| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Chen, E Shohami, R Bass, M Weinstoc. Cerebro-protective effects of ENA713, a novel acetylcholinesterase inhibitor, in closed head injury in the rat. Brain research. vol 784. issue 1-2. 1998-04-30. PMID:9518537. |
ischemia decreases brain acetylcholine (ach) levels and head trauma upregulates acetylcholinesterase (ache) in experimental animal models. |
1998-04-30 |
2023-08-12 |
rat |
| M Alkondon, E F Pereira, W S Cortes, A Maelicke, E X Albuquerqu. Choline is a selective agonist of alpha7 nicotinic acetylcholine receptors in the rat brain neurons. The European journal of neuroscience. vol 9. issue 12. 1998-04-24. PMID:9517478. |
in the present study, we demonstrate that choline, a precursor of acetylcholine (ach) and a product of acetylcholine hydrolysis by acetylcholinesterase (ache), acts as an efficient and relatively selective agonist of alpha7-containing nicotinic acetylcholine receptors (nachr) in neurons cultured from the rat hippocampus, olfactory bulb and thalamus as well as in pc12 cells. |
1998-04-24 |
2023-08-12 |
rat |
| C Opazo, N C Inestros. Crosslinking of amyloid-beta peptide to brain acetylcholinesterase. Molecular and chemical neuropathology. vol 33. issue 1. 1998-04-21. PMID:9493175. |
acetylcholinesterase (ache) is the enzyme responsible for the hydrolysis of the neurotransmitter acetylcholine in the central nervous system. |
1998-04-21 |
2023-08-12 |
Not clear |
| H Kanemitsu, M Suematsu, T Ishii, M Aoki, T Nakagomi, N Kishino, T Iwasawa, M Iwahashi, A Tamur. [Changes in acetylcholine level and its related enzyme activities in rat brain following focal ischemia]. No to shinkei = Brain and nerve. vol 50. issue 1. 1998-04-21. PMID:9493197. |
moreover activities of choline acetyltransferase, which is the synthetic enzyme of acetylcholine, and activities of acetylcholinesterase, which is the degradative enzyme of acetylcholine, were measured in the anterior cortex which was recognized decrease of the acetylcholine level and the hippocampus which could not be detected the difference of the acetylcholine level. |
1998-04-21 |
2023-08-12 |
rat |
| E Moor, E Schirm, J Jacsó, B H Westerin. Effects of neostigmine and atropine on basal and handling-induced acetylcholine output from ventral hippocampus. Neuroscience. vol 82. issue 3. 1998-04-09. PMID:9483538. |
the involvement of muscarinic autoreceptors in the regulation of hippocampal acetylcholine levels during acetylcholinesterase inhibition was examined by perfusing the acetylcholinesterase inhibitor neostigmine bromide (10, 100 or 1000 nm) alone and in the presence of the muscarinic receptor antagonist atropine methylnitrate (10 microm), in resting and behaviourally-activated animals. |
1998-04-09 |
2023-08-12 |
Not clear |
| E Moor, E Schirm, J Jacsó, B H Westerin. Effects of neostigmine and atropine on basal and handling-induced acetylcholine output from ventral hippocampus. Neuroscience. vol 82. issue 3. 1998-04-09. PMID:9483538. |
the handling-evoked increase in acetylcholine levels is only moderately affected by the level of acetylcholinesterase inhibition, despite the participation of autoreceptors in the handling effect at higher levels of acetylcholinesterase inhibition. |
1998-04-09 |
2023-08-12 |
Not clear |
| J M Cermak, T Holler, D A Jackson, J K Blusztaj. Prenatal availability of choline modifies development of the hippocampal cholinergic system. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 12. issue 3. 1998-03-31. PMID:9506479. |
to characterize the neurochemical mechanisms that may mediate this effect, we investigated the development of indices of the cholinergic system in the hippocampus: choline acetyltransferase (chat), acetylcholinesterase (ache), synthesis of acetylcholine (ach) from choline transported by high-affinity choline uptake (hacu), and potassium-evoked ach release. |
1998-03-31 |
2023-08-12 |
rat |
| M Brank, K Zajc-Kreft, S Kreft, R Komel, Z Grubi. Biogenesis of acetylcholinesterase is impaired, although its mRNA level remains normal, in the glucocorticoid-treated rat skeletal muscle. European journal of biochemistry. vol 251. issue 1-2. 1998-03-23. PMID:9492307. |
acetylcholinesterase (ache) is responsible for the hydrolysis of acetylcholine in the neuromuscular junction and other cholinergic synapses. |
1998-03-23 |
2023-08-12 |
rat |
| E Acquas, H C Fibige. Dopaminergic regulation of striatal acetylcholine release: the critical role of acetylcholinesterase inhibition. Journal of neurochemistry. vol 70. issue 3. 1998-03-12. PMID:9489729. |
dopaminergic regulation of striatal acetylcholine release: the critical role of acetylcholinesterase inhibition. |
1998-03-12 |
2023-08-12 |
Not clear |
| E Acquas, H C Fibige. Dopaminergic regulation of striatal acetylcholine release: the critical role of acetylcholinesterase inhibition. Journal of neurochemistry. vol 70. issue 3. 1998-03-12. PMID:9489729. |
