| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J McFerrin, W K Engel, V Askana. Cultured inclusion-body myositis muscle fibers do not accumulate beta-amyloid precursor protein and can be innervated. Neurology. vol 53. issue 9. 2000-01-04. PMID:10599804. |
cultured muscle fibers from patients with sporadic inclusion-body myositis (s-ibm), similar to normal control muscle fibers, 1) did not have beta-amyloid precursor protein (betaapp) immunoreactivity; and 2) became normally innervated, as evidenced by the following features: full cross-striation, continuous contraction, and acetylcholinesterase and acetylcholine receptors accumulated only at neuromuscular junctions. |
2000-01-04 |
2023-08-12 |
Not clear |
| Z Yingge, Z Delu, B Chunli, W Che. Force spectroscopy between acetylcholinesterase molecule and its natural substrate to study the effects of inhibitors and reactivators on enzyme activity. Life sciences. vol 65. issue 21. 1999-12-07. PMID:10576601. |
the force spectrum (fs) between acetylcholinesterase (ache) molecule and its natural substrates acetylcholine (ach) and the influences of ache inhibitors and reactivators have been investigated with atomic force microscopy (afm) at single molecule level in real-time. |
1999-12-07 |
2023-08-12 |
Not clear |
| L S Tonduli, G Testylier, I P Marino, G Lallemen. Triggering of soman-induced seizures in rats: multiparametric analysis with special correlation between enzymatic, neurochemical and electrophysiological data. Journal of neuroscience research. vol 58. issue 3. 1999-11-23. PMID:10518121. |
for the same rat, we associated cortical acetylcholinesterase (ache) activity by microdialysis with both the assay of extracellular acetylcholine (ach) concentrations and electroencephalographic (eeg) recording and power spectrum analysis (gamma band). |
1999-11-23 |
2023-08-12 |
rat |
| F M Jacobsen, L Comas-Día. Donepezil for psychotropic-induced memory loss. The Journal of clinical psychiatry. vol 60. issue 10. 1999-11-10. PMID:10549687. |
donepezil is an acetylcholinesterase inhibitor marketed for treatment of memory loss and behavioral deterioration associated with the acetylcholine deficit of alzheimer's disease. |
1999-11-10 |
2023-08-12 |
Not clear |
| J M Preuss, R G Goldi. Age-related changes in muscarinic cholinoceptor function in guinea-pig and rat airways. Naunyn-Schmiedeberg's archives of pharmacology. vol 360. issue 2. 1999-11-08. PMID:10494888. |
whilst acetylcholinesterase inhibition caused a significant increase in acetylcholine potency, this was independent of animal age. |
1999-11-08 |
2023-08-12 |
rat |
| T Kosasa, Y Kuriya, K Matsui, Y Yamanish. Effect of donepezil hydrochloride (E2020) on basal concentration of extracellular acetylcholine in the hippocampus of rats. European journal of pharmacology. vol 380. issue 2-3. 1999-11-01. PMID:10513568. |
the effects of oral administration of the centrally acting acetylcholinesterase (ache) inhibitors, donepezil hydrochloride (donepezil: e2020: (+/-)-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-indan-1-one monohydrochloride), tacrine (9-amino-1,2,3,4-tetrahydroacridine hydrochloride) and ena-713 (rivastigmine: (s)-n-ethyl-3-[(1-dimethyl-amino)ethyl]-n-methyl-phenylcarbamate hydrogentartrate), which have been developed for the treatment of alzheimer's disease, on the extracellular acetylcholine concentration in the hippocampus of rats were evaluated by using a microdialysis technique without adding cholinesterase inhibitor to the perfusion solution. |
1999-11-01 |
2023-08-12 |
rat |
| Y Bulut, S R Kleeberger, C A Hirshma. Cholinesterase activity is similar in C3H/HeJ and A/J mice and does not account for their different bronchoconstrictor responsiveness. Experimental lung research. vol 25. issue 5. 1999-10-15. PMID:10483521. |
