| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| X Sun, X B Liu, J R Martinez, G H Zhan. Effects of low concentrations of paraoxon on Ca(2+) mobilization in a human parotid salivary cell-line HSY. Archives of oral biology. vol 45. issue 8. 2000-08-18. PMID:10869474. |
inhibition of acetylcholinesterase (ache) by ops leads to a decrease in acetylcholine (ach) breakdown that results in overstimulation of muscarinic cholinergic receptors (mchr). |
2000-08-18 |
2023-08-12 |
human |
| J W Bigbee, K V Sharma, J J Gupta, J L Dupre. Morphogenic role for acetylcholinesterase in axonal outgrowth during neural development. Environmental health perspectives. vol 107 Suppl 1. 2000-07-27. PMID:10229710. |
acetylcholinesterase (ache) is the enzyme that hydrolyzes the neurotransmitter acetylcholine at cholinergic synapses and neuromuscular junctions. |
2000-07-27 |
2023-08-12 |
Not clear |
| L Trabace, A Coluccia, S Gaetani, M Tattoli, R Cagiano, C Pietra, K M Kendrick, V Cuom. In vivo neurochemical effects of the acetylcholinesterase inhibitor ENA713 in rat hippocampus. Brain research. vol 865. issue 2. 2000-07-24. PMID:10821930. |
oral ena713 (0.5, 1.5 and 4.5 mg/kg), an acetylcholinesterase inhibitor (achei), dose-dependently enhanced extracellular acetylcholine concentrations in the hippocampus of freely moving rats. |
2000-07-24 |
2023-08-12 |
rat |
| G Jeyarasasingam, M Yeluashvili, M Qui. Tacrine, a reversible acetylcholinesterase inhibitor, induces myopathy. Neuroreport. vol 11. issue 6. 2000-07-17. PMID:10817586. |
tacrine, an acetylcholinesterase (ache) inhibitor that has been used in the treatment of alzheimer's disease, increases available acetylcholine (ach) levels in the synaptic cleft thereby enhancing the activity of cholinergic pathways. |
2000-07-17 |
2023-08-12 |
rat |
| G Testylier, L Tonduli, G Lallemen. Implication of gamma band in soman-induced seizures. Acta biotheoretica. vol 47. issue 3-4. 2000-07-13. PMID:10855266. |
for the same rat, we associated cortical acetylcholinesterase (ache) activity by microdialysis with both the assay of extracellular acetylcholine (ach) concentrations and electroencephalographic (eeg) recording and power spectrum analysis (gamma band). |
2000-07-13 |
2023-08-12 |
rat |
| J Birks, V Iakovidou, M Tsolak. Rivastigmine for Alzheimer's disease. The Cochrane database of systematic reviews. issue 2. 2000-07-06. PMID:10796621. |
one of the most successful therapeutic strategies for alzheimer's disease has been the use of acetylcholinesterase inhibitors to enhance surviving cholinergic neurotransmission by inhibiting breakdown of released acetylcholine. |
2000-07-06 |
2023-08-12 |
Not clear |
| D H Overstree. Organophosphate pesticides, cholinergic function and cognitive performance in advanced age. Neurotoxicology. vol 21. issue 1-2. 2000-06-30. PMID:10794387. |
there is considerable evidence for a decline in cholinergic indices (choline acetyltransferase, acetylcholinesterase, and muscarinic acetylcholine receptors) with aging. |
2000-06-30 |
2023-08-12 |
Not clear |
| M Aschne. Interactions between pesticides and glia: an unexplored experimental field. Neurotoxicology. vol 21. issue 1-2. 2000-06-30. PMID:10794397. |
it is also well established that acute exposure to the organophosphorous insecticides leads to inhibition of neuronal acetylcholinesterase activity, an enzyme responsible for the inactivation of the neurotransmitter acetylcholine. |
2000-06-30 |
2023-08-12 |
Not clear |
| P Marcho. [The fasciculin-acetylcholinesterase interaction]. Journal de la Societe de biologie. vol 193. issue 6. 2000-06-19. PMID:10783708. |
acetylcholinesterase (ache) terminates the action of the neurotransmitter acetylcholine at cholinergic synapses in the central and peripheral nervous systems. |
2000-06-19 |
2023-08-12 |
mouse |
| V T Nguyen, L L Hall, G Gallacher, A Ndoye, D L Jolkovsky, R J Webber, R Buchli, S A Grand. Choline acetyltransferase, acetylcholinesterase, and nicotinic acetylcholine receptors of human gingival and esophageal epithelia. Journal of dental research. vol 79. issue 4. 2000-06-13. PMID:10831096. |
choline acetyltransferase, acetylcholinesterase, and nicotinic acetylcholine receptors of human gingival and esophageal epithelia. |
2000-06-13 |
2023-08-12 |
human |
| G T Trevisani, N H Hyman, J M Churc. Neostigmine: safe and effective treatment for acute colonic pseudo-obstruction. Diseases of the colon and rectum. vol 43. issue 5. 2000-06-06. PMID:10826417. |
