| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Coelho, J Birk. Physostigmine for Alzheimer's disease. The Cochrane database of systematic reviews. issue 2. 2002-02-28. PMID:11405996. |
the main pharmacological approach for the treatment of alzheimer's disease (ad) has been based on the use of agents potentiating cholinergic transmission, particularly by inhibiting acetylcholinesterase (ache), the enzyme that destroys acetylcholine after it has been secreted into the synaptic clefts. |
2002-02-28 |
2023-08-12 |
Not clear |
| B H Hsieh, J F Deng, J Ger, W J Tsa. Acetylcholinesterase inhibition and the extrapyramidal syndrome: a review of the neurotoxicity of organophosphate. Neurotoxicology. vol 22. issue 4. 2002-02-14. PMID:11577800. |
the mechanism remains to be identified, but may be related to the impediment of the function of acetylcholinesterase to modify nigrostriatal dopaminergic system, which is independent of hydrolyzing acetylcholine. |
2002-02-14 |
2023-08-12 |
Not clear |
| P Drapeau, R R Buss, D W Ali, P Legendre, R L Rotund. Limits to the development of fast neuromuscular transmission in zebrafish. Journal of neurophysiology. vol 86. issue 6. 2002-01-28. PMID:11731551. |
to identify the bases for these changes we compared, in embryos and larvae, the properties and distributions of acetylcholine (ach) receptors (achrs) and acetylcholinesterase (ache) as well as the ultrastructure of the developing neuromuscular junctions (nmjs). |
2002-01-28 |
2023-08-12 |
zebrafish |
| P Cra. Recent developments in Alzheimer's disease. Acta clinica Belgica. vol 56. issue 5. 2002-01-24. PMID:11770221. |
acetylcholine is deficient in alzheimer's disease and can be supplemented in part by treatment with acetylcholinesterase inhibitors. |
2002-01-24 |
2023-08-12 |
mouse |
| G L Larsen, J Loader, D D Nguyen, G N Colasurd. Mechanisms of cholinergic dysfunction in rabbits following recurrent aspiration of cow's milk. Pediatric pulmonology. vol 32. issue 6. 2002-01-10. PMID:11747243. |
segments were assessed for acetylcholine (ach) release by high-performance liquid chromatography ( hplc) with electrochemical detection or acetylcholinesterase (ache) kinetic activity by spectrophotometry. |
2002-01-10 |
2023-08-12 |
Not clear |
| F Amenta, L Parnetti, V Gallai, A Walli. Treatment of cognitive dysfunction associated with Alzheimer's disease with cholinergic precursors. Ineffective treatments or inappropriate approaches? Mechanisms of ageing and development. vol 122. issue 16. 2001-12-31. PMID:11589920. |
the different approaches proposed or tested included intervention with acetylcholine (ach) precursors, stimulation of ach release, use of muscarinic or nicotinic receptor agonists and acetylcholinesterase (ache) or cholinesterase (che) inhibition. |
2001-12-31 |
2023-08-12 |
Not clear |
| T C Rodrigues, M Tubino, O E Godinho, G de Oliveira Net. Flow-injection spectrophotometric determination of paraoxon by its inhibitory effect on the enzyme acetylcholinesterase. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. vol 17. issue 5. 2001-12-31. PMID:11708144. |
the method was based on the determination of the acetic acid formed by the enzymatic reaction of the acetylcholinesterase, immobilized on glass beads, with the substrate acetylcholine. |
2001-12-31 |
2023-08-12 |
Not clear |
| J El Yazal, S N Rao, A Mehl, W Slikke. Prediction of organophosphorus acetylcholinesterase inhibition using three-dimensional quantitative structure-activity relationship (3D-QSAR) methods. Toxicological sciences : an official journal of the Society of Toxicology. vol 63. issue 2. 2001-12-12. PMID:11568366. |
neurotoxic organophosphorous compounds are known to modulate their biological effects through the inhibition of a number of esterases including acetylcholinesterase (ache), the enzyme responsible for the degradation of the neurotransmitter acetylcholine. |
2001-12-12 |
2023-08-12 |
Not clear |
| J Stoja. Slow detection reaction can mimic initial inhibition of an enzymic reaction. Journal of enzyme inhibition. vol 16. issue 2. 2001-10-11. PMID:11342277. |
an analysis of sigmoid-shaped progress curves in the reaction between electric eel acetylcholinesterase (acetylcholine acetylhydrolase, ec 3.1.1.7, ache) and its substrate acetylthiocholine in low concentrations at ph 7 is presented. |
2001-10-11 |
2023-08-12 |
Not clear |
| S Olivera, D Rodriguez-Ithurralde, J M Henle. Regional localization and developmental profile of acetylcholinesterase-evoked increases in [(3)H]-5-fluororwillardiine binding to AMPA receptors in rat brain. British journal of pharmacology. vol 133. issue 7. 2001-10-04. PMID:11487516. |
in addition to its role in hydrolyzing the neurotransmitter acetylcholine, the synaptically enriched enzyme acetylcholinesterase (ache) has been reported to play an important role in the development and remodelling of neural processes and synapses. |
2001-10-04 |
2023-08-12 |
rat |
