| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gertraud Koellner, Thomas Steiner, Charles B Millard, Israel Silman, Joel L Sussma. A neutral molecule in a cation-binding site: specific binding of a PEG-SH to acetylcholinesterase from Torpedo californica. Journal of molecular biology. vol 320. issue 4. 2002-08-27. PMID:12095250. |
this is an untypical acetylcholinesterase inhibitor, since it lacks the cationic moiety typical of the substrate (acetylcholine). |
2002-08-27 |
2023-08-12 |
Not clear |
| Hengshan Zhang, Jing Liu, Carey N Pop. Age-related effects of chlorpyrifos on muscarinic receptor-mediated signaling in rat cortex. Archives of toxicology. vol 75. issue 11-12. 2002-08-13. PMID:11876500. |
a number of studies suggest that in addition to inhibiting acetylcholinesterase (ache), cpf oxon may also interact directly with m2 and/or m4 subtypes of muscarinic acetylcholine receptors (machrs). |
2002-08-13 |
2023-08-12 |
rat |
| U Freo, G Pizzolato, M Dam, C Ori, L Battisti. A short review of cognitive and functional neuroimaging studies of cholinergic drugs: implications for therapeutic potentials. Journal of neural transmission (Vienna, Austria : 1996). vol 109. issue 5-6. 2002-08-06. PMID:12111473. |
acetylcholine precursors, cholinergic agonists and acetylcholinesterase inhibitors) enhance attention and memory in experiment animals, healthy human subjects and alzheimer disease patients. |
2002-08-06 |
2023-08-12 |
human |
| Gertjan J M den Hartog, Erik Vegt, Wim J F van der Vijgh, Guido R M M Haenen, Aalt Bas. Hypochlorous acid is a potent inhibitor of acetylcholinesterase. Toxicology and applied pharmacology. vol 181. issue 3. 2002-07-24. PMID:12079432. |
decreased acetylcholinesterase activity could allow accumulation of acetylcholine and increased airway muscle tension. |
2002-07-24 |
2023-08-12 |
Not clear |
| Lauren R Plageman, Giovanni M Pauletti, Kenneth A Ska. Characterization of acetylcholinesterase in Caco-2 cells. Experimental biology and medicine (Maywood, N.J.). vol 227. issue 7. 2002-07-19. PMID:12094012. |
acetylcholinesterase (acetylcholine hydrolase, ec 3.1.1.7) was solubilized from cultured caco-2 cells. |
2002-07-19 |
2023-08-12 |
Not clear |
| M-M Mesulam, A Guillozet, P Shaw, A Levey, E G Duysen, O Lockridg. Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine. Neuroscience. vol 110. issue 4. 2002-06-12. PMID:11934471. |
acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine. |
2002-06-12 |
2023-08-12 |
mouse |
| M-M Mesulam, A Guillozet, P Shaw, A Levey, E G Duysen, O Lockridg. Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine. Neuroscience. vol 110. issue 4. 2002-06-12. PMID:11934471. |
they also show that butyrylcholinesterase can potentially substitute for acetylcholinesterase and that this enzyme is likely to play a constitutive (rather than just back-up) role in the hydrolysis of acetylcholine in the normal brain. |
2002-06-12 |
2023-08-12 |
mouse |
| Analía Richeri, Lorena Viettro, Rebeca Chávez-Genaro, Geoffrey Burnstock, Timothy Cowen, M Mónica Braue. Effects of infantile/prepubertal chronic estrogen treatment and chemical sympathectomy with guanethidine on developing cholinergic nerves of the rat uterus. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 50. issue 6. 2002-06-11. PMID:12019300. |
cholinergic nerves were visualized using a combination of acetylcholinesterase histochemistry and the immunohistochemical demonstration of the vesicular acetylcholine transporter (vacht). |
2002-06-11 |
2023-08-12 |
rat |
| F R de la Torre, L Ferrari, A Salibiá. Freshwater pollution biomarker: response of brain acetylcholinesterase activity in two fish species. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 131. issue 3. 2002-06-06. PMID:11912052. |
the effect of prolonged exposure at two sites along the reconquista river (argentina), a highly polluted peri-urban water body, on brain acetylcholinesterase (ache, ec 3.1.1.7, acetylcholine acetylhydrolase) of two teleosts was examined. |
2002-06-06 |
2023-08-12 |
Not clear |
| M Shapira, C K Thompson, H Soreq, G E Robinso. Changes in neuronal acetylcholinesterase gene expression and division of labor in honey bee colonies. Journal of molecular neuroscience : MN. vol 17. issue 1. 2002-05-10. PMID:11665858. |
because acetylcholinesterase (ache) hydrolyzes acetylcholine, a major neurotransmitter associated with learning in the insect brain, we searched for changes in ache expression in the brain during bee behavioral development. |
2002-05-10 |
2023-08-12 |
bee |