neostigmine enhances excitatory parasympathetic activity by competing with acetylcholine for attachment to acetylcholinesterase at sites of cholinergic transmission and enhancing cholinergic action. |
2000-06-06 |
2023-08-12 |
Not clear |
| T Harkany, B Penke, P G Luite. beta-Amyloid excitotoxicity in rat magnocellular nucleus basalis. Effect of cortical deafferentation on cerebral blood flow regulation and implications for Alzheimer's disease. Annals of the New York Academy of Sciences. vol 903. 2000-06-02. PMID:10818528. |
both neuroanatomical and neurochemical observations pin-point that infusion of a beta into the rat basal forebrain significantly decreases choline-acetyltransferase and acetylcholinesterase activities and the population of--probably--m2 muscarinic acetylcholine receptors in the cerebral cortex. |
2000-06-02 |
2023-08-12 |
rat |
| C Bessou, J B Giugia, C J Franks, L Holden-Dye, L Ségala. Mutations in the Caenorhabditis elegans dystrophin-like gene dys-1 lead to hyperactivity and suggest a link with cholinergic transmission. Neurogenetics. vol 2. issue 1. 2000-04-07. PMID:9933302. |
finally, the dys-1 mutants are hypersensitive to acetylcholine and to the acetylcholinesterase inhibitor aldicarb, suggesting that dys-1 mutations affect cholinergic transmission. |
2000-04-07 |
2023-08-12 |
human |
| S Palmero, G Bardi, L Coniglio, C Falug. Presence and localization of molecules related to the cholinergic system in developing rat testis. European journal of histochemistry : EJH. vol 43. issue 4. 2000-03-22. PMID:10682265. |
in the present study, a contribution is given to the localization of some cholinergic-like molecules, such as acetylcholinesterase (ache), nicotinic acetylcholine and muscarinic acetylcoline (nachr and machr, respectively) receptors during postnatal development of the testis. |
2000-03-22 |
2023-08-12 |
rat |
| M D Cassell, H Yi, W T Talma. Glycine receptor (gephyrin) immunoreactivity is present on cholinergic neurons in the dorsal vagal complex. Neuroscience. vol 95. issue 2. 2000-02-29. PMID:10658629. |
the responses to glycine, like those to acetylcholine, are blocked by administration of a muscarinic receptor antagonist and prolonged by administration of an acetylcholinesterase inhibitor. |
2000-02-29 |
2023-08-12 |
rat |
| S Nurrish, L Ségalat, J M Kapla. Serotonin inhibition of synaptic transmission: Galpha(0) decreases the abundance of UNC-13 at release sites. Neuron. vol 24. issue 1. 2000-02-25. PMID:10677040. |
release of acetylcholine from motor neurons was assayed by measuring the sensitivity of intact animals to the acetylcholinesterase inhibitor aldicarb. |
2000-02-25 |
2023-08-12 |
caenorhabditis_elegans |
| P Kasa, H Papp, I Kovacs, M Forgon, B Penke, H Yamaguch. Human amyloid-beta1-42 applied in vivo inhibits the fast axonal transport of proteins in the sciatic nerve of rat. Neuroscience letters. vol 278. issue 1-2. 2000-02-22. PMID:10643815. |
by using immunohistochemistry we explored the inhibitory effects of human amyloid-beta1-42 applied in vivo on the fast axonal transport of acetylcholinesterase, the amyloid precursor protein, the vesicular acetylcholine transporter and synaptophysin in the sciatic nerve of rat. |
2000-02-22 |
2023-08-12 |
human |
| G Leitinger, P J Simmon. Cytochemical evidence that acetylcholine is a neurotransmitter of neurons that make excitatory and inhibitory outputs in the locust ocellar visual system. The Journal of comparative neurology. vol 416. issue 3. 2000-02-15. PMID:10602093. |
the third method was the histochemical detection at the electron microscope level of acetylcholinesterase, the enzyme responsible for the breakdown of acetylcholine. |
2000-02-15 |
2023-08-12 |
Not clear |
| J Giugia, K Gieseler, M Arpagaus, L Ségala. Mutations in the dystrophin-like dys-1 gene of Caenorhabditis elegans result in reduced acetylcholinesterase activity. FEBS letters. vol 463. issue 3. 2000-01-19. PMID:10606735. |
in addition dys-1 mutants are hypersensitive to acetylcholine and acetylcholinesterase inhibitors. |
2000-01-19 |
2023-08-12 |
caenorhabditis_elegans |
| F J Muñoz, R Aldunate, N C Inestros. Peripheral binding site is involved in the neurotrophic activity of acetylcholinesterase. Neuroreport. vol 10. issue 17. 2000-01-19. PMID:10619655. |
acetylcholinesterase (ache) catalyses the hydrolysis of the neurotransmitter acetylcholine and it has been implicated in several non-cholinergic actions, including neurite outgrowth and amyloid formation. |
2000-01-19 |
2023-08-12 |
Not clear |