| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R E Papka, H H Traurig, M Schemann, J Collins, T Copelin, K Wilso. Cholinergic neurons of the pelvic autonomic ganglia and uterus of the female rat: distribution of axons and presence of muscarinic receptors. Cell and tissue research. vol 296. issue 2. 1999-07-12. PMID:10382273. |
however, the histochemical reaction for acetylcholinesterase provides only indirect evidence of acetylcholine location and is a nonspecific marker for cholinergic nerves. |
1999-07-12 |
2023-08-12 |
rat |
| S Olivera, D Rodriguez-Ithurralde, J M Henle. Acetylcholinesterase potentiates [3H]fluorowillardiine and [3H]AMPA binding to rat cortical membranes. Neuropharmacology. vol 38. issue 4. 1999-07-02. PMID:10221754. |
in addition to its action at cholinergic synapses acetylcholinesterase (ache) has been proposed to modulate neuronal activity by mechanisms unrelated to the hydrolysis of acetylcholine. |
1999-07-02 |
2023-08-12 |
rat |
| M R Schetinger, C D Bonan, S S Frassetto, A T Wyse, R C Schierholt, A Webber, R D Dias, J J Sarkis, C A Nett. Pre-conditioning to global cerebral ischemia changes hippocampal acetylcholinesterase in the rat. Biochemistry and molecular biology international. vol 47. issue 3. 1999-05-27. PMID:10204084. |
this is in agreement with previous evidence that acetylcholinesterase inhibition and maintenance of acetylcholine levels are beneficial for cell surviving after cerebral ischemia. |
1999-05-27 |
2023-08-12 |
rat |
| G Testylier, N Micoud, S Martinez, G Lallemen. Simultaneous in vivo determination of acetylcholinesterase activity and acetylcholine release in the cortex of waking rat by microdialysis. Effects of VX. Journal of neuroscience methods. vol 81. issue 1-2. 1999-05-12. PMID:9696310. |
simultaneous in vivo determination of acetylcholinesterase activity and acetylcholine release in the cortex of waking rat by microdialysis. |
1999-05-12 |
2023-08-12 |
rat |
| G Testylier, N Micoud, S Martinez, G Lallemen. Simultaneous in vivo determination of acetylcholinesterase activity and acetylcholine release in the cortex of waking rat by microdialysis. Effects of VX. Journal of neuroscience methods. vol 81. issue 1-2. 1999-05-12. PMID:9696310. |
we have designed a microdialysis technique to measure acetylcholinesterase (ache) activity in the cortex of freely moving rats while simultaneously measuring the release of acetylcholine (ach). |
1999-05-12 |
2023-08-12 |
rat |
| B Surendra Nath, R P Surendra Kuma. Toxic impact of organophosphorus insecticides on acetylcholinesterase activity in the silkworm, Bombyx mori L. Ecotoxicology and environmental safety. vol 42. issue 2. 1999-05-11. PMID:10051365. |
toxic impact of organophosphorus insecticides on acetylcholinesterase activity in the silkworm, bombyx mori l. the effect of widely used commercial-grade organophosphorus insecticides, namely, fenitrothion and ethion, on acetylcholinesterase activity and acetylcholine levels in brain, fat body, and silk gland of bombyx mori on days 1, 3, and 5 and food intake of the fifth instar were studied. |
1999-05-11 |
2023-08-12 |
Not clear |
| B Surendra Nath, R P Surendra Kuma. Toxic impact of organophosphorus insecticides on acetylcholinesterase activity in the silkworm, Bombyx mori L. Ecotoxicology and environmental safety. vol 42. issue 2. 1999-05-11. PMID:10051365. |
acetylcholinesterase activity was found to be inhibited, followed by a concomitant increase in acetylcholine levels in the target tissues. |
1999-05-11 |
2023-08-12 |
Not clear |
| J E Keymer, J Gaete, G Kameid, J Alvare. Acetylcholinesterase and inhibitors: effects upon normal and regenerating nerves of the rat. The European journal of neuroscience. vol 11. issue 3. 1999-04-26. PMID:10103097. |
in peripheral nerves, the function of acetylcholinesterase (ache) is not related to hydrolysis of acetylcholine. |
1999-04-26 |
2023-08-12 |
rat |
| J E Lachowicz, D Lowe, R A Duffy, V Ruperto, L A Taylor, H Guzik, J Brown, J G Berger, M Tice, R McQuade, J Kozlowski, J Clader, C D Strader, N Murgol. SCH 57790: a novel M2 receptor selective antagonist. Life sciences. vol 64. issue 6-7. 1999-03-25. PMID:10069520. |
as a decrease in cholinergic neurons has been observed in alzheimer's disease (ad), therapeutic approaches to ad include inhibition of acetylcholinesterase to increase acetylcholine levels. |
1999-03-25 |
2023-08-12 |
human |
| K L Davi. Alzheimer's disease: seeking new ways to preserve brain function. Interview by Alice V. Luddington. Geriatrics. vol 54. issue 2. 1999-03-03. PMID:10024872. |
the cholinesterase inhibitors tacrine and donepezil block acetylcholinesterase and therefore preserve the neurotransmitter acetylcholine. |
1999-03-03 |
2023-08-12 |
Not clear |
| A Morett. Experimental and clinical toxicology of anticholinesterase agents. Toxicology letters. vol 102-103. 1999-02-25. PMID:10022304. |
