| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J E Lachowicz, R A Duffy, V Ruperto, J Kozlowski, G Zhou, J Clader, W Billard, H Binch, G Crosby, M Cohen-Williams, C D Strader, V Coffi. Facilitation of acetylcholine release and improvement in cognition by a selective M2 muscarinic antagonist, SCH 72788. Life sciences. vol 68. issue 22-23. 2001-06-21. PMID:11392630. |
current treatment of alzheimer's disease (ad) requires acetylcholinesterase inhibition to increase acetylcholine (ach) concentrations in the synaptic cleft. |
2001-06-21 |
2023-08-12 |
human |
| C R Walker, B W Wilso. Regulation of acetylcholinesterase in cultured muscle by chemical agents and electrical stimulation. Neuroscience. vol 1. issue 3. 2001-06-14. PMID:11370230. |
cultures of 11 day old chick embryo pectoral muscle were used to study the effects of direct electrical stimulation and neurochemicals such as acetylcholine, acetyl-beta-methylcholine, tetrodotoxin, and d-tubocurarine on the acetylcholinesterase levels of muscle. |
2001-06-14 |
2023-08-12 |
chicken |
| C R Walker, B W Wilso. Regulation of acetylcholinesterase in cultured muscle by chemical agents and electrical stimulation. Neuroscience. vol 1. issue 3. 2001-06-14. PMID:11370230. |
tetrodotoxin, acetylcholine and its analog acetyl-beta-methylcholine increased acetylcholinesterase levels and reduced spontaneous contractions. |
2001-06-14 |
2023-08-12 |
chicken |
| N D Volkow, Y S Ding, J S Fowler, S J Gatle. Imaging brain cholinergic activity with positron emission tomography: its role in the evaluation of cholinergic treatments in Alzheimer's dementia. Biological psychiatry. vol 49. issue 3. 2001-06-07. PMID:11230872. |
positron emission tomography is a medical imaging method that can be used to measure the concentration, kinetics, and distribution of cholinergic-enhancing drugs directly in the human brain and assess the effects of the drugs at markers of cholinergic cell viability (vesicular transporters, acetylcholinesterase), at muscarininc and nicotinic receptors, at extracellular acetylcholine, at markers of brain function (glucose metabolism and blood flow), and on amyloid plaque burden in vivo in the brains of patients with alzheimer's disease. |
2001-06-07 |
2023-08-12 |
human |
| A B Belousov, B F O'Hara, J V Denisov. Acetylcholine becomes the major excitatory neurotransmitter in the hypothalamus in vitro in the absence of glutamate excitation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 6. 2001-06-07. PMID:11245685. |
this activity was suppressed with acetylcholine (ach) receptor antagonists and was potentiated by eserine, an inhibitor of acetylcholinesterase, suggesting its cholinergic nature. |
2001-06-07 |
2023-08-12 |
Not clear |
| J Bomser, J E Casid. Activation of extracellular signal-regulated kinases (ERK 44/42) by chlorpyrifos oxon in Chinese hamster ovary cells. Journal of biochemical and molecular toxicology. vol 14. issue 6. 2001-05-31. PMID:11083088. |
acetylcholinesterase inhibition explains most but not all of the toxicological manifestations of exposure to the major organophosphorus insecticide chlorpyrifos (cp) and its metabolically activated form chlorpyrifos oxon (cpo); cpo is also reported to interact with muscarinic acetylcholine receptors and alter secondary messenger status. |
2001-05-31 |
2023-08-12 |
human |
| Z Yingge, B Chunli, W Chen, Z Del. Force spectroscopy between acetylcholine and single acetylcholinesterase molecules and the effects of inhibitors and reactivators studied by atomic force microscopy. The Journal of pharmacology and experimental therapeutics. vol 297. issue 2. 2001-05-21. PMID:11303072. |
force spectroscopy between acetylcholine and single acetylcholinesterase molecules and the effects of inhibitors and reactivators studied by atomic force microscopy. |
2001-05-21 |
2023-08-12 |
Not clear |
| M Samochocki, M Zerlin, R Jostock, P J Groot Kormelink, W H Luyten, E X Albuquerque, A Maelick. Galantamine is an allosterically potentiating ligand of the human alpha4/beta2 nAChR. Acta neurologica Scandinavica. Supplementum. vol 176. 2001-05-17. PMID:11261808. |
originally established as a reversible inhibitor of the acetylcholine-degrading enzyme acetylcholinesterase (ache), galantamine also acts as an allosterically potentiating ligand (apl) on nicotinic acetylcholine receptors (nachr). |
2001-05-17 |
2023-08-12 |
human |
| C Erb, J Troost, S Kopf, U Schmitt, K Löffelholz, H Soreq, J Klei. Compensatory mechanisms enhance hippocampal acetylcholine release in transgenic mice expressing human acetylcholinesterase. Journal of neurochemistry. vol 77. issue 2. 2001-05-17. PMID:11299326. |
compensatory mechanisms enhance hippocampal acetylcholine release in transgenic mice expressing human acetylcholinesterase. |
2001-05-17 |
2023-08-12 |
mouse |
| Y C Hou, P D Chao, S Y Che. Honokiol and magnolol increased hippocampal acetylcholine release in freely-moving rats. The American journal of Chinese medicine. vol 28. issue 3-4. 2001-05-10. PMID:11154051. |
