| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Asaad Khalid, M Kamran Azim, Shehnaz Parveen, Atta-ur-Rahman, M Iqbal Choudhar. Structural basis of acetylcholinesterase inhibition by triterpenoidal alkaloids. Biochemical and biophysical research communications. vol 331. issue 4. 2005-07-19. PMID:15959931. |
acetylcholinesterase plays a crucial role in the metabolism of neurotransmitter, acetylcholine. |
2005-07-19 |
2023-08-12 |
Not clear |
| Silvia Olivera-Bravo, Isabel Ivorra, Andrés Morale. The acetylcholinesterase inhibitor BW284c51 is a potent blocker of Torpedo nicotinic AchRs incorporated into the Xenopus oocyte membrane. British journal of pharmacology. vol 144. issue 1. 2005-06-28. PMID:15644872. |
this work was aimed to determine if 1,5-bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide (bw284c51), the most selective acetylcholinesterase inhibitor (achei), affects the nicotinic acetylcholine (ach) receptor (achr) function. |
2005-06-28 |
2023-08-12 |
xenopus_laevis |
| Hsiao-chung Tsai, Ruey-an Doon. Simultaneous determination of pH, urea, acetylcholine and heavy metals using array-based enzymatic optical biosensor. Biosensors & bioelectronics. vol 20. issue 9. 2005-06-24. PMID:15681196. |
urease and acetylcholinesterase (ache) were used as model enzymes and were co-entrapped with the sensing probe, fitc-dextran, in the sol-gel matrix to measure ph, urea, acetylcholine (ach) and heavy metals (enzyme inhibitors). |
2005-06-24 |
2023-08-12 |
Not clear |
| Changiz Geula, Sultan Darves. Butyrylcholinesterase, cholinergic neurotransmission and the pathology of Alzheimer's disease. Drugs of today (Barcelona, Spain : 1998). vol 40. issue 8. 2005-06-07. PMID:15510242. |
in particular, recent evidence indicates that along with acetylcholinesterase, butyrylcholinesterase catalyzes the hydrolysis of acetylcholine, and thus serves as a co-regulator of cholinergic transmission. |
2005-06-07 |
2023-08-12 |
Not clear |
| K Sembulingam, Prema Sembulingam, A Namasivaya. Effect of Ocimum sanctum Linn on the changes in central cholinergic system induced by acute noise stress. Journal of ethnopharmacology. vol 96. issue 3. 2005-05-24. PMID:15619567. |
the ethanolic extract from the leaves of ocimum sanctum linn was screened for its effects on the noise induced changes in the central cholinergic system of albino rats by investigating the acetylcholine content and acetylcholinesterase activity in discrete areas of brain. |
2005-05-24 |
2023-08-12 |
rat |
| K Sembulingam, Prema Sembulingam, A Namasivaya. Effect of Ocimum sanctum Linn on the changes in central cholinergic system induced by acute noise stress. Journal of ethnopharmacology. vol 96. issue 3. 2005-05-24. PMID:15619567. |
exposure to noise (10 khz:100 db) stress for 30 min caused a significant reduction in total acetylcholine content and increase in the activity of acetylcholinesterase in cerebral cortex, corpus striatum, hypothalamus and hippocampus of brain. |
2005-05-24 |
2023-08-12 |
rat |
| Xavier Cousin, Uwe Strähle, Arnaud Chatonne. Are there non-catalytic functions of acetylcholinesterases? Lessons from mutant animal models. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 27. issue 2. 2005-05-16. PMID:15666354. |
acetylcholinesterase (ache) hydrolyses acetylcholine (ach) ensuring the fast clearance of released neurotransmitter at cholinergic synapses. |
2005-05-16 |
2023-08-12 |
Not clear |