their acute toxic effect in the central and peripheral nervous system is due to inhibition of acetylcholinesterase (ache) at nerve endings which causes accumulation of acetylcholine and consequently overstimulation of the nicotinic and muscarinic receptors. |
1999-02-25 |
2023-08-12 |
Not clear |
| J McFerrin, W K Engel, V Askana. Impaired innervation of cultured human muscle overexpressing betaAPP experimentally and genetically: relevance to inclusion-body myopathies. Neuroreport. vol 9. issue 14. 1999-01-20. PMID:9831451. |
innervated normal cultured muscle fibers were continuously contracting and fully cross-striated, and they had acetylcholine receptors (achrs) and acetylcholinesterase (ache) accumulated only at the neuromuscular junctions (nmjs). |
1999-01-20 |
2023-08-12 |
human |
| R M Nitsch, S Rossner, C Albrecht, M Mayhaus, J Enderich, R Schliebs, M Wegner, T Arendt, H von der Kamme. Muscarinic acetylcholine receptors activate the acetylcholinesterase gene promoter. Journal of physiology, Paris. vol 92. issue 3-4. 1999-01-13. PMID:9789819. |
muscarinic acetylcholine receptors activate the acetylcholinesterase gene promoter. |
1999-01-13 |
2023-08-12 |
human |
| N Kishibayashi, A Karasaw. Effects of KW-5092 on antroduodenal coordination and gastric emptying in guinea-pigs. The Journal of pharmacy and pharmacology. vol 50. issue 9. 1999-01-08. PMID:9811166. |
kw-5092 (2-[1-[2-[[5-(piperidinomethyl)-2-furanyl] methylamino]ethyl]imidazonylidin-2-ylidenene]malononitrile fumarate) is a novel gastroprokinetic agent with both acetylcholine release facilitatory and acetylcholinesterase inhibitory activity. |
1999-01-08 |
2023-08-12 |
Not clear |
| N Kishibayashi, A Karasaw. Effects of KW-5092 on antroduodenal coordination and gastric emptying in guinea-pigs. The Journal of pharmacy and pharmacology. vol 50. issue 9. 1999-01-08. PMID:9811166. |
cisapride, a gastroprokinetic agent with acetylcholine release facilitatory activity, also increased coordination whereas neither acetylcholine nor the acetylcholinesterase inhibitor neostigmine affected it. |
1999-01-08 |
2023-08-12 |
Not clear |
| N Kishibayashi, A Karasaw. Effects of KW-5092 on antroduodenal coordination and gastric emptying in guinea-pigs. The Journal of pharmacy and pharmacology. vol 50. issue 9. 1999-01-08. PMID:9811166. |
these results suggest that acetylcholine release facilitation, but not acetylcholinesterase inhibition, is involved in the enhancement by kw-5092 of antroduodenal coordination and gastric emptying. |
1999-01-08 |
2023-08-12 |
Not clear |
| R A Giniatullin, L G Magazani. Desensitization of the post-synaptic membrane of neuromuscular synapses induced by spontaneous quantum secretion of mediator. Neuroscience and behavioral physiology. vol 28. issue 4. 1998-12-21. PMID:9762720. |
factors promoting the desensitization of the post-synaptic cholinergic membrane (inhibition of acetylcholinesterase and addition of proadifen) to levels greater than a certain (critical) frequency of endplate miniature current of the order of 50 spikes/sec were found to result in accumulation of activity and progressive reductions in the sensitivity of the post-synaptic membrane to the mediator acetylcholine. |
1998-12-21 |
2023-08-12 |
Not clear |
| S Darvesh, S E MacDonald, A M Losier, E Martin, D A Hopkins, J A Armou. Cholinesterases in cardiac ganglia and modulation of canine intrinsic cardiac neuronal activity. Journal of the autonomic nervous system. vol 71. issue 2-3. 1998-12-11. PMID:9760044. |
cholinergic neurotransmission plays a significant role in intrinsic cardiac ganglia with the action of acetylcholine being terminated by acetylcholinesterase (ache, ec 3.1.1.7). |
1998-12-11 |
2023-08-12 |
Not clear |
| M G Giovannini, C Scali, L Bartolini, B Schmidt, G Pepe. Effect of subchronic treatment with metrifonate and tacrine on brain cholinergic function in aged F344 rats. European journal of pharmacology. vol 354. issue 1. 1998-11-09. PMID:9726626. |
extracellular acetylcholine levels were measured by transversal microdialysis in vivo; choline acetyltransferase and acetylcholinesterase activities were measured ex vivo by means of radiometric methods. |
1998-11-09 |
2023-08-12 |
rat |
| R E Carson, D O Kiesewetter, E Jagoda, M G Der, P Herscovitch, W C Eckelma. Muscarinic cholinergic receptor measurements with [18F]FP-TZTP: control and competition studies. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 18. issue 10. 1998-11-09. PMID:9778190. |
third, the sensitivity of [18f]fp-tztp binding to changes in brain acetylcholine (ach) was assessed by administering physostigmine, an acetylcholinesterase (ache) inhibitor, by intravenous infusion (100 to 200 microg x kg(-1) x h(-1)) beginning 30 minutes before tracer injection (n = 7). |
1998-11-09 |
2023-08-12 |
monkey |