| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Archana Hazarika, S N Sarkar, Sunil Hajare, Meena Kataria, J K Mali. Influence of malathion pretreatment on the toxicity of anilofos in male rats: a biochemical interaction study. Toxicology. vol 185. issue 1-2. 2003-03-11. PMID:12505439. |
toxicity of organophosphates stems mainly from the accumulation of acetylcholine due to inhibition of acetylcholinesterase (ache). |
2003-03-11 |
2023-08-12 |
rat |
| Talma Brenner, Yasmine Hamra-Amitay, Tama Evron, Neli Boneva, Shlomo Seidman, Hermona Sore. The role of readthrough acetylcholinesterase in the pathophysiology of myasthenia gravis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 17. issue 2. 2003-02-28. PMID:12554700. |
alternative splicing induces, under abnormal cholinergic neurotransmission, overproduction of the rare "readthrough" acetylcholinesterase variant ache-r. we explored the pathophysiological relevance of this phenomenon in patients with myasthenia gravis (mg) and rats with experimental autoimmune mg (eamg), neuromuscular junction diseases with depleted acetylcholine receptors. |
2003-02-28 |
2023-08-12 |
rat |
| Richard B Rosse, Stephen I Deutsc. Adjuvant galantamine administration improves negative symptoms in a patient with treatment-refractory schizophrenia. Clinical neuropharmacology. vol 25. issue 5. 2003-01-13. PMID:12410061. |
galantamine is distinguished from other acetylcholinesterase inhibitors by its positive allosteric modulatory properties, improving the efficiency of transduction of the acetylcholine signal at nicotinic receptors. |
2003-01-13 |
2023-08-12 |
Not clear |
| Fu-Ming Zhou, Charles J Wilson, John A Dan. Cholinergic interneuron characteristics and nicotinic properties in the striatum. Journal of neurobiology. vol 53. issue 4. 2003-01-13. PMID:12436423. |
a high concentration of acetylcholinesterase in the striatum rapidly terminates the ach signal, and thereby minimizes desensitization of nicotinic acetylcholine receptors. |
2003-01-13 |
2023-08-12 |
Not clear |
| C Flores-Flores, A Nissim, S Shochat, H Sore. Development of human antibody fragments directed towards synaptic acetylcholinesterase using a semi-synthetic phage display library. Journal of neural transmission. Supplementum. issue 62. 2003-01-10. PMID:12456061. |
current alzheimer's disease therapies suppress acetylcholine hydrolysis by inhibiting acetylcholinesterase (ache) at cholinergic synapses. |
2003-01-10 |
2023-08-12 |
human |
| H Geerts, L Finkel, R Carr, A Spiro. Nicotinic receptor modulation: advantages for successful Alzheimer's disease therapy. Journal of neural transmission. Supplementum. issue 62. 2003-01-10. PMID:12456064. |
galantamine is a modest acetylcholinesterase inhibitor (achei) that is also an allosteric potentiating ligand (apl) of nicotinic acetylcholine receptors (nachrs). |
2003-01-10 |
2023-08-12 |
Not clear |
| Mohamed B Abou-Donia, Anjelika M Dechkovskaia, Larry B Goldstein, Deepti U Shah, Sarah L Bullman, Wasiuddin A Kha. Uranyl acetate-induced sensorimotor deficit and increased nitric oxide generation in the central nervous system in rats. Pharmacology, biochemistry, and behavior. vol 72. issue 4. 2003-01-08. PMID:12062578. |
the levels of nitric oxide as marker for increased oxidative stress, and the integrity of the cholinergic system as reflected in acetylcholinesterase (ache) activity and m2 muscarinic acetylcholine receptors ligand binding, were determined. |
2003-01-08 |
2023-08-12 |
rat |
