| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M B Skaddan, M R Kilbourn, S E Snyder, P S Sherma. Acetylcholinesterase inhibition increases in vivo N-(2-[18F]fluoroethyl)-4-piperidyl benzilate binding to muscarinic acetylcholine receptors. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 21. issue 2. 2001-03-08. PMID:11176279. |
although the inhibition of acetylcholinesterase remains the primary treatment of alzheimer's disease, little is known of the results of increased acetylcholine levels on muscarinic receptor occupancy or function. |
2001-03-08 |
2023-08-12 |
rat |
| M B Skaddan, M R Kilbourn, S E Snyder, P S Sherma. Acetylcholinesterase inhibition increases in vivo N-(2-[18F]fluoroethyl)-4-piperidyl benzilate binding to muscarinic acetylcholine receptors. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 21. issue 2. 2001-03-08. PMID:11176279. |
using n-(2-[18f]fluoroethyl)-4-piperidyl benzilate ([18f]fepb), a moderate affinity (ki = 1.7 nmol/l) nonsubtype-selective muscarinic receptor antagonist, the authors examined the sensitivity of equilibrium in vivo radioligand binding in rat brain with changes in endogenous acetylcholine levels produced by treatments with acetylcholinesterase inhibitors. |
2001-03-08 |
2023-08-12 |
rat |
| M B Skaddan, M R Kilbourn, S E Snyder, P S Sherma. Acetylcholinesterase inhibition increases in vivo N-(2-[18F]fluoroethyl)-4-piperidyl benzilate binding to muscarinic acetylcholine receptors. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 21. issue 2. 2001-03-08. PMID:11176279. |
this agonist-induced increase of in vivo machr radioligand binding offers a new method for monitoring of the efficacy of acetylcholinesterase inhibitors or other drugs to enhance acetylcholine actions at the muscarinic receptors. |
2001-03-08 |
2023-08-12 |
rat |
| M P Cuajungco, K Y Fagét, X Huang, R E Tanzi, A I Bus. Metal chelation as a potential therapy for Alzheimer's disease. Annals of the New York Academy of Sciences. vol 920. 2001-02-08. PMID:11193167. |
at present, the treatment of symptoms includes use of acetylcholinesterase inhibitors, which enhance acetylcholine levels and improve cognitive functioning. |
2001-02-08 |
2023-08-12 |
Not clear |
| A S Torrão, F M Carmona, J Lindstrom, L R Britt. Expression of cholinergic system molecules during development of the chick nervous system. Brain research. Developmental brain research. vol 124. issue 1-2. 2001-02-01. PMID:11113515. |
there are suggestions of the participation of nicotinic acetylcholine receptors (nachrs), the acetylcholine degradation enzyme, acetylcholinesterase (ache), and the acetylcholine synthesizing enzyme, choline acetyltransferase (chat), in the development of the nervous system. |
2001-02-01 |
2023-08-12 |
chicken |
| C Bartolucci, E Perola, C Pilger, G Fels, D Lamb. Three-dimensional structure of a complex of galanthamine (Nivalin) with acetylcholinesterase from Torpedo californica: implications for the design of new anti-Alzheimer drugs. Proteins. vol 42. issue 2. 2001-02-01. PMID:11119642. |
galanthamine, a tertiary alkaloid extracted from several species of amarylidacae, is so far the only drug that shows a dual activity, being both an acetylcholinesterase inhibitor and an allosteric potentiator of the nicotinic response induced by acetylcholine and competitive agonists. |
2001-02-01 |
2023-08-12 |
Not clear |
| K H Jones, A M Dechkovskaia, E A Herrick, A A Abdel-Rahman, W A Khan, M B Abou-Doni. Subchronic effects following a single sarin exposure on blood-brain and blood-testes barrier permeability, acetylcholinesterase, and acetylcholine receptors in the central nervous system of rat: a dose-response study. Journal of toxicology and environmental health. Part A. vol 61. issue 8. 2001-01-11. PMID:11132698. |
subchronic effects following a single sarin exposure on blood-brain and blood-testes barrier permeability, acetylcholinesterase, and acetylcholine receptors in the central nervous system of rat: a dose-response study. |
2001-01-11 |
2023-08-12 |
rat |
| D S Woodruff-Pak, I S Santo. Nicotinic modulation in an animal model of a form of associative learning impaired in Alzheimer's disease. Behavioural brain research. vol 113. issue 1-2. 2001-01-03. PMID:10942028. |
galantamine induces allosteric modulation of nicotinic cholinergic receptors to increase acetylcholine release as well as acting as an acetylcholinesterase inhibitor. |
2001-01-03 |
2023-08-12 |
Not clear |
| H R Lam, O Ladefoged, G Ostergaard, U Hass, S P Lund, L Simonse. Four weeks' inhalation exposure of Long Evans rats to 4-tert-butyltoluene: effect on evoked potentials, behaviour, and brain neurochemistry. Pharmacology & toxicology. vol 87. issue 1. 2001-01-02. PMID:10987210. |
synaptosomal choline acetyltransferase activity increased and acetylcholinesterase activity was unchanged suggesting increased synaptosomal ability for acetylcholine synthesis. |
2001-01-02 |
2023-08-12 |
rat |
| A Maelick. Allosteric modulation of nicotinic receptors as a treatment strategy for Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 11 Suppl 1. 2000-12-28. PMID:10971047. |
