| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Abdel-Rahman, Suzanne Abou-Donia, Eman El-Masry, Ashok Shetty, Mohamed Abou-Doni. Stress and combined exposure to low doses of pyridostigmine bromide, DEET, and permethrin produce neurochemical and neuropathological alterations in cerebral cortex, hippocampus, and cerebellum. Journal of toxicology and environmental health. Part A. vol 67. issue 2. 2004-02-04. PMID:14675905. |
animals exposed to both stress and chemical exhibited decreased brain acetylcholinesterase (ache) activity in the midbrain, brainstem, and cerebellum and decreased m2 muscarinic acetylcholine (ach) receptor ligand binding in the midbrain and cerebellum. |
2004-02-04 |
2023-08-12 |
rat |
| Laura A Volpicelli-Daley, Anna Hrabovska, Ellen G Duysen, Shawn M Ferguson, Randy D Blakely, Oksana Lockridge, Allan I Leve. Altered striatal function and muscarinic cholinergic receptors in acetylcholinesterase knockout mice. Molecular pharmacology. vol 64. issue 6. 2004-01-16. PMID:14645660. |
acetylcholinesterase knockout (ache-/-) mice were used to investigate the neuronal adaptations to diminished synaptic acetylcholine (ach) metabolism. |
2004-01-16 |
2023-08-12 |
mouse |
| M Faimali, C Falugi, L Gallus, V Piazza, G Tagliafierr. Involvement of acetyl choline in settlement of Balanus amphitrite. Biofouling. vol 19 Suppl. 2004-01-14. PMID:14618723. |
acetylcholinesterase (ache, the lythic enzyme of acetylcholine) activity was detected, for the first time, by biochemical and histoenzymological methods, in the thoracic muscles, gut wall and cement gland. |
2004-01-14 |
2023-08-12 |
Not clear |
| Chantal J G M Smulders, Tjerk J H Bueters, Regina G D M Van Kleef, Henk P M Vijverber. Selective effects of carbamate pesticides on rat neuronal nicotinic acetylcholine receptors and rat brain acetylcholinesterase. Toxicology and applied pharmacology. vol 193. issue 2. 2004-01-05. PMID:14644616. |
selective effects of carbamate pesticides on rat neuronal nicotinic acetylcholine receptors and rat brain acetylcholinesterase. |
2004-01-05 |
2023-08-12 |
rat |
| Yeon-Kye Kim, Byung-Soo Koo, Dae-Jong Gong, Young-Choon Lee, Jeong-Heon Ko, Cheorl-Ho Ki. Comparative effect of Prunus persica L. BATSCH-water extract and tacrine (9-amino-1,2,3,4-tetrahydroacridine hydrochloride) on concentration of extracellular acetylcholine in the rat hippocampus. Journal of ethnopharmacology. vol 87. issue 2-3. 2003-12-29. PMID:12860300. |
in this study, the effects of oral administration of ppe on the extracellular acetylcholine concentration in the hippocampus of rats were evaluated, and compared to that of tacrine (9-amino-1,2,3,4-tetrahydroacridine hydrochloride), a well-known and centrally acting acetylcholinesterase (ache) inhibitor, which had been developed for the treatment of alzheimer's disease. |
2003-12-29 |
2023-08-12 |
rat |
| L M Gerstein, E L Dovedova, N S Popov. [Mechanism of nootropic digam action in hypofunction of brain dopaminergic system]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 103. issue 7. 2003-12-29. PMID:12938655. |
using microchemical methods for detection of dopamine (da), noradrenaline (na), serotonin (s) and its metabolite--5'-hydroxyindolilacetic acid (5'-hiaa) as well as the activity of neuromediator-utilising enzymes--mao a and b and enzymes of acetylcholine metabolism--cholinacetyltranspherase (chat) and acetylcholinesterase (ache), we revealed that synthetic gaba-derivative compound diagram (250 mg/kg during 10 days) normalized functioning of dopaminergic and acetylcholinergic systems in sensormotor cortex and caudate nucleus of wistar rats with haloperidol-induced (0.5 mg/kg during 30 days) bradykinesia. |