honokiol and magnolol, phenolic compounds isolated from the stem bark of magnolia officinalis, have been demonstrated to increase choline acetyltransferase activity, inhibit acetylcholinesterase, promote potassium-induced acetylcholine release and exhibit neurotrophic function in in vitro studies. |
2001-05-10 |
2023-08-12 |
rat |
| M Barbosa, O Rios, M Velásquez, J Villalobos, J Ehrmann. Acetylcholinesterase and butyrylcholinesterase histochemical activities and tumor cell growth in several brain tumors. Surgical neurology. vol 55. issue 2. 2001-05-10. PMID:11301094. |
the hydrolysis enzymes of the acetylcholine, acetylcholinesterase, and butyrylcholinesterase are involved in non-cholinergic functions such as proliferation processes and cellular adhesion. |
2001-05-10 |
2023-08-12 |
Not clear |
| K V Sharma, C Koenigsberger, S Brimijoin, J W Bigbe. Direct evidence for an adhesive function in the noncholinergic role of acetylcholinesterase in neurite outgrowth. Journal of neuroscience research. vol 63. issue 2. 2001-04-26. PMID:11169626. |
acetylcholinesterase (ache) can promote neurite outgrowth through a mechanism that is independent of its role in hydrolyzing the neurotransmitter acetylcholine. |
2001-04-26 |
2023-08-12 |
Not clear |
| K Gieseler, M C Mariol, C Bessou, M Migaud, C J Franks, L Holden-Dye, L Ségala. Molecular, genetic and physiological characterisation of dystrobrevin-like (dyb-1) mutants of Caenorhabditis elegans. Journal of molecular biology. vol 307. issue 1. 2001-04-26. PMID:11243807. |
we characterised c. elegans dyb-1 mutants and showed that: (1) their behavioural phenotype resembles that of dystrophin (dys-1) mutants; (2) the phenotype of dyb-1 dys-1 double mutants is not different from the single ones; (3) dyb-1 mutants are more sensitive than wild-type animals to reductions of acetylcholinesterase levels and have an increased response to acetylcholine; (4) dyb-1 mutations alone do not lead to muscle degeneration, but synergistically produce a progressive myopathy when combined with a mild myod/hlh-1 mutation. |
2001-04-26 |
2023-08-12 |
caenorhabditis_elegans |
| D S Woodruff-Pak, R W Vogel, G L Wen. Galantamine: effect on nicotinic receptor binding, acetylcholinesterase inhibition, and learning. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 4. 2001-04-19. PMID:11172080. |
the allosterically potentiating ligand galantamine (gal) modulates nicotinic cholinergic receptors to increase acetylcholine release as well as acting as an acetylcholinesterase (ache) inhibitor. |
2001-04-19 |
2023-08-12 |
Not clear |
| H Soreq, S Seidma. Acetylcholinesterase--new roles for an old actor. Nature reviews. Neuroscience. vol 2. issue 4. 2001-04-19. PMID:11283752. |
the discovery of the first neurotransmitter--acetylcholine--was soon followed by the discovery of its hydrolysing enzyme, acetylcholinesterase. |
2001-04-19 |
2023-08-12 |
Not clear |
| A Dekundy, P Blaszczak, R Kaminski, W A Tursk. On the interactions between antimuscarinic atropine and NMDA receptor antagonists in anticholinesterase-treated mice. Archives of toxicology. vol 74. issue 11. 2001-04-12. PMID:11218047. |
both organophosphate (op) and carbamate pesticides may produce seizures and death commonly attributed to the inhibition of acetylcholinesterase (ache) and subsequent excess of acetylcholine (ach). |
2001-04-12 |
2023-08-12 |
mouse |
| M A Benedito, R Camarin. Rapid eye movement sleep deprivation induces an increase in acetylcholinesterase activity in discrete rat brain regions. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 34. issue 1. 2001-04-05. PMID:11151034. |
a previous report showed that 96 h of rem sleep deprivation in rats induced an increase in the activity of brainstem acetylcholinesterase (achase), the enzyme which inactivates acetylcholine (ach) in the synaptic cleft. |
2001-04-05 |
2023-08-12 |
rat |
| A Das, M Dikshit, C Nat. Profile of acetylcholinesterase in brain areas of male and female rats of adult and old age. Life sciences. vol 68. issue 13. 2001-03-29. PMID:11253171. |
inhibition of acetylcholinesterase (ache)-metabolizing enzyme of acetylcholine, is presently the most important therapeutic target for development of cognitive enhancers. |
2001-03-29 |
2023-08-12 |
rat |
| M Guadarrama-Naveda, L C de Cabrera, S Matos-Bastida. Intermediate syndrome secondary to ingestion of chlorpiriphos. Veterinary and human toxicology. vol 43. issue 1. 2001-03-22. PMID:11205075. |
these clinical manifestations occur from liposoluble organophosphates or metabolites with long-lasting half time, causeing delayed inhibition of acetylcholinesterase and subsequent burn out of the neuromuscular junction from acetylcholine overstimulation. |
2001-03-22 |
2023-08-12 |
Not clear |
| M B Skaddan, M R Kilbourn, S E Snyder, P S Sherma. Acetylcholinesterase inhibition increases in vivo N-(2-[18F]fluoroethyl)-4-piperidyl benzilate binding to muscarinic acetylcholine receptors. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 21. issue 2. 2001-03-08. PMID:11176279. |
acetylcholinesterase inhibition increases in vivo n-(2-[18f]fluoroethyl)-4-piperidyl benzilate binding to muscarinic acetylcholine receptors. |
2001-03-08 |
2023-08-12 |
rat |