2006-07-28. PMID:16611014. |
the vascular responses to abeta peptides, acetylcholine, bradykinin and sodium nitroprusside and their modulation by acetylcholinesterase inhibitors were examined in the base of a vacuum induced blister raised on the rat hind footpad using laser doppler flowmetry. |
2006-07-28 |
2023-08-12 |
rat |
| R M Freitas, F C F Sousa, G S B Viana, M M F Fontele. Acetylcholinesterase activities in hippocampus, frontal cortex and striatum of Wistar rats after pilocarpine-induced status epilepticus. Neuroscience letters. vol 399. issue 1-2. 2006-06-30. PMID:16481111. |
experimental manipulations suggest that in vivo administration of cholinergic agonists or inhibitors of acetylcholinesterase (ache) increases the concentration of acetylcholine. |
2006-06-30 |
2023-08-12 |
rat |
| Niamh Durcan, Richard W Costello, W Graham McLean, Jan Blusztajn, Beata Madziar, Anthony G Fenech, Ian P Hall, Gerard J Gleich, Lorcan McGarvey, Marie-Therese Wals. Eosinophil-mediated cholinergic nerve remodeling. American journal of respiratory cell and molecular biology. vol 34. issue 6. 2006-06-29. PMID:16456188. |
eosinophils also induced the expression of several cholinergic genes involved in the synthesis, storage, and metabolism of acetylcholine, including the enzymes choline acetyltransferase, vesicular acetylcholine transferase, and acetylcholinesterase. |
2006-06-29 |
2023-08-12 |
Not clear |
| Niamh Durcan, Richard W Costello, W Graham McLean, Jan Blusztajn, Beata Madziar, Anthony G Fenech, Ian P Hall, Gerard J Gleich, Lorcan McGarvey, Marie-Therese Wals. Eosinophil-mediated cholinergic nerve remodeling. American journal of respiratory cell and molecular biology. vol 34. issue 6. 2006-06-29. PMID:16456188. |
the observed eosinophil-induced changes in enzyme content were associated with a reduction in intracellular neural acetylcholine but an increase in choline content, suggesting increased acetylcholine turnover and a reduction in acetylcholinesterase activity, in turn suggesting reduced catabolism of acetylcholine. |
2006-06-29 |
2023-08-12 |
Not clear |
| T Zuchner, N Schliebe, R Schlieb. Zinc uptake is mediated by M1 muscarinic acetylcholine receptors in differentiated SK-SH-SY5Y cells. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 24. issue 1. 2006-06-26. PMID:16406470. |
apart from cholinergic markers like choline acetyltransferase and acetylcholinesterase, there have been reports on changes in muscarinic acetylcholine receptors (machr) as well as on influences of zinc metabolism in the disease. |
2006-06-26 |
2023-08-12 |
human |
| Marko Jevsek, Alexander Jaworski, Luis Polo-Parada, Natalie Kim, Jihua Fan, Lynn T Landmesser, Steven J Burde. CD24 is expressed by myofiber synaptic nuclei and regulates synaptic transmission. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 16. 2006-06-23. PMID:16606832. |
the genes encoding several synaptic proteins, including acetylcholine receptors, acetylcholinesterase, and the muscle-specific kinase, musk, are expressed selectively by a small number of myofiber nuclei positioned near the synaptic site. |
2006-06-23 |
2023-08-12 |
mouse |
| Xiu-ling Ji, Liu Yang, Zhe-min Shen, Jin-ping Cheng, Gui-wen Jin, Li-ya Qu, Wen-hua Wan. Neurotransmitter level changes in domestic ducks (Shaoxing duck) growing up in typical mercury contaminated area in China. Journal of environmental sciences (China). vol 17. issue 2. 2006-06-22. PMID:16295900. |
an increased content of acetylcholine (ach) in brain and blood and a decreased activity of acetylcholinesterase (ache) in blood were observed. |
2006-06-22 |
2023-08-12 |
Not clear |
| Qing Chang, Lisa M Savage, Paul E Gol. Microdialysis measures of functional increases in ACh release in the hippocampus with and without inclusion of acetylcholinesterase inhibitors in the perfusate. Journal of neurochemistry. vol 97. issue 3. 2006-06-22. PMID:16579834. |
because brain extracellular acetylcholine (ach) levels are near detection limits in microdialysis samples, an acetylcholinesterase (ache) inhibitor such as neostigmine is often added to microdialysis perfusates to increase ach levels in the dialysate, a practice that raises concerns that the inhibitor might alter the results. |
2006-06-22 |
2023-08-12 |
Not clear |
| G Petroianu, K Arafat, B C Sasse, H Star. Multiple enzyme inhibitions by histamine H3 receptor antagonists as potential procognitive agents. Die Pharmazie. vol 61. issue 3. 2006-05-17. PMID:16599255. |
some of the new compounds proved in a slightly modified colorimetric ellmann's assay to be potent inhibitors of acetylcholinesterase and of butyrylcholinesterase which is another catalytic enzyme hydrolysing acetylcholine. |
2006-05-17 |
2023-08-12 |
Not clear |