2003-12-29 |
2023-08-12 |
rat |
| Bin Li, Ellen G Duysen, Laura A Volpicelli-Daley, Allan I Levey, Oksana Lockridg. Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice. Pharmacology, biochemistry, and behavior. vol 74. issue 4. 2003-12-15. PMID:12667913. |
acetylcholinesterase (ache) hydrolyzes acetylcholine to terminate cholinergic neurotransmission. |
2003-12-15 |
2023-08-12 |
mouse |
| Min Wu, Samuel S Newton, Joshua B Atkins, Changqing Xu, Ronald S Duman, Meenakshi Alrej. Acetylcholinesterase inhibitors activate septohippocampal GABAergic neurons via muscarinic but not nicotinic receptors. The Journal of pharmacology and experimental therapeutics. vol 307. issue 2. 2003-12-10. PMID:12966162. |
acetylcholinesterase (ache) inhibitors, which increase synaptic levels of available acetylcholine (ach) by preventing its degradation, are the most extensively prescribed drugs for the treatment of alzheimer's disease. |
2003-12-10 |
2023-08-12 |
rat |
| J H Heeroma, J J Plomp, E W Roubos, M Verhag. Development of the mouse neuromuscular junction in the absence of regulated secretion. Neuroscience. vol 120. issue 3. 2003-12-04. PMID:12895513. |
these data suggest that regulated secretion is not essential for initial axon path finding, clustering of acetylcholine receptors, acetylcholinesterase or the formation of synapses. |
2003-12-04 |
2023-08-12 |
mouse |
| Yvain Nicolet, Oksana Lockridge, Patrick Masson, Juan C Fontecilla-Camps, Florian Nacho. Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products. The Journal of biological chemistry. vol 278. issue 42. 2003-12-03. PMID:12869558. |
they are divided into two groups: acetylcholinesterase, involved in the hydrolysis of the neurotransmitter acetylcholine, and butyrylcholinesterase of unknown function. |
2003-12-03 |
2023-08-12 |
human |
| Federico A Dajas-Bailador, Kaisa Heimala, Susan Wonnacot. The allosteric potentiation of nicotinic acetylcholine receptors by galantamine is transduced into cellular responses in neurons: Ca2+ signals and neurotransmitter release. Molecular pharmacology. vol 64. issue 5. 2003-11-25. PMID:14573772. |
nachr-mediated [3h]noradrenaline release from hippocampal slices was also potentiated by galantamine, with an additional component attributable to acetylcholinesterase inhibition and subsequent increase in acetylcholine. |
2003-11-25 |
2023-08-12 |
Not clear |
| Jianxin Shi, Kaihsu Tai, J Andrew McCammon, Palmer Taylor, David A Johnso. Nanosecond dynamics of the mouse acetylcholinesterase cys69-cys96 omega loop. The Journal of biological chemistry. vol 278. issue 33. 2003-11-10. PMID:12759360. |
the paradox of high substrate turnover occurring within the confines of a deep, narrow gorge through which acetylcholine must traverse to reach the catalytic site of acetylcholinesterase has suggested the existence of transient gorge enlargements that would enhance substrate accessibility. |
2003-11-10 |
2023-08-12 |
mouse |
| Christopher D Herzog, Kelly A Nowak, Martin Sarter, John P Brun. Microdialysis without acetylcholinesterase inhibition reveals an age-related attenuation in stimulated cortical acetylcholine release. Neurobiology of aging. vol 24. issue 6. 2003-10-29. PMID:12927768. |
microdialysis without acetylcholinesterase inhibition reveals an age-related attenuation in stimulated cortical acetylcholine release. |
2003-10-29 |
2023-08-12 |
rat |