the two most common approaches to correcting these cholinergic deficits are to increase the synaptic availability of acetylcholine (ach) by inhibiting acetylcholinesterase (ache), or to mimic the effects of ach (nicotinic agonists) by acting directly on nicotinic receptors. |
2000-12-28 |
2023-08-12 |
Not clear |
| S Lilienfeld, W Pary. Galantamine: additional benefits to patients with Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 11 Suppl 1. 2000-12-28. PMID:10971048. |
galantamine, a novel treatment for alzheimer's disease (ad), has a dual mechanism of action, combining allosteric modulation of nicotinic acetylcholine receptors with reversible, competitive inhibition of acetylcholinesterase. |
2000-12-28 |
2023-08-12 |
Not clear |
| R Zwart, R G van Kleef, C Gotti, C J Smulders, H P Vijverber. Competitive potentiation of acetylcholine effects on neuronal nicotinic receptors by acetylcholinesterase-inhibiting drugs. Journal of neurochemistry. vol 75. issue 6. 2000-12-28. PMID:11080202. |
the effects of the acetylcholinesterase inhibitors physostigmine and tacrine on alpha4beta2 and alpha4beta4 subtypes of neuronal nicotinic acetylcholine (ach) receptors, expressed in xenopus laevis oocytes, have been investigated. |
2000-12-28 |
2023-08-12 |
xenopus_laevis |
| S A Kardos, L G Sultato. Interactions of the organophosphates paraoxon and methyl paraoxon with mouse brain acetylcholinesterase. Toxicological sciences : an official journal of the Society of Toxicology. vol 58. issue 1. 2000-11-30. PMID:11053548. |
the mechanism of acute toxicity of the organophosphorus insecticides has been known for many years to be inhibition of the critical enzyme acetylcholinesterase (ec 3.1.1.7), with the resulting excess acetylcholine accumulation leading to symptoms of cholinergic excess. |
2000-11-30 |
2023-08-12 |
mouse |
| T Oue, A Yoneda, H Shima, P Pur. Muscarinic acetylcholine receptor expression in aganglionic bowel. Pediatric surgery international. vol 16. issue 4. 2000-11-07. PMID:10898227. |
in hirschsprung's disease (hd) there exists an overabundance of acetylcholine (ach), which in turn stimulates excessive production of the enzyme acetylcholinesterase. |
2000-11-07 |
2023-08-12 |
Not clear |
| G Jeyarasasingam, M Yeluashvili, M Qui. Nitric oxide is involved in acetylcholinesterase inhibitor-induced myopathy in rats. The Journal of pharmacology and experimental therapeutics. vol 295. issue 1. 2000-11-03. PMID:10991996. |
excess activation of muscle nicotinic acetylcholine receptors due to genetic mutations, as seen in slow channel congenital myasthenic syndrome, or acetylcholinesterase (ache) inhibition results in muscle cell degeneration. |
2000-11-03 |
2023-08-12 |
rat |
| Y Ikarashi, M Yuzurihara, M Shinoda, Y Maruyam. Effect of 2-deoxy-D-glucose on acetylcholine and histamine levels in gastric juice of pylorus-ligated rats anesthetized with urethane. Journal of chromatography. B, Biomedical sciences and applications. vol 742. issue 2. 2000-11-01. PMID:10901134. |
acetylcholine (ach) in gastric juice was detected and measured by pretreatment of acetylcholinesterase inhibitor, 1 mm eserine (1 ml/rat, p.o. |
2000-11-01 |
2023-08-12 |
rat |
| H Shinotoh, H Namba, K Fukushi, S Nagatsuka, N Tanaka, A Aotsuka, S Tanada, T Iri. Brain acetylcholinesterase activity in Alzheimer disease measured by positron emission tomography. Alzheimer disease and associated disorders. vol 14 Suppl 1. 2000-10-17. PMID:10850739. |
brain acetylcholinesterase activity was measured in 14 patients with alzheimer disease and 14 age-matched control subjects by positron emission tomography with a radioactive acetylcholine analogue. |
2000-10-17 |
2023-08-12 |
human |
| W A Khan, A M Dechkovskaia, E A Herrick, K H Jones, M B Abou-Doni. Acute sarin exposure causes differential regulation of choline acetyltransferase, acetylcholinesterase, and acetylcholine receptors in the central nervous system of the rat. Toxicological sciences : an official journal of the Society of Toxicology. vol 57. issue 1. 2000-10-13. PMID:10966517. |
acute sarin exposure causes differential regulation of choline acetyltransferase, acetylcholinesterase, and acetylcholine receptors in the central nervous system of the rat. |
2000-10-13 |
2023-08-12 |
rat |
| A De Jaco, M A Ajmone-Cat, P Baldelli, E Carbone, G Augusti-Tocco, S Biagion. Modulation of acetylcholinesterase and voltage-gated Na(+) channels in choline acetyltransferase- transfected neuroblastoma clones. Journal of neurochemistry. vol 75. issue 3. 2000-09-12. PMID:10936194. |
we studied the activity, localization, and secretion of acetylcholinesterase in view of its possible role in the modulation of the morphogenetic action of acetylcholine and of its proposed role of a regulator of neurite outgrowth. |
2000-09-12 |
2023-08-12 |
Not clear |
| H Shinotoh, H Namba, K Fukushi, S Nagatsuka, N Tanaka, A Aotsuka, T Ota, S Tanada, T Iri. Progressive loss of cortical acetylcholinesterase activity in association with cognitive decline in Alzheimer's disease: a positron emission tomography study. Annals of neurology. vol 48. issue 2. 2000-08-28. PMID:10939570. |
we measured brain acetylcholinesterase activity in 30 patients with alzheimer's disease (ad) and 14 age-matched controls by positron emission tomography (pet) and using a carbon 11-labeled acetylcholine analogue. |
2000-08-28 |
2023-08-12 |
Not clear |