| Lynnette J Cook, Luk W Ho, Lin Wang, Edith Terrenoire, Carol Brayne, John Grimley Evans, John Xuereb, Nigel J Cairns, Dragana Turic, Paul Hollingworth, Pamela J Moore, Luke Jehu, Nicola Archer, Sarah Walter, Catherine Foy, Amanda Edmondson, John Powell, Simon Lovestone, Julie Williams, David C Rubinsztei. Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further study. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 132B. issue 1. 2005-05-12. PMID:15690550. |
consistent deficits in the cholinergic system are evident in the brains of alzheimer's disease (ad) patients, including reductions in the activities of acetylcholine, acetylcholinesterase (ache), and choline acetyltransferase (chat), increased butyrylcholinesterase (bche) activity, and a selective loss of nicotinic acetylcholine receptors (nachrs). |
2005-05-12 |
2023-08-12 |
Not clear |
| Tatsuya Kikuchi, Ming-Rong Zhang, Nobuo Ikota, Kiyoshi Fukushi, Toshimitsu Okamura, Kazutoshi Suzuki, Yasushi Arano, Toshiaki Iri. N-[18F] fluoroethylpiperidin-4ylmethyl acetate, a novel lipophilic acetylcholine analogue for PET measurement of brain acetylcholinesterase activity. Journal of medicinal chemistry. vol 48. issue 7. 2005-05-05. PMID:15801847. |
n-[18f] fluoroethylpiperidin-4ylmethyl acetate, a novel lipophilic acetylcholine analogue for pet measurement of brain acetylcholinesterase activity. |
2005-05-05 |
2023-08-12 |
human |
| Tatsuya Kikuchi, Ming-Rong Zhang, Nobuo Ikota, Kiyoshi Fukushi, Toshimitsu Okamura, Kazutoshi Suzuki, Yasushi Arano, Toshiaki Iri. N-[18F] fluoroethylpiperidin-4ylmethyl acetate, a novel lipophilic acetylcholine analogue for PET measurement of brain acetylcholinesterase activity. Journal of medicinal chemistry. vol 48. issue 7. 2005-05-05. PMID:15801847. |
the reduction of acetylcholinesterase (ache) activity in the brain has been measured in dementia disorders such as alzheimer's disease and dementia with lewy bodies using (11)c-labeled acetylcholine analogues, n-[(11)c]methylpiperidin-4-yl acetate and propionate, and positron emission tomography (pet). |
2005-05-05 |
2023-08-12 |
human |
| Pamela J Lein, Allison D Frye. Organophosphorus insecticides induce airway hyperreactivity by decreasing neuronal M2 muscarinic receptor function independent of acetylcholinesterase inhibition. Toxicological sciences : an official journal of the Society of Toxicology. vol 83. issue 1. 2005-05-02. PMID:15470232. |
we previously demonstrated that the organophosphorus (op) insecticide chlorpyrifos potentiates vagally induced bronchoconstriction independent of acetylcholinesterase (ache) inhibition by decreasing the function of neuronal m2 muscarinic receptors that normally inhibit acetylcholine release from parasympathetic nerves supplying airway smooth muscle. |
2005-05-02 |
2023-08-12 |
Not clear |
| Boris Bryk, Liat BenMoyal-Segal, Erez Podoly, Oded Livnah, Arik Eisenkraft, Shai Luria, Amir Cohen, Yoav Yehezkelli, Ariel Hourvitz, Hermona Sore. Inherited and acquired interactions between ACHE and PON1 polymorphisms modulate plasma acetylcholinesterase and paraoxonase activities. Journal of neurochemistry. vol 92. issue 5. 2005-04-28. PMID:15715671. |
the 5.5 mb chromosome 7q21-22 ache/pon1 locus harbours the ache gene encoding the acetylcholine hydrolyzing, organophosphate (op)-inhibitable acetylcholinesterase protein and the paraoxonase gene pon1, yielding the op-hydrolyzing pon1 enzyme which also displays arylesterase activity. |
2005-04-28 |
2023-08-12 |
Not clear |
| C H Opperman, S Chan. Nematode acetylcholinesterases: molecular forms and their potential role in nematode behavior. Parasitology today (Personal ed.). vol 8. issue 12. 2005-04-21. PMID:15463554. |
acetylcholine activity is terminated by hydrolysis by acetylcholinesterase (ache). |
2005-04-21 |
2023-08-12 |
Not clear |