| Seyed K Tayebati, Dahuk El-Assouad, Alberto Ricci, Francesco Ament. Immunochemical and immunocytochemical characterization of cholinergic markers in human peripheral blood lymphocytes. Journal of neuroimmunology. vol 132. issue 1-2. 2003-01-02. PMID:12417445. |
the totality of peripheral blood lymphocytes express acetylcholine (ach) immunoreactivity, choline acetyltransferase (chat), acetylcholinesterase (ache), vesicular ach transporter (vacht) and m(2)-m(5) muscarinic cholinergic receptor protein immunoreactivity. |
2003-01-02 |
2023-08-12 |
human |
| Takasuke Fujimura, Haruo Kobayashi, Tadahiko Suzuki, Itaru Sato, Shigeo Har. [Neurotoxicity in sodium azide poisoning]. Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology. vol 15. issue 3. 2002-12-24. PMID:12415870. |
measurements of the activities of acetylcholinesterase (ache) and choline acetyltransferase (chat), enzymes that hydrolyze and synthesize acetylcholine (ach) and high-affinity choline uptake (hacu), a rate-limiting step in the synthesis of ach, were determined in the presence of various concentrations of sodium azide in vitro. |
2002-12-24 |
2023-08-12 |
mouse |
| L Jaganathan, R Boopath. A direct method to visualise the aryl acylamidase activity on cholinesterases in polyacrylamide gels. BMC biochemistry. vol 1. 2002-12-18. PMID:11231883. |
the function of acetylcholinesterase is to hydrolyse acetylcholine, thereby terminating the neurotransmission at cholinergic synapse, while the precise physiological function of butyrylcholinesterase has not been identified. |
2002-12-18 |
2023-08-12 |
Not clear |
| N Nunes-Tavares, A Nery da Matta, C M Batista e Silva, G M N Araújo, S R W Louro, A Hassón-Voloc. Inhibition of acetylcholinesterase from Electrophorus electricus (L.) by tricyclic antidepressants. The international journal of biochemistry & cell biology. vol 34. issue 9. 2002-12-17. PMID:12009302. |
the effects of tricyclic antidepressants drugs (tca) amitriptyline, imipramine and nortriptyline, on purified electrophorus electricus (l.) acetylcholinesterase (ache; acetylcholine hydrolase, ec 3.1.1.7) were studied using kinetic methods and specific fluorescent probe propidium. |
2002-12-17 |
2023-08-12 |
Not clear |
| Jorge Andres Rodriguez, Ana Maria Buzaleh, Mariana Fossati, Julio Azcurra, Alcira Maria Del Carmen Batll. The effects of some porphyrinogenic drugs on the brain cholinergic system. Cellular and molecular biology (Noisy-le-Grand, France). vol 48. issue 1. 2002-12-02. PMID:11929041. |
in central nervous system, acetylcholinesterase (ache) and butyrylcholinesterase (buche) hydrolyse acetylcholine. |
2002-12-02 |
2023-08-12 |
Not clear |
| Sean Lilienfel. Galantamine--a novel cholinergic drug with a unique dual mode of action for the treatment of patients with Alzheimer's disease. CNS drug reviews. vol 8. issue 2. 2002-11-25. PMID:12177686. |
it is a reversible, competitive inhibitor of acetylcholinesterase (ache), and is the only drug actively marketed for the treatment of ad with proven activity as an allosteric modulator of nicotinic acetylcholine receptors (nachrs). |
2002-11-25 |
2023-08-12 |
Not clear |
| Ali Abdel-Rahman, Ashok K Shetty, Mohamed B Abou-Doni. Disruption of the blood-brain barrier and neuronal cell death in cingulate cortex, dentate gyrus, thalamus, and hypothalamus in a rat model of Gulf-War syndrome. Neurobiology of disease. vol 10. issue 3. 2002-11-15. PMID:12270692. |
all animals were evaluated for: (i) the disruption of the blood-brain barrier (bbb) using intravenous horseradish peroxidase (hrp) injections and endothelial barrier antigen (eba) immunostaining; (ii) neuronal cell death using h&e staining, silver staining, and glial fibrillary acidic protein (gfap) immunostaining; and (iii) acetylcholinesterase (ache) activity and m2-muscarinic acetylcholine receptors (m2-achr). |