| M U Delmonte Corrado, H Politi, M Ognibene, C Angelini, F Trielli, P Ballarini, C Falug. Synthesis of the signal molecule acetylcholine during the developmental cycle of Paramecium primaurelia (Protista, Ciliophora) and its possible function in conjugation. The Journal of experimental biology. vol 204. issue Pt 11. 2001-09-27. PMID:11441032. |
we recently discovered, in mating-competent paramecium primaurelia, the presence of functionally related molecules of the cholinergic system: the neurotransmitter acetylcholine (ach), both its nicotinic and muscarinic receptors and its lytic enzyme acetylcholinesterase (ache). |
2001-09-27 |
2023-08-12 |
Not clear |
| J M Daniel, G P Dohanic. Acetylcholine mediates the estrogen-induced increase in NMDA receptor binding in CA1 of the hippocampus and the associated improvement in working memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 17. 2001-09-20. PMID:11517282. |
in the current experiments, elevating endogenous levels of acetylcholine in ovariectomized rats by 3 d of continuous administration of physostigmine, an acetylcholinesterase inhibitor, increased nmda receptor binding in ca1 as measured by quantitative autoradiography. |
2001-09-20 |
2023-08-12 |
rat |
| M Sungur, M Güve. Intensive care management of organophosphate insecticide poisoning. Critical care (London, England). vol 5. issue 4. 2001-09-06. PMID:11511334. |
the inhibition of acetylcholinesterase causes accumulation of acetylcholine at synapses, and overstimulation of neurotransmission occurs as a result of this accumulation. |
2001-09-06 |
2023-08-12 |
Not clear |
| B Lockhart, M Closier, K Howard, C Steward, P Lestag. Differential inhibition of [3H]-oxotremorine-M and [3H]-quinuclinidyl benzilate binding to muscarinic receptors in rat brain membranes with acetylcholinesterase inhibitors. Naunyn-Schmiedeberg's archives of pharmacology. vol 363. issue 4. 2001-08-16. PMID:11330337. |
however, fasciculin-2, a potent peptide inhibitor of acetylcholinesterase (ic50 24 nm), did prevent catabolism of acetylcholine in rat brain membranes with an atypical inhibition isotherm of [3h]-oxotremorine-m binding, thus permitting an estimation of the "global affinity" of acetylcholine (ki 85 nm) for [3h]-oxotremorine-m-labelled muscarinic receptors in rat brain. |
2001-08-16 |
2023-08-12 |
rat |
| H Maruyama, T L Rakow, I N Maruyam. Synaptic exocytosis and nervous system development impaired in Caenorhabditis elegans unc-13 mutants. Neuroscience. vol 104. issue 2. 2001-08-16. PMID:11377834. |
consistent with the phenotypes, the mutants accumulated abnormally high levels of the neurotransmitter acetylcholine and were resistant to acetylcholinesterase inhibitors. |
2001-08-16 |
2023-08-12 |
caenorhabditis_elegans |
| G Folkerts, J Kloek, P Geppetti, H J Van der Linde, F P Nijkam. Factors that determine acetylcholine responsiveness of guinea pig tracheal tubes. European journal of pharmacology. vol 420. issue 2-3. 2001-08-09. PMID:11408037. |
in contrast, a response was hardly observed in tissues with an intact epithelial layer (674+/-81 mg), which was due to both the synthesis of nitric oxide and the activity of acetylcholinesterase, since the contractions to acetylcholine were significantly enhanced after preincubation with n(omega)-nitro-l-arginine methyl ester (l-name) or physostigmine (1374+/-65 and 1120+/-65 mg, respectively). |
2001-08-09 |
2023-08-12 |
Not clear |
| L R Britto, A S Alves, J M Lindstrom, A S Torrã. Differential localization of acetylcholinesterase in relation to pre- and postsynaptic nicotinic receptors in the chick brain. Brain research. vol 898. issue 1. 2001-07-19. PMID:11292459. |
immunofluorescence and confocal microscopy were combined to study the distribution of acetylcholinesterase in relation to the localization of the beta2 subunit of the nicotinic acetylcholine receptors in the chick brain. |
2001-07-19 |
2023-08-12 |
chicken |
| L A Naves, W Van der Kloo. Repetitive nerve stimulation decreases the acetylcholine content of quanta at the frog neuromuscular junction. The Journal of physiology. vol 532. issue Pt 3. 2001-07-12. PMID:11313435. |
when the solution contained 10 microm neostigmine (neo) 3000 stimuli reduced [integral]mepcs by 60 %, because with acetylcholinesterase (ache) inhibited, [integral]mepc size is more sensitive to changes in acetylcholine (ach) content. |
2001-07-12 |
2023-08-12 |
Not clear |
| C R Walker, B W Wilso. Regulation of acetylcholinesterase in chick muscle cultures after treatment with diisopropylphosphorofluoridate: ribonucleic acid and protein synthesis. Neuroscience. vol 1. issue 6. 2001-07-12. PMID:11370244. |
in addition, it has been shown that acetylcholine, acetyl-beta-methylcholine and choline increase the acetylcholinesterase content of the cultures. |
2001-07-12 |
2023-08-12 |
chicken |
| N R Cutler, J J Srame. Review of the next generation of Alzheimer's disease therapeutics: challenges for drug development. Progress in neuro-psychopharmacology & biological psychiatry. vol 25. issue 1. 2001-06-21. PMID:11263756. |
currently, the only fda-approved ad therapies are a group of acetylcholinesterase inhibitors which slow the turnover of the neurotransmitter acetylcholine in the synapse. |
2001-06-21 |
2023-08-12 |
Not clear |