this study examined the effects of different levels of acetylcholinesterase (ache) inhibition on dopaminergic regulation of striatal acetylcholine (ach) release as estimated by in vivo brain microdialysis. |
1998-03-12 |
2023-08-12 |
Not clear |
| Q Xin, R M Wightma. Transport of choline in rat brain slices. Brain research. vol 776. issue 1-2. 1998-02-24. PMID:9439804. |
a substance in brain tissue, presumably acetylcholinesterase, prevents the use of differential measurements of acetylcholine because choline sensors became sensitive to acetylcholine. |
1998-02-24 |
2023-08-12 |
rat |
| M Grifman, A Arbel, D Ginzberg, D Glick, S Elgavish, B Shaanan, H Sore. In vitro phosphorylation of acetylcholinesterase at non-consensus protein kinase A sites enhances the rate of acetylcholine hydrolysis. Brain research. Molecular brain research. vol 51. issue 1-2. 1998-02-17. PMID:9427520. |
in vitro phosphorylation of acetylcholinesterase at non-consensus protein kinase a sites enhances the rate of acetylcholine hydrolysis. |
1998-02-17 |
2023-08-12 |
human |
| R J Callister, P Sa. The removal of acetylcholine by diffusion at nicotinic synapses in the rat otic ganglion. The Journal of physiology. vol 505 ( Pt 1). 1998-02-03. PMID:9409480. |
we have examined the clearance of synaptically released acetylcholine in the otic ganglion when acetylcholinesterase was blocked with eserine. |
1998-02-03 |
2023-08-12 |
rat |
| R J Callister, P Sa. The removal of acetylcholine by diffusion at nicotinic synapses in the rat otic ganglion. The Journal of physiology. vol 505 ( Pt 1). 1998-02-03. PMID:9409480. |
when acetylcholinesterase is blocked, acetylcholine accumulates because its removal by diffusion is slow. |
1998-02-03 |
2023-08-12 |
rat |
| K K Hicks, E Seifen, J R Stimers, R H Kenned. Diabetes with and without ketoacidosis on right atrial pacemaker rate and autonomic responsiveness. The American journal of physiology. vol 273. issue 4. 1997-12-10. PMID:9362257. |
the sensitivity to the negative chronotropic action of acetylcholine was enhanced by iddm, whereas the response to carbachol (a cholinergic agonist not readily metabolized by acetylcholinesterase) was not changed. |
1997-12-10 |
2023-08-12 |
rat |
| M L Capece, R Lydi. cAMP and protein kinase A modulate cholinergic rapid eye movement sleep generation. The American journal of physiology. vol 273. issue 4. 1997-12-10. PMID:9362309. |
microinjection of cholinergic agonists and acetylcholinesterase inhibitors into the mprf induces a rem sleep-like state, and microdialysis data reveal increased mprf levels of acetylcholine during rem sleep. |
1997-12-10 |
2023-08-12 |
Not clear |
| D P Hill, K A Robertso. Characterization of the cholinergic neuronal differentiation of the human neuroblastoma cell line LA-N-5 after treatment with retinoic acid. Brain research. Developmental brain research. vol 102. issue 1. 1997-11-19. PMID:9298234. |
following induction with ra, the neural crest-like la-n-5 cells undergo differentiation into cholinergic neurons with increased expression of a variety of neural-specific markers including neurofilaments, growth associated protein-43, tetanus toxin binding sites, receptors for neurotrophic factors, neuropeptides, choline acetyl transferase, vesicular acetylcholine transporter, and acetylcholinesterase with a concomitant decrease in the expression of non-neuronal markers. |
1997-11-19 |
2023-08-12 |
human |
| R Camarini, M A Benedit. Rapid eye movement (REM) sleep deprivation reduces rat frontal cortex acetylcholinesterase (EC 3.1.1.7) activity. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 30. issue 5. 1997-11-18. PMID:9283633. |
acetylcholinesterase (achase) controls acetylcholine (ach) availability in the synaptic cleft. |
1997-11-18 |
2023-08-12 |
rat |
| T Christova, Z Grozdanovic, R Gossra. Nitric oxide synthase (NOS) I during postnatal development in rat and mouse skeletal muscle. Acta histochemica. vol 99. issue 3. 1997-11-12. PMID:9381914. |
beginning with postnatal day (pd) 1 in both fiber types dystrophin, dystrophin-associated glycoproteins (dag), beta-dystroglycan, alpha-sarcoglycan (adhalin) and spectrin were present in the junctional and extrajunctional sarcolemma, while utrophin, acetylcholinesterase, alpha-bungarotoxin labeled acetylcholine receptors were concentrated in the nmj of both fiber types. |
1997-11-12 |
2023-08-12 |
mouse |
| P Kása, Z Rakonczay, K Guly. The cholinergic system in Alzheimer's disease. Progress in neurobiology. vol 52. issue 6. 1997-11-05. PMID:9316159. |
although the disease is characterized by multiple deficits of neurotransmitters in the brain, this overview emphasizes the structural and neurochemical localization of the elements of the acetylcholine system (choline acetyltransferase, acetylcholinesterase, and muscarinic and nicotinic acetylcholine receptors) in the non-demented brain and in alzheimer's disease brain samples. |
1997-11-05 |
2023-08-12 |
Not clear |