acetylcholinesterase and butyrylcholinesterase inhibition increased airway responses to acetylcholine in both strains, but did not eliminate or decrease the differences in airway responsiveness to ach previously seen in the two strains. |
1999-10-15 |
2023-08-12 |
mouse |
| D Grisaru, M Sternfeld, A Eldor, D Glick, H Sore. Structural roles of acetylcholinesterase variants in biology and pathology. European journal of biochemistry. vol 264. issue 3. 1999-10-14. PMID:10491113. |
apart from its catalytic function in hydrolyzing acetylcholine, acetylcholinesterase (ache) affects cell proliferation, differentiation and responses to various insults, including stress. |
1999-10-14 |
2023-08-12 |
human |
| G Testylier, M Maalouf, A E Butt, A A Miasnikov, R W Dyke. Evidence for homeostatic adjustments of rat somatosensory cortical neurons to changes in extracellular acetylcholine concentrations produced by iontophoretic administration of acetylcholine and by systemic diisopropylfluorophosphate treatment. Neuroscience. vol 91. issue 3. 1999-10-08. PMID:10391467. |
we describe the responses of single units in the awake (24 cells) or urethane-anesthetized (37 cells) rat somatosensory cortex during repeated iontophoretic pulses (1.0 s, 85 na) of acetylcholine, both before and after systemic treatment with the irreversible acetylcholinesterase inhibitor diisopropylfluorophosphate (i.p., 0.3-0.5 ld50). |
1999-10-08 |
2023-08-12 |
rat |
| G Testylier, M Maalouf, A E Butt, A A Miasnikov, R W Dyke. Evidence for homeostatic adjustments of rat somatosensory cortical neurons to changes in extracellular acetylcholine concentrations produced by iontophoretic administration of acetylcholine and by systemic diisopropylfluorophosphate treatment. Neuroscience. vol 91. issue 3. 1999-10-08. PMID:10391467. |
our results suggest that dynamic, homeostatic mechanisms control neuronal excitability by adjusting the balance between excitatory and inhibitory influences within the cortical circuitry and that these mechanisms are engaged by prolonged increases in extracellular acetylcholine levels caused by repeated pulses of acetylcholine and by acetylcholinesterase inhibition. |
1999-10-08 |
2023-08-12 |
rat |
| P Krzywkowski, O Ghribi, J Gagné, C Chabot, S Kar, J Rochford, G Massicotte, J Poirie. Cholinergic systems and long-term potentiation in memory-impaired apolipoprotein E-deficient mice. Neuroscience. vol 92. issue 4. 1999-10-08. PMID:10426483. |
choline acetyltransferase activity, hippocampal acetylcholine release, nicotinic and muscarinic (m1 and m2) receptor binding sites and acetylcholinesterase cell or terminal density showed no signs of alteration in either three-month or 9.5-month-old apolipoprotein e-deficient mice compared to controls. |
1999-10-08 |
2023-08-12 |
mouse |
| M M El-Etri, M Ennis, E R Griff, M T Shiple. Evidence for cholinergic regulation of basal norepinephrine release in the rat olfactory bulb. Neuroscience. vol 93. issue 2. 1999-10-07. PMID:10465445. |
local infusion of the acetylcholinesterase inhibitor soman (0.4 mm) into the olfactory bulb increased basal norepinephrine levels by 134% of control, suggesting that endogenously released acetylcholine modulates norepinephrine release. |
1999-10-07 |
2023-08-12 |
rat |
| S H Astrow, H Qiang, C P K. Perisynaptic Schwann cells at neuromuscular junctions revealed by a novel monoclonal antibody. Journal of neurocytology. vol 27. issue 9. 1999-09-14. PMID:10447241. |
in frog muscles, axotomy induces sprouting of psc processes beyond clusters of acetylcholine receptors and acetylcholinesterase at denervated junctional branches. |
1999-09-14 |
2023-08-12 |
Not clear |
| A Iliev, V Traykov, D Prodanov, G Mantchev, K Yakimova, I Krushkov, N Boyadjiev. Effect of the acetylcholinesterase inhibitor galanthamine on learning and memory in prolonged alcohol intake rat model of acetylcholine deficit. Methods and findings in experimental and clinical pharmacology. vol 21. issue 4. 1999-09-09. PMID:10399139. |