| Francisco Javier Gil-Bea, Mónica García-Alloza, Jon Domínguez, Beatriz Marcos, María Javier Ramíre. Evaluation of cholinergic markers in Alzheimer's disease and in a model of cholinergic deficit. Neuroscience letters. vol 375. issue 1. 2005-04-18. PMID:15664119. |
in post-mortem frontal cortex from ad patients, acetylcholine (ach) levels, cholinacetyltransferase (chat) and acetylcholinesterase (ache) activity were all reduced compared to controls. |
2005-04-18 |
2023-08-12 |
rat |
| T K Manojkumar, Chunzhi Cui, Kwang S Ki. Theoretical insights into the mechanism of acetylcholinesterase-catalyzed acylation of acetylcholine. Journal of computational chemistry. vol 26. issue 6. 2005-04-13. PMID:15739192. |
acylation of acetylcholine (ach) catalyzed by acetylcholinesterase (ache) has been studied using high-level theoretical calculations on a model system that mimics the reaction center of the enzyme, and compared with uncatalyzed acylation reaction. |
2005-04-13 |
2023-08-12 |
Not clear |
| Hugo Geert. Indicators of neuroprotection with galantamine. Brain research bulletin. vol 64. issue 6. 2005-04-01. PMID:15639548. |
as galantamine is a modest acetylcholinesterase inhibitor in addition to being an allosteric modulator of nicotinic acetylcholine receptors, it is interesting to study the clinical effects of this compound in the light of its neurochemical properties to discern potential neuroprotective effects. |
2005-04-01 |
2023-08-12 |
Not clear |
| R Nikolo. Alzheimer's disease therapy - an update. Drug news & perspectives. vol 11. issue 4. 2005-03-30. PMID:15616667. |
the two major pharmacological principles of cholinergic therapy are 1) reduction of acetylcholine hydrolysis by means of acetylcholinesterase (ache) inhibitors; and 2) direct stimulation of nicotinic or muscarinic receptors with selective agonists. |
2005-03-30 |
2023-08-12 |
Not clear |
| A I Skorinkin, A R Shaĭkhutdinov. [The reconstruction of the dynamics of acetylcholine concentration in synaptic cleft in response to a monoquantum signal]. Biofizika. vol 49. issue 5. 2005-03-25. PMID:15526473. |
by using the experimental data and the model of cholinereceptor activation kinetics in frog nervous-muscular junction, the function of acetylcholine release from the nervous terminal and the function of acetylcholinesterase activity in synaptic cleft were reproduced and approximated. |
2005-03-25 |
2023-08-12 |
Not clear |
| b' Giulia D\'Intino, Michela Paradisi, Mercedes Fernandez, Alessandro Giuliani, Luigi Aloe, Luciana Giardino, Laura Calz\\xc3\\xa. Cognitive deficit associated with cholinergic and nerve growth factor down-regulation in experimental allergic encephalomyelitis in rats. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 8. 2005-03-24. PMID:15710875.' |
treatment aimed to restore acetylcholine content through chronic administration of selective acetylcholinesterase inhibitors (rivastigmine and donepezil) restores cognitive performance, choline acetyltransferase activity, and nerve growth factor mrna expression. |
2005-03-24 |
2023-08-12 |
rat |
| David E Johnson, Frank M Nedza, Douglas K Spracklin, Karen M Ward, Anne W Schmidt, Philip A Iredale, Dennis M Godek, Hans Rollem. The role of muscarinic receptor antagonism in antipsychotic-induced hippocampal acetylcholine release. European journal of pharmacology. vol 506. issue 3. 2005-03-22. PMID:15627430. |
olanzapine and clozapine produce robust increases in hippocampal acetylcholine release during acetylcholinesterase inhibition, while other antipsychotics, including thioridazine, have only small effects. |
2005-03-22 |
2023-08-12 |
human |