| Karl W K Tsim, Eric A Barnar. The signaling pathways mediated by P2Y nucleotide receptors in the formation and maintenance of the skeletal neuromuscular junction. Neuro-Signals. vol 11. issue 1. 2002-05-09. PMID:11943883. |
the muscle cell surface contains a high local density of acetylcholine (ach) receptors (achrs), acetylcholinesterase (ache) and their interacting macromolecules at the nmj, forming the postsynaptic specializations. |
2002-05-09 |
2023-08-12 |
Not clear |
| Jasmina Minic, Jordi Molgó, Evert Karlsson, Eric Krejc. Regulation of acetylcholine release by muscarinic receptors at the mouse neuromuscular junction depends on the activity of acetylcholinesterase. The European journal of neuroscience. vol 15. issue 3. 2002-05-07. PMID:11876771. |
regulation of acetylcholine release by muscarinic receptors at the mouse neuromuscular junction depends on the activity of acetylcholinesterase. |
2002-05-07 |
2023-08-12 |
mouse |
| T Bur. Donepezil and related cholinesterase inhibitors as mood and behavioral controlling agents. Current psychiatry reports. vol 2. issue 6. 2002-04-30. PMID:11122998. |
acetylcholinesterase inhibitors (cheis) enhance neuronal transmission by increasing the availability of acetylcholine in muscarinic and nicotinic receptors. |
2002-04-30 |
2023-08-12 |
Not clear |
| Timo Erkinjuntti, Alexander Kurz, Serge Gauthier, Roger Bullock, Sean Lilienfeld, ChandrasekharRao Venkata Damaraj. Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial. Lancet (London, England). vol 359. issue 9314. 2002-04-30. PMID:11965273. |
galantamine amplifies the acetylcholine response by inhibiting acetylcholinesterase and modulating nicotinic receptors. |
2002-04-30 |
2023-08-12 |
Not clear |
| Tai C Kwon. Organophosphate pesticides: biochemistry and clinical toxicology. Therapeutic drug monitoring. vol 24. issue 1. 2002-04-23. PMID:11805735. |
the mechanism of toxicity is the inhibition of acetylcholinesterase, resulting in an accumulation of the neurotransmitter acetylcholine and the continued stimulation of acetylcholine receptors. |
2002-04-23 |
2023-08-12 |
Not clear |
| Tai C Kwon. Organophosphate pesticides: biochemistry and clinical toxicology. Therapeutic drug monitoring. vol 24. issue 1. 2002-04-23. PMID:11805735. |
the standard treatment consists of reactivation of the inhibited acetylcholinesterase with an oxime antidote and reversal of the biochemical effects of acetylcholine with atropine. |
2002-04-23 |
2023-08-12 |
Not clear |
| K H Dannelly, Y Liu, S K Ghos. Pseudomonas aeruginosa corneal infection affects cholinergic enzymes in rat lacrimal gland. Archives of microbiology. vol 177. issue 1. 2002-04-22. PMID:11797044. |
choline acetyltransferase and acetylcholinesterase are known to be responsible for synthesis and degradation of acetylcholine, respectively, binding receptors on acini and plasma cells, modulating their activity, and constituting the principle regulator of tear secretion. |
2002-04-22 |
2023-08-12 |
rat |
| P F Zabrodskii, V F Kirichuk, V G Germanchu. Role of anticholinesterase mechanism in suppression of antibody formation during acute poisoning with organophosphorus compounds. Bulletin of experimental biology and medicine. vol 131. issue 5. 2002-03-22. PMID:11550055. |
acetylcholine activated acetylcholinesterase in intact t cells. |
2002-03-22 |
2023-08-12 |
rat |
| Jen-Tzer Gau, Michelle L Steinhilb, Tzu-Cheg Kao, Constance J D'Amato, James R Gaut, Kirk A Frey, R Scott Turne. Stable beta-secretase activity and presynaptic cholinergic markers during progressive central nervous system amyloidogenesis in Tg2576 mice. The American journal of pathology. vol 160. issue 2. 2002-03-19. PMID:11839594. |
at 14, 18, and 23 months of age there were no significant differences between wild-type and transgenic mice in four distinct central nervous system cholinergic indices--choline acetyltransferase and acetylcholinesterase activities, and binding to vesicular acetylcholine transporter and na(+)-dependent high-affinity choline uptake sites. |
2002-03-19 |
2023-08-12 |
mouse |
| E X Albuquerque, M D Santos, M Alkondon, E F Pereira, A Maelick. Modulation of nicotinic receptor activity in the central nervous system: a novel approach to the treatment of Alzheimer disease. Alzheimer disease and associated disorders. vol 15 Suppl 1. 2002-03-18. PMID:11669505. |
currently, cholinergic deficit is usually corrected by increasing the amount of acetylcholine in the synapse by inhibiting acetylcholinesterase (ache). |
2002-03-18 |
2023-08-12 |
Not clear |