effect of the acetylcholinesterase inhibitor galanthamine on learning and memory in prolonged alcohol intake rat model of acetylcholine deficit. |
1999-09-09 |
2023-08-12 |
rat |
| C A Nurse, M Zhan. Acetylcholine contributes to hypoxic chemotransmission in co-cultures of rat type 1 cells and petrosal neurons. Respiration physiology. vol 115. issue 2. 1999-08-27. PMID:10385033. |
recent evidence has strengthened the case for acetylcholine (ach) as a co-released transmitter: (i) cultured type 1 cells express several cholinergic markers including the vesicular ach transporter (vacht), intracellular acetylcholinesterase (ache), and occasional clear cored vesicles (approximately 50 nm diameter); (ii) the frequency of spontaneous synaptic activity, as well as the hypoxia-induced depolarization recorded in 'juxtaposed' pn in co-culture, were partially suppressed by the nicotinic ach receptor (nachr) blocker, mecamylamine (2 microm); (iii) consistent with the presence of extracellular ache, ach-mediated membrane noise in type 1 cells as well as the hypoxia-evoked pn response in co-culture were potentiated in a few cases by the ache inhibitor, eserine (100 microm). |
1999-08-27 |
2023-08-12 |
rat |
| D Kaufer, A Friedman, S Seidman, H Sore. Anticholinesterases induce multigenic transcriptional feedback response suppressing cholinergic neurotransmission. Chemico-biological interactions. vol 119-120. 1999-08-19. PMID:10421471. |
cholinesterase inhibitors (anti-ches) include a wide range of therapeutic, agricultural and warfare agents all aimed to inhibit the catalytic activity of the acetylcholine (ach) hydrolysing enzyme acetylcholinesterase (ache). |
1999-08-19 |
2023-08-12 |
mouse |
| P Grillner, A Bonci, T H Svensson, G Bernardi, N B Mercur. Presynaptic muscarinic (M3) receptors reduce excitatory transmission in dopamine neurons of the rat mesencephalon. Neuroscience. vol 91. issue 2. 1999-08-02. PMID:10366013. |
furthermore, the acetylcholinesterase inhibitor, physostigmine (50 microm), decreased the amplitude of the excitatory synaptic potentials, indicating that ambient acetylcholine can depress this potential. |
1999-08-02 |
2023-08-12 |
rat |
| M J Titmus, H J Tsai, R Lima, S B Udi. Effects of choline and other nicotinic agonists on the tectum of juvenile and adult Xenopus frogs: a patch-clamp study. Neuroscience. vol 91. issue 2. 1999-08-02. PMID:10366031. |
moreover, the ability of choline to activate these receptors suggests that this metabolite of acetylcholine may permit paracrine activation of presynaptic receptors even though the tectum contains high acetylcholinesterase activity. |
1999-08-02 |
2023-08-12 |
xenopus_laevis |
| K Tuovinen, E Kaliste-Korhonen, F M Raushel, O Hännine. Success of pyridostigmine, physostigmine, eptastigmine and phosphotriesterase treatments in acute sarin intoxication. Toxicology. vol 134. issue 2-3. 1999-07-26. PMID:10403635. |
the acute toxicity of organophosphorus (op) compounds in mammals is due to their irreversible inhibition of acetylcholinesterase (ache) in the nervous system, which leads to increased synaptic acetylcholine levels. |
1999-07-26 |
2023-08-12 |
mouse |
| G Bicke. Histochemistry of classical neurotransmitters in antennal lobes and mushroom bodies of the honeybee. Microscopy research and technique. vol 45. issue 3. 1999-07-15. PMID:10344769. |
acetylcholinesterase histochemistry, immunocytochemical staining for nicotinic acetylcholine receptors, and mapping for alpha-bungarotoxin binding sites indicate cholinergic synaptic interactions in the antennal lobe and a cholinergic pathway via a subset of olfactory projection neurons into the mushroom bodies. |
1999-07-15 |
2023-08-12 |
bee |