2002-11-15 |
2023-08-12 |
rat |
| Kazuo Isoma, Masago Ishikawa, Megumi Ohta, Yoichiro Ogawa, Hiroshi Hasegawa, Tadayuki Kohda, Junzo Kame. Effects of T-82, a new quinoline derivative, on cholinesterase activity and extracellular acetylcholine concentration in rat brain. Japanese journal of pharmacology. vol 88. issue 2. 2002-11-04. PMID:11928722. |
the effects of t-82 (2-[2-(1-benzylpiperidin-4-yl)ethyl]-2,3-dihydro-9-methoxy-1h-pyrrolo [3,4-b]quinolin-1-one hemifumarate), a new quinoline derivative, on acetylcholinesterase (ache) activity and acetylcholine (ach) release were compared with those of the well-known cholinesterase inhibitors tacrine and e2020. |
2002-11-04 |
2023-08-12 |
human |
| Ho-Jin Heo, Seong-Chan Hong, Hong-Yon Cho, Bumshik Hong, Hye-Kyung Kim, Eun-Ki Kim, Dong-Hoon Shi. Inhibitory effect of zeatin, isolated from Fiatoua villosa, on acetylcholinesterase activity from PC12 cells. Molecules and cells. vol 13. issue 1. 2002-10-10. PMID:11911460. |
acetylcholinesterase (ache) inhibitors, which enhance cholinergic transmission by reducing the enzymatic degradation of acetylcholine, are the only source of the compound that is currently approved for the treatment of alzheimer's disease (ad). |
2002-10-10 |
2023-08-12 |
Not clear |
| T Carbonell, I Masip, F Sánchez-Baeza, M Delgado, E Araya, O Llorens, F Corcho, J J Pérez, E Pérez-Payá, A Messegue. Identification of selective inhibitors of acetylcholinesterase from a combinatorial library of 2,5-piperazinediones. Molecular diversity. vol 5. issue 3. 2002-09-30. PMID:12197070. |
increasing the acetylcholine concentration in brain by modulating acetylcholinesterase (ache) activity is among the most promising strategies. |
2002-09-30 |
2023-08-12 |
Not clear |
| b' Jean Massouli\\xc3\\xa. The origin of the molecular diversity and functional anchoring of cholinesterases. Neuro-Signals. vol 11. issue 3. 2002-09-25. PMID:12138250.' |
vertebrates possess two cholinesterases, acetylcholinesterase (ache) and butyrylcholinesterase (bche) which both hydrolyze acetylcholine, but differ in their specificity towards other substrates, and in their sensitivity to inhibitors. |
2002-09-25 |
2023-08-12 |
mouse |
| Jeremy Kua, Yingkai Zhang, J Andrew McCammo. Studying enzyme binding specificity in acetylcholinesterase using a combined molecular dynamics and multiple docking approach. Journal of the American Chemical Society. vol 124. issue 28. 2002-09-18. PMID:12105904. |
a combined molecular dynamics simulation and multiple ligand docking approach is applied to study the binding specificity of acetylcholinesterase (ache) with its natural substrate acetylcholine (ach), a family of substrate analogues, and choline. |
2002-09-18 |
2023-08-12 |
cat |
| Ivan Bednar, David Paterson, Amelia Marutle, Therese M Pham, Marie Svedberg, Ewa Hellström-Lindahl, Malahat Mousavi, Jennifer Court, Christopher Morris, Elaine Perry, Abdul Mohammed, Xiao Zhang, Agneta Nordber. Selective nicotinic receptor consequences in APP(SWE) transgenic mice. Molecular and cellular neurosciences. vol 20. issue 2. 2002-08-29. PMID:12093166. |
the nicotinic (nachrs) and muscarinic (machrs) acetylcholine receptors and acetylcholinesterase (ache) activity were studied in the brains of app(swe) transgenic mice (tg+) and age-matched nontransgenic controls (tg-) that were between 4 and 19 months of age. |
2002-08-29 |
2023-08-12 |
mouse |