| I Amy Bany, Meng-Qiu Dong, Michael R Koell. Genetic and cellular basis for acetylcholine inhibition of Caenorhabditis elegans egg-laying behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 22. 2003-10-02. PMID:12954868. |
in addition, increasing synaptic acetylcholine by reducing acetylcholinesterase activity, with either mutations or the inhibitor aldicarb, decreased egg laying. |
2003-10-02 |
2023-08-12 |
caenorhabditis_elegans |
| Sultan Darvesh, David A Hopkin. Differential distribution of butyrylcholinesterase and acetylcholinesterase in the human thalamus. The Journal of comparative neurology. vol 463. issue 1. 2003-08-29. PMID:12811800. |
it has been hypothesized that acetylcholinesterase (ache) and butyrylcholinesterase (buche) are coregulators of the duration of action of acetylcholine in cholinergic neurotransmission, suggesting that buche may also have an important role in the brain. |
2003-08-29 |
2023-08-12 |
human |
| Edgar Luttmann, Elmar Linnemann, Gregor Fel. Galanthamine as bis-functional ligand for the acetylcholinesterase. Journal of molecular modeling. vol 8. issue 6. 2003-08-18. PMID:12140604. |
acetylcholinesterase plays a key role in the development of alzheimer's disease as this enzyme is responsible for cleavage of the neurotransmitter acetylcholine, and, according to recent investigations, also promotes aggregation of beta-amyloid peptides, which causes plaque formation in synaptic areas. |
2003-08-18 |
2023-08-12 |
Not clear |
| Susana G Rossi, Ian M Dickerson, Richard L Rotund. Localization of the calcitonin gene-related peptide receptor complex at the vertebrate neuromuscular junction and its role in regulating acetylcholinesterase expression. The Journal of biological chemistry. vol 278. issue 27. 2003-08-18. PMID:12707285. |
together, these studies suggest a specific role for cgrp released by spinal cord motoneurons in modulating synaptic transmission at the neuromuscular junction by locally inhibiting the expression of acetylcholinesterase, the enzyme responsible for terminating acetylcholine neurotransmission. |
2003-08-18 |
2023-08-12 |
Not clear |
| Vladimir Piotrovsky, Achiel Van Peer, Nancy Van Osselaer, Martin Armstrong, Jeroen Aerssen. Galantamine population pharmacokinetics in patients with Alzheimer's disease: modeling and simulations. Journal of clinical pharmacology. vol 43. issue 5. 2003-08-18. PMID:12751272. |
galantamine is a reversible, competitive inhibitor of acetylcholinesterase and an allosteric modulator of nicotinic acetylcholine receptors. |
2003-08-18 |
2023-08-12 |
Not clear |
| Kaustubha D Patil, Robin A Buerki, Popat N Pati. Potentiation of acetylcholine action by huperzine-A and physostigmine on some vertebrate effectors, including human iris sphincter muscle. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. vol 19. issue 2. 2003-08-07. PMID:12804058. |
the main objective of this investigation was to compare the acetylcholine potentiating action of huperzine-a with acetylcholinesterase inhibitor physostigmine on the frog rectus abdominus muscle, rat phrenic nerve diaphragm preparation, guinea pig ileum and human iris sphincter muscle. |
2003-08-07 |
2023-08-12 |
human |
| H L Fernandez, M Chen, I Nadelhaft, J A Dur. Calcitonin gene-related peptides: their binding sites and receptor accessory proteins in adult mammalian skeletal muscles. Neuroscience. vol 119. issue 2. 2003-07-30. PMID:12770550. |
thus, gracilis muscles express cgrpalpha-specific binding sites which are predominantly localized in the muscle's motor endplate regions where ramp1, rcp, cgrpalpha, acetylcholine receptors, and acetylcholinesterase are detected in high concentrations. |
2003-07-30 |
2023-08-12 |
rat |